{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:09:00Z","timestamp":1789236540468,"version":"build-2803163510"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.116993","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T15:59:36Z","timestamp":1690991976000},"page":"116993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"PB","title":["Buddleja officinalis Maxim.: A review of its botany, ethnopharmacology, phytochemistry, pharmacology, and therapeutic potential for ophthalmic diseases"],"prefix":"10.1016","volume":"318","author":[{"given":"Meng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Peng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Jiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-You","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Xue","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116993_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1472-6882-9-21","article-title":"Assessment of the medicinal potentials of the methanol extracts of the leaves and stems of Buddleja saligna","volume":"9","author":"Adedapo","year":"2009","journal-title":"BMC Compl. Alternative Med."},{"issue":"4","key":"10.1016\/j.jep.2023.116993_bib2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1080\/14756360802565072","article-title":"Antioxidant phenylpropanoid glycosides from Buddleja davidii","volume":"24","author":"Ahmad","year":"2009","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"2","key":"10.1016\/j.jep.2023.116993_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3358\/shokueishi.42.84","article-title":"Analytical method for Buddleja colorants in foods","volume":"42","author":"Aoki","year":"2001","journal-title":"Shokuhin Eiseigaku Zasshi"},{"issue":"24","key":"10.1016\/j.jep.2023.116993_bib4","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1080\/14786419.2022.2025593","article-title":"Anti-inflammation and anti-arthritic effects of compounds from Buddleja coriacea","volume":"36","author":"Apaza Ticona","year":"2022","journal-title":"Nat. Prod. Res."},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib5","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.3390\/ijms24033016","article-title":"Host-derived cytotoxic agents in chronic inflammation and disease progression","volume":"24","author":"Arnhold","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3\u20134","key":"10.1016\/j.jep.2023.116993_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.fitote.2005.03.009","article-title":"Photoprotective activity of Buddleja scordioides","volume":"76","author":"Avila Acevedo","year":"2005","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.jep.2023.116993_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","article-title":"Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB","volume":"314","author":"Bai","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"14","key":"10.1016\/j.jep.2023.116993_bib8","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.1039\/D0RA00774A","article-title":"Ameliorative effect of urolithin A on d-gal-induced liver and kidney damage in aging mice via its antioxidative, anti-inflammation and antiapoptotic properties","volume":"10","author":"Chen","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2023.116993_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2021.102456","article-title":"P hotochemical reaction to increase melanogenesis using Buddleja officinalis and blue light-emitting diode irradiation in B16F10","volume":"35","author":"Cho","year":"2021","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"19","key":"10.1016\/j.jep.2023.116993_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911016","article-title":"Molecular mechanisms of anti-inflammation phytochemicals","volume":"23","author":"Cruz-Martins","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2023.116993_bib11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s11418-008-0255-y","article-title":"Free-radical-scavenging principles from Phlomis caucasica","volume":"62","author":"Delazar","year":"2008","journal-title":"J. Nat. Med."},{"issue":"6","key":"10.1016\/j.jep.2023.116993_bib12","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2010.02.043","article-title":"Anti-inflammation agents: present and future","volume":"140","author":"Dinarello","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jep.2023.116993_bib13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ophtha.2019.04.017","article-title":"HAWK and HARRIER: Phase 3, multicenter, randomized, double-masked trials of brolucizumab for neovascular age-related macular degeneration","volume":"127","author":"Dugel","year":"2020","journal-title":"Ophthalmology"},{"issue":"23","key":"10.1016\/j.jep.2023.116993_bib14","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1080\/14786419.2017.1378213","article-title":"Chemical composition of Buddleja polystachya aerial parts and its bioactivity against Aedes aegypti","volume":"32","author":"El-Gamal","year":"2018","journal-title":"Nat. Prod. Res."},{"issue":"14","key":"10.1016\/j.jep.2023.116993_bib15","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.3390\/molecules24142556","article-title":"Anti-diabetic effects and mechanisms of dietary polysaccharides","volume":"24","author":"Ganesan","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib16","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1172\/JCI114485","article-title":"Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo","volume":"85","author":"Garrett","year":"1990","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.jep.2023.116993_bib17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2174\/1568026623666221222142217","article-title":"Exploring the multitarget potential of iridoids: advances and applications","volume":"23","author":"Grover","year":"2023","journal-title":"Curr. Top. Med. Chem."