{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:59:56Z","timestamp":1783018796499,"version":"3.54.6"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007854","name":"Central Institute of Medicinal and Aromatic Plants","doi-asserted-by":"publisher","award":["HCP-0007"],"award-info":[{"award-number":["HCP-0007"]}],"id":[{"id":"10.13039\/501100007854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jep.2023.116603","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T02:30:40Z","timestamp":1683167440000},"page":"116603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Vasorelaxant property of 2-phenyl ethyl alcohol isolated from the spent floral distillate of damask rose (Rosa damascena Mill.) and its possible mechanism"],"prefix":"10.1016","volume":"313","author":[{"given":"Munmun Kumar","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumari","family":"Savita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Rani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Chanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Swaroop","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116603_bib1","series-title":"Identification of Essential Oil Components by Gas Chromatography\/mass Spectrometry\u2019","author":"Adams","year":"2007"},{"key":"10.1016\/j.jep.2023.116603_bib2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.fct.2004.11.013","article-title":"The FEMA GRAS assessment of phenethyl alcohol, aldehydes, acids, and related acetals and esters used as flavor ingredients","volume":"43","author":"Adams","year":"2005","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116603_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ffj.1487","article-title":"Gas chromotographic investigation of rose concrete, absolute and solid residue","volume":"20","author":"Ayci","year":"2005","journal-title":"Flavour Fragrance J."},{"issue":"4","key":"10.1016\/j.jep.2023.116603_bib4","first-page":"319","article-title":"Effect of hydro-alcoholic extract of Rosa damascena on cardiovascular responses in normotensive rat","volume":"5","author":"Baniasad","year":"2015","journal-title":"Avicenna J. Phytomed."},{"key":"10.1016\/j.jep.2023.116603_bib5","first-page":"45","article-title":"Turkish rose oil","volume":"17","author":"Baser","year":"1992","journal-title":"Perfum. Flavor."},{"key":"10.1016\/j.jep.2023.116603_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jsfa.2740640408","article-title":"Volatile oil composition of Turkish rose (Rosa damascena)","volume":"64","author":"Bayrak","year":"1994","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.jep.2023.116603_bib7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fphys.2014.00389","article-title":"BK channel activators and their therapeutic perspectives","volume":"5","author":"Bentzen","year":"2014","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.jep.2023.116603_bib8","first-page":"295","article-title":"Pharmacological effects of Rosa damascena","volume":"14","author":"Boskabady","year":"2011","journal-title":"Iran J. Basic Med. Sci."},{"key":"10.1016\/j.jep.2023.116603_bib9","article-title":"Lifestyle and hypertension: an evidence-based review","volume":"4","author":"Bruno","year":"2018","journal-title":"J. Hypertens. Manag."},{"issue":"165","key":"10.1016\/j.jep.2023.116603_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.lfs.2016.09.018","article-title":"Glabridin-induced vasorelaxation: evidence for a role of BKCa channels and cyclic GMP","volume":"15","author":"Chanda","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2023.116603_bib11","first-page":"91","article-title":"Antidepressant-like effect of aqueous extract from Rosa damascena in mice","volume":"1","author":"Dolati","year":"2011","journal-title":"Avicenna J. Phytomed."},{"issue":"5","key":"10.1016\/j.jep.2023.116603_bib12","first-page":"555","article-title":"Variation in scent compounds of oil-bearing rose (Rosa damascene Mill.) produced by headspace solid phase microextraction, hydrodistillation and solvent extraction","volume":"10","author":"Erbas","year":"2016","journal-title":"Record Nat. Prod."},{"key":"10.1016\/j.jep.2023.116603_bib13","first-page":"625","article-title":"Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial","volume":"11","author":"Farnia","year":"2015","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.jep.2023.116603_bib14","series-title":"Medicinal Plants","first-page":"234","article-title":"Rosa rugosaThunb","author":"Foster","year":"1990"},{"issue":"1","key":"10.1016\/j.jep.2023.116603_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-8741(95)01286-M","article-title":"In vitro screening of traditional medicines for anti-hypertensive effect based on inhibition of the angiotensin converting enzyme (ACE)","volume":"48","author":"Hansen","year":"1995","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116603_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.611109","article-title":"Antihypertensive effect of a novel angiotensin II receptor blocker fluorophenyl benzimidazole: contribution of cGMP, voltage-dependent calcium channels and BKCa channels to vasorelaxant mechanisms","volume":"12","author":"Iqbal","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116603_bib17","first-page":"710","article-title":"Productivity, oil content, composition, and bioactivity of oil-bearing rose accessions","volume":"46","author":"Kovatcheva","year":"2011","journal-title":"Hortic. Sci. (Stuttg.)"},{"issue":"5","key":"10.1016\/j.jep.2023.116603_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1023\/B:CONC.0000011120.71479.7f","article-title":"Studies on Turkish rose concrete, absolute and hydrosol","volume":"39","author":"Kukcuoglu","year":"2003","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.jep.2023.116603_bib19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1476-5381.1993.tb12851.x","article-title":"Evaluation of the relaxant effects of SCA40, a novel charybdotoxin-sensitive potassium channel opener, in Guinea-pig isolated trachealis","volume":"108","author":"Laurent","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116603_bib20","first-page":"43","article-title":"Progress in essential oils: rose oil and extracts","volume":"16","author":"Lawrence","year":"1991","journal-title":"Perfum. Flavor."