{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:46:55Z","timestamp":1790707615752,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jep.2023.116531","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T01:47:26Z","timestamp":1683510446000},"page":"116531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Essential oil of Sicilian Prangos ferulacea (L.) Lindl. and its major component, \u03b2\u2212ocimen, affect contractility in rat small and large intestine"],"prefix":"10.1016","volume":"313","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-6529","authenticated-orcid":false,"given":"Maria Grazia","family":"Zizzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5118-9347","authenticated-orcid":false,"given":"Adele","family":"Cicio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0583-0487","authenticated-orcid":false,"given":"Maurizio","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116531_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2141\/jpsa.0210042","article-title":"Characteristics of essential oils of Apiaceae family: their chemical compositions, in vitro properties and effects on broiler production","volume":"59","author":"Ali","year":"2022","journal-title":"J. Poultry Sci."},{"key":"10.1016\/j.jep.2023.116531_bib2","series-title":"Experimental Physiology","first-page":"16","article-title":"Introduction to apparatus and instruments","author":"Andrew","year":"1972"},{"key":"10.1016\/j.jep.2023.116531_bib3","series-title":"Changes in Composition and Antioxidant and Antimicrobial Activities of Essential Oil of Fennel (Foeniculum Vulgare Mill.) Fruit at Different Stages of Maturity","first-page":"187","author":"Anwar","year":"2009"},{"key":"10.1016\/j.jep.2023.116531_bib4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s13105-017-0566-0","article-title":"Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1- and D2-like receptors","volume":"73","author":"Auteri","year":"2016","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.jep.2023.116531_bib5","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.3390\/molecules27217430","article-title":"Chemical composition and biological activities of Prangos ferulacea essential oils","volume":"27","author":"Badalamenti","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116531_bib6","article-title":"Chemodiversity of volatile oil contents of various parts of 10 iranian Prangos ferulacea accessions, with analysis of antiradical potential","volume":"14","author":"Bagherifar","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2023.116531_bib7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","article-title":"Biological effects of essential oils - a review","volume":"46","author":"Bakkali","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116531_bib8","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bcab.2018.04.009","article-title":"Evaluation of oil profiles, total phenols and phenolic compounds in Prangos ferulacea leaves and flowers and their effects on antioxidant activities","volume":"14","author":"Bazdar","year":"2018","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"10.1016\/j.jep.2023.116531_bib9","first-page":"661","article-title":"Relaxant effects of carvacrol on Guinea pig tracheal chains and its possible mechanisms","volume":"58","author":"Boskabady","year":"2003","journal-title":"Pharmazie"},{"key":"10.1016\/j.jep.2023.116531_bib10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/14786419.2019.1598996","article-title":"Composition and biological activities of the essential oil from a Sicilian accession of Prangos ferulacea (L.) Lindl","volume":"35","author":"Bruno","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.116531_bib11","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2307\/4114493","article-title":"The genera of the umbelliferae : a nomenclator","volume":"49","author":"Burtt","year":"1993","journal-title":"Kew Bull."},{"key":"10.1016\/j.jep.2023.116531_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23061430","article-title":"Hydroxyl group and vasorelaxant effects of perillyl alcohol, carveol, limonene on aorta smooth muscle of rats","volume":"23","author":"Cardoso-Teixeira","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116531_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2217\/thy.11.7","article-title":"Functional abdominal pain and irritable bowel syndrome in children and adolescents","volume":"8","author":"Chiou","year":"2011","journal-title":"Therapy"},{"key":"10.1016\/j.jep.2023.116531_bib14","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.foodchem.2005.12.006","article-title":"Antioxidant properties of Prangos ferulacea (L.) Lindl., Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. from Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on glutathione-S-transferase","volume":"100","author":"\u00c7oruh","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116531_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0163-7258(93)90024-8","article-title":"Calcium-channel blockers and gastrointestinal motility: basic and clinical aspects","volume":"60","author":"De Ponti","year":"1993","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2023.116531_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.lfs.2018.08.053","article-title":"Moderate-intensity exercise and