},{"issue":"7","key":"10.1016\/j.jep.2023.116993_bib18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/ptr.1893","article-title":"Effect on capillary permeability in rabbits of iridoids from Buddleia scordioides","volume":"20","author":"Gutierrez","year":"2006","journal-title":"Phytother Res."},{"issue":"1","key":"10.1016\/j.jep.2023.116993_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1021\/np0300131","article-title":"Saponins from the flower buds of Buddleja officinalis","volume":"67","author":"Guo","year":"2004","journal-title":"J Nat Prod"},{"issue":"5","key":"10.1016\/j.jep.2023.116993_bib20","doi-asserted-by":"crossref","first-page":"F988","DOI":"10.1152\/ajprenal.00327.2004","article-title":"High glucose-induced oxidative stress inhibits Na+\/glucose cotransporter activity in renal proximal tubule cells","volume":"288","author":"Han","year":"2005","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib21","first-page":"1460","article-title":"Linarin prevents LPS-induced acute lung injury by suppressing oxidative stress and inflammation via inhibition of TXNIP\/NLRP3 and NF-\u03baB pathways","volume":"42","author":"Han","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.jep.2023.116993_bib22","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1016\/S0021-9258(17)35860-X","article-title":"Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors","volume":"261","author":"Herron","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib23","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0378-8741(00)00189-6","article-title":"Antioxidant activity of phenylethanoid glycosides from Brandisia hancei","volume":"71","author":"He","year":"2000","journal-title":"J. Ethnopharmacol."},{"issue":"14","key":"10.1016\/j.jep.2023.116993_bib24","doi-asserted-by":"crossref","first-page":"DES174","DOI":"10.1167\/iovs.17-23528","article-title":"Advances in functional restoration of the lacrimal glands","volume":"59","author":"Hirayama","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.jep.2023.116993_bib25","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1080\/14786419.2021.1952577","article-title":"Anti-inflammation and antioxidant activities of chemical constituents from the flower buds of Buddleja officinalis","volume":"36","author":"Huang","year":"2022","journal-title":"Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.jep.2023.116993_bib26","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3892\/etm.2021.10830","article-title":"Animal models of dry eye disease: useful, varied and evolving (Review)","volume":"22","author":"Huang","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.jep.2023.116993_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcb.21592","article-title":"Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle","volume":"104","author":"Jin","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2023.116993_bib28","article-title":"Activation of AMPK by Buddleja officinalis Maxim. Flower extract contributes to protecting hepatocytes from oxidative stress","author":"Jung","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1\u20132","key":"10.1016\/j.jep.2023.116993_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbapap.2005.08.017","article-title":"MAPK signalling pathways as molecular targets for anti-inflammation therapy--from molecular mechanisms to therapeutic benefits","volume":"1754","author":"Kaminska","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/ars.2006.1456","article-title":"Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells","volume":"9","author":"Kim","year":"2007","journal-title":"Antioxidants Redox Signal."},{"issue":"4","key":"10.1016\/j.jep.2023.116993_bib31","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1248\/bpb.30.805","article-title":"Cudratricusxanthone A isolated from the root bark of Cudrania tricuspidata inhibits the proliferation of vascular smooth muscle cells through the suppression of PDGF-receptor beta tyrosine kinase","volume":"30","author":"Kim","year":"2007","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.jep.2023.116993_bib32","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cellimm.2011.02.002","article-title":"Linarin isolated from Buddleja officinalis prevents hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells","volume":"268","author":"Kim","year":"2011","journal-title":"Cell. Immunol."},{"issue":"8","key":"10.1016\/j.jep.2023.116993_bib33","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1248\/bpb.29.1608","article-title":"Neuroprotective effect of Buddleja officinalis extract on transient middle cerebral artery occlusion in rats","volume":"29","author":"Lee","year":"2006","journal-title":"Biol. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jep.2005.01.005","article-title":"Inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by acteoside through blocking of AP-1 activation","volume":"97","author":"Lee","year":"2005","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2023.116993_bib35","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.4014\/jmb.2102.02015","article-title":"Anti-obesity and lipid metabolism effects of ulmus davidiana var. japonica in mice fed a high-fat diet","volume":"31","author":"Lee","year":"2021","journal-title":"J. Microbiol. Biotechnol."},{"issue":"6","key":"10.1016\/j.jep.2023.116993_bib36","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3181\/0710-RM-286","article-title":"Effect of Buddleja officinalis on high-glucose-induced vascular inflammation in human umbilical vein endothelial cells","volume":"233","author":"Lee","year":"2008","journal-title":"Exp Biol Med (Maywood)"},{"issue":"12","key":"10.1016\/j.jep.2023.116993_bib37","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/ptr.2547","article-title":"Buddleja officinalis inhibits high glucose-induced matrix metalloproteinase activity in human umbilical vein endothelial cells","volume":"22","author":"Lee","year":"2008","journal-title":"Phytother Res."