},{"issue":"9","key":"10.1016\/j.jep.2023.116603_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.tins.2010.06.004","article-title":"BK channel activation: structural and functional insights","volume":"33","author":"Lee","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jep.2023.116603_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jtcme.2015.09.005","article-title":"Rosa damascenaas holy ancient herb with novel applications","volume":"6","author":"Mahboubi","year":"2016","journal-title":"J. Tradit. Complement. Med."},{"issue":"20","key":"10.1016\/j.jep.2023.116603_bib23","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1001\/archinte.158.20.2225","article-title":"Herbal medicine for the treatment of cardiovascular disease","volume":"158","author":"Mashour","year":"1998","journal-title":"Arch. Intern. Med."},{"issue":"9587","key":"10.1016\/j.jep.2023.116603_bib24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(07)61299-9","article-title":"Essential hypertension","volume":"370","author":"Messerli","year":"2007","journal-title":"The lancet"},{"issue":"1","key":"10.1016\/j.jep.2023.116603_bib25","first-page":"29","article-title":"Isolation and identification of phenylethyl alcohol from Pichia anomala SKM-T","volume":"50","author":"Mo","year":"2007","journal-title":"J. Appl. Biol. Chem."},{"key":"10.1016\/j.jep.2023.116603_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s43094-020-00142-x","article-title":"Evaluation of anti-hypertensive activity of ancient Unani cardiovascular drug \u201cSaad Kufi\u201d (Cyperus scariosus) in adrenaline induced hypertensive rats","volume":"6","author":"Nafees","year":"2020","journal-title":"Future J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.jep.2023.116603_bib27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s11418-012-0666-7","article-title":"Rose oil (from Rosa damascena Mill.) vapor attenuates depression-induced oxidative toxicity in rat brain","volume":"67","author":"Naz\u0131roglu","year":"2013","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116603_bib28","article-title":"Hypertension","volume":"4","author":"Oparil","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jep.2023.116603_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0015-6264(75)90088-7","article-title":"Fragrance raw materials monographs. Phenylethyl alcohol","volume":"13","author":"Opdyke","year":"1975","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2023.116603_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/1091581812471688","article-title":"The pharmacokinetics of phenylethyl alcohol (PEA): safety evaluation comparisons in rats, rabbits, and humans","volume":"32","author":"Politano","year":"2013","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.jep.2023.116603_bib31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/10915819009078732","article-title":"Final report on the safety assessment of phenethyl alcohol","volume":"9","author":"Rev","year":"1990","journal-title":"J. Am. Coll. Toxicol."},{"key":"10.1016\/j.jep.2023.116603_bib32","doi-asserted-by":"crossref","first-page":"S224","DOI":"10.1016\/j.fct.2011.10.028","article-title":"Fragrance material review on phenylethyl alcohol","volume":"50","author":"Scognamiglio","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"24","key":"10.1016\/j.jep.2023.116603_bib33","doi-asserted-by":"crossref","first-page":"7480","DOI":"10.3390\/molecules26247480","article-title":"Conjugated metabolites of hydroxytyrosol and tyrosol contribute to the maintenance of nitric oxide balance in human aortic endothelial cells at physiologically relevant concentrations","volume":"26","author":"Serreli","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116603_bib34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2017.01.044","article-title":"Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits antihypertensive activity in rats through increase in intracellular cGMP level and blockade of calcium channels","volume":"799","author":"Singh","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116603_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2022.115487","article-title":"Secondary metabolic profile of rose-scented geranium: a tool for characterization, distinction and quality control of Indian genotypes","volume":"187","author":"Upadhyay","year":"2022","journal-title":"Ind. Crop. Prod."},{"issue":"17","key":"10.1016\/j.jep.2023.116603_bib36","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1080\/14786419.2010.520162","article-title":"Volatile constituents of essential oil and rose water of damask rose (Rosa damascene Mill.) cultivars from North Indian hills","volume":"25","author":"Verma","year":"2011","journal-title":"Nat. Prod. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123004713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123004713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:37:20Z","timestamp":1759945040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123004713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":36,"alternative-id":["S0378874123004713"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116603","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vasorelaxant property of 2-phenyl ethyl alcohol isolated from the spent floral distillate of damask rose (Rosa damascena Mill.) and its possible mechanism","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116603","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116603"}}