{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:07:19Z","timestamp":1793239639113,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005194","name":"Analysis and Testing Foundation of Kunming University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011190","name":"Kunming Institute of Botany, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31960093"],"award-info":[{"award-number":["31960093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973210"],"award-info":[{"award-number":["81973210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019IC003"],"award-info":[{"award-number":["2019IC003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jep.2023.116493","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T20:03:43Z","timestamp":1681243423000},"page":"116493","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Essential oil of lemon myrtle (Backhousia citriodora) induces S-phase cell cycle arrest and apoptosis in HepG2 cells"],"prefix":"10.1016","volume":"312","author":[{"given":"Yun-Fen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3236-6598","authenticated-orcid":false,"given":"Yang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Yue","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Xing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6654-8878","authenticated-orcid":false,"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116493_bib1","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1158\/0008-5472.CAN-04-0494","article-title":"Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents","volume":"64","author":"Achanta","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2023.116493_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1677\/joe.0.1800497","article-title":"Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells","volume":"180","author":"Angeloni","year":"2004","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jep.2023.116493_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2017.07.282","article-title":"Backhousia citriodora leaf extract: a new active solution to control hyper-seborrhea for multi-ethnic skins","volume":"137","author":"Attia","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jep.2023.116493_bib4","doi-asserted-by":"crossref","first-page":"18060","DOI":"10.1073\/pnas.1018858109","article-title":"Estrogen receptor prevents p53-dependent apoptosis in breast cancer","volume":"109","author":"Bailey","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jep.2023.116493_bib5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/s41586-022-05082-5","article-title":"Ordered and deterministic cancer genome evolution after p53 loss","volume":"608","author":"Baslan","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jep.2023.116493_bib6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.biochi.2018.02.013","article-title":"Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule","volume":"153","author":"Bayala","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.jep.2023.116493_bib7","series-title":"Choosing Your Treatment - the Complementary Medicine Evaluation Committee","first-page":"32","author":"Bennett","year":"1999"},{"key":"10.1016\/j.jep.2023.116493_bib8","doi-asserted-by":"crossref","first-page":"30117","DOI":"10.1074\/jbc.M112.367326","article-title":"p53, a target of estrogen receptor (ER) alpha, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells","volume":"287","author":"Berger","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2023.116493_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.devcel.2008.01.013","article-title":"CDK inhibitors: cell cycle regulators and beyond","volume":"14","author":"Besson","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jep.2023.116493_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/cancers6010079","article-title":"The complex relationship between liver cancer and the cellcycle: a story of multiple regulations","volume":"6","author":"Bisteau","year":"2014","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2023.116493_bib11","doi-asserted-by":"crossref","first-page":"3149362","DOI":"10.1155\/2018\/3149362","article-title":"Anticancer properties of essential oils and other natural products","author":"Blowman","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.116493_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2121-14-32","article-title":"Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis","volume":"14","author":"Brentnall","year":"2013","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.jep.2023.116493_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biopha.2003.11.006","article-title":"Essential oil of Australian lemon myrtle (Backhousia citriodora) in the treatment of molluscum contagiosum in children","volume":"58","author":"Burke","year":"2004","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116493_bib14","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/CM9.0000000000001474","article-title":"Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020","volume":"134","author":"Cao","year":"2021","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jep.2023.116493_bib15","doi-asserted-by":"crossref","first-page":"102675","DOI":"10.1016\/j.dnarep.2019.102675","article-title":"Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway","volume":"82","author":"Codrich","year":"2019","journal-title":"DNA Repair"},{"key":"10.1016\/j.jep.2023.116493_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/excr.1995.1356","article-title":"Inhibition of the melanoma cell cycle and regulation at the G1\/S transition by 