{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:07:51Z","timestamp":1793858871006,"version":"4.6.1"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jep.2023.116831","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T17:44:48Z","timestamp":1687715088000},"page":"116831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Glehnia littoralis Fr. Schmidtex Miq.: A systematic review on ethnopharmacology, chemical composition, pharmacology and quality control"],"prefix":"10.1016","volume":"317","author":[{"given":"Shiyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116831_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04710","article-title":"Protective effect of bergapten in acetic acid-induced colitis in rats, protective effect of bergapten in acetic acid-induced colitis in rats","volume":"6","author":"Adakudugu","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2023.116831_bib2","series-title":"Mongolian Traditional Medical Formulae","first-page":"201","author":"Ba","year":"2007"},{"key":"10.1016\/j.jep.2023.116831_bib3","first-page":"154","article-title":"Identification of radix glehniae and its counterfeit","volume":"14","author":"Bi","year":"2003","journal-title":"Shi Zhen Guo Yi Guo Yao"},{"key":"10.1016\/j.jep.2023.116831_bib4","article-title":"Quality control of glehniae radix, the root of Glehnia littoralis fr. schmidt ex miq., along its value chains","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116831_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.sajb.2019.05.027","article-title":"Hot water extract of Glehnia littoralis leaf showed skin-whitening and anti-wrinkle properties","volume":"127","author":"Choe","year":"2019","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2023.116831_bib6","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.7314\/APJCP.2015.16.18.8113","article-title":"Glehnia littoralis root extract induces G0\/G1 phase cell cycle arrest in the MCF-7 human breast cancer cell line","volume":"16","author":"Cruz","year":"2015","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.jep.2023.116831_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.trac.2014.06.021","article-title":"Coupling ultra-high-pressure liquid chromatography with mass spectrometry for in vitro drug-metabolism studies","volume":"63","author":"Dany","year":"2014","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.jep.2023.116831_bib8","first-page":"95","article-title":"Isolation and identification of bergapten in dry root of Glehnia littoralis and preliminary determination of its antitumor activity in vitro","volume":"19","author":"Dong","year":"2010","journal-title":"J. Plant Resour. Environ."},{"key":"10.1016\/j.jep.2023.116831_bib9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1080\/10286020.2017.1327948","article-title":"Biotransformation of total coumarins of radix glehniae by lecanicillium attenuatum W-1-9","volume":"20","author":"Dong","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.116831_bib10","first-page":"27","article-title":"Investigation of isolation, purification, structural identification and in vitro immunological function of polysaccharides in glehniae radix","volume":"24","author":"Du","year":"2018","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.116831_bib11","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0031-9422(90)80107-R","article-title":"Isolation of b-phenyllactic acid related compounds from pseudomonas syringae","volume":"29","author":"Evidente","year":"1990","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2023.116831_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/14786419.2014.886206","article-title":"A new aromatic glycoside from Glehnia littoralis","volume":"28","author":"Feng","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.116831_bib13","first-page":"1740","article-title":"Effects of the SFE-CO2 extraction from radix glehniae on the immune functions of immune-suppressed mice and chemical components analysis","volume":"30","author":"Feng","year":"2020","journal-title":"Chin. J. Hosp. Pharm."