{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:03:33Z","timestamp":1783577013600,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004572","name":"National Health Commission of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jep.2023.116405","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T07:32:06Z","timestamp":1679643126000},"page":"116405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["A proteoglycan isolated from Ganoderma lucidum attenuates diabetic kidney disease by inhibiting oxidative stress-induced renal fibrosis both in vitro and in vivo"],"prefix":"10.1016","volume":"310","author":[{"given":"Yanna","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-7655","authenticated-orcid":false,"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2023.116405_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/jcp.2005.035592","article-title":"Distinguishing diabetic nephropathy from other causes of glomerulosclerosis: an update","volume":"60","author":"Alsaad","year":"2007","journal-title":"J. Clin. Pathol."},{"issue":"12A","key":"10.1016\/j.jep.2023.116405_bib2","doi-asserted-by":"crossref","first-page":"10L","DOI":"10.1016\/j.amjcard.2008.09.068","article-title":"Microvascular complications of diabetes mellitus: renal protection accompanies cardiovascular protection","volume":"102","author":"Brown","year":"2008","journal-title":"Am. J. Cardiol."},{"issue":"5\u20136","key":"10.1016\/j.jep.2023.116405_bib3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1089\/ars.2006.8.691","article-title":"NADPH oxidases in cardiovascular health and disease","volume":"8","author":"Cave","year":"2006","journal-title":"Antioxidants Redox Signal."},{"issue":"4","key":"10.1016\/j.jep.2023.116405_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/labinvest.2017.2","article-title":"APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db\/db mice from renal injury","volume":"97","author":"Cha","year":"2017","journal-title":"Lab. Invest.; J. Tech. Method. Pathol."},{"issue":"7","key":"10.1016\/j.jep.2023.116405_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10071080","article-title":"Rice husk silica liquid protects pancreatic \u03b2 cells from streptozotocin-induced oxidative damage","volume":"10","author":"Chen","year":"2021","journal-title":"Antioxidants"},{"issue":"2\u20133","key":"10.1016\/j.jep.2023.116405_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1900\/RDS.2013.10.88","article-title":"Dyslipidemia, kidney disease, and cardiovascular disease in diabetic patients","volume":"10","author":"Chen","year":"2013","journal-title":"Rev. Diabet. Stud. : Reg. Dev. Stud."},{"key":"10.1016\/j.jep.2023.116405_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"9","key":"10.1016\/j.jep.2023.116405_bib8","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1681\/ASN.V891405","article-title":"Effects of supplementation with vitamin C or E on albuminuria, glomerular TGF-beta, and glomerular size in diabetes","volume":"8","author":"Craven","year":"1997","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jep.2023.116405_bib9","article-title":"Quercetin inhibited mesangial cell proliferation of early diabetic nephropathy through the Hippo pathway","volume":"146","author":"Du","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.jep.2023.116405_bib10","first-page":"85","article-title":"Autologous transplantation of adipose-derived mesenchymal stem cells ameliorates streptozotocin-induced diabetic nephropathy in rats by inhibiting oxidative stress, pro-inflammatory cytokines and the p38 MAPK signaling pathway","volume":"30","author":"Fang","year":"2012","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.jep.2023.116405_bib11","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bbadis.2016.01.001","article-title":"High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt\/beta-catenin and p38 MAPK","volume":"1862","author":"Gilardini Montani","year":"2016","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.jep.2023.116405_bib12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s00125-007-0837-3","article-title":"Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells","volume":"51","author":"Giunti","year":"2008","journal-title":"Diabetologia"},{"issue":"7\u20138","key":"10.1016\/j.jep.2023.116405_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/CS20130065","article-title":"Nox as a target for diabetic complications","volume":"125","author":"Gorin","year":"2013","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.jep.2023.116405_bib14","first-page":"1457","article-title":"Effects of rebamipide in a model of experimental diabetes and on the synthesis of transforming growth factor-beta and fibronectin, and lipid peroxidation induced by high glucose in cultured mesangial cells","volume":"281","author":"Ha","year":"1997","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jep.2023.116405_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2018.02.013","article-title":"Reactive oxygen species promote tubular injury in diabetic nephropathy: the role of the mitochondrial ros-txnip-nlrp3 biological