12-O-tetradecanoylphorbol-13-acetate (TPA) by modulation of CDK2 activity","volume":"221","author":"Coppock","year":"1995","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2023.116493_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1475-2867-13-27","article-title":"Antiproliferative and apoptotic effects of beta-elemene on human hepatoma HepG2 cells","volume":"13","author":"Dai","year":"2013","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.jep.2023.116493_bib18","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.3389\/fonc.2020.01252","article-title":"P53 affects PGC1alpha stability through AKT\/GSK-3beta to enhance cisplatin sensitivity in non-small cell lung cancer","volume":"10","author":"Deng","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jep.2023.116493_bib19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00044-017-1779-z","article-title":"Effect of citral and citral related compounds on viability of pancreatic and human B-lymphoma cell lines","volume":"26","author":"Di Mola","year":"2017","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.jep.2023.116493_bib20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1076\/apab.105.2.125.12927","article-title":"Apoptosis and anti-apoptosis genes in the Bcl-2 family","volume":"105","author":"Dietrich","year":"1997","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.jep.2023.116493_bib21","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.3390\/ijms21061960","article-title":"The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer","volume":"21","author":"Ding","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116493_bib22","doi-asserted-by":"crossref","first-page":"15819","DOI":"10.1038\/s41598-019-52461-6","article-title":"Electrochemotherapy induces tumor regression and decreases the proliferative index in canine cutaneous squamous cell carcinoma","volume":"9","author":"Dos Anjos","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116493_bib23","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1002\/cam4.816","article-title":"beta-caryophyllene and beta-caryophyllene oxide-natural compounds of anticancer and analgesic properties","volume":"5","author":"Fidyt","year":"2016","journal-title":"Cancer Med-Us"},{"key":"10.1016\/j.jep.2023.116493_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/molecules23010123","article-title":"Chemical composition and evaluation of the biological properties of the essential oil of the dietary phytochemical Lippia citriodora","volume":"23","author":"Fitsiou","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116493_bib25","doi-asserted-by":"crossref","first-page":"20702","DOI":"10.1038\/s41598-020-77732-5","article-title":"Spontaneous intake of essential oils after a negative postnatal experience has long-term effects on blood transcriptome in chickens","volume":"10","author":"Foury","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116493_bib26","doi-asserted-by":"crossref","first-page":"42011","DOI":"10.1074\/jbc.M106423200","article-title":"Key role of a downstream specificity protein 1 site in cell cycle-regulated transcription of the AP endonuclease gene APE1\/APEX in NIH3T3 cells","volume":"276","author":"Fung","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2023.116493_bib27","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1093\/emboj\/18.20.5609","article-title":"Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo","volume":"18","author":"Gaiddon","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.jep.2023.116493_bib28","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.3390\/ijms19103219","article-title":"The emerging role of cyclin-dependent kinases (CDKs) in pancreatic ductal adenocarcinoma","volume":"19","author":"Garcia-Reyes","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116493_bib29","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1091\/mbc.e10-01-0028","article-title":"A Galphai-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate","volume":"21","author":"Ghosh","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jep.2023.116493_bib30","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jep.2023.116493_bib31","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/sj.onc.1208351","article-title":"Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization","volume":"24","author":"Hanson","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2023.116493_bib32","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0278-6915(01)00103-X","article-title":"Toxicity of Australian essential oil Backhousia citriodora (Lemon myrtle). Part 1. Antimicrobial activity and in vitro cytotoxicity","volume":"40","author":"Hayes","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116493_bib33","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0278-6915(03)00159-5","article-title":"Toxicity of Australian essential oil Backhousia citriodora (lemon myrtle). Part 2. Absorption and histopathology following application to human skin","volume":"41","author":"Hayes","year":"2003","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116493_bib34","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3390\/molecules24071394","article-title":"Correlation between chemical composition and antifungal activity of Clausena lansium essential oil against Candida spp","volume":"24","author":"He","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116493_bib35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijsu.2018.02.055","article-title":"Caspase-3, a key apoptotic protein, as a prognostic marker in gastric cancer after curative