{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:34:59Z","timestamp":1783571699452,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jep.2023.116561","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T21:19:26Z","timestamp":1682716766000},"page":"116561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Piperlonguminine attenuates renal fibrosis by inhibiting TRPC6"],"prefix":"10.1016","volume":"313","author":[{"given":"Lei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianchao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuna","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-qiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2023.116561_bib1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/17460441.2018.1463988","article-title":"Computational modeling of human oral bioavailability: what will be next?","volume":"13","author":"Cabrera-P\u00e9rez","year":"2018","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.jep.2023.116561_bib2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.biopha.2018.02.090","article-title":"Central role of dysregulation of TGF-\u03b2\/Smad in CKD progression and potential targets of its treatment","volume":"101","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2023.116561_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12882-019-1298-x","article-title":"The role of podocyte damage in the etiology of ischemia-reperfusion acute kidney injury and post-injury fibrosis","volume":"20","author":"Chen","year":"2019","journal-title":"BMC Nephrol."},{"issue":"5","key":"10.1016\/j.jep.2023.116561_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143645","article-title":"Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-\u03b2 signaling in kidney fibroblasts","volume":"131","author":"Chen","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.jep.2023.116561_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1681\/ASN.V132431","article-title":"Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats","volume":"13","author":"Debelle","year":"2002","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"issue":"5","key":"10.1016\/j.jep.2023.116561_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrneph.2014.31","article-title":"Novel targets of antifibrotic and anti-inflammatory treatment in CKD","volume":"10","author":"Decl\u00e8ves","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.jep.2023.116561_bib7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/kisup.2014.2","article-title":"Overview of the cellular and molecular basis of kidney fibrosis","volume":"4","author":"Eddy","year":"2014","journal-title":"Kidney Int. Suppl."},{"issue":"4","key":"10.1016\/j.jep.2023.116561_bib8","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12272-021-01319-5","article-title":"Canonical transient receptor potential channels and their modulators: biology, pharmacology and therapeutic potentials","volume":"44","author":"Gao","year":"2021","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2023.116561_bib9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jep.2018.10.023","article-title":"Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-\u03b2 signaling pathways in mice","volume":"231","author":"Gu","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116561_bib10","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3389\/fphar.2020.00996","article-title":"Huangkui capsule ameliorates renal fibrosis in a unilateral ureteral obstruction mouse model through TRPC6 dependent signaling pathways","volume":"11","author":"Gu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116561_bib11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"issue":"6","key":"10.1016\/j.jep.2023.116561_bib12","doi-asserted-by":"crossref","first-page":"L1161","DOI":"10.1152\/ajplung.00159.2021","article-title":"TRPC6, a therapeutic target for pulmonary hypertension","volume":"321","author":"Jain","year":"2021","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2023.116561_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.drudis.2019.10.014","article-title":"A drug-likeness toolbox facilitates ADMET study in drug discovery","volume":"25","author":"Jia","year":"2020","journal-title":"Drug Discov. Today"},{"issue":"8","key":"10.1016\/j.jep.2023.116561_bib14","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/ptr.2630","article-title":"Antihyperlipidemic compounds from the fruit of Piper longum L","volume":"23","author":"Jin","year":"2009","journal-title":"Phytother Res."},{"issue":"4","key":"10.1016\/j.jep.2023.116561_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040856","article-title":"Effects of TRPC6 inactivation on glomerulosclerosis and renal fibrosis in aging rats","volume":"10","author":"Kim","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jep.2023.116561_bib16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1600-0749.2005.00281.x","article-title":"Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression","volume":"19","author":"Kim","year":"2006","journal-title":"Pigm. Cell Res."},{"issue":"7","key":"10.1016\/j.jep.2023.116561_bib17","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00109-018-1648-3","article-title":"Trpc6 inactivation confers protection in a model of severe nephrosis in rats","volume":"96","author":"Kim","year":"2018","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.jep.2023.116561_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.fct.2013.04.027","article-title":"Barrier protective effects of piperlonguminine in LPS-induced inflammation in vitro and in vivo","volume":"58","author":"Lee","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"20","key":"10.1016\/j.jep.2023.116561_bib19","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1073\/pnas.1815354116","article-title":"In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease","volume":"116","author":"Lin","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jep.2023.116561_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4490081","article-title":"Study on the mechanism of Liuwei Dihuang pills in treating Parkinson's disease based on network pharmacology","volume":"2021","author":"Lin","year":"2021","journal-title":"BioMed Res. Int."},{"issue":"12","key":"10.1016\/j.jep.2023.116561_bib21","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2023.116561_bib22","article-title":"TRPC6 attenuates cortical astrocytic apoptosis and inflammation in cerebral ischemic\/reperfusion injury","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2023.116561_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114126","article-title":"Effects of triangle grass decoction on bone metabolism in rats with chronic kidney disease complicated with mineral and bone abnormalities","volume":"275","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116561_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153650","article-title":"Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action","volume":"91","author":"Liu","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116561_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8319283","article-title":"TGF-\u03b21\/Smads and miR-21 in renal fibrosis and inflammation","author":"Loboda","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2023.116561_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7534181","article-title":"Tetrandrine attenuates podocyte injury by inhibiting TRPC6-mediated RhoA\/ROCK1 pathway","author":"Mao","year":"2022","journal-title":"Anal. Cell Pathol."