{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:10:41Z","timestamp":1778551841636,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jep.2023.116477","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T00:12:02Z","timestamp":1680912722000},"page":"116477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Inhibitory effect of hydroalcoholic extract of Cunila spicata Benth. on phlogistic agents-induced cellular migration in the airways of mice"],"prefix":"10.1016","volume":"311","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-9236","authenticated-orcid":false,"given":"Valfredo","family":"Schlemper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1211-3585","authenticated-orcid":false,"given":"Caroline Baldessar","family":"Dal Molin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Frankenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maique Weber","family":"Biavatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana Regina","family":"de Mello Schlemper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116477_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1590\/S1516-89132009000200026","article-title":"Essential oil yield and composition of Lamiaceae species growing in Southern Brazil","volume":"52","author":"Agostini","year":"2009","journal-title":"Braz. Arch. Biol. Technol."},{"key":"10.1016\/j.jep.2023.116477_bib2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00436-009-1455-4","article-title":"Chemical composition and toxicity of the essential oils from Cunila species (Lamiaceae) on the cattle tick Rhipicephalus (Boophilus) microplus","volume":"105","author":"Apel","year":"2009","journal-title":"Parasitol. Res. J."},{"key":"10.1016\/j.jep.2023.116477_bib3","doi-asserted-by":"crossref","DOI":"10.1111\/vde.12754","article-title":"Dose-dependent pruritogenic and inflammatory effects of intradermal injections of histamine, compound 48\/80 and anti-canine IgE in healthy dogs","volume":"30","author":"Banovic","year":"2019","journal-title":"Vet. Dermatol."},{"key":"10.1016\/j.jep.2023.116477_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejphar.2013.08.033","article-title":"Reduction of carrageenan-induced acute pulmonary inflammation in mice by novel thiazolidinedione derivative LPSF\/RA-4","volume":"15","author":"Barbosa","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116477_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-4269-3-32","article-title":"The use of zootherapeutics in folk veterinary medicine in the district of Cubati, Para\u00edba State, Brazil","volume":"3","author":"Barboza","year":"2007","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2023.116477_bib6","article-title":"Effects of aliskiren, an RAAS inhibitor, on a carrageenan-induced pleurisy model of rats","volume":"9","author":"Bayir","year":"2019","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.jep.2023.116477_bib7","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1172\/JCI26150","article-title":"The H1 histamine receptor regulates allergic lung responses","volume":"116","author":"Bryce","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2023.116477_bib8","series-title":"Hematologia e Bioqu\u00edmica Cl\u00ednica Veterin\u00e1ria","article-title":"Hematologia de mam\u00edferos: animais de laborat\u00f3rio e esp\u00e9cies variadas","author":"Campbell","year":"2006"},{"key":"10.1016\/j.jep.2023.116477_bib9","article-title":"Caminho das Tropas: a import\u00e2ncia da preserva\u00e7\u00e3o hist\u00f3rica e cultural como meio de preserva\u00e7\u00e3o ambiental no Vale do Para\u00edba","volume":"1","author":"Carpegeani","year":"2009","journal-title":"Rev. Ci\u00eanc. Hum. Unitau"},{"key":"10.1016\/j.jep.2023.116477_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1365-2567.2005.02148.x","article-title":"Increased carrageenan-induced acute lung inflammation in old rats","volume":"115","author":"Corsini","year":"2005","journal-title":"Immunol."},{"key":"10.1016\/j.jep.2023.116477_bib11","series-title":"Dicion\u00e1rio das plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas","author":"Corr\u00eaa","year":"1984"},{"key":"10.1016\/j.jep.2023.116477_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0024-3205(01)01387-X","article-title":"Additional evidence for the anti-inflammatory and anti-allergic properties of the sesquiterpene polygodial","volume":"70","author":"Cunha","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2023.116477_bib13","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1096\/fj.00-0526hyp","article-title":"Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat","volume":"15","author":"Cuzzocrea","year":"2001","journal-title":"Faseb. J."},{"key":"10.1016\/j.jep.2023.116477_bib14","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.4049\/jimmunol.176.11.7062","article-title":"The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells","volume":"176","author":"Dunford","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2023.116477_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10384-005-0314-9","article-title":"Disodium cromoglycate inhibits capsaicin-induced eosinophil infiltration of conjunctiva independent of mast cells","volume":"50","author":"Ebihara","year":"2006","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.jep.2023.116477_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/10412905.2009.9700159","article-title":"Chemical variations on the essential oils of Cunila spicata Benth. (Lamiaceae), an aromatic and medicinal plant from South Brazil","volume":"21","author":"Echeverrigaray","year":"2009","journal-title":"J. Essent. Oil Res."