axis","volume":"16","author":"Han","year":"2018","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.jep.2023.116405_bib16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1046\/j.1523-1755.2001.059002702.x","article-title":"Progression of diabetic nephropathy","volume":"59","author":"Hovind","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2023.116405_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4314415","article-title":"Effects and mechanism of Ganoderma lucidum polysaccharides in the treatment of diabetic nephropathy in streptozotocin-induced diabetic rats","volume":"2022","author":"Hu","year":"2022","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2023.116405_bib18","first-page":"82","volume":"12","author":"Huang","year":"2021"},{"issue":"1","key":"10.1016\/j.jep.2023.116405_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ki.2008.128","article-title":"Proteinuria in diabetic kidney disease: a mechanistic viewpoint","volume":"74","author":"Jefferson","year":"2008","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.jep.2023.116405_bib20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3109\/0886022X.2015.1068031","article-title":"Role of ERK1\/2 and JNK phosphorylation in iodine contrast agent-induced apoptosis in diabetic rat kidneys","volume":"37","author":"Jiao","year":"2015","journal-title":"Ren. Fail."},{"issue":"7","key":"10.1016\/j.jep.2023.116405_bib21","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1681\/ASN.V571483","article-title":"The expression of NADPH oxidase components in human glomerular mesangial cells-detection of protein and messenger-RNA for p47phox, p67phox, and p22phox","volume":"5","author":"Jones","year":"1995","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.jep.2023.116405_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3181\/0705-MR-134","article-title":"Diabetic nephropathy: mechanisms of renal disease progression","volume":"233","author":"Kanwar","year":"2008","journal-title":"Exp. Biol. Med."},{"issue":"8","key":"10.1016\/j.jep.2023.116405_bib23","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.2337\/diabetes.49.8.1381","article-title":"Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats","volume":"49","author":"Lal","year":"2000","journal-title":"Diabetes"},{"issue":"20","key":"10.1016\/j.jep.2023.116405_bib24","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1021\/acs.jafc.9b00540","article-title":"Arginyl-fructosyl-glucose, a major maillard reaction product of red ginseng, attenuates cisplatin-induced acute kidney injury by regulating nuclear factor kappa B and phosphatidylinositol 3-kinase\/protein kinase B signaling pathways","volume":"67","author":"Li","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116405_bib25","first-page":"581","volume":"202","author":"Li","year":"2018"},{"issue":"10","key":"10.1016\/j.jep.2023.116405_bib26","doi-asserted-by":"crossref","first-page":"8294","DOI":"10.3390\/nu7105395","article-title":"Anti-tumor effect of steamed codonopsis lanceolata in H22 tumor-bearing mice and its possible mechanism","volume":"7","author":"Li","year":"2015","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jep.2023.116405_bib27","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1080\/09168451.2020.1805718","article-title":"A proteoglycan extract from Ganoderma Lucidum protects pancreatic beta-cells against STZ-induced apoptosis","volume":"84","author":"Liang","year":"2020","journal-title":"Biosci., Biotechnol., Biochem."},{"key":"10.1016\/j.jep.2023.116405_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-13-9867-4_1","article-title":"Ganoderma (lingzhi) in traditional Chinese medicine and Chinese culture","volume":"1181","author":"Lin","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jep.2023.116405_bib29","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.redox.2015.09.009","article-title":"Reciprocal regulation of TGF-beta and reactive oxygen species: a perverse cycle for fibrosis","volume":"6","author":"Liu","year":"2015","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.jep.2023.116405_bib30","doi-asserted-by":"crossref","first-page":"F414","DOI":"10.1152\/ajprenal.00393.2016","article-title":"Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-kappa B-TNF-alpha and TGF-beta 1-MAPK-fibronectin pathways","volume":"313","author":"Malik","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jep.2023.116405_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2022.100152","article-title":"Ganoderma Lucidum Polysaccharide Peptide attenuates post myocardial infarction fibrosis via down-regulating TGF-\u03b21\/SMAD and relieving oxidative stress","volume":"4","author":"Meng","year":"2022","journal-title":"Pharmacological Research - Modern Chinese Medicine"},{"issue":"3","key":"10.1016\/j.jep.2023.116405_bib32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/ATVBAHA.107.157339","article-title":"Oleate induces a myofibroblast-like phenotype in mesangial cells","volume":"28","author":"Mishra","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.jep.2023.116405_bib33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1681\/ASN.2007091048","article-title":"The