{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:17:24Z","timestamp":1790860644652,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070356"],"award-info":[{"award-number":["32070356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jep.2023.116731","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T11:19:04Z","timestamp":1685791144000},"page":"116731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Mailuoning oral liquid attenuates convalescent cerebral ischemia by inhibiting AMPK\/mTOR-associated apoptosis and promoting CREB\/BDNF-mediated neuroprotection"],"prefix":"10.1016","volume":"317","author":[{"given":"Xiaoqiong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhua","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-2874","authenticated-orcid":false,"given":"Ninghua","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116731_bib1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tins.2010.02.001","article-title":"CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models","volume":"33","author":"Benito","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jep.2023.116731_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their receptors: a convergence point for many signalling pathways","volume":"4","author":"Chao","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jep.2023.116731_bib3","first-page":"39","article-title":"Effect of Mailuoning oral liquid on platelet aggregation and thrombosis","volume":"4","author":"Chen","year":"2004","journal-title":"Pharmaceut. Clin. Res."},{"key":"10.1016\/j.jep.2023.116731_bib4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jep.2017.01.004","article-title":"Protective effects of Tongxinluo on cerebral ischemia\/reperfusion injury related to Connexin 43\/Calpain II\/Bax\/Caspase-3 pathway in rat","volume":"198","author":"Cheng","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib5","doi-asserted-by":"crossref","first-page":"9765","DOI":"10.3390\/ijms22189765","article-title":"AMPK-mTOR signaling and cellular adaptations in hypoxia","volume":"22","author":"Chun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116731_bib6","first-page":"447","article-title":"Progress in the researches on pharmacological action and clinical application of Mailuoning","volume":"16","author":"Du","year":"1996","journal-title":"Zhong Guo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.jep.2023.116731_bib7","first-page":"23","article-title":"Comparison of the efficacy of Mailuoning oral liquid and injection on arteriosclerosis obliterans","volume":"6","author":"Fan","year":"2004","journal-title":"Pharmaceut. Clin. Res."},{"key":"10.1016\/j.jep.2023.116731_bib8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fphar.2020.00298","article-title":"Neuroprotective effect of Danhong injection on cerebral ischemia-reperfusion injury in rats by activation of the PI3K-Akt pathway","volume":"11","author":"Feng","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib9","first-page":"3445","article-title":"Animal models of ischemic stroke and their application in clinical research","volume":"9","author":"Fluri","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2023.116731_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1152\/physrev.00011.2017","article-title":"Neuronal cell death","volume":"98","author":"Fricker","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2023.116731_bib11","first-page":"304","article-title":"Mailuoning oral liquid combined with rehabilitation training for patients with cerebral thrombosis and its sequelae","volume":"20","author":"He","year":"2012","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.116731_bib12","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/2211-5463.12301","article-title":"Sodium hydrosulfide attenuates cerebral ischemia\/reperfusion injury by suppressing overactivated autophagy in rats","volume":"7","author":"Jiang","year":"2017","journal-title":"FEBS Open Biol."},{"key":"10.1016\/j.jep.2023.116731_bib13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jep.2023.116731_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13578-020-00441-z","article-title":"Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia","volume":"10","author":"Lai","year":"2020","journal-title":"Cell Biosci."},{"key":"10.1016\/j.jep.2023.116731_bib15","first-page":"74","article-title":"Clinical study of Mailuoning oral liquid in the treatment of acute ischemic stroke","volume":"4","author":"Lei","year":"2012","journal-title":"China Med. Eng."},{"key":"10.1016\/j.jep.2023.116731_bib16","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s11481-020-09978-9","article-title":"Pretreatment of indobufen and aspirin and their combinations with clopidogrel or ticagrelor alleviates inflammasome mediated pyroptosis via inhibiting NF-\u03baB\/NLRP3 pathway in ischemic stroke","volume":"16","author":"Li","year":"2021","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112365","article-title":"Ginkgo diterpene lactones inhibit cerebral ischemia\/reperfusion induced inflammatory response in astrocytes via TLR4\/NF-\u03baB pathway in rats","volume":"249","author":"Li","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib18","article-title":"Acute administration of metformin protects against neuronal apoptosis induced by cerebral ischemia-reperfusion injury via regulation of the AMPK\/CREB\/BDNF pathway","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib19","doi-asserted-by":"crossref","first-page":"19587","DOI":"10.18632\/aging.203369","article-title":"LncRNA AC136007.2 alleviates cerebral ischemic-reperfusion injury by suppressing autophagy","volume":"13","author":"Liu","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.jep.2023.116731_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2023.116731_bib21","first-page":"1171","article-title":"Effects of Mailuoning oral liquid against cerebral ischemia-reperfusion in rats","volume":"7","author":"Luo","year":"2006","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"10.1016\/j.jep.2023.116731_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113776","article-title":"Salvianolic acids for injection alleviates cerebral ischemia\/reperfusion injury by switching M1\/M2 phenotypes and inhibiting NLRP3 inflammasome\/pyroptosis axis in microglia in vivo and in