{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:55:32Z","timestamp":1783529732705,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174125"],"award-info":[{"award-number":["82174125"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jep.2023.116487","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T15:31:51Z","timestamp":1681313511000},"page":"116487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Zuojinwan ameliorates CUMS-induced depressive-like behavior through inducing ubiquitination of MyD88 via SPOP\/MyD88\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"312","author":[{"given":"Weiwei","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunhan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jep.2023.116487_bib1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1001\/jamapsychiatry.2013.1111","article-title":"Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study","volume":"70","author":"Benros","year":"2013","journal-title":"JAMA Psychiatr."},{"issue":"2","key":"10.1016\/j.jep.2023.116487_bib2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The bidirectional relationship of depression and inflammation: double trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.jep.2023.116487_bib3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/01616412.2020.1866353","article-title":"Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4\/MyD88\/NF-\u03baB signaling pathway in mice","volume":"43","author":"Bi","year":"2021","journal-title":"Neurol. Res."},{"key":"10.1016\/j.jep.2023.116487_bib4","article-title":"Integrated microbiome-metabolomics analysis reveals the potential therapeutic mechanism of Zuo-Jin-Wan in ulcerative colitis","volume":"98","author":"Cai","year":"2021","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2009.09.002","article-title":"Cytokines and CNS development","volume":"64","author":"Deverman","year":"2009","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41398-020-0808-8","article-title":"Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus","volume":"10","author":"Du","year":"2020","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/npp.2016.125","article-title":"Danger signals and inflammasomes: stress-evoked sterile inflammation in mood disorders","volume":"42","author":"Fleshner","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"13","key":"10.1016\/j.jep.2023.116487_bib8","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1038\/s41386-019-0501-x","article-title":"N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects","volume":"44","author":"Foga\u00e7a","year":"2019","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.jep.2023.116487_bib9","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/mp.2016.3","article-title":"A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression","volume":"21","author":"Goldsmith","year":"2016","journal-title":"Mol. Psychiatr."},{"issue":"9","key":"10.1016\/j.jep.2023.116487_bib10","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/s41590-019-0454-6","article-title":"The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation","volume":"20","author":"Guillamot","year":"2019","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12974-019-1474-8","article-title":"Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K\/AKT\/FoxO1 pathway","volume":"16","author":"Guo","year":"2019","journal-title":"J. Neuroinflammat."},{"issue":"7","key":"10.1016\/j.jep.2023.116487_bib12","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1038\/s41423-020-0411-1","article-title":"SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association","volume":"18","author":"Hu","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"5963","key":"10.1016\/j.jep.2023.116487_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1126\/science.1183021","article-title":"Regulation of adaptive immunity by the innate immune system","volume":"327","author":"Iwasaki","year":"2010","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jep.2023.116487_bib14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/s41375-019-0661-z","article-title":"CRL3-SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88\/NF-\u03baB signaling","volume":"34","author":"Jin","year":"2020","journal-title":"Leukemia"},{"issue":"11","key":"10.1016\/j.jep.2023.116487_bib16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1176\/appi.ajp.2015.15020152","article-title":"Inflammation: depression fans the flames and feasts on the heat","volume":"172","author":"Kiecolt-Glaser","year":"2015","journal-title":"Am. J. Psychiatr."},{"issue":"11","key":"10.1016\/j.jep.2023.116487_bib17","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3349\/ymj.2021.62.11.1023","article-title":"Activation of CpG-ODN-induced TLR9 signaling inhibited by interleukin-37 in U937 human macrophages","volume":"62","author":"Kim","year":"2021","journal-title":"Yonsei Med. J."},{"issue":"5","key":"10.1016\/j.jep.2023.116487_bib18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies","volume":"135","author":"K\u00f6hler","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"issue":"1\u20133","key":"10.1016\/j.jep.2023.116487_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2008.05.043","article-title":"On the mechanism of antidepressant-like action of berberine chloride","volume":"589","author":"Kulkarni","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2023.116487_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008188","article-title":"SPOP promotes ubiquitination and degradation of MyD88 to suppress the innate immune response","volume":"16","author":"Li","year":"2020","journal-title":"PLoS Pathog."