},{"issue":"6","key":"10.1016\/j.jep.2023.116561_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2023.116561_bib28","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/978-3-319-05161-1_12","article-title":"Physiological functions and regulation of TRPC channels","volume":"223","author":"Ong","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2023.116561_bib29","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/ptr.2432","article-title":"Antiplatelet activities of newly synthesized derivatives of piperlongumine","volume":"22","author":"Park","year":"2008","journal-title":"Phytother Res."},{"issue":"2\u20133","key":"10.1016\/j.jep.2023.116561_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0143-4160(90)90060-8","article-title":"Assessment of Fura-2 for measurements of cytosolic free calcium","volume":"11","author":"Roe","year":"1990","journal-title":"Cell Calcium"},{"issue":"5","key":"10.1016\/j.jep.2023.116561_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Ruiz-Ortega","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2023.116561_bib32","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3389\/fphar.2019.01596","article-title":"ErHuang formula improves renal fibrosis in diabetic nephropathy rats by inhibiting CXCL6\/JAK\/STAT3 signaling pathway","volume":"10","author":"Shen","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116561_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5063636","article-title":"Liuwei Dihuang pill attenuates diabetic nephropathy by inhibiting renal fibrosis via TGF-\/Smad2\/3 pathway","volume":"2022","author":"Shu","year":"2022","journal-title":"Comput. Math. Methods Med."},{"issue":"3","key":"10.1016\/j.jep.2023.116561_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1165\/rcmb.2014-0235OC","article-title":"Notch activation of Ca2+ signaling in the development of hypoxic pulmonary vasoconstriction and pulmonary hypertension","volume":"53","author":"Smith","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"179","key":"10.1016\/j.jep.2023.116561_bib35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/978-3-540-34891-7_35","article-title":"Phospholipase C-coupled receptors and activation of TRPC channels","author":"Trebak","year":"2007","journal-title":"Handb. Exp. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2023.116561_bib36","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1172\/JCI76767","article-title":"Gq signaling causes glomerular injury by activating TRPC6","volume":"125","author":"Wang","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2023.116561_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117532","article-title":"The antitumor role of a newly discovered \u03b1-d-glucan from Holotrichia diomphalia Bates as a selective blocker of aldolase A","volume":"255","author":"Wang","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"15","key":"10.1016\/j.jep.2023.116561_bib38","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1016\/0006-2952(88)90277-8","article-title":"Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction","volume":"37","author":"Weisman","year":"1988","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2023.116561_bib39","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrneph.2009.100","article-title":"The role of transient receptor potential channels in kidney disease","volume":"5","author":"Woudenberg-Vrenken","year":"2009","journal-title":"Nat. Rev. Nephrol."},{"issue":"13","key":"10.1016\/j.jep.2023.116561_bib40","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jcc.10306","article-title":"Detailed analysis of grid-based molecular docking: a case study of CDOCKER-A CHARMm-based MD docking algorithm","volume":"24","author":"Wu","year":"2003","journal-title":"J. Comput. Chem."},{"issue":"4","key":"10.1016\/j.jep.2023.116561_bib41","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.kint.2016.09.039","article-title":"Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho","volume":"91","author":"Wu","year":"2017","journal-title":"Kidney Int."},{"issue":"31","key":"10.1016\/j.jep.2023.116561_bib42","article-title":"Liuwei Dihuang pill cures postmenopausal osteoporosis with kidney-Yin deficiency: potential therapeutic targets identified based on gene expression profiling","volume":"97","author":"Xu","year":"2018","journal-title":"Medicine (Baltim.)"},{"issue":"3","key":"10.1016\/j.jep.2023.116561_bib43","doi-asserted-by":"crossref","first-page":"e5879","DOI":"10.1097\/MD.0000000000005879","article-title":"Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-\u03b2\/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues","volume":"96","author":"Xu","year":"2017","journal-title":"Medicine (Baltim.)"},{"issue":"1","key":"10.1016\/j.jep.2023.116561_bib44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11418-013-0770-3","article-title":"Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice","volume":"68","author":"Yamaguchi","year":"2014","journal-title":"J. Nat. Med."},{"issue":"11","key":"10.1016\/j.jep.2023.116561_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2020.129684","article-title":"Piperlonguminine a new mitochondrial aldehyde dehydrogenase activator protects the heart from ischemia\/reperfusion injury","volume":"1864","author":"Yoval-S\u00e1nchez","year":"2020","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"17","key":"10.1016\/j.jep.2023.116561_bib46","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/CIRCULATIONAHA.108.782458","article-title":"A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension","volume":"119","author":"Yu","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2023.116561_bib47","article-title":"An n-of-1 trial service in clinical practice: testing the effectiveness of Liuwei Dihuang decoction for kidney-yin deficiency syndrome","author":"Yu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.116561_bib48","article-title":"Transient receptor potential channel 6 knockout ameliorates kidney fibrosis by inhibition of epithelial-mesenchymal transition","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2023.116561_bib49","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.2147\/DDDT.S338439","article-title":"Network pharmacology and experimental validation to reveal the pharmacological mechanisms of Liuwei Dihuang decoction against intervertebral disc degeneration","volume":"15","author":"Zhang","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"issue":"6368","key":"10.1016\/j.jep.2023.116561_bib50","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1126\/science.aal4178","article-title":"A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models","volume":"358","author":"Zhou","year":"2017","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.jep.2023.116561_bib51","doi-asserted-by":"crossref","first-page":"14351","DOI":"10.1002\/jcp.28137","article-title":"Paeonol reverses promoting effect of the HOTAIR\/miR-124\/Notch1 axis on renal interstitial fibrosis in a rat model","volume":"234","author":"Zhou","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2023.116561_bib52","article-title":"Liuwei Dihuang pills inhibit podocyte injury and alleviate IgA nephropathy by directly altering mesangial cell-derived exosome function and secretion","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123004294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123004294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:37:58Z","timestamp":1759945078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123004294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":52,"alternative-id":["S0378874123004294"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116561","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piperlonguminine attenuates renal fibrosis by inhibiting TRPC6","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116561"}}