vitro","volume":"270","author":"Ma","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib23","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.3390\/molecules23092401","article-title":"Neuroprotective effects of radix scrophulariae on cerebral ischemia and reperfusion injury via MAPK pathways","volume":"23","author":"Meng","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116731_bib24","first-page":"880","article-title":"Effect of Mailuoning injectable powder on experimental vascular occlusion angeitides in rats","volume":"31","author":"Miao","year":"2008","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.jep.2023.116731_bib25","first-page":"1347","article-title":"Effects of Mailuoning injection on blood-brain barrier permeability after ischemia reperfusion injury in rats","volume":"36","author":"Pang","year":"2014","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2023.116731_bib26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0301-0082(01)00002-8","article-title":"Alteration of second messengers during acute cerebral ischemia - adenylate cyclase, cyclic AMP-dependent protein kinase, and cyclic AMP response element binding protein","volume":"65","author":"Tanaka","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jep.2023.116731_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jep.2023.116731_bib28","first-page":"1","article-title":"Effects of Mailuoning oral liquid and butylphthalide on cognitive function and ER stress related indexes in patients with vascular dement","author":"Wang","year":"2022","journal-title":"Chin. Arch. Tradit. Chin."},{"key":"10.1016\/j.jep.2023.116731_bib29","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4103\/1673-5374.233441","article-title":"Puerarin protects rat brain against ischemia\/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway","volume":"13","author":"Wang","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jep.2023.116731_bib30","first-page":"351","article-title":"Mechanism of Huoxue Tongluo decoction in treatment of erectile dysfunction caused by ischemic stroke based on network pharmacology","volume":"13","author":"Wang","year":"2021","journal-title":"Chin. Herb Med."},{"key":"10.1016\/j.jep.2023.116731_bib31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0254-6272(13)60108-9","article-title":"Mailuoning prevents high-glucose-mediated human umbilical vein endothelial cells apoptosis","volume":"33","author":"Wang","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2023.116731_bib32","first-page":"27","article-title":"Anti-ischemic effect of Mailuoning oral liquid","volume":"2","author":"Wang","year":"2004","journal-title":"Pharmaceut. Clin. Res."},{"key":"10.1016\/j.jep.2023.116731_bib33","first-page":"815","article-title":"Pharmacodynamics and potential synergistic effects of Mailuoning injection on cardiovascular protection, based on molecular docking","volume":"13","author":"Wu","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116731_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115379","article-title":"Metabolomics-based study of the potential interventional effects of Xiao-Xu-Ming decoction on cerebral ischemia\/reperfusion rats","volume":"295","author":"Wu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3389\/fphar.2020.00523","article-title":"Icariside II, a PDE5 inhibitor, suppresses oxygen-glucose deprivation\/reperfusion-induced primary hippocampal neuronal death through activating the PKG\/CREB\/BDNF\/TrkB signaling pathway","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib36","first-page":"1","article-title":"Neuroprotective effect of Mailuoning on MCAO rats and its antioxidant mechanism","volume":"7","author":"Yang","year":"2017","journal-title":"Acta Neuropharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib37","article-title":"Mailuoning for acute ischaemic stroke","volume":"1","author":"Yang","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2023.116731_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153526","article-title":"Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK\/mTOR-mediated autophagy","volume":"85","author":"Yang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116731_bib39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2023.116731_bib40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/pca.1260","article-title":"Analysis of marker compounds with anti-platelet aggregation effects in Mailuoning injection using platelet binding assay combined with HPLC-DAD-ESI-MS and solid-phase extraction technique","volume":"22","author":"Yu","year":"2011","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jep.2023.116731_bib41","first-page":"32","article-title":"The efficacy of Mailuoning oral liquid on deep venous thrombosis","volume":"2","author":"Zhang","year":"2005","journal-title":"Pharmaceut. Clin. Res."},{"key":"10.1016\/j.jep.2023.116731_bib42","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4103\/1673-5374.266059","article-title":"Ligustilide protects PC12 cells from oxygen-glucose deprivation\/reoxygenation-induced apoptosis via the LKB1-AMPK-mTOR signaling pathway","volume":"15","author":"Zhao","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jep.2023.116731_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113943","article-title":"Xuesaitong exerts long-term neuroprotection for stroke recovery by inhibiting the ROCKII pathway, in vitro and in vivo","volume":"272","author":"Zhou","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116731_bib44","article-title":"Notoginsenoside R1 improves cerebral ischemia\/reperfusion injury by promoting neurogenesis via the BDNF\/Akt\/CREB pathway","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123005998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123005998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:40:38Z","timestamp":1759945238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123005998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":44,"alternative-id":["S0378874123005998"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116731","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mailuoning oral liquid attenuates convalescent cerebral ischemia by inhibiting AMPK\/mTOR-associated apoptosis and promoting CREB\/BDNF-mediated neuroprotection","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116731"}}