},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1142\/S0192415X1000807X","article-title":"Anti-inflammation effect of Buddleja officinalis on vascular inflammation in human umbilical vein endothelial cells","volume":"38","author":"Lee","year":"2010","journal-title":"Am. J. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2023.116993_bib39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1258\/ebm.2009.009222","article-title":"Buddleja officinalis suppresses high glucose-induced vascular smooth muscle cell proliferation: role of mitogen-activated protein kinases, nuclear factor-kappaB and matrix metalloproteinases","volume":"235","author":"Lee","year":"2010","journal-title":"Exp Biol Med (Maywood)"},{"issue":"6","key":"10.1016\/j.jep.2023.116993_bib40","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1080\/09273948.2020.1841804","article-title":"Allergy and dry eye disease","volume":"29","author":"Leonardi","year":"2021","journal-title":"Ocul. Immunol. Inflamm."},{"issue":"2","key":"10.1016\/j.jep.2023.116993_bib41","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1172\/JCI117409","article-title":"Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice","volume":"94","author":"Liao","year":"1994","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.jep.2023.116993_bib42","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1021\/np990092+","article-title":"Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation","volume":"62","author":"Liao","year":"1999","journal-title":"J Natural Prod"},{"issue":"10","key":"10.1016\/j.jep.2023.116993_bib43","first-page":"613","article-title":"[Phenylethanoids from flos buddlejae]","volume":"22","author":"Li","year":"1997","journal-title":"China J. Chin. Mater. Med."},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib44","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/ICO.0000000000000292","article-title":"Effects of androgen on ultrastructure of corneal epithelium and function of the tear film in BALB\/c mice","volume":"34","author":"Li","year":"2015","journal-title":"Cornea"},{"issue":"7","key":"10.1016\/j.jep.2023.116993_bib45","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.2337\/diabetes.54.7.2227","article-title":"Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin","volume":"54","author":"Li","year":"2005","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jep.2023.116993_bib46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/molecules23020271","article-title":"Chemical constituents and antioxidant, anti-inflammation and anti-tumor activities of melilotus officinalis (linn.)","volume":"23","author":"Liu","year":"2018","journal-title":"Pall. Molecules."},{"issue":"5","key":"10.1016\/j.jep.2023.116993_bib47","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1142\/S0192415X19500514","article-title":"Anti-oxidant in China: a thirty-year journey","volume":"47","author":"Liu","year":"2019","journal-title":"Am. J. Chin. Med."},{"issue":"12","key":"10.1016\/j.jep.2023.116993_bib48","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1080\/14786419.2021.1944138","article-title":"Glycosides from Buddleja officinalis with their protective effects on photoreceptor cells in light-damaged mouse retinas","volume":"36","author":"Long","year":"2022","journal-title":"Nat. Prod. Res."},{"issue":"23","key":"10.1016\/j.jep.2023.116993_bib49","first-page":"6178","article-title":"[A new hexenol glycoside from Buddleja officinalis]","volume":"46","author":"Long","year":"2021","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2023.116993_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107886","article-title":"Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K\/Akt\/VEGF signaling pathway in diabetic retinopathy","volume":"190","author":"Lu","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.jep.2023.116993_bib51","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1210\/en.2006-1440","article-title":"Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I","volume":"148","author":"Maile","year":"2007","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib52","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1248\/bpb.18.463","article-title":"Study on anti-cataract drugs from natural sources. II. Effects of buddlejae flos on in vitro aldose reductase activity","volume":"18","author":"Matsuda","year":"1995","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.jep.2023.116993_bib53","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jep.2006.07.006","article-title":"CML-1 inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in endothelial cells through inhibition of IkBalpha kinaseelial cells through inhibition of IkBalpha kinase","volume":"109","author":"Mo","year":"2007","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2023.116993_bib54","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1089\/jmf.2017.4061","article-title":"Angelica sinensis supercritical fluid CO2 extract attenuates D-galactose-induced liver and kidney impairment in mice by suppressing oxidative stress and inflammation","volume":"21","author":"Mo","year":"2018","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2023.116993_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106206","article-title":"Current trends in pharmaceutical treatment of dry eye disease: a review","volume":"175","author":"Mohamed","year":"2022","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2023.116993_bib56","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/978-1-0716-1298-9_23","article-title":"siRNA therapeutics in ocular diseases","volume":"2282","author":"Moreno-Monta\u00f1\u00e9s","year":"2021","journal-title":"Methods Mol. Biol."