{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:19:36Z","timestamp":1778631576090,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001776","name":"University of Western Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001776","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973437"],"award-info":[{"award-number":["81973437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274080"],"award-info":[{"award-number":["82274080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jep.2023.116285","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T12:43:00Z","timestamp":1678970580000},"page":"116285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition"],"prefix":"10.1016","volume":"311","author":[{"given":"Ruowei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-4925","authenticated-orcid":false,"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-8158","authenticated-orcid":false,"given":"Xian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116285_bib1","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.4049\/jimmunol.167.12.7077","article-title":"IFN-\u03b3-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes","volume":"167","author":"Bone-Larson","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2023.116285_bib2","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/liv.13866","article-title":"Role and mechanisms of autophagy in acetaminophen\u2010induced liver injury","volume":"38","author":"Chao","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.jep.2023.116285_bib3","first-page":"1","article-title":"Pien Tze Huang (PZH) as a multifunction medicinal agent in traditional Chinese medicine (TCM): a review on cellular, molecular and physiological mechanisms","volume":"21","author":"Chen","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.jep.2023.116285_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2036.2009.04175.x","article-title":"The current management of acute liver failure","volume":"31","author":"Craig","year":"2010","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2023.116285_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13020-020-00311-3","article-title":"Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice","volume":"15","author":"Deng","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116285_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","article-title":"Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential","volume":"10","author":"Du","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2023.116285_bib7","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.3892\/ol.2014.1989","article-title":"Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway","volume":"7","author":"He","year":"2014","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2023.116285_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.580968","article-title":"CD4+ T cells mediate the development of liver fibrosis in high fat diet-induced NAFLD in humanized mice","volume":"11","author":"Her","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2023.116285_bib9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver\u2014from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.116285_bib10","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.3390\/molecules24183274","article-title":"Therapeutic potential of Pien-Tze-Huang: a review on its chemical composition, pharmacology, and clinical application","volume":"24","author":"Huang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116285_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jchromb.2016.05.021","article-title":"Identification and quantification of the anti-inflammatory constituents in Pian-Tze-Huang by liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometry","volume":"1027","author":"Huang","year":"2016","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2023.116285_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111814","article-title":"Pien-Tze-Huang, a Chinese patent formula, attenuates NLRP3 inflammasome-related neuroinflammation by enhancing autophagy via the AMPK\/mTOR\/ULK1 signaling pathway","volume":"141","author":"Huang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116285_bib13","first-page":"305","article-title":"Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome","volume":"119","author":"Imaeda","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2023.116285_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep39075","article-title":"NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis","volume":"6","author":"Itani","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116285_bib15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/toxsci\/kfaa002","article-title":"Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure","volume":"174","author":"Jaeschke","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jep.2023.116285_bib16","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.1021\/acs.jafc.0c01901","article-title":"Ferulic acid inactivates Shigella flexneri through cell membrane destruction, biofilm retardation, and altered gene expression","volume":"68","author":"Kang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116285_bib17","doi-asserted-by":"crossref","first-page":"62040","DOI":"10.1039\/C5RA07838E","article-title":"Pathways involved in acetaminophen hepatotoxicity with specific targets for inhibition\/downregulation","volume":"5","author":"Karthivashan","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2023.116285_bib18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bcp.2018.05.014","article-title":"Globular adiponectin protects rat hepatocytes against acetaminophen-induced cell death via modulation of the inflammasome activation and ER stress: critical role of autophagy induction","volume":"154","author":"Kim","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2023.116285_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mayocp.2013.09.016","article-title":"Drug-induced liver injury","volume":"89","author":"Leise","year":"2014","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.jep.2023.116285_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113076","article-title":"The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease","volume":"151","author":"Lian","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116285_bib21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.intimp.2014.02.009","article-title":"Protective