},{"key":"10.1016\/j.jep.2023.116831_bib14","first-page":"158","article-title":"New divanilloylglucopyranoses from Glehnia littoralis","volume":"5","author":"Gu","year":"2010","journal-title":"Asian Journal of Traditional Medicines"},{"key":"10.1016\/j.jep.2023.116831_bib15","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3746\/jkfn.2018.47.11.1103","article-title":"Whitening and anti-wrinkle effects of glehniae radix leaf extracts according to extraction solvent","volume":"47","author":"Gu","year":"2018","journal-title":"Journal of the Korean Society of Food Science and Nutrition"},{"key":"10.1016\/j.jep.2023.116831_bib16","first-page":"2564","article-title":"Antitussive and expectorant effects of Glehnia littoralis fr. schmidt ex miq","volume":"22","author":"He","year":"2020","journal-title":"Modernization of Traditional Chinese Medicine and Materia Madica-World Science and Technology"},{"key":"10.1016\/j.jep.2023.116831_bib17","first-page":"1","article-title":"Glehnia littoralis root extract inhibits fat accumulation in 3T3-L1 cells and high-fat diet-induced obese mice by downregulating adipogenic gene expression","volume":"2018","author":"Hong","year":"2018","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.116831_bib18","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1021\/jf204297e","article-title":"Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory activity of imperatorin from Glehnia littoralis","volume":"60","author":"Huang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116831_bib19","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1248\/cpb.49.584","article-title":"Water-soluble constituents of Glehnia littoralis fruit","volume":"49","author":"Ishikawa","year":"2001","journal-title":"Chem. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2023.116831_bib20","series-title":"Dictionary of Chinese Ethnic Medicine","first-page":"388","author":"Jia","year":"2016"},{"key":"10.1016\/j.jep.2023.116831_bib21","first-page":"4535","article-title":"Extractions from roots of Glehnia littoralis (EEAR) on hepatocellular carcinoma cells via miR-34a-5p\/PEG10 proliferation and apoptosis","volume":"41","author":"Jin","year":"2021","journal-title":"Chinese Journal of Gerontology"},{"key":"10.1016\/j.jep.2023.116831_bib22","first-page":"175","article-title":"Ethanol fractional purification, physicochemical properties and antioxidant activity of polysaccharides from glehnia radix","volume":"36","author":"Jing","year":"2020","journal-title":"Food and Machinery"},{"key":"10.1016\/j.jep.2023.116831_bib23","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.ijbiomac.2021.04.178","article-title":"Structural characterization and biological activities of a novel polysaccharide from Glehnia littoralis and its application in preparation of nano-silver","volume":"183","author":"Jing","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.116831_bib24","first-page":"185","article-title":"Optimization of cellulase aynergistic ultrasonic-assisted extraction of polysaccharide from glehniae radix and its physicochemical properties and immunomodulatory activity","volume":"43","author":"Jing","year":"2022","journal-title":"Science and Technology of Food Industry"},{"key":"10.1016\/j.jep.2023.116831_bib25","first-page":"560","article-title":"Antimicrobial and antioxidant activity of Saposhnikovia divaricate, Peucedanum japonicum and Glehnia littoralis","volume":"80","author":"Kim","year":"2018","journal-title":"Indian J. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2023.116831_bib26","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1248\/cpb.46.1939","article-title":"New glycosides and furocoumarin from the Glehnia littoralis root and rhizoma","volume":"46","author":"Kitajima","year":"1998","journal-title":"Chem. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2023.116831_bib27","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1248\/cpb.46.1595","article-title":"Monoterpenoid glycosides of Glehnia littoralis root and rhizoma","volume":"46","author":"Kitajima","year":"1998","journal-title":"Chem. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2023.116831_bib28","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1248\/cpb.46.1404","article-title":"Coumarin glycosides of Glehnia lifforalis root and rhizoma","volume":"46","author":"Kitajima","year":"1998","journal-title":"Chem. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2023.116831_bib29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.foodchem.2009.09.096","article-title":"Constituents isolated from Glehnia littoralis suppress proliferations of human cancer cells and mmp expression in ht1080 cells","volume":"120","author":"Kong","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116831_bib30","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.bmcl.2014.04.046","article-title":"Pyranocoumarins from Glehnia littoralis inhibit the lps-induced no production in macrophage raw 264.7 cells","volume":"24","author":"Lee","year":"2014","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2023.116831_bib31","first-page":"81","article-title":"Chemical constituents from starfish asterias rollestoni","volume":"13","author":"Li","year":"2004","journal-title":"J. Chin. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2023.116831_bib32","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.fitote.2008.01.002","article-title":"A new isoxazol from Glehnia littoralis","volume":"79","author":"Li","year":"2008","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2023.116831_bib33","first-page":"40","article-title":"Quality evaluation of radix glehniae (Glehnia littoralis) by HPLC-DAD: chromatographic fingerprinting and quantitative analysis of the herbs from different regions of China","volume":"5","author":"Li","year":"2010","journal-title":"Asian Journal of Traditional Medicines"},{"key":"10.1016\/j.jep.2023.116831_bib34","first-page":"7","article-title":"Research progress on glehniae radix","volume":"20","author":"Li","year":"2018","journal-title":"Food and Drug"},{"key":"10.1016\/j.jep.2023.116831_bib35","first-page":"9481","article-title":"Study on antitumor effect in vitro of different extractions by water from roots of Glehnia littoralis","volume":"37","author":"Liu","year":"2009","journal-title":"Journal of Anhui Agricultural Sciences"},{"key":"10.1016\/j.jep.2023.116831_bib36","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/bmc.1517","article-title":"Quantitative analysis of nine coumarins in rat urine and bile after oral administration of radix glehniae extract by high-performance liquid chromatography\u2013electrospray ionization tandem mass spectrometry","volume":"25","author":"Liu","year":"2011","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2023.116831_bib37","first-page":"936","article-title":"Effect of radix glehniae stem and leaf extract on immune function in immunosuppressed mice","volume":"23","author":"Lv","year":"2012","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"10.1016\/j.jep.2023.116831_bib38","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.virs.2022.01.027","article-title":"Psoralen inhibits hepatitis B viral replication by down-regulating the host transcriptional machinery of viral promoters","volume":"37","author":"Ma","year":"2022","journal-title":"Virol. Sin."},{"key":"10.1016\/j.jep.2023.116831_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0031-9422(97)00528-1","article-title":"Psoralen and other linear furanocoumarins as phytoalexins in Glehnia littoralis","volume":"47","author":"Masuda","year":"1998","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2023.116831_bib40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1055\/s-2006-957872","article-title":"Antibacterial and antifungal polyine compounds from Glehnia littoralis ssp","volume":"62","author":"Matsuura","year":"1996","journal-title":"Leiocarpa. Planta Medica"},{"key":"10.1016\/j.jep.2023.116831_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0378-8741(95)90037-3","article-title":"Antiviral screening of British Columbian medicinal plants","volume":"49","author":"McCutcheon","year":"1995","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116831_bib42","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1021\/jf010219c","article-title":"Comparison of the essential oils of Glehnia littoralis from northern and southern Japan","volume":"49","author":"Miyazawa","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116831_bib43","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jep.2004.03.040","article-title":"The antioxidant effects of aqueous and organic extracts of Panax quinquefolium, Panax notoginseng, Codonopsis pilosula, Pseudostellaria heterophylla and Glehnia littoralis","volume":"93","author":"Ng","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116831_bib44","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1248\/cpb.38.1084","article-title":"Studies on the antitumor-promoting activity of naturally occurring substances. II. inhibition of tumor-promoter-enhanced phospholipid metabolism by Umbelliferous materials","volume":"38","author":"Okuyama","year":"1990","journal-title":"Chem. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2023.116831_bib45","first-page":"491","article-title":"Analgesic components of glehnia root (Glehnia littoralis)","volume":"52","author":"Okuyama","year":"1998","journal-title":"Natural Medicines"},{"key":"10.1016\/j.jep.2023.116831_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/conphys\/coy002","article-title":"Conservation choice on the rare endangered plants Glehnia littoralis","volume":"6","author":"Pan","year":"2018","journal-title":"Conservation Physiology"},{"key":"10.1016\/j.jep.2023.116831_bib47","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.4103\/0366-6999.211554","article-title":"Pretreated Glehnia littoralis extract prevents neuronal death following transient global cerebral ischemia through increases of superoxide dismutase 1 and brain-derived neurotrophic factor expressions in the gerbil hippocampal cornu ammonis 1 area","volume":"130","author":"Park","year":"2017","journal-title":"Chinese Med J"},{"key":"10.1016\/j.jep.2023.116831_bib48","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4103\/0366-6999.226894","article-title":"Glehnia