renin angiotensin system blockade improve the renovascular hypertension (2K1C)-induced gastric dysmotility in rats","volume":"210","author":"de Sousa Lima","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2023.116531_bib17","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1021\/jf804013j","article-title":"Acetylcholinesterase inhibitory activity and chemical composition of commercial essential oils","volume":"57","author":"Dohi","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116531_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9268468","article-title":"An overview of the biological effects of some mediterranean essential oils on human health","volume":"2017","author":"Elshafie","year":"2017","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2023.116531_bib19","series-title":"Essential Oil's Chemical Composition and Pharmacological Properties. Essential Oils - Oils of Nature","author":"Fokou","year":"2020"},{"key":"10.1016\/j.jep.2023.116531_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101550","article-title":"Nitric oxide in cellular adaptation and disease","volume":"34","author":"Gantner","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2023.116531_bib21","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.2001.280.4.G546","article-title":"Different types of contractions in rat colon and their modulation by oxidative stress","volume":"280","author":"Gonzalez","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jep.2023.116531_bib22","first-page":"261","volume":"81","author":"Grundy","year":"2019","journal-title":"Visceral Pain"},{"key":"10.1016\/j.jep.2023.116531_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ptr.4686","article-title":"Monoterpenes with analgesic activity - a systematic review","volume":"27","author":"Guimar\u00e3es","year":"2013","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2023.116531_bib24","article-title":"Herbal medicines in functional dyspepsia\u2014untapped opportunities not without risks","volume":"33","author":"Gwee","year":"2021","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.jep.2023.116531_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24091675","article-title":"Antispasmodic effect of essential oils and their constituents: a review","volume":"24","author":"Heghes","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116531_bib26","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.phrs.2008.09.001","article-title":"Potentiation by cholinesterase inhibitors of cholinergic activity in rat isolated stomach and colon","volume":"58","author":"Jarvie","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2023.116531_bib27","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3389\/fpsyt.2020.00601","article-title":"Herbal therapies in functional gastrointestinal disorders: a narrative review and clinical implication","volume":"11","author":"Kim","year":"2020","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.jep.2023.116531_bib28","author":"Marotti"},{"key":"10.1016\/j.jep.2023.116531_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3819714","article-title":"Natural antispasmodics: source, stereochemical configuration, and biological activity","volume":"2018","author":"Mart\u00ednez-P\u00e9rez","year":"2018","journal-title":"BioMed Res. Int."},{"issue":"6 19","key":"10.1016\/j.jep.2023.116531_bib30","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s11101-020-09688-3","article-title":"The Prangos genus: a comprehensive review on traditional use, phytochemistry, and pharmacological activities","volume":"19","author":"Mottaghipisheh","year":"2020","journal-title":"Phytochem. Rev. 2020"},{"key":"10.1016\/j.jep.2023.116531_bib31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1211\/jpp.61.03.0011","article-title":"1,8-Cineole induces relaxation in rat and Guinea-pig airway smooth muscle","volume":"61","author":"Nascimento","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2023.116531_bib32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1472-8206.2009.00768.x","article-title":"Vasorelaxant effects of the monoterpenic phenol isomers, carvacrol and thymol, on rat isolated aorta","volume":"24","author":"Peixoto-Neves","year":"2010","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2023.116531_bib33","article-title":"Use of natural health products in children: qualitative analysis of parents' experiences","volume":"59","author":"Pike","year":"2013","journal-title":"Can. Fam. Physician"},{"key":"10.1016\/j.jep.2023.116531_bib34","article-title":"Complementary mechanisms of modulation of spontaneous phasic contractions by the gaseous signalling molecules NO, H2S, HNO and the polysulfide Na2S3 in the rat colon","author":"Pouokam","year":"2021","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.jep.2023.116531_bib35","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3389\/fphar.2022.831963","article-title":"Interaction of medicinal plants and their active constituents with potassium ion channels: a systematic review","volume":"13","author":"Rajabian","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116531_bib36","first-page":"141","article-title":"Antispasmodic effect of osthole and Prangos ferulacea extract on rat uterus smooth muscle motility","volume":"7","author":"Sadraei","year":"2012","journal-title":"Res Pharm