{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:07:39Z","timestamp":1785276459602,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004561","name":"Ministry of Science and Higher Education of the Republic of Kazakhstan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jep.2023.116660","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T17:26:08Z","timestamp":1685294768000},"page":"116660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Chemical composition and cardiotropic activity of Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.f."],"prefix":"10.1016","volume":"315","author":[{"given":"A.O.","family":"Whaley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.Y.","family":"Ivkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-2004","authenticated-orcid":false,"given":"K.A.","family":"Zhaparkulova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.N.","family":"Olusheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.B.","family":"Serebryakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"Smirnov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-7711","authenticated-orcid":false,"given":"E.D.","family":"Semivelichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Yu.","family":"Grishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Karpov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.I.","family":"Eletckaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.","family":"Kozhanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8381-5330","authenticated-orcid":false,"given":"L.N.","family":"Ibragimova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-8816","authenticated-orcid":false,"given":"K.T.","family":"Tastambek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-5599","authenticated-orcid":false,"given":"A.M.","family":"Seitaliyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.I.","family":"Terninko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.B.","family":"Sakipova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.N.","family":"Shikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-9059","authenticated-orcid":false,"given":"M.N.","family":"Povydysh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-5924","authenticated-orcid":false,"given":"A.K.","family":"Whaley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2023.116660_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jpbs.JPBS_175_19","article-title":"Preparation of medicinal plants: basic extraction and fractionation procedures for experimental purposes","volume":"12","author":"Abubakar","year":"2020","journal-title":"J. Pharm. BioAllied Sci."},{"issue":"4","key":"10.1016\/j.jep.2023.116660_bib2","article-title":"In vitro antioxidant and antibacterial properties and total phenolic contents of essential oils from Thymus vulgaris, T. kotschyanus, Ziziphora tenuior and Z. clinopodioides","volume":"38","author":"Aliakbarlu","year":"2013","journal-title":"Turk. J. Biochem."},{"issue":"9","key":"10.1016\/j.jep.2023.116660_bib3","first-page":"1635","article-title":"The evaluation of medicinal properties of Ziziphora clinopodioides","volume":"12","author":"Beikmohammadi","year":"2011","journal-title":"World Appl. Sci. J."},{"issue":"2","key":"10.1016\/j.jep.2023.116660_bib4","article-title":"Chemical components and antibacterial activities of essential oil of wild, in vitro and acclimatised plants of Ziziphora tenuior L","volume":"26","author":"Dakah","year":"2019","journal-title":"Int. Food Res. J."},{"key":"10.1016\/j.jep.2023.116660_bib6","series-title":"Prevention and Treatment of Experimental Myocarditis and Myocardial Infarction","first-page":"153","author":"Dzhumagalieva","year":"1963"},{"issue":"1","key":"10.1016\/j.jep.2023.116660_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2174\/1871525717666190114145137","article-title":"The cardiovascular protective effects of chrysin: a narrative review on experimental researches","volume":"17","author":"Farkhondeh","year":"2019","journal-title":"Cardiovasc. Hematol. Agents Med. Chem."},{"issue":"10","key":"10.1016\/j.jep.2023.116660_bib8","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/chir.20862","article-title":"Enantioselectivity of hydroxylation of racemic piperitone by fungi","volume":"22","author":"Grudniewska","year":"2010","journal-title":"Chirality"},{"issue":"10","key":"10.1016\/j.jep.2023.116660_bib9","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.3390\/molecules27103292","article-title":"A comprehensive review of rosmarinic acid: from phytochemistry to pharmacology and its new insight","volume":"27","author":"Guan","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jep.2023.116660_bib10","first-page":"1","article-title":"In-vivo absorption of pinocembrin-7-O-\u03b2-D-glucoside in rats and its in-vitro biotransformation","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116660_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13020-020-00354-6","article-title":"Integrated metabolomic and transcriptomic profiling reveals the tissue-specific flavonoid compositions and their biosynthesis pathways in Ziziphora bungeana","volume":"15","author":"He","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116660_bib12","first-page":"812","article-title":"Macroscopic and morpho-anatomical diagnostic features of Ziziphora bungeana Juz. from Kazakhstan","volume":"8","author":"Karlygash","year":"2016","journal-title":"Int. J. Pharmacogn. Phytochem. Res."