{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:12:20Z","timestamp":1793722340659,"version":"4.6.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.116936","type":"journal-article","created":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T15:56:51Z","timestamp":1690127811000},"page":"116936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"PA","title":["Moringa oleifera Lam. Leaf improves constipation of rats induced by low-fiber-diet: A proteomics study"],"prefix":"10.1016","volume":"318","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-4317","authenticated-orcid":false,"given":"Zhiyong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingnan","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2023.116936_bib1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ceca.2014.01.006","article-title":"cAMP and Ca2+ signaling in secretory epithelia: crosstalk and synergism","volume":"55","author":"Ahuja","year":"2014","journal-title":"Cell Calcium"},{"issue":"4","key":"10.1016\/j.jep.2023.116936_bib2","first-page":"42","article-title":"Traditional medicinal knowledge on Moringa concanensis nimmo of perambalur district, tamilnadu","volume":"26","author":"Anbazhakan","year":"2007","journal-title":"Ancient Sci. Life"},{"issue":"1","key":"10.1016\/j.jep.2023.116936_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ptr.2023","article-title":"Moringa oleifera: a food plant with multiple medicinal uses","volume":"21","author":"Anwar","year":"2007","journal-title":"Phytother Res."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2023.116936_bib4","first-page":"S5","article-title":"Systematic review on the management of chronic constipation in North America","volume":"100","author":"Brandt","year":"2005","journal-title":"Am. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2023.116936_bib5","first-page":"3","article-title":"Effect of loperamide and bisacodyl on intestinal transit time, fecal weight and short chain fatty acid excretion in the rat","volume":"21","author":"Bustos","year":"1991","journal-title":"Acta Gastroenterol. Latinoam."},{"key":"10.1016\/j.jep.2023.116936_bib6","article-title":"Prevalence and risk factors of functional constipation according to the Rome criteria in China: a systematic review and meta-analysis","volume":"9","author":"Chen","year":"2022","journal-title":"Front. Med."},{"issue":"10","key":"10.1016\/j.jep.2023.116936_bib7","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/ptr.5410","article-title":"Constipation and botanical medicines: an overview","volume":"29","author":"Cirillo","year":"2015","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2023.116936_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/298014","article-title":"Applications of new Technologies and new methods in ZHENG differentiation","volume":"2012","author":"Dai","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"issue":"4","key":"10.1016\/j.jep.2023.116936_bib9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.7897\/2277-4343.04435","article-title":"Indian ayurvedic and traditional medicinal implications of indigenously available plants, herbs and fruits: a review","volume":"4","author":"Ganguly","year":"2013","journal-title":"Int. J. Res. Ayurveda Pharm."},{"issue":"20","key":"10.1016\/j.jep.2023.116936_bib10","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.2174\/1381612043383890","article-title":"Interaction of NO and VIP in gastrointestinal smooth muscle relaxation","volume":"10","author":"Geldre","year":"2004","journal-title":"Curr. Pharmaceut. Des."},{"issue":"2","key":"10.1016\/j.jep.2023.116936_bib11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/jgh.14818","article-title":"Heterogeneous outcome reporting in adult slow-transit constipation studies: systematic review towards a core outcome set","volume":"35","author":"Heemskerk","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"14","key":"10.1016\/j.jep.2023.116936_bib12","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1016\/S0021-9258(18)68692-2","article-title":"Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs","volume":"263","author":"Itoh","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2023.116936_bib13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopha.2017.02.020","article-title":"Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment","volume":"89","author":"Jabri","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116936_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/983139","article-title":"Recent advance in applications of proteomics Technologies on traditional Chinese medicine Research","volume":"2015","author":"Ji","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.116936_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1472-6882-10-68","article-title":"Laxative effects of agarwood on low-fiber diet-induced constipation in rats","volume":"10","author":"Kakino","year":"2010","journal-title":"BMC Compl. Alternative Med."},{"issue":"1","key":"10.1016\/j.jep.2023.116936_bib16","first-page":"185","article-title":"Spicatoside A in red Liriope platyphylla displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling","volume":"43","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2023.116936_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/1472-6882-13-333","article-title":"Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats","volume":"13","author":"Kim","year":"2013","journal-title":"BMC Compl. Alternative Med."