{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:11:05Z","timestamp":1789269065831,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173970"],"award-info":[{"award-number":["82173970"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2060302"],"award-info":[{"award-number":["2060302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002797","name":"Government of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.116962","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:27:59Z","timestamp":1690259279000},"page":"116962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"PA","title":["Total flavonoids of Hippophae rhamnoides L. improves type 2 diabetes symptoms in rats through down-regulating of the DAG\/PRKCA\/MAPK10\/p65\/TNF-\u03b1 signalling pathway"],"prefix":"10.1016","volume":"318","author":[{"given":"Xingjing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1367-8481","authenticated-orcid":false,"given":"Yanru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changle","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jep.2023.116962_bib1","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1039\/D1FO04209B","article-title":"Association between non-tea flavonoid intake and risk of type 2 diabetes: the Australian diabetes, obesity and lifestyle study","volume":"13","author":"Adu","year":"2022","journal-title":"Food Funct."},{"issue":"8","key":"10.1016\/j.jep.2023.116962_bib2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3390\/life12081146","article-title":"Therapeutic potential of quercetin in the management of type-2 diabetes mellitus","volume":"12","author":"Ansari","year":"2022","journal-title":"Life-Basel"},{"issue":"4","key":"10.1016\/j.jep.2023.116962_bib3","doi-asserted-by":"crossref","first-page":"334","DOI":"10.14341\/DM12746","article-title":"Some Mechanisms of inflammation development in type 2 diabetes mellitus","volume":"24","author":"Bochkareva","year":"2021","journal-title":"Diabetes Mellitus"},{"issue":"3","key":"10.1016\/j.jep.2023.116962_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jfutfo.2023.02.001","article-title":"Traditional food, modern food and nutritional value of Sea buckthorn (Hippophae rhamnoides L.): a review","volume":"3","author":"Chen","year":"2023","journal-title":"J.Future Foods"},{"issue":"7","key":"10.1016\/j.jep.2023.116962_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","article-title":"Genetics of diabetes mellitus and diabetes complications","volume":"16","author":"Cole","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2023.116962_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.rvsc.2022.08.022","article-title":"The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats","volume":"152","author":"Dupak","year":"2022","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.jep.2023.116962_bib7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.biopha.2017.08.098","article-title":"A practical guide for induction of type-2 diabetes in rat: incorporating a high-fat diet and streptozotocin","volume":"95","author":"Gheibi","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"20","key":"10.1016\/j.jep.2023.116962_bib8","doi-asserted-by":"crossref","first-page":"6784","DOI":"10.3390\/molecules27206784","article-title":"The role of diacylglycerol kinase in the amelioration of diabetic nephropathy","volume":"27","author":"Hayashi","year":"2022","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.jep.2023.116962_bib9","first-page":"1738","article-title":"Discussion on the etiology and pathogenesis of type 2 diabetes mellitus from the spleen","volume":"43","author":"He","year":"2021","journal-title":"Hebei. J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2023.116962_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114784","article-title":"Integrating network pharmacology and non-targeted metabolomics to explore the common mechanism of Coptis Categorized Formula improving T2DM zebrafish","volume":"284","author":"He","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2023.116962_bib11","first-page":"69","article-title":"Hypoglycemic effect of polysaccharide from Anemarrhena asphodeloides in streptozotocin-induced diabetic rats","volume":"39","author":"Hou","year":"2018","journal-title":"Sci. Technol. Food Ind."},{"issue":"11","key":"10.1016\/j.jep.2023.116962_bib12","first-page":"11946","article-title":"An assessment of insulin resistance (IR) & tumor necrosis factor alpha (TNF-alpha) association with type II diabetes mellitus (T2DM) cases","volume":"5","author":"Iqbal","year":"2018","journal-title":"IAJPS"},{"issue":"1","key":"10.1016\/j.jep.2023.116962_bib13","first-page":"6","article-title":"Discussion of treatment of metabolic diseases from the perspective of spleen, stomach, liver and kidney","volume":"17","author":"Jiang","year":"2022","journal-title":"WCM"},{"issue":"1","key":"10.1016\/j.jep.2023.116962_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/physrev.00041.2018","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2023.116962_bib15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3389\/fphar.2020.00935","article-title":"The potential of anti-diabetic rakau rongoa (maori herbal medicine) to treat type 2 diabetes mellitus (T2DM) mate huka: a review","volume":"11","author":"Koia","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"35","key":"10.1016\/j.jep.2023.116962_bib16","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1360\/TB-2020-0708","article-title":"The dynamics mechanism of islet inflammation during type 2 diabetes progress","volume":"65","author":"Lei","year":"2020","journal-title":"Chin. Sci. B-Chin."},{"issue":"2","key":"10.1016\/j.jep.2023.116962_bib17","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbrc.2019.12.063","article-title":"Hypoxia-inducible factor-1 alpha mediates the expression of mature beta cell-disallowed genes in hypoxia-induced beta cell dedifferentiation","volume":"523","author":"Liu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2023.116962_bib18","first-page":"1","article-title":"Research progress of animal models of diabetic nephropathy","author":"Luo","year":"2023","journal-title":"J. Chengdu. Med. Coll"},{"key":"10.1016\/j.jep.2023.116962_bib19","series-title":"Pharmacopoeia of the People's Republic of China Part 1","first-page":"191","year":"2020"},{"issue":"6","key":"10.1016\/j.jep.2023.116962_bib20","first-page":"23","article-title":"Discussion on the relationship between the physiological characteristics of the spleen and type 2 diabetes mellitus","volume":"28","author":"Ni","year":"2010","journal-title":"J. Tradit. Chin. Med. Lit."