role of inflammatory cytokines in diabetic nephropathy","volume":"19","author":"Navarro-Gonz\u00e1lez","year":"2008","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.jep.2023.116405_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.carbpol.2014.09.051","article-title":"Isolation and characterization of a hyperbranched proteoglycan from Ganoderma Lucidum for anti-diabetes","volume":"117","author":"Pan","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2023.116405_bib35","first-page":"111","volume":"63","author":"Pan","year":"2014"},{"key":"10.1016\/j.jep.2023.116405_bib36","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ijbiomac.2022.01.044","article-title":"Antioxidation of a proteoglycan from Ganoderma lucidum protects pancreatic beta-cells against oxidative stress-induced apoptosis in vitro and in vivo","volume":"200","author":"Pan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.jep.2023.116405_bib37","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1074\/mcp.M800558-MCP200","article-title":"Urinary protein profiles in a rat model for diabetic complications","volume":"8","author":"Schlatzer","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"issue":"6","key":"10.1016\/j.jep.2023.116405_bib38","doi-asserted-by":"crossref","first-page":"F1348","DOI":"10.1152\/ajprenal.00028.2010","article-title":"Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy","volume":"299","author":"Sedeek","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2023.116405_bib39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/CS20120330","article-title":"Renoprotective effects of a novel Nox1\/4 inhibitor in a mouse model of Type 2 diabetes","volume":"124","author":"Sedeek","year":"2013","journal-title":"Clinic. Sci."},{"issue":"1\u20132","key":"10.1016\/j.jep.2023.116405_bib40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1359-6101(99)00035-0","article-title":"TGF-beta in diabetic kidney disease: role of novel signaling pathways","volume":"11","author":"Sharma","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"issue":"3\u20134","key":"10.1016\/j.jep.2023.116405_bib41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1142\/S0192415X01000526","article-title":"Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice","volume":"29","author":"Shieh","year":"2001","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2023.116405_bib42","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nrendo.2010.212","article-title":"Oxidative stress in early diabetic nephropathy: fueling the fire","volume":"7","author":"Singh","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jep.2023.116405_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2016.06.004","article-title":"miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy","volume":"433","author":"Sun","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.jep.2023.116405_bib45","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.semnephrol.2007.01.006","article-title":"AGE, RAGE, and ROS in diabetic nephropathy","volume":"27","author":"Tan","year":"2007","journal-title":"Semin. Nephrol."},{"issue":"12","key":"10.1016\/j.jep.2023.116405_bib46","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.1021\/jf200527y","article-title":"A protein tyrosine phosphatase 1B activity inhibitor from the fruiting bodies of Ganoderma lucidum (Fr.) karst and its hypoglycemic potency on streptozotocin-induced type 2 diabetic mice","volume":"59","author":"Teng","year":"2011","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.jep.2023.116405_bib47","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1517\/14728222.11.8.1011","article-title":"Suppressing renal NADPH oxidase to treat diabetic nephropathy","volume":"11","author":"Tojo","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"issue":"2","key":"10.1016\/j.jep.2023.116405_bib48","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1006\/mvre.1994.1068","article-title":"VITAMIN-E prevents glucose-induced lipid-peroxidation and increased collagen production in cultured rat mesangial cells","volume":"47","author":"Trachtman","year":"1994","journal-title":"Microvasc. Res."},{"issue":"2","key":"10.1016\/j.jep.2023.116405_bib49","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1006\/bbrc.1993.1282","article-title":"Taurine prevents glucose-induced lipid-peroxidation and increased collagen production in cultured rat mesangial cells","volume":"191","author":"Trachtman","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2023.116405_bib50","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.ejmech.2016.11.015","article-title":"A novel class of \u03b1-glucosidase and HMG-CoA reductase inhibitors from ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-Ay mice","volume":"127","author":"Wang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2023.116405_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2022.105257","article-title":"Meroterpenoids with a large conjugated system from Ganoderma lucidum and their inhibitory activities against renal