littoralis extract promotes neurogenesis in the hippocampal dentate gyrus of the adult mouse through increasing expressions of brain-derived neurotrophic factor and tropomyosin-related kinase B","volume":"131","author":"Park","year":"2018","journal-title":"Chinese Med J"},{"key":"10.1016\/j.jep.2023.116831_bib50","first-page":"846","article-title":"Assessment of preliminary processing and its experimental study on the immunoregulation function of radix glehniae polysaccharide","volume":"19","author":"Rong","year":"2013","journal-title":"Chinese Journal of Basic Medicine in Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2023.116831_bib51","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1248\/cpb.28.1847","article-title":"The constituents of Glehnia littoralis fr. schmidt et miq. structure of a new coumarin glycoside, osthenol-7-O-.BETA.-gentiobioside","volume":"28","author":"Sasaki","year":"1980","journal-title":"Chem. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2023.116831_bib52","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s12272-016-0740-x","article-title":"Simultaneous analysis of seven marker compounds from saposhnikoviae radix, glehniae radix and peucedani japonici radix by HPLC\/PDA","volume":"39","author":"Seo","year":"2016","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2023.116831_bib53","doi-asserted-by":"crossref","first-page":"29732","DOI":"10.1039\/C7RA02554H","article-title":"Herb-herb pharmacokinetic interaction between glehniae radix and ophiopogonis radix in rats using superimposed multiple product ion (SMPI) LC-HR-MS\/MS","volume":"7","author":"Shi","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2023.116831_bib54","series-title":"Ethnic Medicine Prescription Preparations","author":"Song","year":"2014"},{"key":"10.1016\/j.jep.2023.116831_bib55","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12041-019-1170-6","article-title":"Mining genes associated with furanocoumarin biosynthesis in an endangered medicinal plant, Glehnia littoralis","volume":"99","author":"Song","year":"2020","journal-title":"J. Genet."},{"key":"10.1016\/j.jep.2023.116831_bib56","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1002\/jssc.201300523","article-title":"Simultaneous isolation of seven compounds from Glehnia littoralis roots by off-line over pressured layer chromatography guided by a TLC antioxidant autographic assay","volume":"36","author":"Su","year":"2013","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jep.2023.116831_bib57","first-page":"22","article-title":"Studies on the Chinese drug shasheng-\u2164. comparison of antitussive and expectorant activities","volume":"26","author":"Tu","year":"1995","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2023.116831_bib96","first-page":"191","article-title":"Study development on pharmacological effect and clinical research of glehniae littoralis","volume":"17","author":"Sun","year":"2015","journal-title":"J. Liaoning Univ. Tradiot. Chinese Med."},{"key":"10.1016\/j.jep.2023.116831_bib58","first-page":"174","article-title":"Identification of crude drug, laiyangshen","volume":"22","author":"Tu","year":"1999","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.jep.2023.116831_bib59","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.procbio.2009.08.016","article-title":"Evaluation of chemical constituents from Glehnia littoralis for antiproliferative activity against HT-29 human colon cancer cells","volume":"45","author":"Um","year":"2010","journal-title":"Process Biochem."},{"key":"10.1016\/j.jep.2023.116831_bib60","first-page":"179","article-title":"Furanocoumarin composition in the fruit of Glehnia littoralis of different geographical origin","volume":"46","author":"Umetsu","year":"1992","journal-title":"Jpn. J. Pharmacogn."},{"key":"10.1016\/j.jep.2023.116831_bib61","series-title":"Study on Chemical Constituents and Biologicalactivity in the Skin of Glehnia Littoralis","author":"Wang","year":"2009"},{"key":"10.1016\/j.jep.2023.116831_bib62","first-page":"48","article-title":"Radix glehniae extract inhibits the migration and invasion abilities of lung cancer cells","volume":"6","author":"Wang","year":"2017","journal-title":"Infection International"},{"key":"10.1016\/j.jep.2023.116831_bib63","first-page":"193","article-title":"A review of research on coumarins from radix glehniae","volume":"15","author":"Wang","year":"2020","journal-title":"Asian Journal of Traditional Medicines"},{"key":"10.1016\/j.jep.2023.116831_bib64","first-page":"1036","article-title":"A new 8-O-4\u2032neolignan from Glehnia littoralis","volume":"43","author":"Wang","year":"2008","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.jep.2023.116831_bib65","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1365\/s10337-009-1230-9","article-title":"Fingerprint chromatogram analysis of radix glehniae by LC coupled with hierarchical clustering analysis","volume":"70","author":"Wang","year":"2009","journal-title":"Chromatographia"},{"key":"10.1016\/j.jep.2023.116831_bib66","first-page":"80","article-title":"Analysis of volatile constituents in root of Glehnia littoralis by GC-MS","volume":"29","author":"Wang","year":"2010","journal-title":"Qilu Pharmaceutical Affair"},{"key":"10.1016\/j.jep.2023.116831_bib67","first-page":"530","article-title":"Isolation and identification of chemical constituents of roots of Glehnia littoralis","volume":"28","author":"Wang","year":"2011","journal-title":"J. Shenyang Pharm. Univ."