surgery","volume":"52","author":"Huang","year":"2018","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.jep.2023.116493_bib36","doi-asserted-by":"crossref","first-page":"9765","DOI":"10.3748\/wjg.v22.i44.9765","article-title":"Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer","volume":"22","author":"Iwasaki","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2023.116493_bib37","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/s41418-018-0198-0","article-title":"SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability","volume":"26","author":"Ju","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2023.116493_bib38","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s10068-020-00795-7","article-title":"Antioxidant and anti-inflammatory activities of phenolic compounds extracted from lemon myrtle (Backhousia citriodora) leaves at various extraction conditions","volume":"29","author":"Kang","year":"2020","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.jep.2023.116493_bib39","doi-asserted-by":"crossref","first-page":"27530","DOI":"10.1038\/srep27530","article-title":"Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation","volume":"6","author":"Kapur","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116493_bib40","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1007\/s10853-017-1756-4","article-title":"Synthesis and characterization of gold-conjugated Backhousia citriodora nanoparticles and their anticancer activity against MCF-7 breast and HepG2 liver cancer cell lines","volume":"53","author":"Khandanlou","year":"2018","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.jep.2023.116493_bib41","first-page":"986","article-title":"Anti-inflammatory effects of lemon myrtle (Backhousia citriodora) leaf extracts in LPS-induced RAW 264.7 cells","volume":"27","author":"Kim","year":"2017","journal-title":"J. Life Sci."},{"key":"10.1016\/j.jep.2023.116493_bib42","first-page":"1","article-title":"Health benefits of australian native foods - an evaluation of health-enhancing compounds","author":"Konczak","year":"2009","journal-title":"Anim. Sci."},{"key":"10.1016\/j.jep.2023.116493_bib43","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1080\/17474124.2021.1991792","article-title":"Current epidemiology in hepatocellular carcinoma","volume":"15","author":"Konyn","year":"2021","journal-title":"Expet Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.116493_bib44","first-page":"1693s","article-title":"BCL-2 gene family and the regulation of programmed cell death","volume":"59","author":"Korsmeyer","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2023.116493_bib45","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3390\/biom11050671","article-title":"Comparison of anticancer activity of dorycnium pentaphyllum extract on MCF-7 and MCF-12A cell line: correlation with invasion and adhesion","volume":"11","author":"Koygun","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2023.116493_bib46","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/tox.22933","article-title":"Citral inhibits N-nitrosodiethylamine-induced hepatocellular carcinoma via modulation of antioxidants and xenobiotic-metabolizing enzymes","volume":"35","author":"Krishnan","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jep.2023.116493_bib47","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3727\/096368914X681054","article-title":"Reversibly immortalized mouse articular chondrocytes acquire long-term proliferative capability while retaining chondrogenic phenotype","volume":"24","author":"Lampot","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jep.2023.116493_bib48","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.2147\/IJGM.S338513","article-title":"Beta-caryophyllene from chilli pepper inhibits the proliferation of non-small cell lung cancer cells by affecting miR-659-3p-targeted sphingosine kinase 1 (SphK1)","volume":"14","author":"Lei","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.jep.2023.116493_bib49","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/ptr.5165","article-title":"Anticancer activities of essential oils constituents and synergy with conventional therapies: a review","volume":"28","author":"Lesgards","year":"2014","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2023.116493_bib50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/1471-2407-11-183","article-title":"beta-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis","volume":"11","author":"Liu","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jep.2023.116493_bib51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12672-017-0298-1","article-title":"Estrogen receptor-beta modulation of the ERalpha-p53 loop regulating gene expression, proliferation, and apoptosis in breast cancer","volume":"8","author":"Lu","year":"2017","journal-title":"Horm Cancer"},{"key":"10.1016\/j.jep.2023.116493_bib52","doi-asserted-by":"crossref","first-page":"109594","DOI":"10.1016\/j.vetpar.2021.109594","article-title":"Acaricidal and repellent activity of the essential oils of Backhousia citriodora, Callistemon viminalis and Cinnamodendron dinisii against Rhipicephalus spp","volume":"300","author":"Lunguinho","year":"2021","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.jep.2023.116493_bib53","doi-asserted-by":"crossref","first-page":"113580","DOI":"10.1016\/j.jep.2020.113580","article-title":"Antioxidative and therapeutic potential of selected Australian plants: a