},{"key":"10.1016\/j.jep.2023.116477_bib17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1189\/jlb.1205744","article-title":"Activation of kinin B1 receptors induces chemotaxis of human neutrophils","volume":"80","author":"Ehrenfeld","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jep.2023.116477_bib18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.aller.2014.10.005","article-title":"Peripheral blood mononuclear cells from severe asthmatic children release lower amounts of IL-12 and IL-4 after LPS stimulation","volume":"43","author":"Falcai","year":"2015","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.jep.2023.116477_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1010626200045","article-title":"Micropropagation of Cunila galioides, a popular medicinal plant of south Brazil","volume":"64","author":"Fracaro","year":"2001","journal-title":"Plant Cell Tissue Organ Cult."},{"key":"10.1016\/j.jep.2023.116477_bib20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00418-015-1332-4","article-title":"Pretreatment with Evans blue, a stimulator of BK (Ca) channels, inhibits compound 48\/80-induced shock, systemic inflammation, and mast cell degranulation in the rat","volume":"144","author":"Fu","year":"2015","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jep.2023.116477_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.22579\/20112629.364","article-title":"Efeito do estresse pr\u00e9-natal na regula\u00e7\u00e3o da inflama\u00e7\u00e3o al\u00e9rgica pulmonar no modelo murino de asma experimental","volume":"20","author":"Gon\u00e7alves","year":"2016","journal-title":"Rev. Orinoquia"},{"key":"10.1016\/j.jep.2023.116477_bib22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1590\/S0074-02762002000700017","article-title":"Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases","volume":"97","author":"Holetz","year":"2002","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.jep.2023.116477_bib23","first-page":"1","article-title":"Histamine in chronic allergic responses","volume":"15","author":"Jutel","year":"2005","journal-title":"J Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.jep.2023.116477_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2332\/allergolint.11-OA-0307","article-title":"Niflumic acid inhibits goblet cell degranulation in a Guinea pig asthma model","volume":"61","author":"Kondo","year":"2012","journal-title":"Allergol. Int."},{"key":"10.1016\/j.jep.2023.116477_bib25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1124\/jpet.103.061739","article-title":"A nitric oxide-releasing salbutamol elicits potent relaxant and anti-inflammatory activities","volume":"310","author":"Lagente","year":"2004","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jep.2023.116477_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-2999(02)02880-7","article-title":"Differential modulation of murine lung inflammation by bradykinin B1 and B2 selective receptor antagonists","volume":"460","author":"Landgraf","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116477_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/02770903.2018.1544641","article-title":"Effect of nintedanib on airway inflammation in a mouse model of acute asthma","volume":"57","author":"Lee","year":"2020","journal-title":"J. Asthma"},{"key":"10.1016\/j.jep.2023.116477_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/pr.57.1.2","article-title":"International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences","volume":"57","author":"Leeb-Lundberg","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jep.2023.116477_bib29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000237250","article-title":"Compound 48\/80-induced conjunctivitis in the mouse: kinetics, susceptibility, and mechanism","volume":"109","author":"Li","year":"1996","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.jep.2023.116477_bib30","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0031-9422(96)00726-1","article-title":"The essential oil composition of Cunila microcephala and Cunila fasciculata","volume":"44","author":"Loreto-Bordignon","year":"1997","journal-title":"Phytochemistry (Elsevier)"},{"key":"10.1016\/j.jep.2023.116477_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0300-483X(94)90220-8","article-title":"Effects of menthofuran, a monoterpene furan on rat liver microsomal enzymes","volume":"89","author":"Madyastha","year":"1994","journal-title":"in vivo. Toxicol"},{"key":"10.1016\/j.jep.2023.116477_bib32","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0031-9422(95)00108-J","article-title":"Linalool and cineole type glucosides from Cunila spicata","volume":"39","author":"Manns","year":"1995","journal-title":"Phytochemistry (Elsevier)"},{"key":"10.1016\/j.jep.2023.116477_bib33","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1055\/s-2006-959534","article-title":"Monoterpene glucosides fromCunila spicata","volume":"60","author":"Manns","year":"1994","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2023.116477_bib34","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.indcrop.2017.09.063","article-title":"Summer savory extracts prepared by novel extraction methods resulted in enhanced biological activity","volume":"109","author":"Ma\u0161kovi\u0107","year":"2017","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2023.116477_bib35","series-title":"Povos e Comunidades Tradicionais do