},{"key":"10.1016\/j.jep.2023.116831_bib68","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuint.2013.09.018","article-title":"Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-\u03baB signal pathway","volume":"63","author":"Wang","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2023.116831_bib69","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.1007\/s00216-016-9828-x","article-title":"A pre-classification strategy based on UPLC-Triple-TOF\/MS for metabolic screening and identification of radix glehniae in rats","volume":"408","author":"Wang","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jep.2023.116831_bib70","first-page":"62","article-title":"Inhibitory effect of radix glehniae extract on the migration and invasion abilities of lung cancer cells","volume":"17","author":"Wang","year":"2018","journal-title":"Traditional Chinese Medicine Journal"},{"key":"10.1016\/j.jep.2023.116831_bib71","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jep.2016.05.023","article-title":"Angelica sinensis in China-a review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis","volume":"190","author":"Wei","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116831_bib72","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3390\/pr9040695","article-title":"Volatiles from selected Apiaceae species cultivated in Poland-antimicrobial activities","volume":"9","author":"Widelski","year":"2021","journal-title":"Processes"},{"key":"10.1016\/j.jep.2023.116831_bib73","first-page":"118","article-title":"LC-MS analysis of volatile oils from Glehnia littoralis by different methods","volume":"34","author":"Wu","year":"2015","journal-title":"Nei Mongol Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2023.116831_bib74","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ijbiomac.2017.08.033","article-title":"Anticancer activity of polysaccharide from Glehnia littoralis on human lung cancer cell line A549","volume":"106","author":"Wu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.116831_bib75","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jpba.2017.08.003","article-title":"A practical strategy for the characterization of ponicidin metabolites in vivo and in vitro by UHPLC-Q-TOF-MS based on nontargeted SWATH data acquisition","volume":"145","author":"Xie","year":"2017","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2023.116831_bib98","doi-asserted-by":"crossref","first-page":"113288","DOI":"10.1016\/j.phytochem.2022.113288","article-title":"Polyacetylenes in herbal medicine: a comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)","volume":"201","author":"Xie","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2023.116831_bib76","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1055\/s-0030-1250044","article-title":"Lignan and neolignan glycosides from the roots of Glehnia littoralis","volume":"76","author":"Xu","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2023.116831_bib77","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.cclet.2008.09.041","article-title":"New lignan glycosides from Glehnia littoralis","volume":"19","author":"Xue","year":"2008","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jep.2023.116831_bib99","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.foodchem.2009.10.063","article-title":"Simultaneous determination of 15 components in radix glehniae by high performance liquid chromatography\u2013electrospray ionization tandem mass spectrometry","volume":"120","author":"Yang","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116831_bib94","article-title":"Ethnopharmacology, phytochemistry, and pharmacology of the genus glehnia: a systematic review","volume":"2019","author":"Yang","year":"2019","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.116831_bib78","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1021\/jf7036517","article-title":"Cytotoxic phenylpropanoids from carrot","volume":"56","author":"Yang","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116831_bib79","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jchromb.2009.12.035","article-title":"Simultaneous