review","volume":"268","author":"Mani","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116493_bib54","doi-asserted-by":"crossref","first-page":"e1004165","DOI":"10.1371\/journal.pgen.1004165","article-title":"Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis","volume":"10","author":"Martinerie","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jep.2023.116493_bib55","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1590\/S0102-695X2011005000082","article-title":"Active caspase-3 detection to evaluate apoptosis induced by Verbena officinalis essential oil and citral in chronic lymphocytic leukaemia cells","volume":"21","author":"Martino","year":"2011","journal-title":"Rev Bras Farmacogn"},{"key":"10.1016\/j.jep.2023.116493_bib56","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature02650","article-title":"Cyclin-dependent kinases regulate the antiproliferative function of Smads","volume":"430","author":"Matsuura","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jep.2023.116493_bib57","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1080\/14786419.2014.981540","article-title":"Essential oil of Cephalotaxus griffithii needle inhibits proliferation and migration of human cervical cancer cells: involvement of mitochondria-initiated and death receptor-mediated apoptosis pathways","volume":"29","author":"Moirangthem","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.116493_bib58","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/sj.onc.1210839","article-title":"MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene","volume":"27","author":"Molli","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2023.116493_bib59","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jcp.21863","article-title":"Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-kappaB signalling pathway in thyroid cancer cells","volume":"221","author":"Morello","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2023.116493_bib60","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/jphp.12403","article-title":"Effects of bergamot essential oil and its extractive fractions on SH-SY5Y human neuroblastoma cell growth","volume":"67","author":"Navarra","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2023.116493_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2018.01.173","article-title":"Formulation, characterisation and antibacterial activity of lemon myrtle and anise myrtle essential oil in water nanoemulsion","volume":"254","author":"Nirmal","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116493_bib62","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fonc.2015.00288","article-title":"Targeting oncogenic mutant p53 for cancer therapy","volume":"5","author":"Parrales","year":"2015","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jep.2023.116493_bib63","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.indcrop.2015.08.024","article-title":"Tapping botanicals for essential oils: progress and hurdles in cancer mitigation","volume":"76","author":"Patel","year":"2015","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2023.116493_bib64","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12920-022-01290-0","article-title":"APEX1 regulates alternative splicing of key tumorigenesis genes in non-small-cell lung cancer","volume":"15","author":"Peng","year":"2022","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.jep.2023.116493_bib65","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1038\/s41598-020-64418-1","article-title":"Cyclin A1 in oocytes prevents chromosome segregation and anaphase entry","volume":"10","author":"Radonova","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116493_bib66","article-title":"Phytochemicals and bioactivities of Australian native lemonmyrtle (Backhousia citriodora) and lemon-scented tea tree (Leptospermum petersonii): a comprehensive review","author":"Saifullah","year":"2022","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.jep.2023.116493_bib67","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.foodchem.2012.07.089","article-title":"Cytoprotective and pro-apoptotic activities of native Australian herbs polyphenolic-rich extracts","volume":"136","author":"Sakulnarmrat","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116493_bib68","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jep.2023.116493_bib69","doi-asserted-by":"crossref","first-page":"112514","DOI":"10.1016\/j.biopha.2021.112514","article-title":"Essential oils as anticancer agents: potential role in malignancies, drug delivery mechanisms, and immune system enhancement","volume":"146","author":"Sharma","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116493_bib70","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.biopha.2017.10.038","article-title":"Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines","volume":"96","author":"Sheikh","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116493_bib71","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.toxrep.2020.01.018","article-title":"Anti-inflammatory and anti-oxidative activities of lemon myrtle (Backhousia citriodora) leaf extract","volume":"7","author":"Shim","year":"2020","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.jep.2023.116493_bib72","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1158\/0008-5472.CAN-08-3628","article-title":"Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells","volume":"69","author":"Shirley","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2023.116493_bib73","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3390\/foods10071596","article-title":"Backhousia citriodora F. Muell. (Lemon Myrtle), an unrivalled source of citral","volume":"10","author":"Southwell","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.jep.2023.116493_bib74","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/01480545.2019.1585445","article-title":"Citral presents cytotoxic and genotoxic effects in human cultured cells","volume":"43","author":"Souza","year":"2020","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116493_bib75","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.jasms.2005.07.008","article-title":"Identification of essential oil components by gas chromatography\/quadrupole mass spectroscopy","volume":"16","author":"Sparkman","year":"2005","journal-title":"Robert P. Adams. J. Am. Soc. Mass Spectr."