{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:54:00Z","timestamp":1785556440708,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2019YFS0527"],"award-info":[{"award-number":["2019YFS0527"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing","doi-asserted-by":"publisher","award":["cstc2021jcyj-msxmX0886"],"award-info":[{"award-number":["cstc2021jcyj-msxmX0886"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jep.2023.116590","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T23:35:59Z","timestamp":1684366559000},"page":"116590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Integrated network pharmacology, transcriptomics, and metabolomics analysis to reveal the mechanism of salt Eucommiae cortex in the treatment of chronic kidney disease mineral bone disorders via the PPARG\/AMPK signaling pathway"],"prefix":"10.1016","volume":"314","author":[{"given":"Jie","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116590_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fendo.2018.00311","article-title":"Augmented fibroblast growth factor-23 secretion in bone locally contributes to impaired bone mineralization in chronic kidney disease in mice","volume":"9","author":"Andrukhova","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.jep.2023.116590_bib2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s00223-020-00777-1","article-title":"Chronic kidney disease-mineral and bone disorders: pathogenesis and management","volume":"108","author":"Cannata-Andia","year":"2021","journal-title":"Calcif. Tissue Int."},{"issue":"6","key":"10.1016\/j.jep.2023.116590_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/genes11060705","article-title":"PPARG Pro12Ala polymorphism with CKD in asians: a meta-analysis combined with a case-control study-A key for reaching null association","volume":"11","author":"Chen","year":"2020","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.jep.2023.116590_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1186\/s13287-021-02628-8","article-title":"PPARbeta\/delta accelerates bone regeneration in diabetic mellitus by enhancing AMPK\/mTOR pathway-mediated autophagy","volume":"12","author":"Chen","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jep.2023.116590_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112333","article-title":"Mangosteen xanthone gamma-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK\/PPARgamma","volume":"144","author":"Chen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116590_bib6","article-title":"The effect of PPARgamma rs1801282 variant on mortality risk among asians with chronic kidney disease: a cohort study and meta-analysis","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Genet."},{"issue":"2","key":"10.1016\/j.jep.2023.116590_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jbmr.4459","article-title":"Cinacalcet improves bone parameters through regulation of osteoclast endoplasmic reticulum stress, autophagy, and apoptotic pathways in chronic kidney disease-mineral and bone disorder","volume":"37","author":"Chiu","year":"2022","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.jep.2023.116590_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100954","article-title":"AMPK phosphorylates PPARdelta to mediate its stabilization, inhibit glucose and glutamine uptake and colon tumor growth","volume":"297","author":"Ding","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jep.2023.116590_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/nu10030265","article-title":"Eucommia ulmoides ameliorates glucotoxicity by suppressing advanced glycation end-products in diabetic mice kidney","volume":"10","author":"Do","year":"2018","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.jep.2023.116590_bib10","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s11914-018-0486-0","article-title":"CKD-MBD: from the pathogenesis to the identification and development of potential novel therapeutic targets","volume":"16","author":"Elias","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.jep.2023.116590_bib11","doi-asserted-by":"crossref","first-page":"838","DOI":"10.3389\/fphar.2020.00838","article-title":"A metabolomics coupled with chemometrics strategy to filter combinatorial discriminatory quality markers of crude and salt-fired Eucommiae cortex","volume":"11","author":"Guo","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2023.116590_bib12","first-page":"116","article-title":"Clinical study on chronic glomerulonephritis treated with shenyan Kangfu pill and valsartan capsules","volume":"23","author":"Hao","year":"2022","journal-title":"J Shanxi Univ Chin Med"},{"key":"10.1016\/j.jep.2023.116590_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/980471","article-title":"Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC study","volume":"2013","author":"Hishida","year":"2013","journal-title":"PPAR Res."},{"issue":"Suppl. 4","key":"10.1016\/j.jep.2023.116590_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/nep.13457","article-title":"Mineral bone disorders in chronic kidney disease","volume":"23","author":"Hou","year":"2018","journal-title":"Nephrology"},{"issue":"18","key":"10.1016\/j.jep.2023.116590_bib15","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.3390\/ijms21186846","article-title":"Osteoporosis in patients with chronic kidney diseases: a systemic review","volume":"21","author":"Hsu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.jep.2023.116590_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21217994","article-title":"Critical role for AMPK in metabolic disease-induced chronic kidney disease","volume":"21","author":"Juszczak","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.116590_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020653","article-title":"Dracunculin inhibits adipogenesis in human bone marrow-derived mesenchymal stromal cells by activating AMPK and Wnt\/beta-catenin signaling","volume":"23","author":"Karadeniz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2023.116590_bib18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.7326\/M17-2640","article-title":"Diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder: synopsis of the kidney disease: improving global outcomes 2017 clinical practice guideline update","volume":"168","author":"Ketteler","year":"2018","journal-title":"Ann. Intern. Med."