},{"issue":"2","key":"10.1016\/j.jep.2023.116660_bib13","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/iep.12312","article-title":"Non-inferiority of microencapsulated mesenchymal stem cells to free cells in cardiac repair after myocardial infarction: a rationale for using paracrine factor(s) instead of cells","volume":"100","author":"Karpov","year":"2019","journal-title":"Int. J. Exp. Pathol."},{"issue":"3","key":"10.1016\/j.jep.2023.116660_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF02976451","article-title":"Isolation of luteolin 7-O-rutinoside and esculetin with potential antioxidant activity from the aerial parts of Artemisia montana","volume":"23","author":"Kim","year":"2000","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2023.116660_bib15","article-title":"Ziziphora clinopodioides flavonoids protect myocardial cell damage from myocardial ischemia-reperfusion injury","volume":"2018","author":"Li","year":"2018","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"10.1016\/j.jep.2023.116660_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9979843","article-title":"Acacetin protects myocardial cells against hypoxia-reoxygenation injury through activation of autophagy","volume":"2021","author":"Liu","year":"2021","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.jep.2023.116660_bib17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fphar.2017.00692","article-title":"Luteolin: a flavonoid that has multiple cardio-protective effects and its molecular mechanisms","volume":"8","author":"Luo","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2023.116660_bib18","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1248\/cpb.36.2475","article-title":"Studies on the Glycosides of Epimedium grandiflorum MORR. var. thunbergianum","volume":"36","author":"Miyase","year":"1988","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2023.116660_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/(SICI)1099-1026(199805\/06)13:3<203::AID-FFJ725>3.0.CO;2-0","article-title":"Phenols and lactones in Italo-Mitcham peppermint oil Mentha \u00d7 piperita L","volume":"13","author":"N\u00e4f","year":"1998","journal-title":"Flavour Fragrance J."},{"issue":"2","key":"10.1016\/j.jep.2023.116660_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1353\/esc.2007.0026","article-title":"Estranging the familiar:\" east\" and\" west\" in Satrapi's persepolis","volume":"31","author":"Naghibi","year":"2005","journal-title":"ESC Engl. Stud. Can."},{"key":"10.1016\/j.jep.2023.116660_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116797","article-title":"Chrysin: pharmacological and therapeutic properties","volume":"235","author":"Naz","year":"2019","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.116660_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1055\/s-2006-961918","article-title":"Schizonodiol, schizonol, and schizonepetosides D and E, monoterpenoids of Schizonepeta tenuifolia Spikes","volume":"55","author":"Oshima","year":"1989","journal-title":"Planta Med."},{"issue":"2","key":"10.1016\/j.jep.2023.116660_bib23","first-page":"73","article-title":"Chemical composition and antibacterial activity of essential oil of Ziziphora hispanica L","volume":"2","author":"Rabah","year":"2013","journal-title":"Glob. J. Res. Med. Plants Indig. Med."},{"issue":"11","key":"10.1016\/j.jep.2023.116660_bib24","doi-asserted-by":"crossref","first-page":"14779","DOI":"10.1021\/acsomega.8b02020","article-title":"Phytotoxic potential of zanthoxylum affine and its major compound linarin as a possible natural herbicide","volume":"3","author":"Rios","year":"2018","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.jep.2023.116660_bib25","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0031-9422(00)90041-4","article-title":"Chrysin-7-rutinoside from the leaves of Dolichandrone falcate","volume":"11","author":"Sankara Subramanian","year":"1972","journal-title":"Phytochemistry"},{"issue":"8","key":"10.1016\/j.jep.2023.116660_bib26","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.phytochem.2008.02.015","article-title":"Accumulation of apocarotenoids in mycorrhizal roots of leek (Allium porrum)","volume":"69","author":"Schliemann","year":"2008","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.jep.2023.116660_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.fitote.2011.11.023","article-title":"Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam.(Lamiaceae)","volume":"83","author":"Senejoux","year":"2012","journal-title":"Fitoterapia"},{"issue":"12","key":"10.1016\/j.jep.2023.116660_bib28","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.3390\/molecules24122323","article-title":"Advances in biosynthesis, pharmacology, and pharmacokinetics of pinocembrin, a promising natural small-molecule drug","volume":"24","author":"Shen","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116660_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153451","article-title":"Monoterpenes and their derivatives as agents for cardiovascular disease management: a systematic review and meta-analysis","volume":"88","author":"Silva","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116660_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111708","article-title":"Acacetin, a flavone with diverse therapeutic potential in cancer, inflammation, infections and other metabolic disorders","volume":"145","author":"Singh","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.jep.2023.116660_bib31","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3390\/molecules21070826","article-title":"Kazakh Ziziphora species as sources of bioactive substances","volume":"21","author":"\u0160mejkal","year":"2016","journal-title":"Molecules"},{"issue":"9\u201310","key":"10.1016\/j.jep.2023.116660_bib32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1515\/znc-2006-9-1011","article-title":"Antibacterial activity and composition of the essential oil of Ziziphora clinopodioides subsp. bungeana (Juz.) Rech. f. from Iran","volume":"61","author":"Sonboli","year":"2006","journal-title":"Z. Naturforsch."},{"key":"10.1016\/j.jep.2023.116660_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10600-018-2296-0","article-title":"Phytochemical and biological studies on Ziziphora bungeana","volume":"54","author":"Srivedavyasasri","year":"2018","journal-title":"Chem. Nat. Compd."},{"issue":"1","key":"10.1016\/j.jep.2023.116660_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1021\/ja01157a108","article-title":"The autoxidation of menthofuran","volume":"72","author":"Woodward","year":"1950","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jep.2023.116660_bib35","article-title":"Acacetin as a potential protective compound against cardiovascular diseases","volume":"2022","author":"Wu","year":"2022","journal-title":"Evid. Based Compl. Alternat. Med."},{"issue":"4","key":"10.1016\/j.jep.2023.116660_bib36","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1021\/jf104387y","article-title":"Flavonoid glycosides from the seeds of Litchi chinensis","volume":"59","author":"Xu","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116660_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-8546-9-1","article-title":"Protective effects of acacetin isolated from Ziziphora clinopodioides Lam.(Xintahua) on neonatal rat cardiomyocytes","volume":"9","author":"Yang","year":"2014","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2023.116660_bib38","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1248\/cpb.32.295","article-title":"Studies on the constituents of palmae plants. I. The constituents of Trachycarpus fortunei (Hook.) H. Wendl","volume":"32","author":"Yasuaki","year":"1984","journal-title":"Chem. Pharm. Bull."},{"issue":"5","key":"10.1016\/j.jep.2023.116660_bib39","doi-asserted-by":"crossref","first-page":"PC76","DOI":"10.1055\/s-0036-1578778","article-title":"Standardization of medicinal herb Ziziphora bungeana Juz.(Lamiaceae) and quantitative determination of pulegone in the essential oil","volume":"82","author":"Zhaparkulova","year":"2016","journal-title":"Planta Med."},{"issue":"24","key":"10.1016\/j.jep.2023.116660_bib40","doi-asserted-by":"crossref","first-page":"8994","DOI":"10.3390\/molecules27248994","article-title":"Multidirectional characterization of phytochemical profile and health-promoting effects of Ziziphora bungeana Juz. extracts","volume":"27","author":"Zhaparkulova","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116660_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4850328","article-title":"Cardioprotective natural compound pinocembrin attenuates acute ischemic myocardial injury via enhancing glycolysis","volume":"2020","author":"Zheng","year":"2020","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123005287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123005287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:40:52Z","timestamp":1759945252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123005287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":40,"alternative-id":["S0378874123005287"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116660","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical composition and cardiotropic activity of Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.f.","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116660"}}