{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:19:34Z","timestamp":1789503574799,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074423"],"award-info":[{"award-number":["82074423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005893","name":"China Academy of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["CI2021A00903"],"award-info":[{"award-number":["CI2021A00903"]}],"id":[{"id":"10.13039\/501100005893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jep.2023.116849","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T02:25:41Z","timestamp":1687919141000},"page":"116849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Ling-Gui-Qi-Hua formula alleviates left ventricular myocardial fibrosis in rats with heart failure with preserved ejection fraction by blocking the transforming growth factor-\u03b21 \/Smads signaling pathway"],"prefix":"10.1016","volume":"317","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-0459","authenticated-orcid":false,"given":"Yujiao","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoju","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116849_bib1","doi-asserted-by":"crossref","first-page":"mjac028","DOI":"10.1093\/jmcb\/mjac028","article-title":"Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus: from pathophysiology to therapeutics","volume":"14","author":"Abudureyimu","year":"2022","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2023.116849_bib2","doi-asserted-by":"crossref","unstructured":"Anker, S.D., Butler, J., Filippatos, G., Ferreira, J.P., Bocchi, E., B\u00f6hm, M., Brunner-La Rocca, H.P., Choi, D.J., Chopra, V., Chuquiure-Valenzuela, E., Giannetti, N., Gomez-Mesa, J.E., Janssens, S., Januzzi, J.L., Gonzalez-Juanatey, J.R., Merkely, B., Nicholls, S.J., Perrone, S.V., Pi\u00f1a, I.L., Ponikowski, P., Senni, M., Sim, D., Spinar, J., Squire, I., Taddei, S., Tsutsui, H., Verma, S., Vinereanu, D., Zhang, J., Carson, P., Lam, C.S.P., Marx, N., Zeller, C., Sattar, N., Jamal, W., Schnaidt, S., Schnee, J.M., Brueckmann, M., Pocock, S.J., Zannad, F., Packer, M., EMPEROR-preserved trial investigators, 2021. Empagliflozin in heart failure with a preserved ejection fraction. N. Engl. J. Med. 385, 1451-1461. https:\/\/doi.org\/10.1056\/NEJMoa2107038.","DOI":"10.1056\/NEJMoa2107038"},{"key":"10.1016\/j.jep.2023.116849_bib3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/CIRCULATIONAHA.121.057812","article-title":"Empagliflozin, health status, and quality of life in patients with heart failure and preserved ejection fraction: the EMPEROR-preserved trial","volume":"145","author":"Butler","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2023.116849_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13020-021-00446-x","article-title":"Potential mechanisms of Guizhi decoction against hypertension based on network pharmacology and dahl salt-sensitive rat model","volume":"16","author":"Chen","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116849_bib5","article-title":"Atractylenolide I ameliorates acetaminophen-induced acute liver injury via the TLR4\/MAPKs\/NF-\u03baB signaling pathways","volume":"13","author":"Du","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116849_bib6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12272-021-01342-6","article-title":"Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics","volume":"44","author":"Deng","year":"2021","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2023.116849_bib7","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrcardio.2017.65","article-title":"Epidemiology of heart failure with preserved ejection fraction","volume":"14","author":"Dunlay","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jep.2023.116849_bib8","first-page":"9","article-title":"Cinnamon aqueous extract attenuates diclofenac sodium and oxytetracycline mediated hepato-renal toxicity and modulates oxidative stress, cell apoptosis, and inflammation in male albino rats","volume":"8","author":"Elshopakey","year":"2021","journal-title":"Vet. Sci."},{"key":"10.1016\/j.jep.2023.116849_bib9","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s11655-022-2892-5","article-title":"A data mining-based study on medication rules of Chinese herbs to treat heart failure with preserved ejection fraction","volume":"28","author":"Guo","year":"2022","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.116849_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6813421","article-title":"The multiple pharmacologic functions and mechanisms of action of Guizhi Fuling formulation","volume":"2022","author":"Gao","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2023.116849_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114344","article-title":"Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis","volume":"183","author":"Guo","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2023.116849_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.594683","article-title":"Gallic acid ameliorates angiotensin II-induced atrial fibrillation by inhibiting immunoproteasome-mediated PTEN degradation in mice","volume":"8","author":"Han","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2023.116849_bib13","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.biopha.2018.11.123","article-title":"Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model","volume":"109","author":"Hussain","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116849_bib14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fphar.2011.00010","article-title":"Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional Chinese herbal medicine","volume":"2","author":"He","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116849_bib15","doi-asserted-by":"crossref","first-page":"9302","DOI":"10.1038\/s41598-018-27599-4","article-title":"Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure","volume":"8","author":"Jin","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116849_bib16","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1097\/HJH.0000000000001327","article-title":"Gallic acid attenuates hypertension, cardiac remodeling, and fibrosis in mice with NG-nitro-L-arginine methyl ester-induced hypertension via regulation of histone deacetylase 1 or histone deacetylase 2","volume":"35","author":"Jin","year":"2017","journal-title":"J. Hypertens."