},{"key":"10.1016\/j.jep.2023.116493_bib76","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.3390\/molecules19056838","article-title":"A new diterpene from Litsea cubeba fruits: structure elucidation and capability to induce apoptosis in HeLa cells","volume":"19","author":"Trisonthi","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116493_bib77","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/ajr.12256","article-title":"A brief review of the application and pharmacology of ethnomedicines of Indigenous Australians","volume":"24","author":"Tucci","year":"2016","journal-title":"Aust. J. Rural Health"},{"key":"10.1016\/j.jep.2023.116493_bib78","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00018-005-5017-3","article-title":"Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death","volume":"62","author":"Wang","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jep.2023.116493_bib79","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jep.2023.116493_bib80","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.gendis.2021.01.004","article-title":"Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs)","volume":"8","author":"Wu","year":"2021","journal-title":"Genes Dis."},{"key":"10.1016\/j.jep.2023.116493_bib81","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1002\/ctm2.356","article-title":"Emerging roles of the solute carrier family in pancreatic cancer","volume":"11","author":"Wu","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.jep.2023.116493_bib82","first-page":"6524","article-title":"gamma-terpineol inhibits cell growth and induces apoptosis in human liver cancer BEL-7402 cells in vitro","volume":"7","author":"Wu","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jep.2023.116493_bib83","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10616-012-9453-2","article-title":"The in vitro study of apoptosis in NB4 cell induced by citral","volume":"65","author":"Xia","year":"2013","journal-title":"Cytotechnology"},{"key":"10.1016\/j.jep.2023.116493_bib84","doi-asserted-by":"crossref","first-page":"154536","DOI":"10.1016\/j.phymed.2022.154536","article-title":"Nuciferine attenuates atherosclerosis by regulating the proliferation and migration of VSMCs through the Calm4\/MMP12\/AKT pathway in ApoE(-\/-) mice fed with High-Fat-Diet","volume":"108","author":"Xiao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116493_bib85","doi-asserted-by":"crossref","first-page":"115782","DOI":"10.1016\/j.indcrop.2022.115782","article-title":"Effects of geographical location and environmental factors on metabolite content and immune activity of Echinacea purpurea in China based on metabolomics analysis","volume":"189","author":"Xu","year":"2022","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2023.116493_bib86","first-page":"1183","article-title":"Apoptosis-Mediated anticancer activity of geraniol inhibits NF-kappa B, MAPK, and JAK-STAT-3 signaling pathways in human thyroid cancer cells","volume":"18","author":"Yang","year":"2022","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.jep.2023.116493_bib87","first-page":"2548","article-title":"Formulation, characterization, and antitumor properties of trans- and cis-citral in the 4T1 breast cancer xenograft mouse model","volume":"32","author":"Zeng","year":"2015","journal-title":"Pharm Res-Dordr."},{"key":"10.1016\/j.jep.2023.116493_bib88","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10549-012-2263-6","article-title":"Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor alpha (ERalpha) re-expression","volume":"136","author":"Zhang","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jep.2023.116493_bib89","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/molecules26010167","article-title":"Chemical composition, antibacterial, anti-Inflammatory, and enzyme inhibitory activities of essential oil from rhynchanthus beesianus rhizome","volume":"26","author":"Zhao","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116493_bib90","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1039\/C7SC05442D","article-title":"Isotopic graphene-isolated-Au-nanocrystals with cellular Raman-silent signals for cancer cell pattern recognition","volume":"9","author":"Zou","year":"2018","journal-title":"Chem. Sci."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123003616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123003616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:51:12Z","timestamp":1778752272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123003616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":90,"alternative-id":["S0378874123003616"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116493","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Essential oil of lemon myrtle (Backhousia citriodora) induces S-phase cell cycle arrest and apoptosis in HepG2 cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116493","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116493"}}