{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:26:03Z","timestamp":1784784363985,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST111-2321-B-039-007"],"award-info":[{"award-number":["MOST111-2321-B-039-007"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","award":["CMU111-MF-28"],"award-info":[{"award-number":["CMU111-MF-28"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007300","name":"China Medical University","doi-asserted-by":"publisher","award":["CMU111-MF-43"],"award-info":[{"award-number":["CMU111-MF-43"]}],"id":[{"id":"10.13039\/501100007300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jep.2023.116687","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T12:29:18Z","timestamp":1685017758000},"page":"116687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Analysis of target organs of Houttuynia cordata: A study on the anti-inflammatory effect of upper respiratory system"],"prefix":"10.1016","volume":"315","author":[{"given":"Tin-Yun","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yi","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7422-9308","authenticated-orcid":false,"given":"Guan-Ling","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-0138","authenticated-orcid":false,"given":"Pei-Yung","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6507-8015","authenticated-orcid":false,"given":"Chien-Yun","family":"Hsiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116687_bib1","first-page":"79","article-title":"Natural immunomodulators treat the cytokine storm in SARS-CoV-2","volume":"13","author":"Abbas","year":"2023","journal-title":"Adv. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2023.116687_bib2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/1440-1681.13620","article-title":"Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R\/JAK\/STAT augmentation in a rat model that mimics moderate and severe Covid-19 pathology","volume":"49","author":"Al-Ani","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.jep.2023.116687_bib3","doi-asserted-by":"crossref","first-page":"23379","DOI":"10.1039\/D0RA03774E","article-title":"Natural products' role against COVID-19","volume":"10","author":"Antonio","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2023.116687_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.37796\/2211-8039.1017","article-title":"Evaluation of the level of biomolecules isolated from date palm seeds (Phoenix dactylifera) and in vitro antioxidant property","volume":"10","author":"Bentrad","year":"2020","journal-title":"Biomedicine"},{"key":"10.1016\/j.jep.2023.116687_bib5","first-page":"914","article-title":"Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis","volume":"20","author":"Cen","year":"2022","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116687_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/JCMA.0000000000000732","article-title":"A Houttuynia cordata-based Chinese herbal formula improved symptoms of allergic rhinitis during the COVID-19 pandemic","volume":"85","author":"Chang","year":"2022","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.jep.2023.116687_bib7","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1002\/jat.4198","article-title":"Acute and subacute toxicity evaluation of Houttuynia cordata ethanol extract and plasma metabolic profiling analysis in both male and female rats","volume":"41","author":"Chen","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.jep.2023.116687_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jep.2010.08.022","article-title":"Application of bioactivity database of Chinese herbal medicine on the therapeutic prediction, drug development, and safety evaluation","volume":"132","author":"Cheng","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib9","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1039\/D2FO02369E","article-title":"Sodium houttuyfonate derived from Houttuynia cordata Thunb improves intestinal malfunction via maintaining gut microflora stability in Candida albicans overgrowth aggravated ulcerative colitis","volume":"14","author":"Cheng","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116687_bib10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jep.2016.10.059","article-title":"Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation","volume":"194","author":"Chou","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4161\/viru.26083","article-title":"Animal models of sepsis","volume":"5","author":"Fink","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.jep.2023.116687_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4236\/cm.2013.43015","article-title":"Houttuynia cordata Thunb: a review of phytochemistry and pharmacology and quality control","volume":"4","author":"Fu","year":"2013","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116687_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110461","article-title":"Chlorogenic acid ameliorated non-alcoholic steatohepatitis via alleviating hepatic inflammation initiated by LPS\/TLR4\/MyD88 signaling pathway","volume":"376","author":"Gu","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2023.116687_bib14","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1016\/j.biomaterials.2007.07.005","article-title":"Noninvasive nuclear factor-\u03baB bioluminescence imaging for the assessment of host-biomaterial interaction in transgenic mice","volume":"28","author":"Ho","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.jep.2023.116687_bib15","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1021\/acs.jafc.6b03327","article-title":"Corn silk extract and its bioactive peptide ameliorated lipopolysaccharide-induced inflammation in mice via nuclear factor-\u03baB signaling pathway","volume":"65","author":"Ho","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116687_bib16","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.1039\/D0FO01324B","article-title":"The protective effect of quercetin on retinal inflammation in mice: the involvement of tumor necrosis factor\/nuclear factor-\u03baB signaling pathways","volume":"11","author":"Ho","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116687_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5625\/lar.2012.28.2.137","article-title":"Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model","volume":"28","author":"Kim","year":"2012","journal-title":"Lab. Anim. Res."},{"key":"10.1016\/j.jep.2023.116687_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e10386","article-title":"The therapeutic potential of Houttuynia cordata: a current review","volume":"8","author":"Laldinsangi","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2023.116687_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jep.2008.03.018","article-title":"Immunomodulatory and anti-SARS activities of Houttuynia cordata","volume":"118","author":"Lau","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jep.2008.01.013","article-title":"Suppressive effects of Houttuynia cordata Thunb (Saururaceae) extract on Th2 immune response","volume":"117","author":"Lee","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib21","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/ptr.4905","article-title":"Houttuynia cordata Thunb. volatile oil exhibited anti-inflammatory effects in vivo and inhibited nitric oxide and tumor necrosis factor-alpha production in LPS-stimulated mouse peritoneal macrophages in vitro","volume":"27","author":"Li","year":"2013","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2023.116687_bib22","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jep.2010.10.048","article-title":"Houttuynia