{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T22:59:57Z","timestamp":1784588397104,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"am","delay-in-days":179,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.116869","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T01:07:51Z","timestamp":1688000871000},"page":"116869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"PA","title":["Longdan Xiegan decoction ameliorates vulvovaginal candidiasis by inhibiting the NLRP3 inflammasome via the Toll-like receptor \/MyD88 pathway"],"prefix":"10.1016","volume":"318","author":[{"given":"Xin","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxiang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116869_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3390\/jof7020119","article-title":"Immune sensing of Candida albicans","volume":"7","author":"Bojang","year":"2021","journal-title":"J. Fungi. (Basel)."},{"key":"10.1016\/j.jep.2023.116869_bib2","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.3389\/fimmu.2019.02364","article-title":"Targeting the aryl hydrocarbon receptor with indole-3-aldehyde protects from vulvovaginal candidiasis via the IL-22-IL-18 cross-talk","volume":"10","author":"Borghi","year":"2019","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2023.116869_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/0022034510381264","article-title":"TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk","volume":"90","author":"Brown","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jep.2023.116869_bib4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2217\/fmb-2018-0299","article-title":"Candida albicans vaginitis in a murine model is reduced by polypeptide-enriched gastrodia elata extracts","volume":"14","author":"Cai","year":"2019","journal-title":"Future Microbiol."},{"key":"10.1016\/j.jep.2023.116869_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0966-842X(01)02094-7","article-title":"Virulence factors of Candida albicans","volume":"9","author":"Calderone","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jep.2023.116869_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00394-015-1113-9","article-title":"Relation between neonatal malnutrition and gene expression: inflammasome function in infections caused by Candida Albicans","volume":"56","author":"Da Costa","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jep.2023.116869_bib7","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1016\/S1473-3099(18)30103-8","article-title":"Global burden of recurrent vulvovaginal candidiasis: a systematic review","volume":"18","author":"Denning","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jep.2023.116869_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03619","article-title":"Low prevalence of antifungal resistant Candida africana, in the C. albicans complex causing vulvovaginal candidiasis","volume":"6","author":"Farahyar","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2023.116869_bib9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3109\/1040841X.2015.1091805","article-title":"Vulvovaginal candidiasis: epidemiology, microbiology and risk factors","volume":"42","author":"Gon\u00e7alves","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.jep.2023.116869_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/myc.13385","article-title":"Effects of oestrogen on vulvovaginal candidosis","volume":"65","author":"He","year":"2022","journal-title":"Mycoses"},{"key":"10.1016\/j.jep.2023.116869_bib11","article-title":"Efficacy of Longdan Xiegan Decoction on the treatment of eczema: a systematic review and meta-analysis","author":"Hu","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med. eCAM"},{"key":"10.1016\/j.jep.2023.116869_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116041","article-title":"Effects of n-butanol extract of pulsatilla decoction on the NLRP3 inflammasome in macrophages infected with Candida albicans","volume":"304","author":"Hu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2023.116869_bib13","first-page":"1578","article-title":"Mechanism of n-butanol alcohol extract of Baitouweng Decoction in treatment of vulvovaginal candidiasis based on negative regulation of NLRP3 inflammasome via PKC\u03b4\/NLRC4\/IL-1Ra axis","volume":"48","author":"Hu","year":"2023","journal-title":"China J. Chin. Mater. Med."},{"issue":"4","key":"10.1016\/j.jep.2023.116869_bib14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4161\/viru.1.4.11482","article-title":"Fungal pathogen recognition by the NLRP3 inflammasome","volume":"1","author":"Joly","year":"2010","journal-title":"Virulence"},{"key":"10.1016\/j.jep.2023.116869_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110183","article-title":"Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system","volume":"38","author":"Kumwenda","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2023.116869_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00622-21","article-title":"Recurrent vulvovaginal candidiasis: a dynamic interkingdom biofilm disease of Candida and lactobacillus","volume":"6","author":"McKloud","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.jep.2023.116869_bib17","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3390\/antibiotics10060628","article-title":"Anti-Candida activity of hyaluronic acid combined with lactobacillus crispatus lyophilised supernatant: a new antifungal strategy","volume":"10","author":"Parolin","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2023.116869_bib18","first-page":"4201","article-title":"Effect of chloroform extracts from Longdan Xiegan decoction in inhibiting hydrolytic enzyme activity of Candida albicans isolated from VVC patients","volume":"42","author":"Pu","year":"2017","journal-title":"China J. Chin. Mater. Med."},{"issue":"7","key":"10.1016\/j.jep.2023.116869_bib19","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1142\/S0192415X20500846","article-title":"Using network pharmacology for systematic understanding of geniposide in ameliorating inflammatory responses in colitis through suppression of NLRP3 inflammasome in macrophage by AMPK\/Sirt1 dependent signaling","volume":"48","author":"Pu","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2023.116869_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cellimm.2014.11.004","article-title":"Microbicidal activity of neutrophils is inhibited by isolates from recurrent vaginal candidiasis (RVVC) caused by Candida albicans through fungal thioredoxin reductase","volume":"293","author":"Ratti","year":"2015","journal-title":"Cell. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2023.116869_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00645-17","article-title":"Candidalysin drives epithelial signaling, neutrophil recruitment, and immunopathology at the vaginal mucosa","volume":"86","author":"Richardson","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jep.2023.116869_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.semcdb.2018.02.026","article-title":"Candida innate immunity at the mucosa","volume":"89","author":"Richardson","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2023.116869_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.544480","article-title":"Pathogenesis and clinical relevance of Candida biofilms in vulvovaginal candidiasis","volume":"11","author":"Rodr\u00edguez-Cerdeira","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2023.116869_bib24","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.3389\/fmicb.2019.02669","article-title":"A Role for yeast\/pseudohyphal cells of Candida albicans in the correlated expression of NLRP3 inflammasome inducers in women with acute vulvovaginal candidiasis","volume":"10","author":"Roselletti","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2023.116869_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.867914","article-title":"Experimental and clinical studies on the effects of natural products on noxious agents-induced lung disorders, a review","volume":"9","author":"Saadat","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2023.116869_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00478-18","article-title":"Pharmacodynamic and immunomodulatory effects of micafungin on host responses against biofilms of Candida parapsilosis in comparison to those of Candida albicans","volume":"62","author":"Simitsopoulou","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2023.116869_bib27","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1080\/14656566.2018.1476490","article-title":"Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species","volume":"19","author":"Sobel","year":"2018","journal-title":"Expert opin. Pharmacother."},{"key":"10.1016\/j.jep.2023.116869_bib28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ajog.2019.04.018","article-title":"Reply","volume":"221","author":"Swidsinski","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jep.2023.116869_bib29","doi-asserted-by":"crossref","first-page":"91.e91","DOI":"10.1016\/j.ajog.2018.10.023","article-title":"Vulvovaginal candidiasis: histologic lesions are primarily polymicrobial and invasive and do not contain biofilms","volume":"220","author":"Swidsinski","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"9","key":"10.1016\/j.jep.2023.116869_bib30","first-page":"1284","article-title":"Effect of Qibudan on expression of TLR2 in tuberculosis infection","volume":"27","author":"Wang","year":"2011","journal-title":"Chin. Pharmacol. Bull."},{"issue":"8","key":"10.1016\/j.jep.2023.116869_bib31","first-page":"714","article-title":"Effect of baicalin on MyD88-dependent pathway in tuberculosis infection","volume":"27","author":"Wu","year":"2011","journal-title":"Chinese J Immunol"},{"issue":"12","key":"10.1016\/j.jep.2023.116869_bib32","first-page":"1986","article-title":"Effect of baicalin on expression of Toll-like receptor 2, 3, 4, 7 in Newcastle disease virus-infected CEFs","volume":"29","author":"Xu","year":"2017","journal-title":"Acta Agric. Zhejiangensis"},{"issue":"10","key":"10.1016\/j.jep.2023.116869_bib33","first-page":"1884","article-title":"Systematic evaluation of the curative effect of longdan Xiegan decoction on vulvovaginal candidiasis","volume":"32","author":"Xu","year":"2020","journal-title":"Clinical Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2023.116869_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116353","article-title":"The aqueous extracts of Ageratum conyzoides inhibit inflammation by suppressing NLRP3 inflammasome activation","volume":"309","author":"Xu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116869_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jep.2018.05.018","article-title":"Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the Dectin-1 signaling pathway","volume":"223","author":"Yang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116869_bib36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-1-0716-2549-1_14","article-title":"Methods related to the immunopathogenesis of vulvovaginal candidiasis and associated neutrophil anergy","volume":"2542","author":"Yano","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2023.116869_bib37","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/IAI.00861-13","article-title":"Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis","volume":"82","author":"Yano","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jep.2023.116869_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00684-17","article-title":"Novel mechanism behind the immunopathogenesis of vulvovaginal candidiasis: \"neutrophil anergy\"","volume":"86","author":"Yano","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jep.2023.116869_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.739385","article-title":"Leukotrienes are dispensable for vaginal neutrophil recruitment as part of the immunopathological response during experimental vulvovaginal candidiasis","volume":"12","author":"Yano","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2023.116869_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111291","article-title":"Longdan Xiegan Decoction alleviates experimental autoimmune uveitis in rats by inhibiting Notch signaling pathway activation and Th17 cell differentiation","volume":"136","author":"Yin","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.jep.2023.116869_bib41","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2217\/FMB.15.47","article-title":"Medically important fungi respond to azole drugs: an update","volume":"10","author":"Zavrel","year":"2015","journal-title":"Future Microbiol."},{"key":"10.1016\/j.jep.2023.116869_bib42","first-page":"2516","article-title":"Butyl alcohol extract of Baitouweng Decoction alleviates vulvovaginal candidiasis in mice by downregulating NLRP3 inflammasome and related signal pathways","volume":"47","author":"Zhang","year":"2022","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2023.116869_bib43","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1002\/ptr.7123","article-title":"Clinical research on traditional Chinese medicine treatment for bacterial vaginosis","volume":"35","author":"Zhao","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2023.116869_bib44","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.2147\/DDDT.S385136","article-title":"Decoding the Key functional combined components group and uncovering the molecular mechanism of longdan Xiegan decoction in treating uveitis","volume":"16","author":"Zheng","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2023.116869_bib45","article-title":"Verbena attenuates adriamycin-induced renal tubular injury via inhibition of ROS-ERK1\/2-NLRP3 signal pathway","volume":"2022","author":"Zhou","year":"2022","journal-title":"Evid. base Compl. Alternative Med. : eCAM"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123007377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123007377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:02:54Z","timestamp":1736402574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123007377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":45,"alternative-id":["S0378874123007377"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116869","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longdan Xiegan decoction ameliorates vulvovaginal candidiasis by inhibiting the NLRP3 inflammasome via the Toll-like receptor \/MyD88 pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116869"}}