},{"issue":"6","key":"10.1016\/j.jep.2023.116590_bib19","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s11914-018-0491-3","article-title":"Updates in CKD-associated osteoporosis","volume":"16","author":"Khairallah","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.jep.2023.116590_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.kint.2018.08.030","article-title":"Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease","volume":"95","author":"Kikuchi","year":"2019","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.jep.2023.116590_bib21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00223-020-00788-y","article-title":"Old and new drugs for the management of bone disorders in CKD","volume":"108","author":"Komaba","year":"2021","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jep.2023.116590_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112240","article-title":"You-Gui-Yin improved the reproductive dysfunction of male rats with chronic kidney disease via regulating the HIF1\u03b1-STAT5 pathway","volume":"246","author":"Li","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2023.116590_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13030383","article-title":"ROR2 is epigenetically regulated in endometrial cancer","volume":"13","author":"Liu","year":"2021","journal-title":"Cancers"},{"issue":"12","key":"10.1016\/j.jep.2023.116590_bib24","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.3390\/molecules23123321","article-title":"Evaluation of the Absorption Behavior of Main Component Compounds of Salt-Fried Herb Ingredients in Qing'e Pills by Using Caco-2 Cell Model","volume":"23","author":"Lu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116590_bib25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.biopha.2018.06.092","article-title":"The intervention effect of zuogui pill on chronic kidney disease-mineral and bone disorder regulatory factor","volume":"106","author":"Ma","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.jep.2023.116590_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093109","article-title":"Bone disease in nephropathic cystinosis: beyond renal osteodystrophy","volume":"21","author":"Machuca-Gayet","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2023.116590_bib27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/BOR.0000000000000626","article-title":"Renal insufficiency and bone loss","volume":"31","author":"Ott","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"issue":"1","key":"10.1016\/j.jep.2023.116590_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s12011-018-1362-6","article-title":"Du-Zhong (Eucommia ulmoides Oliv.) cortex extract alleviates lead acetate-induced bone loss in rats","volume":"187","author":"Qi","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.jep.2023.116590_bib29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/nyas.14293","article-title":"Deletion of Wnt5a in osteoclasts results in bone loss through decreased bone formation","volume":"1463","author":"Roberts","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.jep.2023.116590_bib30","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s11655-016-2604-0","article-title":"Positive Effects of Qing'e Pill (\u9752\u86fe\u4e38) on Trabecular Microarchitecture and its Mechanical Properties in Osteopenic Ovariectomised Mice","volume":"25","author":"Shuai","year":"2019","journal-title":"Chin. J. Integr. Med."},{"issue":"2","key":"10.1016\/j.jep.2023.116590_bib31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1142\/S0192415X19500137","article-title":"Ethnobotany, phytochemistry and pharmacological properties of Eucommia ulmoides: a review","volume":"47","author":"Wang","year":"2019","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2023.116590_bib32","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.12659\/MSM.909285","article-title":"Peroxisome proliferator-activated receptor (PPARgamma) plays a protective role in cigarette smoking-induced inflammation via AMP-activated protein kinase (AMPK) signaling","volume":"24","author":"Wang","year":"2018","journal-title":"Med. Sci. Monit."},{"issue":"1","key":"10.1016\/j.jep.2023.116590_bib33","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1038\/s41598-022-10769-w","article-title":"Network pharmacology of iridoid glycosides from Eucommia ulmoides Oliver against osteoporosis","volume":"12","author":"Wang","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jep.2023.116590_bib34","article-title":"Effects of tonifying kidney and strengthen bone therapy on non-dialysis patients with chronic kidney disease-mineral and bone disorder: a protocol for the systematic review and meta-analysis of randomized controlled trials","volume":"100","author":"Wu","year":"2021","journal-title":"Medicine (Baltim.)"},{"issue":"3","key":"10.1016\/j.jep.2023.116590_bib35","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3892\/or.2020.7916","article-title":"VSP17 suppresses the migration and invasion of triplenegative breast cancer cells through inhibition of the EMT process via the PPARgamma\/AMPK signaling pathway","volume":"45","author":"Xu","year":"2021","journal-title":"Oncol. Rep."},{"issue":"20","key":"10.1016\/j.jep.2023.116590_bib36","first-page":"4027","article-title":"Regression analysis of serum bone metabolic markers and traditional Chinese medicine syndromes in patients with CKD-MBD","volume":"42","author":"Yang","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jep.2023.116590_bib37","article-title":"A data mining-based analysis of medication rules in treating bone marrow suppression by kidney-tonifying method","author":"You","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"issue":"19","key":"10.1016\/j.jep.2023.116590_bib38","first-page":"138","article-title":"Professor Zhang Yu's experience in treating chronic renal failure with modified dabuyuan decoction","volume":"18","author":"Yu","year":"2021","journal-title":"China Medical Herald"},{"key":"10.1016\/j.jep.2023.116590_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114422","article-title":"Discovering the main \"reinforce kidney to strengthening Yang\" active components of salt Morinda officinalis based on the spectrum-effect relationship combined with chemometric methods","volume":"207","author":"Zhang","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"10.1016\/j.jep.2023.116590_bib40","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1080\/21655979.2021.2023789","article-title":"Shenqi Yanshen Formula (SQYSF) protects against chronic kidney disease by modulating gut microbiota","volume":"13","author":"Zhang","year":"2022","journal-title":"Bioengineered"},{"issue":"22","key":"10.1016\/j.jep.2023.116590_bib41","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1021\/acs.jafc.8b01312","article-title":"Eucommia ulmoides oliver: a potential feedstock for bioactive products","volume":"66","author":"Zhu","year":"2018","journal-title":"J. Agric. Food Chem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123004580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123004580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:46:43Z","timestamp":1759945603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123004580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":41,"alternative-id":["S0378874123004580"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116590","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated network pharmacology, transcriptomics, and metabolomics analysis to reveal the mechanism of salt Eucommiae cortex in the treatment of chronic kidney disease mineral bone disorders via the PPARG\/AMPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116590","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116590"}}