},{"issue":"9","key":"10.1016\/j.jep.2023.116993_bib57","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1248\/cpb.52.1086","article-title":"Terpenic and phenolic glycosides from leaves of Breynia officinalis HEMSL","volume":"52","author":"Morikawa","year":"2004","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"11","key":"10.1016\/j.jep.2023.116993_bib58","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.3390\/ph14111104","article-title":"Linarin, a glycosylated flavonoid, with potential therapeutic attributes: a comprehensive review","volume":"14","author":"Mottaghipisheh","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2023.116993_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173349","article-title":"Pleiotropic effects of anti-diabetic drugs: a comprehensive review","volume":"884","author":"Nath","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2023.116993_bib60","doi-asserted-by":"crossref","first-page":"9195","DOI":"10.3390\/molecules18089195","article-title":"Inhibition of lipopolysaccharide-induced proinflammatory responses by Buddleja officinalis extract in BV-2 microglial cells via negative regulation of NF-kB and ERK1\/2 signaling","volume":"18","author":"Oh","year":"2013","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib61","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/ICU.0000000000000569","article-title":"Advances in dry eye disease treatment","volume":"30","author":"O'Neil","year":"2019","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.jep.2023.116993_bib62","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8609285","article-title":"Sipjeondaebo-tang alleviates oxidative stress-mediated liver injury through activation of the CaMKK2-AMPK signaling pathway","author":"Park","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.jep.2023.116993_bib63","first-page":"72","article-title":"[Effects of extract of Buddleja officinalis eye drops on androgen receptors of lacrimal gland cells of castrated rats with dry eye]","volume":"32","author":"Peng","year":"2012","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"issue":"11","key":"10.1016\/j.jep.2023.116993_bib64","first-page":"1011","article-title":"[Effects of extract of Buddleja officinalis on prevention of dry eye in castrated rabbits]","volume":"44","author":"Peng","year":"2008","journal-title":"Chin. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.jep.2023.116993_bib65","first-page":"43","article-title":"Effects of extract of Buddleja officinalis eye drops on androgen receptors of lacrimal gland cells of castrated rats with dry eye","volume":"3","author":"Peng","year":"2010","journal-title":"Int. J. Ophthalmol."},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib66","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3736\/jcim20100308","article-title":"Effects of eye drops of Buddleja officinalis Maxim. extract on lacrimal gland cell apoptosis in castrated rats with dry eye","volume":"8","author":"Peng","year":"2010","journal-title":"J. Chin. Integr. Med."},{"issue":"6","key":"10.1016\/j.jep.2023.116993_bib67","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02976861","article-title":"Antioxidative constituents from Buddleia officinalis","volume":"26","author":"Piao","year":"2003","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2023.116993_bib68","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejmech.2015.04.040","article-title":"The role of antioxidants in the chemistry of oxidative stress: a review","volume":"97","author":"Pisoschi","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2023.116993_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116063","article-title":"Review on potential effects of traditional Chinese medicine on glaucoma","volume":"304","author":"Qi","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116993_bib70","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5916243","article-title":"The effect of Buddleja officinalis Maxim eye drops on morphology and apoptosis in lacrimal gland of experimental dry eye rabbit model","author":"Qin","year":"2019","journal-title":"J Ophthalmol"},{"issue":"12","key":"10.1016\/j.jep.2023.116993_bib71","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.freeradbiomed.2008.09.002","article-title":"PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways","volume":"45","author":"Ramanan","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.jep.2023.116993_bib72","doi-asserted-by":"crossref","first-page":"8687","DOI":"10.3390\/molecules17078687","article-title":"Buddleja officinalis Maximowicz extract inhibits lipid accumulation on adipocyte differentiation in 3T3-L1 cells and high-fat mice","volume":"17","author":"Roh","year":"2012","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jep.2023.116993_bib73","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.atherosclerosis.2006.03.018","article-title":"Infection with a periodontal pathogen increases mononuclear cell adhesion to human aortic endothelial cells","volume":"190","author":"Roth","year":"2007","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.jep.2023.116993_bib74","doi-asserted-by":"crossref","first-page":"9514","DOI":"10.1002\/jcb.28227","article-title":"The effects of microRNAs in activating neovascularization pathways in diabetic retinopathy","volume":"120","author":"Satari","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2023.116993_bib75","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.nutres.2017.09.002","article-title":"Caulerpa okamurae extract inhibits adipogenesis in 3T3-L1 adipocytes and prevents high-fat diet-induced obesity in C57BL\/6 mice","volume":"47","author":"Sharma","year":"2017","journal-title":"Nutr. Res."