fibrosis","volume":"161","author":"Wang","year":"2022","journal-title":"Fitoterapia"},{"issue":"10075","key":"10.1016\/j.jep.2023.116405_bib52","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jep.2023.116405_bib53","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ki.1992.330","article-title":"High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta","volume":"42","author":"Wolf","year":"1992","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2023.116405_bib54","volume":"8","author":"Wu","year":"2013"},{"issue":"6","key":"10.1016\/j.jep.2023.116405_bib55","doi-asserted-by":"crossref","first-page":"F1622","DOI":"10.1152\/ajprenal.00078.2009","article-title":"Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells","volume":"297","author":"Wu","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.jep.2023.116405_bib56","volume":"63","author":"Xie","year":"2019"},{"issue":"1\u20132","key":"10.1016\/j.jep.2023.116405_bib57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mce.2013.01.007","article-title":"Activation of RhoA\/ROCK regulates NF-kappa B signaling pathway in experimental diabetic nephropathy","volume":"369","author":"Xie","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jep.2023.116405_bib58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.lfs.2021.119068","article-title":"Astragaloside IV protects against podocyte apoptosis by inhibiting oxidative stress via activating PPAR gamma-Klotho-FoxO1 axis in diabetic nephropathy","volume":"269","author":"Xing","year":"2021","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.jep.2023.116405_bib59","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2174\/138945007782151298","article-title":"Kinetics, role and therapeutic implications of endogenous soluble form of receptor for advanced glycation end products (sRAGE) in diabetes","volume":"8","author":"Yamagishi","year":"2007","journal-title":"Curr. Drug Targets"},{"issue":"3","key":"10.1016\/j.jep.2023.116405_bib60","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.phrs.2009.01.006","article-title":"Regulation of advanced glycation end product (AGE)-receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease","volume":"60","author":"Yamagishi","year":"2009","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.jep.2023.116405_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110319","article-title":"Liquidambaric acid inhibits Wnt\/\u03b2-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2","volume":"38","author":"Yan","year":"2022","journal-title":"Cell Rep."},{"issue":"20","key":"10.1016\/j.jep.2023.116405_bib62","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1016\/j.yexcr.2013.10.006","article-title":"Emodin attenuates high glucose-induced TGF-beta 1 and fibronectin expression in mesangial cells through inhibition of NF-kappa B pathway","volume":"319","author":"Yang","year":"2013","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.jep.2023.116405_bib63","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.yexcr.2016.06.005","article-title":"Berberine attenuates high glucose-induced fibrosis by activating the G protein-coupled bile acid receptor TGR5 and repressing the S1P2\/MAPK signaling pathway in glomerular mesangial cells","volume":"346","author":"Yang","year":"2016","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.jep.2023.116405_bib64","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1254\/jphs.FP0050041","article-title":"The antioxidative effects of Astragalus saponin I protect against development of early diabetic nephropathy","volume":"101","author":"Yin","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2023.116405_bib65","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2147\/DDDT.S162288","article-title":"Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK\/NF-kappa B signaling pathways in diabetic nephropathy","volume":"12","author":"Zhang","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"issue":"14","key":"10.1016\/j.jep.2023.116405_bib67","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1073\/pnas.120055097","article-title":"Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db\/db diabetic mice","volume":"97","author":"Ziyadeh","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"13","key":"10.1016\/j.jep.2023.116405_bib68","first-page":"3590","article-title":"Transforming growth factor-beta-1 induces cachexia and systemic fibrosis without an antitumor effect in nude-mice","volume":"51","author":"Zugmaier","year":"1991","journal-title":"Cancer Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123002738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123002738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:58:56Z","timestamp":1736402336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123002738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":66,"alternative-id":["S0378874123002738"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116405","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A proteoglycan isolated from Ganoderma lucidum attenuates diabetic kidney disease by inhibiting oxidative stress-induced renal fibrosis both in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116405"}}