{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:51:05Z","timestamp":1777722665662,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81904198"],"award-info":[{"award-number":["81904198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.116935","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T02:18:33Z","timestamp":1689819513000},"page":"116935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"PA","title":["Molecular mechanism of PSORI-CM01 for psoriasis by regulating the inflammatory cytokines network"],"prefix":"10.1016","volume":"318","author":[{"given":"Mingxiang","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuda","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116935_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119256","article-title":"Development of flavanone and its derivatives as topical agents against psoriasis: the prediction of therapeutic efficiency through skin permeation evaluation and cell-based assay","volume":"581","author":"Alalaiwe","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jep.2023.116935_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.27","article-title":"Searching online mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes","volume":"58","author":"Amberger","year":"2017","journal-title":"Curr. Protocol. Bioinform."},{"issue":"4","key":"10.1016\/j.jep.2023.116935_bib3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/msj.20191","article-title":"Systems pharmacology","volume":"77","author":"Boran","year":"2010","journal-title":"The Mount Sinai journal of medicine, New York"},{"key":"10.1016\/j.jep.2023.116935_bib4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fimmu.2020.00529","article-title":"CCR4(+) skin-tropic phenotype as a feature of central memory CD8(+) T cells in healthy subjects and psoriasis patients","volume":"11","author":"Casciano","year":"2020","journal-title":"Front. Immunol."},{"issue":"28","key":"10.1016\/j.jep.2023.116935_bib5","doi-asserted-by":"crossref","first-page":"46381","DOI":"10.18632\/oncotarget.18453","article-title":"Clinic characteristics of psoriasis in China: a nationwide survey in over 12000 patients","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.jep.2023.116935_bib6","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3390\/molecules20011594","article-title":"Identification and quantitative characterization of PSORI-CM01, a Chinese medicine formula for psoriasis therapy, by liquid chromatography coupled with an LTQ Orbitrap mass spectrometer","volume":"20","author":"Chen","year":"2015","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jep.2023.116935_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"issue":"8","key":"10.1016\/j.jep.2023.116935_bib8","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S1995-7645(14)60113-9","article-title":"Effect of Yinxieling decoction on PASI, TNF-\u03b1 and IL-8 in patients with psoriasis vulgaris","volume":"7","author":"Dai","year":"2014","journal-title":"Asian Pac. J. Tropical Med."},{"issue":"W1","key":"10.1016\/j.jep.2023.116935_bib9","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2023.116935_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.acc.2020.04.004","article-title":"Cytokines in psoriasis","volume":"100","author":"de Alcantara","year":"2021","journal-title":"Adv. Clin. Chem."},{"issue":"11","key":"10.1016\/j.jep.2023.116935_bib11","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-014475","article-title":"Oral Chinese herbal medicine for psoriasis vulgaris: protocol for a randomised, double-blind, double-dummy, multicentre clinical trial","volume":"7","author":"Deng","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.jep.2023.116935_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112208","article-title":"Melissa officinalis ssp. altissima extracts: a therapeutic approach targeting psoriasis in mice","volume":"246","author":"Dimitris","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"10281","key":"10.1016\/j.jep.2023.116935_bib13","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet (London, England)"},{"issue":"4","key":"10.1016\/j.jep.2023.116935_bib14","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/jid.2011.458","article-title":"A single intradermal injection of IFN-gamma induces an inflammatory state in both non-lesional psoriatic and healthy skin","volume":"132","author":"Johnson-Huang","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"D1","key":"10.1016\/j.jep.2023.116935_bib15","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.jep.2023.116935_bib16","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2023.116935_bib17","first-page":"1","article-title":"Gene expression of PSORI-CM01 and yinxieling in the treatment of psoriasis vulgaris","author":"Lu","year":"2021","journal-title":"Evid. base Compl. Alternative Med."},{"issue":"6","key":"10.1016\/j.jep.2023.116935_bib18","first-page":"519","article-title":"Psoriasis predisposition and occupational triggering factors in the appraisal of occupational medical expertises","volume":"12","author":"Mahler","year":"2014","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG"},{"key":"10.1016\/j.jep.2023.116935_bib19","series-title":"Clinical Observation and Mechanism Exploration of PSORI-CM02, Yinxieling Tablet on Stable Plaque Psoriasis","author":"Meng","year":"2018"},{"issue":"5","key":"10.1016\/j.jep.2023.116935_bib20","first-page":"645","article-title":"S3 Guideline for the treatment of psoriasis vulgaris, update - short version part 1 - systemic treatment","volume":"16","author":"Nast","year":"2018","journal-title":"Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG"},{"key":"10.1016\/j.jep.2023.116935_bib22","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"Bmj"},{"issue":"1","key":"10.1016\/j.jep.2023.116935_bib23","doi-asserted-by":"crossref","first-page":"e286","DOI":"10.1002\/ctm2.286","article-title":"Add-on