effect of tormentic acid from Potentilla chinensis against lipopolysaccharide\/D-galactosamine induced fulminant hepatic failure in mice","volume":"19","author":"Lin","year":"2014","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2023.116285_bib22","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1039\/C8FO01078A","article-title":"Polydatin protects against acetaminophen-induced hepatotoxicity in mice via anti-oxidative and anti-apoptotic activities","volume":"9","author":"Liu","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116285_bib23","series-title":"Public Health Service Policy on Humane Care and Use of Laboratory Animals","year":"1986"},{"key":"10.1016\/j.jep.2023.116285_bib24","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1177\/0271678X20943823","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"40","author":"Percie du Sert","year":"2020","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.jep.2023.116285_bib25","series-title":"Pharmacopoeia of the People's Republic of China (Part I)","first-page":"963","year":"2020"},{"key":"10.1016\/j.jep.2023.116285_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113643","article-title":"Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3 inflammasome activation","volume":"169","author":"Shan","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2023.116285_bib27","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3892\/ijo.2014.2772","article-title":"Pien Tze Huang inhibits metastasis of human colorectal carcinoma cells via modulation of TGF-\u03b21\/ZEB\/miR-200 signaling network","volume":"46","author":"Shen","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jep.2023.116285_bib28","doi-asserted-by":"crossref","first-page":"9715","DOI":"10.1007\/s11033-012-1836-0","article-title":"Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"39","author":"Shi","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2023.116285_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2020.107397","article-title":"Homotherapy for heteropathy active components and mechanisms of Qiang-Huo-Sheng-Shi decoction for treatment of rheumatoid arthritis and osteoarthritis","volume":"89","author":"Shi","year":"2020","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.jep.2023.116285_bib30","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.3892\/etm.2017.4972","article-title":"Pien Tze Huang inhibits the proliferation of colorectal cancer cells by increasing the expression of miR-34c-5p","volume":"14","author":"Wan","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2023.116285_bib31","article-title":"Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2023.116285_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41401-021-00641-4","article-title":"Sapidolide A alleviates acetaminophen-induced acute liver injury by inhibiting NLRP3 inflammasome activation in macrophages","volume":"43","author":"Wang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2023.116285_bib33","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1039\/D0FO02894K","article-title":"Protective effect of Que Zui tea hot-water and aqueous ethanol extract against acetaminophen-induced liver injury in mice via inhibition of oxidative stress, inflammation, and apoptosis","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116285_bib34","first-page":"289","article-title":"Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury","volume":"252","author":"Williams","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.116285_bib35","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jhep.2016.11.017","article-title":"Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure","volume":"66","author":"Woolbright","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.116285_bib36","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/iub.2625","article-title":"Ferulic acid ameliorates acetaminophen\u2010induced acute liver injury by promoting AMPK\u2010mediated protective autophagy","volume":"74","author":"Wu","year":"2022","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jep.2023.116285_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.601716","article-title":"Cardamonin reduces acetaminophen-induced acute liver injury in mice via activating autophagy and NFE2L2 signaling","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116285_bib38","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2023.116285_bib39","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1039\/c3fo60071h","article-title":"Protective effect of apigenin on mouse acute liver injury induced by acetaminophen is associated with increment of hepatic glutathione reductase activity","volume":"4","author":"Yang","year":"2013","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116285_bib40","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.acthis.2018.06.006","article-title":"Pien Tze Huang ameliorates liver injury by inhibiting the PERK\/eIF2\u03b1 signaling pathway in alcohol and high-fat diet rats","volume":"120","author":"Yang","year":"2018","journal-title":"Acta Histochem."},{"key":"10.1016\/j.jep.2023.116285_bib41","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3389\/fphar.2020.00162","article-title":"Fisetin prevents acetaminophen-induced liver injury by promoting autophagy","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116285_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-8546-5-1","article-title":"Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke","volume":"5","author":"Zhang","year":"2010","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116285_bib43","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature10510","article-title":"The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus","volume":"477","author":"Zhao","year":"2011","journal-title":"Nature"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123001538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123001538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:54:55Z","timestamp":1778630095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123001538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":43,"alternative-id":["S0378874123001538"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116285","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116285","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116285"}}