},{"issue":"7300","key":"10.1016\/j.jep.2023.116487_bib20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature09121","article-title":"Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR\/IL-1R signalling","volume":"465","author":"Lin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jep.2023.116487_bib39","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.brainresbull.2017.08.008","article-title":"Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice","volume":"134","author":"Liu","year":"2017","journal-title":"Brain Res. Bull."},{"issue":"16","key":"10.1016\/j.jep.2023.116487_bib21","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1001\/jama.294.16.2064","article-title":"Suicide prevention strategies: a systematic review","volume":"294","author":"Mann","year":"2005","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.jep.2023.116487_bib22","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1017\/S0033291719001454","article-title":"Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels","volume":"49","author":"Osimo","year":"2019","journal-title":"Psychol. Med."},{"issue":"2","key":"10.1016\/j.jep.2023.116487_bib23","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib24","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020560","article-title":"Microglia in health and disease","volume":"8","author":"Ransohoff","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.jep.2023.116487_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153606","article-title":"Xiao-Chai-Hu-Tang ameliorates tumor growth in cancer comorbid depressive symptoms via modulating gut microbiota-mediated TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"88","author":"Shao","year":"2021","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.jep.2023.116487_bib26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s12640-019-00147-2","article-title":"NF-\u03baB-Mediated neuroinflammation in Parkinson's disease and potential therapeutic effect of polyphenols","volume":"37","author":"Singh","year":"2020","journal-title":"Neurotox. Res."},{"issue":"3","key":"10.1016\/j.jep.2023.116487_bib27","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: a social signal transduction theory of depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. Bull."},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.yexcr.2019.03.004","article-title":"Productive transcription of miR-124-3p by RelA and RNA polymerase II directs RIP1 ubiquitination-dependent apoptosis resistance during hypoxia","volume":"378","author":"Song","year":"2019","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12943-019-1124-x","article-title":"The emerging role of SPOP protein in tumorigenesis and cancer therapy","volume":"19","author":"Song","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2023.116487_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1472-6882-14-279","article-title":"Zuo Jin Wan reverses P-gp-mediated drug-resistance by inhibiting activation of the PI3K\/Akt\/NF-\u03baB pathway","volume":"14","author":"Sui","year":"2014","journal-title":"BMC Compl. Alternat. Med."},{"key":"10.1016\/j.jep.2023.116487_bib31","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3389\/fphar.2019.01034","article-title":"Rb1, the primary active ingredient in panax ginseng C.A. Meyer, exerts antidepressant-like effects via the BDNF-trkb-CREB pathway","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116487_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112713","article-title":"Effects of Zuojin pill on depressive behavior and gastrointestinal function in rats with chronic unpredictable mild stress: role of the brain-gut axis","volume":"254","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib33","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1038\/s41598-017-03590-3","article-title":"Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine","volume":"7","author":"Xie","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jep.2023.116487_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045136","article-title":"Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factors","volume":"7","author":"Xing","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jep.2023.116487_bib35","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tins.2015.08.001","article-title":"Depression as a microglial disease","volume":"38","author":"Yirmiya","year":"2015","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2023.116487_bib36","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12906-018-2356-9","article-title":"Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis","volume":"18","author":"Yu","year":"2018","journal-title":"BMC Compl. Alternative Med."},{"issue":"10","key":"10.1016\/j.jep.2023.116487_bib37","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1158\/0008-5472.CAN-18-0215","article-title":"MYD88 L265P mutation in lymphoid malignancies","volume":"78","author":"Yu","year":"2018","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.jep.2023.116487_bib38","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s00213-018-4915-7","article-title":"Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats","volume":"235","author":"Zhu","year":"2018","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123003550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123003550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:00:53Z","timestamp":1736402453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123003550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":39,"alternative-id":["S0378874123003550"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116487","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zuojinwan ameliorates CUMS-induced depressive-like behavior through inducing ubiquitination of MyD88 via SPOP\/MyD88\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116487"}}