},{"key":"10.1016\/j.jep.2023.116849_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15925-1","article-title":"Gallic acid reduces blood pressure and attenuates oxidative stress and cardiac hypertrophy in spontaneously hypertensive rats","volume":"7","author":"Jin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116849_bib18","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.jcmg.2018.11.031","article-title":"Relationship between focal and diffuse fibrosis assessed by CMR and clinical outcomes in heart failure with preserved ejection fraction","volume":"12","author":"Kanagala","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.jep.2023.116849_bib19","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.foodchem.2017.07.058","article-title":"Planar chromatographic screening and quantification of coumarin in food, confirmed by mass spectrometry","volume":"239","author":"Kr\u00fcger","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116849_bib20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jpba.2014.06.027","volume":"98","author":"Kong","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2023.116849_bib21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1741-7015-9-48","article-title":"Metabolic syndrome: definitions and controversies","volume":"9","author":"Kassi","year":"2011","journal-title":"BMC Med."},{"key":"10.1016\/j.jep.2023.116849_bib22","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1089\/jmf.2009.1365","article-title":"Platelet anti-aggregation activities of compounds from Cinnamomum cassia","volume":"13","author":"Kim","year":"2010","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2023.116849_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11655-022-3627-3","article-title":"Therapeutic efficacy of Shexiang Baoxin pill combined with exercise in patients with heart failure with preserved ejection fraction: a single-center, double-blind, randomized controlled trial","volume":"29","author":"Liu","year":"2023","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.116849_bib24","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3390\/plants11060716","article-title":"Mitigation of gastric damage using cinnamomum cassia extract: network pharmacological analysis of active compounds and protection effects in rats","volume":"11","author":"Lee","year":"2022","journal-title":"Plants"},{"key":"10.1016\/j.jep.2023.116849_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/13880209.2021.1885450","article-title":"Hypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette super-family G member 2","volume":"59","author":"Liang","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2023.116849_bib26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3892\/etm.2021.9720","article-title":"Poricoic acid A suppresses TGF-\u03b21-induced renal fibrosis and proliferation via the PDGF-C, Smad3 and MAPK pathways","volume":"21","author":"Li","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2023.116849_bib27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11596-020-2178-0","article-title":"Paeoniflorin attenuates myocardial fibrosis in isoprenaline-induced chronic heart failure rats via inhibiting P38 MAPK pathway","volume":"40","author":"Liu","year":"2020","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.jep.2023.116849_bib28","doi-asserted-by":"crossref","first-page":"272","DOI":"10.21037\/cdt.2019.06.01","article-title":"Effect of paeoniflorin on cardiac remodeling in chronic heart failure rats through the transforming growth factor \u03b21\/Smad signaling pathway","volume":"9","author":"Liu","year":"2019","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"10.1016\/j.jep.2023.116849_bib29","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.biopha.2018.12.090","article-title":"Paeoniflorin improves pressure overload-induced cardiac remodeling by modulating the MAPK signaling pathway in spontaneously hypertensive rats","volume":"111","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116849_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biopha.2017.09.105","article-title":"Paeoniflorin ameliorates Adriamycin-induced nephrotic syndrome through the PPAR\u03b3\/ANGPTL4 pathway in vivo and vitro","volume":"96","author":"Lu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116849_bib31","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.3892\/mmr.2015.3712","article-title":"Pachymic acid protects H9c2 cardiomyocytes from lipopolysaccharide-induced inflammation and apoptosis by inhibiting the extracellular signal-regulated kinase 1\/2 and p38 pathways","volume":"12","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2023.116849_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/328152","article-title":"Large dosage of chishao in formulae for cholestatic hepatitis: a systematic review and meta-analysis","volume":"2014","author":"Ma","year":"2014","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2023.116849_bib33","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jep.2023.116849_bib34","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.119.044491","article-title":"Effects of sacubitril-valsartan versus valsartan in women compared with men with heart failure and preserved ejection fraction: insights from PARAGON-HF","volume":"141","author":"McMurray","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2023.116849_bib35","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.foodchem.2017.03.128","article-title":"Interaction between natural antioxidants derived from cinnamon and cocoa in binary and complex mixtures","volume":"231","author":"Muhammad","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116849_bib36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2023.116849_bib37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCULATIONAHA.114.009625","article-title":"Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction","volume":"131","author":"Mohammed","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2023.116849_bib38","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-med-042220-022745","article-title":"Heart failure with preserved ejection fraction: mechanisms and treatment