and sensitive determination of xanthotoxin, psoralen, isoimpinellin and bergapten in rat plasma by liquid chromatography-electrospray ionization mass spectrometry","volume":"878","author":"Yang","year":"2010","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jep.2023.116831_bib80","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1016\/j.chroma.2010.04.076","article-title":"A practical strategy for the characterization of coumarins in radix glehniae by liquid chromatography coupled with triple quadrupole-linear ion trap mass spectrometry","volume":"1217","author":"Yang","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2023.116831_bib81","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3109\/08923971003671108","article-title":"Anti-inflammatory effects of Glehnia littoralis extract in acute and chronic cutaneous inflammation","volume":"32","author":"Yoon","year":"2010","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2023.116831_bib82","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1254\/jphs.09168FP","article-title":"Anti-inflammatory activity of methylene chloride fraction from Glehnia littoralis extract via suppression of NF-kappa B and mitogen-activated protein kinase activity","volume":"112","author":"Yoon","year":"2010","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2023.116831_bib83","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1248\/cpb.50.73","article-title":"Constituents of theunderground parts of Glehnia littoralis","volume":"50","author":"Yuan","year":"2002","journal-title":"Chem. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2023.116831_bib84","first-page":"183","article-title":"Glycosides from Glehnia littoralis","volume":"19","author":"Yuan","year":"2002","journal-title":"J. Shenyang Pharm. Univ."},{"key":"10.1016\/j.jep.2023.116831_bib85","first-page":"2089","article-title":"Recent progresses in studies on bioactive lignans from plants","volume":"32","author":"Zhang","year":"2007","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2023.116831_bib86","first-page":"757","volume":"38","author":"Zhang","year":"2008"},{"key":"10.1016\/j.jep.2023.116831_bib87","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1080\/14786419.2019.1586697","article-title":"Chemical constituents from Glehnia littoralis and their chemotaxonomic significance","volume":"34","author":"Zhang","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.116831_bib88","first-page":"1070","article-title":"A new coumarin glycoside from Glehnia littoralis","volume":"42","author":"Zhao","year":"2007","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.jep.2023.116831_bib89","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1142\/S0192415X03001612","article-title":"Genetic distinction of radix adenophorae from its adulterants by the DNA sequence of 5S-rRNA spacer domains","volume":"31","author":"Zhao","year":"2003","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2023.116831_bib90","first-page":"73","article-title":"Effect of bergapten on apoptosis of hepg2 and hep3b cells through PI3K\/Akt pathway","volume":"26","author":"Zhao","year":"2020","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.116831_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114040","article-title":"Shashen-Maidong decoction improved chronic intermittent hypoxia-induced cognitive impairment through regulating glutamatergic signaling pathway","volume":"274","author":"Zhao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116831_bib92","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/chrsci\/49.3.209","article-title":"Simultaneous determination of six major active furocoumarins in radix glehniae by HPLC-DAD","volume":"49","author":"Zheng","year":"2011","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jep.2023.116831_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115654","article-title":"Shashen-Maidong decoction inhibited cancer growth under intermittent hypoxia conditions by suppressing oxidative stress and inflammation","volume":"299","author":"Zheng","year":"2022","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123006992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123006992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:49:01Z","timestamp":1759945741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123006992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":96,"alternative-id":["S0378874123006992"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116831","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glehnia littoralis Fr. Schmidtex Miq.: A systematic review on ethnopharmacology, chemical composition, pharmacology and quality control","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116831"}}