},{"issue":"5","key":"10.1016\/j.jep.2023.116936_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24050896","article-title":"Laxative effect of spicatoside A by cholinergic regulation of enteric nerve in loperamide-induced constipation: ICR mice model","volume":"24","author":"Kim","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jep.2023.116936_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2014.05.022","article-title":"Application of proteomics to determine the mechanism of action of traditional Chinese medicine remedies","volume":"155","author":"Lao","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116936_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114644","article-title":"Therapeutic effect of Moringa oleifera leaves on constipation mice based on pharmacodynamics and serum metabonomics","volume":"282","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"14","key":"10.1016\/j.jep.2023.116936_bib21","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1016\/S0021-9258(19)39064-7","article-title":"Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli","volume":"265","author":"Linder","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2023.116936_bib22","doi-asserted-by":"crossref","first-page":"112362","DOI":"10.1016\/j.jep.2019.112362","article-title":"In-depth transcriptomic and proteomic analyses of the hippocampus and cortex in a rat model after cerebral ischemic injury and repair by Shuxuetong (SXT) injection","volume":"249","author":"Liu","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.jep.2023.116936_bib23","first-page":"775","article-title":"Moringa oleifera: a natural gift-A review","volume":"2","author":"Mahmood","year":"2010","journal-title":"J. Pharmaceut. Sci."},{"issue":"5","key":"10.1016\/j.jep.2023.116936_bib24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/MOP.0000000000000938","article-title":"Medications for constipation in 2020","volume":"32","author":"Medina-Centeno","year":"2020","journal-title":"Curr. Opin. Pediatr."},{"issue":"2","key":"10.1016\/j.jep.2023.116936_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/MED.0000000000000707","article-title":"Gastrointestinal hormones and regulation of gastric emptying","volume":"29","author":"Mori","year":"2022","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"1","key":"10.1016\/j.jep.2023.116936_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/apt.12124","article-title":"Levels of satisfaction with current chronic constipation treatment options in Europe - an internet survey","volume":"37","author":"Muller-Lissner","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2023.116936_bib27","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fmicb.2019.00324","article-title":"Lactobacillus casei strain shirota alleviates constipation in adults by increasing the pipecolinic acid level in the gut","volume":"10","author":"Ou","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2023.116936_bib28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.rvsc.2017.06.002","article-title":"Substance P and the neurokinin-1 receptor expression in dog ileum with and without inflammation","volume":"114","author":"Polidoro","year":"2017","journal-title":"Res. Vet. Sci."},{"issue":"Suppl. l","key":"10.1016\/j.jep.2023.116936_bib29","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.regpep.2012.05.087","article-title":"Beginnings: a reflection on the history of gastrointestinal endocrinology","volume":"177","author":"Rehfeld","year":"2012","journal-title":"Regul. Pept."},{"issue":"6","key":"10.1016\/j.jep.2023.116936_bib30","article-title":"Chronic constipation in adults: contemporary perspectives and clinical challenges. 1: epidemiology, diagnosis, clinical associations, pathophysiology and investigation","volume":"33","author":"Scott","year":"2021","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"4","key":"10.1016\/j.jep.2023.116936_bib31","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1152\/physrev.00001.2005","article-title":"PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis","volume":"85","author":"Seino","year":"2005","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.jep.2023.116936_bib32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/apha.12430","article-title":"The role of serotonin and its receptors in activation of immune responses and inflammation","volume":"213","author":"Shajib","year":"2015","journal-title":"Acta Physiol."},{"issue":"6","key":"10.1016\/j.jep.2023.116936_bib33","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/ptr.5325","article-title":"Review of the safety and efficacy of Moringa oleifera","volume":"29","author":"Stohs","year":"2015","journal-title":"Phytother Res."},{"issue":"3","key":"10.1016\/j.jep.2023.116936_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0092-8674(93)90376-2","article-title":"A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion","volume":"75","author":"Sollner","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jep.2023.116936_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.691363","article-title":"The role of calmodulin vs. Synaptotagmin in exocytosis","volume":"14","author":"Xue","year":"2021","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2023.116936_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nm.3751","article-title":"Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance","volume":"21","author":"Yoda","year":"2015","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.jep.2023.116936_bib38","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00210-016-1259-x","article-title":"The signaling of amitriptyline-induced inhibitory effect on electrical field stimulation response in colon smooth muscle","volume":"389","author":"Zaw","year":"2016","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2023.116936_bib39","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1089\/jmf.2017.4109","article-title":"Lactobacillus plantarum YS-3 prevents activated carbon-induced constipation in mice","volume":"21","author":"Zhao","year":"2018","journal-title":"J. Med. Food"},{"issue":"8","key":"10.1016\/j.jep.2023.116936_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160398","article-title":"Total glucosides of paeony promote intestinal motility in slow transit constipation rats through amelioration of interstitial cells of cajal","volume":"11","author":"Zhu","year":"2016","journal-title":"PLoS One"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:05:10Z","timestamp":1736402710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123008048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":39,"alternative-id":["S0378874123008048"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116936","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moringa oleifera Lam. Leaf improves constipation of rats induced by low-fiber-diet: A proteomics study","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116936","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116936"}}