strategies","volume":"73","author":"Omote","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.jep.2023.116849_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153798","article-title":"Cardioprotective activity of ethyl acetate extract of Cinnamomi Ramulus against myocardial ischemia\/reperfusion injury in rats via inhibiting NLRP3 inflammasome activation and pyroptosis","volume":"93","author":"Peng","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116849_bib40","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/med.21743","article-title":"Evolution of the adaptogenic concept from traditional use to medical systems: pharmacology of stress- and aging-related diseases","volume":"41","author":"Panossian","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jep.2023.116849_bib41","doi-asserted-by":"crossref","first-page":"22220","DOI":"10.3390\/molecules201219837","article-title":"Multi-optimization of ultrasonic-assisted enzymatic extraction of atratylodes macrocephala polysaccharides and antioxidants using response surface methodology and desirability function approach","volume":"20","author":"Pu","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116849_bib42","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4103\/0974-8490.89743","article-title":"Cardioprotective effects of gallic acid in diabetes-induced myocardial dysfunction in rats","volume":"3","author":"Patel","year":"2011","journal-title":"Pharmacogn. Res."},{"key":"10.1016\/j.jep.2023.116849_bib43","doi-asserted-by":"crossref","first-page":"18200","DOI":"10.1007\/s11356-019-05223-w","article-title":"Gallic acid protects particulate matter (PM10) triggers cardiac oxidative stress and inflammation causing heart adverse events in rats","volume":"26","author":"Radan","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jep.2023.116849_bib44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12968-018-0477-4","article-title":"Associations and prognostic significance of diffuse myocardial fibrosis by cardiovascular magnetic resonance in heart failure with preserved ejection fraction","volume":"20","author":"Roy","year":"2018","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.jep.2023.116849_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/srep34790","article-title":"Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity","volume":"6","author":"Ryu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116849_bib46","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jacc.2016.02.018","article-title":"Extracellular volume fraction for characterization of patients with heart failure and preserved ejection fraction","volume":"67","author":"Rommel","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2023.116849_bib47","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1056\/NEJMoa2206286","article-title":"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction","volume":"387","author":"Solomon","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2023.116849_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.854501","article-title":"Clinical implications of plasma galectin-3 in heart failure with preserved ejection eraction: a meta-analysis","volume":"9","author":"Shi","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.jep.2023.116849_bib49","doi-asserted-by":"crossref","DOI":"10.1177\/09603271211064532","article-title":"Gallic acid protects against isoproterenol-induced cardiotoxicity in rats","volume":"41","author":"Shackebaei","year":"2022","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.jep.2023.116849_bib50","first-page":"1130","article-title":"Does gallic acid improve cardiac function by attenuation of oxidative stress and inflammation in an elastase-induced lung injury? Iran","volume":"23","author":"Sohrabi","year":"2020","journal-title":"J. Basic. Med. Sci."},{"key":"10.1016\/j.jep.2023.116849_bib51","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1016\/j.jacc.2019.09.063","article-title":"Echocardiographic features of patients with heart failure and preserved left ventricular ejection fraction","volume":"74","author":"Shah","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2023.116849_bib52","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jpba.2016.07.031","article-title":"Characterization and quantification of monoterpenoids in different types of peony root and the related Paeonia species by liquid chromatography coupled with ion trap and time-of-flight mass spectrometry","volume":"129","author":"Shi","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2023.116849_bib53","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jcmg.2014.04.022","article-title":"CMR-verified diffuse myocardial fibrosis is associated with diastolic dysfunction in HFpEF","volume":"7","author":"Su","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.jep.2023.116849_bib54","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijbiomac.2014.04.010","article-title":"Biological activities and potential health benefits of polysaccharides from poria cocos and their derivatives","volume":"68","author":"Sun","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.116849_bib55","doi-asserted-by":"crossref","unstructured":"Solomon, S.D., Zile, M., Pieske, B., Voors, A., Shah, A., Kraigher-Krainer, E., Shi, V., Bransford, T., Takeuchi, M., Gong, J., Lefkowitz, M., Packer, M., McMurray, J.J.V., Prospective comparison of ARNI with ARB on management of heart failure with preserved ejection fraction (PARAMOUNT) investigators, 2012. the angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomized controlled trial. Lancet 380, 1387-1395. https:\/\/doi.org\/10.1016\/S0140-6736(12)61227-6.","DOI":"10.1016\/S0140-6736(12)61227-6"},{"key":"10.1016\/j.jep.2023.116849_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.2848","article-title":"Natriuretic peptides: role in the diagnosis and management of heart failure: a scientific statement from the heart failure association of the European society of cardiology, heart failure society of America and Japanese heart failure society","author":"Tsutsui","year":"2023","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jep.2023.116849_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113904","article-title":"Fibrosis of the diabetic heart: clinical significance, molecular mechanisms, and therapeutic opportunities","volume":"176","author":"Tuleta","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jep.2023.116849_bib58","first-page":"1081","article-title":"Establishment of a rat model of heart failure with preserved ejection fraction and evaluation of the cardiac structure and function by echocardiography","volume":"30","author":"Tang","year":"2021","journal-title":"Chin. J. Ultrasonogr."