cordata, a novel and selective COX-2 inhibitor with anti-inflammatory activity","volume":"133","author":"Li","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115761","article-title":"The synergistic effect and mechanisms of flavonoids and polysaccharides from Houttuynia cordata on H1N1-induced pneumonia in mice","volume":"302","author":"Ling","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib24","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.3390\/v14071588","article-title":"Network pharmacology and molecular docking elucidate the underlying pharmacological mechanisms of the herb Houttuynia cordata in treating pneumonia caused by SARS-CoV-2","volume":"14","author":"Liu","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.jep.2023.116687_bib25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jep.2005.09.012","article-title":"Anti-inflammatory effect of Houttuynia cordata injection","volume":"104","author":"Lu","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/bph.16069","article-title":"Chlorogenic acid reduces inflammation by inhibiting the elevated expression of KAT2A to ameliorate lipopolysaccharide-induced acute lung injury","author":"Lv","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/bs.ircmb.2017.07.007","article-title":"NF-\u03baB and the transcriptional control of inflammation","volume":"335","author":"Mitchell","year":"2018","journal-title":"Int. Rev. Cell. Mol. Biol."},{"key":"10.1016\/j.jep.2023.116687_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/10815589221141841","article-title":"COVID-19's immuno-pathology and cardiovascular diseases","volume":"71","author":"Nasab","year":"2023","journal-title":"J. Invest. Med."},{"key":"10.1016\/j.jep.2023.116687_bib29","doi-asserted-by":"crossref","first-page":"10710","DOI":"10.1039\/D2FO01619B","article-title":"The combination of sodium alginate and chlorogenic acid enhances the therapeutic effect on ulcerative colitis by the regulation of inflammation and the intestinal flora","volume":"13","author":"Niu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116687_bib30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1142\/S0192415X05003028","article-title":"Anti-inflammatory activity of herbal medicines: inhibition of nitric oxide production and tumor necrosis factor-alpha secretion in an activated macrophage-like cell line","volume":"33","author":"Park","year":"2005","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2023.116687_bib31","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/ph15091079","article-title":"Pharmacological effects of Houttuynia cordata Thunb (H. cordata): a comprehensive review","volume":"15","author":"Rafiq","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2023.116687_bib32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physiolgenomics.2001.5.3.147","article-title":"Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation","volume":"5","author":"Saban","year":"2001","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.jep.2023.116687_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jep.2018.03.038","article-title":"Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: a review","volume":"220","author":"Shingnaisui","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib34","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1021\/acschemneuro.1c00371","article-title":"Quercitrin rapidly alleviated depression-like behaviors in lipopolysaccharide-treated mice: the involvement of PI3K\/AKT\/NF-\u03baB signaling suppression and CREB\/BDNF signaling restoration in the hippocampus","volume":"12","author":"Sun","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jep.2023.116687_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111037","article-title":"A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: a bedside-to-bench study","volume":"133","author":"Tsai","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116687_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154353","article-title":"The traditional Chinese medicine Houttuynia cordata Thunb decoction alters intestinal barrier function via an EGFR dependent MAPK (ERK1\/2) signalling pathway","volume":"105","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116687_bib37","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1002\/fsn3.1922","article-title":"Effect of houttuynia on improving lung injury in chronic obstructive pulmonary disease by regulating the TLR4 signaling pathway","volume":"9","author":"Wang","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jep.2023.116687_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115541","article-title":"Anti-inflammatory, antipyretic efficacy and safety of inhaled Houttuynia cordata thunb. essential oil formulation","volume":"297","author":"Wong","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib39","article-title":"Houttuynia cordata Thunb: an ethnopharmacological review","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jep.2015.07.015","article-title":"Houttuynia cordata Thunb. polysaccharides ameliorates lipopolysaccharide-induced acute lung injury in mice","volume":"173","author":"Xu","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/09546634.2019.1657792","article-title":"Clinical efficacy of herbal extracts in treatment of mild to moderate acne vulgaris: an 8-week, double-blinded, randomized, controlled trial","volume":"32","author":"Yang","year":"2021","journal-title":"J. Dermatol. Treat."},{"key":"10.1016\/j.jep.2023.116687_bib42","first-page":"223","article-title":"Quality evaluation of Houttuynia cordata Thunb. by high performance liquid chromatography with photodiode-array detection (HPLC-DAD)","volume":"27","author":"Yang","year":"2014","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2023.116687_bib43","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/jmf.2021.K.0144","article-title":"Bioactive components of Houttuynia cordata Thunb and their potential mechanisms against COVID-19 using network pharmacology and molecular docking approaches","volume":"25","author":"Yuan","year":"2022","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2023.116687_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113889","article-title":"The role of SARS-CoV-2 accessory proteins in immune evasion","volume":"156","author":"Zandi","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116687_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.733618","article-title":"Evaluating the therapeutic mechanisms of selected active compounds in Houttuynia cordata Thunb. in pulmonary fibrosis via network phatmacology analysis","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116687_bib46","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jep.2018.02.016","article-title":"Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection","volume":"218","author":"Zhu","year":"2018","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412300555X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412300555X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:39:55Z","timestamp":1759945195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412300555X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":46,"alternative-id":["S037887412300555X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116687","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of target organs of Houttuynia cordata: A study on the anti-inflammatory effect of upper respiratory system","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116687"}}