Sci"},{"key":"10.1016\/j.jep.2023.116531_bib37","first-page":"137","article-title":"Antispasmodic effects of Prangos ferulacea acetone extract and its main component osthole on ileum contraction","volume":"8","author":"Sadraei","year":"2013","journal-title":"Res Pharm Sci"},{"key":"10.1016\/j.jep.2023.116531_bib38","first-page":"352","article-title":"Nitric oxide in the gut","volume":"3","author":"Salzman","year":"1995","journal-title":"New Horiz"},{"key":"10.1016\/j.jep.2023.116531_bib39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.coph.2014.07.009","article-title":"Importance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility","volume":"0","author":"Savidge","year":"2014","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jep.2023.116531_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143171","article-title":"TRPM8 channel activation induced by monoterpenoid rotundifolone underlies mesenteric artery relaxation","volume":"10","author":"Silva","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2023.116531_bib41","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.3390\/ijms21114152","article-title":"Antioxidant, anti-inflammatory, and microbial-modulating activities of essential oils: implications in colonic pathophysiology","volume":"21","author":"Spisni","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116531_bib42","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00173.2006","article-title":"M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: findings obtained with muscarinic-receptor knockout mouse","volume":"292","author":"Takeuchi","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jep.2023.116531_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22020926","article-title":"Functions of muscarinic receptor subtypes in gastrointestinal smooth muscle: a review of studies with receptor-knockout mice","volume":"22","author":"Tanahashi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116531_bib44","article-title":"Roles of M2 and M3 muscarinic receptors in the generation of rhythmic motor activity in mouse small intestine","volume":"25","author":"Tanahashi","year":"2013","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.jep.2023.116531_bib46","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jpba.2018.06.026","article-title":"Acetylcholinesterase-inhibitory activity of Iranian plants: combined HPLC\/bioassay-guided fractionation, molecular networking and docking strategies for the dereplication of active compounds","volume":"158","author":"Ulubelen","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2023.116531_bib47","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/sj.bjp.0706955","article-title":"Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice","volume":"149","author":"Unno","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116531_bib48","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20154800","article-title":"\u03b2-Citronellol, an alcoholic monoterpene with inhibitory properties on the contractility of rat trachea","volume":"49","author":"Vasconcelos","year":"2016","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.jep.2023.116531_bib49","article-title":"Angiotensin II type II receptors and colonic dysmotility in 2,4-dinitrofluorobenzenesulfonic acid-induced colitis in rats","volume":"29","author":"Zizzo","year":"2017","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.jep.2023.116531_bib50","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/pr.2016.91","article-title":"Postnatal development of the dopaminergic signaling involved in the modulation of intestinal motility in mice","volume":"80","author":"Zizzo","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jep.2023.116531_bib51","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13105-022-00892-7","article-title":"Aging modifies receptor expression but not muscular contractile response to angiotensin II in rat jejunum","volume":"78","author":"Zizzo","year":"2022","journal-title":"J. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.jep.2023.116531_bib54","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s00210-022-02366-5","article-title":"Inhibition of uterine contractility by guanine-based purines in non-pregnant rats","volume":"396","author":"Zizzo","year":"2023","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.jep.2023.116531_bib52","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/j.1476-5381.2011.01498.x","article-title":"Adenosine negatively regulates duodenal motility in mice: role of A 1 and A 2A receptors","volume":"164","author":"Zizzo","year":"2011","journal-title":"Br. J. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123003999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123003999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:41:05Z","timestamp":1759945265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123003999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":52,"alternative-id":["S0378874123003999"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116531","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Essential oil of Sicilian Prangos ferulacea (L.) Lindl. and its major component, \u03b2\u2212ocimen, affect contractility in rat small and large intestine","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116531"}}