},{"key":"10.1016\/j.jep.2023.116849_bib59","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3389\/fphar.2020.01054","article-title":"Efficacy, chemical constituents, and pharmacological actions of radix paeoniae rubra and radix paeoniae alba","volume":"11","author":"Tan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116849_bib60","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrcardio.2017.57","article-title":"Redefining the identity of cardiac fibroblasts","volume":"14","author":"Tallquist","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jep.2023.116849_bib61","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3390\/molecules24030511","article-title":"Evaluation of the hepatotoxicity of the Zhi-Zi-Hou-Po decoction by combining UPLC-Q-exactive-MS-based metabolomics and HPLC-MS\/MS-based geniposide tissue distribution","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116849_bib62","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/13880209.2015.1024330","article-title":"The protective effect of atractylenolide I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture","volume":"54","author":"Wang","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2023.116849_bib63","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ijbiomac.2022.07.070","article-title":"A review on the advances in the extraction methods and structure elucidation of Poria cocos polysaccharide and its pharmacological activities and drug carrier applications","volume":"217","author":"Xu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.116849_bib64","first-page":"909","article-title":"Effects of Ling-Gui-Qi-Hua decoction on the glycolipid metabolism and cardiac function in rats with heart failure with preserved ejection fraction","volume":"38","author":"Xiong","year":"2021","journal-title":"Tianjin J. Chin. Med."},{"key":"10.1016\/j.jep.2023.116849_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2021.713490","article-title":"Untargeted metabolomics and targeted quantitative analysis of temporal and spatial variations in specialized metabolites accumulation in Poria cocos (schw.) Wolf (fushen)","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2023.116849_bib66","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3389\/fphar.2020.01121","article-title":"Gallic acid attenuates angiotensin II-induced hypertension and vascular dysfunction by inhibiting the degradation of endothelial nitric oxide synthase","volume":"11","author":"Yan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116849_bib67","first-page":"861","article-title":"Analysis of chemical composition of Gui Zhi Fu Ling capsule based on UPLC-ESI-Q-TOF-MS\/MS technique","author":"Yang","year":"2020","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2023.116849_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800807","article-title":"Gallic acid suppresses cardiac hypertrophic remodeling and heart failure","volume":"63","author":"Yan","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2023.116849_bib69","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s13063-021-05232-6","article-title":"A double-blinded, placebo-controlled randomized trial evaluating the efficacy and safety of Zhigancao tang granules for treating HFpEF: study protocol for a randomized controlled trial","volume":"22","author":"Zhang","year":"2021","journal-title":"Trials"},{"key":"10.1016\/j.jep.2023.116849_bib70","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12933-021-01312-8","article-title":"Dapagliflozin: a sodium-glucose cotransporter 2 inhibitor, attenuates angiotensin II-induced cardiac fibrotic remodeling by regulating TGF\u03b21\/Smad signaling","volume":"20","author":"Zhang","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.jep.2023.116849_bib71","article-title":"Sacubitril\/valsartan reduces fibrosis and alleviates high-salt diet-induced HFpEF in rats","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116849_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106173","article-title":"Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2\/HO-1 signaling pathway and inhibited foam cell formation in VSMCs","volume":"80","author":"Zhao","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2023.116849_bib73","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jep.2018.08.023","article-title":"The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: a review","volume":"226","author":"Zhu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116849_bib74","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10735-013-9491-x","article-title":"Paeoniflorin attenuates pressure overload-induced cardiac remodeling via inhibition of TGF\u03b2\/Smads and NF-\u03baB pathways","volume":"44","author":"Zhou","year":"2013","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.jep.2023.116849_bib75","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/CIRCULATIONAHA.110.011031","article-title":"Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction","volume":"124","author":"Zile","year":"2011","journal-title":"Circulation"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123007171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123007171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:51:15Z","timestamp":1759945875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123007171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":75,"alternative-id":["S0378874123007171"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116849","relation":{"is-supplemented-by":[{"id-type":"uri","id":"https:\/\/figshare.com\/s\/dfd9a54eb0d5b5a40123","asserted-by":"subject"}]},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ling-Gui-Qi-Hua formula alleviates left ventricular myocardial fibrosis in rats with heart failure with preserved ejection fraction by blocking the transforming growth factor-\u03b21 \/Smads signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116849"}}