},{"issue":"4","key":"10.1016\/j.jep.2023.116993_bib76","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1440-1797.2012.01572.x","article-title":"Oxidative stress, anti-oxidant therapies and chronic kidney disease","volume":"17","author":"Small","year":"2012","journal-title":"Nephrology"},{"issue":"3","key":"10.1016\/j.jep.2023.116993_bib77","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/molecules21030343","article-title":"Genetic and epigenetic approaches for the possible detection of adulteration and auto-adulteration in saffron (crocus sativus L.) spice","volume":"21","author":"Soffritti","year":"2016","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.jep.2023.116993_bib78","doi-asserted-by":"crossref","first-page":"H2587","DOI":"10.1111\/1750-3841.13435","article-title":"Identification of the major components of Buddleja officinalis extract and their metabolites in rat urine by UHPLC-LTQ-orbitrap","volume":"81","author":"Sun","year":"2016","journal-title":"J. Food Sci."},{"issue":"4","key":"10.1016\/j.jep.2023.116993_bib79","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4103\/tcmj.tcmj_281_20","article-title":"Retrospective evaluation of the curative effect of traditional Chinese medicine on dry eye disease","volume":"33","author":"Su","year":"2021","journal-title":"Tzu Chi Med. J."},{"issue":"12","key":"10.1016\/j.jep.2023.116993_bib80","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1248\/bpb.32.1952","article-title":"Total peroxynitrite scavenging capacity of phenylethanoid and flavonoid glycosides from the flowers of Buddleja officinalis","volume":"32","author":"Tai","year":"2009","journal-title":"Biol. Pharm. Bull."},{"issue":"11","key":"10.1016\/j.jep.2023.116993_bib81","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1016\/j.bmcl.2011.03.078","article-title":"A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis","volume":"21","author":"Tai","year":"2011","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2023.116993_bib82","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.fct.2012.12.018","article-title":"In vitro anti-inflammation effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells","volume":"53","author":"Wang","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"11","key":"10.1016\/j.jep.2023.116993_bib83","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.3390\/molecules22111877","article-title":"Optimization of the extraction conditions for Buddleja officinalis Maxim. Using response surface methodology and exploration of the optimum harvest time","volume":"22","author":"Xie","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116993_bib84","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jpba.2018.10.030","article-title":"Chemical profiles and quality evaluation of Buddleja officinalis flowers by HPLC-DAD and HPLC-Q-TOF-MS\/MS","volume":"164","author":"Xie","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"8","key":"10.1016\/j.jep.2023.116993_bib85","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/jssc.201901062","article-title":"Separation of acteoside and linarin from Buddlejae Flos by high-speed countercurrent chromatography and their anti-inflammation activities","volume":"43","author":"Xie","year":"2020","journal-title":"J. Separ. Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.116993_bib86","first-page":"114","article-title":"Effects of extract of Buddleja officinalis on partial inflammation of lacrimal gland in castrated rabbits with dry eye","volume":"3","author":"Yao","year":"2010","journal-title":"Int. J. Ophthalmol."},{"issue":"9","key":"10.1016\/j.jep.2023.116993_bib87","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.21037\/tp-21-385","article-title":"Application of vitamin A palmitate eye gel and nurse value of Watson's theory of caring in children with dry eye after strabismus surgery: a randomized trial","volume":"10","author":"Yang","year":"2021","journal-title":"Transl. Pediatr."},{"issue":"4","key":"10.1016\/j.jep.2023.116993_bib88","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3390\/molecules25041017","article-title":"Potential therapeutic anti-inflammation and immunomodulatory effects of dihydroflavones, flavones, and flavonols","volume":"25","author":"Zaragoz\u00e1","year":"2020","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.jep.2023.116993_bib89","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/jcsm.12838","article-title":"Anti-diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications","volume":"12","author":"Zhang","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"5","key":"10.1016\/j.jep.2023.116993_bib90","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.crfs.2022.07.007","article-title":"Anti-inflammation activity of flavonols via inhibiting MAPK and NF-\u03baB signaling pathways in RAW264.7 macrophages","volume":"20","author":"Zhong","year":"2022","journal-title":"Curr. Res. Food Sci."},{"issue":"17","key":"10.1016\/j.jep.2023.116993_bib91","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1039\/D2FO01075E","article-title":"Acidic polysaccharides from Buddleja officinalis inhibit angiogenesis via the Nrf2\/ARE pathway to attenuate diabetic retinopathy","volume":"13","author":"Zhu","year":"2022","journal-title":"Food Funct."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:07:38Z","timestamp":1736402858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123008619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":91,"alternative-id":["S0378874123008619"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116993","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Buddleja officinalis Maxim.: A review of its botany, ethnopharmacology, phytochemistry, pharmacology, and therapeutic potential for ophthalmic diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116993","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116993"}}