effect of PSORI-CM01 to topical calcipotriol for moderate psoriasis vulgaris: a multi-center, randomized, double-blind pilot study","volume":"11","author":"Parker","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.jep.2023.116935_bib24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jep.2016.12.046","article-title":"Anti-psoriatic potential of Solanum xanthocarpum stem in Imiquimod-induced psoriatic mice model","volume":"198","author":"Parmar","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2023.116935_bib25","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis pathogenesis and treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.jep.2023.116935_bib26","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"W1","key":"10.1016\/j.jep.2023.116935_bib27","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.jep.2023.116935_bib28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jaad.2017.05.019","article-title":"Psoriasis and suicidality: a systematic review and meta-analysis","volume":"77","author":"Singh","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"D1","key":"10.1016\/j.jep.2023.116935_bib29","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.jep.2023.116935_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4196\/kjpp.2020.24.3.213","article-title":"Salvianolic acid B ameliorates psoriatic changes in imiquimod-induced psoriasis on BALB\/c mice by inhibiting inflammatory and keratin markers via altering phosphatidylinositol-3-kinase\/protein kinase B signaling pathway","volume":"24","author":"Wang","year":"2020","journal-title":"KOREAN J. PHYSIOL. PHARMACOL. : official journal of the Korean Physiological Society and the Korean Society of Pharmacology"},{"key":"10.1016\/j.jep.2023.116935_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12906-016-1234-6","article-title":"Formula PSORI-CM01 eliminates psoriasis by inhibiting the expression of keratinocyte cyclin B2","volume":"16","author":"Wei","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"issue":"12","key":"10.1016\/j.jep.2023.116935_bib32","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.3390\/ijms18122684","article-title":"Molecular mechanisms and management of a cutaneous inflammatory disorder: psoriasis","volume":"18","author":"Woo","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.116935_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00109-015-1338-3","article-title":"Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-kappaB and proinflammatory cytokines","volume":"94","author":"Wu","year":"2016","journal-title":"J. Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2023.116935_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s40484-018-0161-6","article-title":"Computational methods and applications for quantitative systems pharmacology","volume":"7","author":"Xie","year":"2019","journal-title":"Quantitative biology"},{"issue":"11","key":"10.1016\/j.jep.2023.116935_bib35","first-page":"2673","article-title":"Optimization of yinxieling capsule with orthogonal design","volume":"25","author":"Yan","year":"2014","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"issue":"2","key":"10.1016\/j.jep.2023.116935_bib36","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.21037\/apm-20-2575","article-title":"Comparison of PSORI-CM01 granules and Yinxieling tablets for patients with chronic plaque psoriasis: a pilot study for a randomized, double-blinded, double-dummy, multicentre trial","volume":"10","author":"Yao","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.jep.2023.116935_bib37","article-title":"Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2\/STAT3 signal pathways","volume":"123","author":"Yuan","year":"2020","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.jep.2023.116935_bib38","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.biopha.2017.05.127","article-title":"Astilbin decreases proliferation and improves differentiation in HaCaT keratinocytes","volume":"93","author":"Zhang","year":"2017","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.jep.2023.116935_bib39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.intimp.2018.09.048","article-title":"Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin disease","volume":"65","author":"Zhang","year":"2018","journal-title":"Int. Immunopharm."},{"issue":"8","key":"10.1016\/j.jep.2023.116935_bib40","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1002\/ptr.7155","article-title":"Rosmarinic acid protects mice from imiquimod induced psoriasis-like skin lesions by inhibiting the IL-23\/Th17 axis via regulating Jak2\/Stat3 signaling pathway","volume":"35","author":"Zhang","year":"2021","journal-title":"Phytother Res. : PT"},{"key":"10.1016\/j.jep.2023.116935_bib41","article-title":"The paeonol target gene autophagy-related 5 has a potential therapeutic value in psoriasis treatment","volume":"9","author":"Zhang","year":"2021","journal-title":"PeerJ"},{"issue":"D1","key":"10.1016\/j.jep.2023.116935_bib42","doi-asserted-by":"crossref","first-page":"D1398","DOI":"10.1093\/nar\/gkab953","article-title":"Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents","volume":"50","author":"Zhou","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:05:01Z","timestamp":1736402701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123008036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":41,"alternative-id":["S0378874123008036"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116935","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular mechanism of PSORI-CM01 for psoriasis by regulating the inflammatory cytokines network","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116935"}}