Pampa","author":"Mazurana","year":"2016"},{"key":"10.1016\/j.jep.2023.116477_bib36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1590\/S0102-86502011000600013","article-title":"Methylene blue administration in the compound 48\/80-induced anaphylactic shock: hemodynamic study in pigs","volume":"26","author":"Menardi","year":"2011","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.jep.2023.116477_bib37","first-page":"76","article-title":"Metodologia aplicada a levantamentos etnoveterin\u00e1rios","volume":"9","author":"Monteiro","year":"2011","journal-title":"Vet. Foco"},{"key":"10.1016\/j.jep.2023.116477_bib38","first-page":"115","article-title":"Carrageenan-induced paw edema in the rat and mouse","volume":"225","author":"Morris","year":"2003","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2023.116477_bib39","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1590\/S0034-72802011000500004","article-title":"Efeito do dinitrato de isossorbida sobre a hiperalgesia corneana induzida por lipopolissacar\u00eddeo","volume":"70","author":"Paula","year":"2011","journal-title":"Rev. Bras. Oftalmol."},{"key":"10.1016\/j.jep.2023.116477_bib41","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3390\/molecules16021253","article-title":"Chemical and pharmacological aspects of capsaicin","volume":"16","author":"Reyes-Escogido","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116477_bib42","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1007\/s00213-018-5034-1","article-title":"Effect of cannabidiolic acid and \u03949 -tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain","volume":"235","author":"Rock","year":"2018","journal-title":"Psychopharmacol."},{"key":"10.1016\/j.jep.2023.116477_bib43","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.foodchem.2006.09.032","article-title":"Antimicrobial activity of the essential oils of Brazilian species of the genus Cunila against foodborne pathogens and spoiling bacteria","volume":"103","author":"Sandri","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116477_bib44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jep.2013.08.035","article-title":"Antiedematogenic effects of the polar fractions of Persea cordata Mez. (Lauraceae) on microvascular extravasation in rat skin","volume":"150","author":"Schlemper","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116477_bib45","series-title":"Plantas da medicina popular do Rio Grande do Sul","author":"Sim\u00f5es","year":"1994"},{"key":"10.1016\/j.jep.2023.116477_bib46","series-title":"Adverse Effects of Herbal Drugs","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-49340-9","author":"Smett","year":"1992"},{"key":"10.1016\/j.jep.2023.116477_bib47","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1590\/S0004-282X1970000100011","article-title":"C\u00e2maras de sedimenta\u00e7\u00e3o no estudo otol\u00f3gico do l\u00edquido cefalorraqueano","volume":"28","author":"Spina-Fran\u00e7a","year":"1970","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/j.jep.2023.116477_bib48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","article-title":"Silencing nociceptor neurons reduces allergic airway inflammation","volume":"87","author":"Talbot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.jep.2023.116477_bib49","first-page":"351","article-title":"Volatile constituents from aerial parts of Cunila spicata","volume":"13","author":"van Baren","year":"2001","journal-title":"JEOR"},{"key":"10.1016\/j.jep.2023.116477_bib50","first-page":"298","article-title":"El g\u00e9nero Cunila (Lamiaceae, Mentheae) en Argentina","volume":"44","author":"Xifreda","year":"2006","journal-title":"Darwiniana"},{"key":"10.1016\/j.jep.2023.116477_bib51","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3390\/ijms20071733","article-title":"The role of histamine in the pathophysiology of asthma and the clinical efficacy of antihistamines in asthma therapy","volume":"20","author":"Yamauchi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116477_bib52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2018.08.015","article-title":"Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1\/NRF2 pathway in rats","volume":"5","author":"Yang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116477_bib53","article-title":"Anti-inflammatory and antinociceptive effects of Curcuma kwangsiensis and its bioactive terpenoids in vivo and in vitro","volume":"15","author":"Yuan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116477_bib54","article-title":"Diallyl disulfide suppresses inflammatory and oxidative machineries following carrageenan injection-induced paw edema in mice","volume":"15","author":"Zhang","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2023.116477_bib55","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pbb.2013.02.014","article-title":"Chronic psychological stress exaggerates the compound 48\/80-induced scratching behavior of mice","volume":"105","author":"Zhao","year":"2013","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123003458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123003458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:00:41Z","timestamp":1736402441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123003458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":54,"alternative-id":["S0378874123003458"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116477","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitory effect of hydroalcoholic extract of Cunila spicata Benth. on phlogistic agents-induced cellular migration in the airways of mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116477"}}