},{"issue":"2","key":"10.1016\/j.jep.2023.116962_bib21","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s40200-020-00679-x","article-title":"Role of mitochondria in pathogenesis of type 2 diabetes mellitus","volume":"19","author":"Prasun","year":"2020","journal-title":"J. Diabetes Metab. Disord."},{"issue":"3","key":"10.1016\/j.jep.2023.116962_bib22","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.fshw.2022.09.012","article-title":"Seabuckthorn juice alleviates allergic symptoms in shrimp-induced food allergy mice","volume":"12","author":"Ren","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"issue":"2","key":"10.1016\/j.jep.2023.116962_bib23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.clnu.2019.02.006","article-title":"Plant-derived natural agents as dietary supplements for the regulation of glycosylated hemoglobin: a review of clinical trials","volume":"39","author":"Rezaeiamiri","year":"2020","journal-title":"Clin. Nutr."},{"issue":"5","key":"10.1016\/j.jep.2023.116962_bib24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/07315724.2005.10719488","article-title":"Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis","volume":"24","author":"Song","year":"2005","journal-title":"J. Am. Coll. Nutr."},{"issue":"2\u20133","key":"10.1016\/j.jep.2023.116962_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1385\/JMN:16:2-3:159","article-title":"Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain","volume":"16","author":"Spector","year":"2001","journal-title":"J. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2023.116962_bib26","first-page":"142","article-title":"Hypolipidemic and hypoglycemic effects of total flavonoids from pomace of fructus Hippophae","volume":"13","author":"Sun","year":"2018","journal-title":"WCM"},{"issue":"21","key":"10.1016\/j.jep.2023.116962_bib27","first-page":"5522","article-title":"Research progress on chemical constituents and pharmacological activities of seabuckthorn and prediction of its Q-markers","volume":"46","author":"Wang","year":"2021","journal-title":"China J. Chin. Mater. Med."},{"issue":"10","key":"10.1016\/j.jep.2023.116962_bib28","first-page":"3712","article-title":"Research progress of anti-meta-inflammation treatment of type 2 diabetes with heat-clearing Chinese herbal compound","volume":"23","author":"Xiao","year":"2021","journal-title":"M. Tradit. Chin. Med. W. Sci. & Tech"},{"issue":"2","key":"10.1016\/j.jep.2023.116962_bib29","first-page":"602","article-title":"Effects of Shenxiao Tongluo Decoction on renal inflammatory injury and levels of MCP-1 and TNF-\u03b1 in spontaneously diabetic db\/db mice","volume":"44","author":"Yang","year":"2022","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"6","key":"10.1016\/j.jep.2023.116962_bib30","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: review of the underlying molecular mechanisms","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.jep.2023.116962_bib31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/jdi.12441","article-title":"Different role of zinc transporter 8 between type 1 diabetes mellitus and type 2 diabetes mellitus","volume":"7","author":"Yi","year":"2016","journal-title":"J. Diabetes. Invest"},{"issue":"3","key":"10.1016\/j.jep.2023.116962_bib32","first-page":"154","article-title":"PKC and Diabetic nephropathy","author":"Yi","year":"2006","journal-title":"Med Rec"},{"key":"10.1016\/j.jep.2023.116962_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fendo.2022.976465","article-title":"Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus","volume":"13","author":"You","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2023.116962_bib34","first-page":"11","article-title":"Translating traditional herbal formulas into modern drugs: a network-based analysis of Xiaoyao decoction","volume":"15","author":"Zhang","year":"2020","journal-title":"Chin. Med.Uk"},{"key":"10.1016\/j.jep.2023.116962_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174769","article-title":"Exploring the synergistic and complementary effects of berberine and paeoniflorin in the treatment of type 2 diabetes mellitus by network pharmacology","volume":"919","author":"Zhang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2023.116962_bib36","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4239\/wjd.v5.i6.860","article-title":"Molecular mechanisms of AGE\/RAGE-mediated fibrosis in the diabetic heart","volume":"5","author":"Zhao","year":"2014","journal-title":"World J. Diabetes"},{"issue":"6","key":"10.1016\/j.jep.2023.116962_bib37","first-page":"152","article-title":"Research progress on anti-cardiovascular disease and metabolic syndrome of total flavonoids of seabuckthorn","volume":"28","author":"Zhou","year":"2012","journal-title":"Pharmacol. Clin. Chin. Mater. Clin. Med."},{"key":"10.1016\/j.jep.2023.116962_bib38","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.diabres.2006.06.007","article-title":"Type 2 diabetes mellitus as inflammatory disease","volume":"74","author":"Zozulinska","year":"2006","journal-title":"Diabetes Res. Clin. Pract."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:51:01Z","timestamp":1778752261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123008309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":38,"alternative-id":["S0378874123008309"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116962","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total flavonoids of Hippophae rhamnoides L. improves type 2 diabetes symptoms in rats through down-regulating of the DAG\/PRKCA\/MAPK10\/p65\/TNF-\u03b1 signalling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116962"}}