{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:47:52Z","timestamp":1785394072904,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014035","name":"Armed Forces Health Surveillance Branch","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.117007","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:23:07Z","timestamp":1691367787000},"page":"117007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"PB","title":["Ex vivo and in vitro antiplasmodial activity and toxicity of Caesalpinia decapetala (Roth) Alston (Fabaceae)"],"prefix":"10.1016","volume":"318","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-7492","authenticated-orcid":false,"given":"Douglas O.","family":"Ochora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-4707","authenticated-orcid":false,"given":"Caroline","family":"Murithi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rael J.","family":"Masai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Abdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Cheruyiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Katuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savina","family":"Asiimwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Nabatanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin","family":"Anywar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannington","family":"Oryem-Origa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Namukobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esezah K.","family":"Kakudidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiy","family":"Yenesew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoseah M.","family":"Akala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Kamau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117007_bib1","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jep.2014.05.060","article-title":"Medicinal plants used in malaria treatment by Prometra herbalists in Uganda","volume":"155","author":"Adia","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117007_bib2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4269\/ajtmh.2011.10-0674","article-title":"Antimalarial drug sensitivity profile of western Kenya Plasmodium falciparum field isolates determined by a SYBR green I in vitro assay and molecular analysis","volume":"85","author":"Akala","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.jep.2023.117007_bib4","first-page":"505","article-title":"Medicinal plants used in the treatment and prevention of malaria in Cegere sub-county, Northern Uganda","volume":"14","author":"Anywar","year":"2016","journal-title":"J Ethn & A R"},{"key":"10.1016\/j.jep.2023.117007_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112205","article-title":"Indigenous traditional knowledge of medicinal plants used by herbalists in treating opportunistic infections among people living with HIV\/AIDS in Uganda","volume":"246","author":"Anywar","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117007_bib6","first-page":"1169","article-title":"In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum","volume":"38","author":"Basco","year":"1994","journal-title":"Chem"},{"key":"10.1016\/j.jep.2023.117007_bib45","series-title":"Kenya trees, shrubs, and lianas","author":"Beentje","year":"1994"},{"key":"10.1016\/j.jep.2023.117007_bib7","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1211\/jpp.61.11.0001","article-title":"Antimalarial compounds isolated from plants used in traditional medicine","volume":"61","author":"Bero","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2023.117007_bib8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4001\/003.019.0201","article-title":"A review of recent efforts at biological control of Caesalpinia decapetala (Roth) Alston (Fabaceae) in South Africa","volume":"19","author":"Byrne","year":"2011","journal-title":"Afr. Entomol."},{"key":"10.1016\/j.jep.2023.117007_bib9","first-page":"1","article-title":"Caesalpinia decapetala (Roith) Alston Fabaceae","volume":"4","author":"Chaudhary","year":"2021","journal-title":"Ethn. of Mt. Reg."},{"issue":"4","key":"10.1016\/j.jep.2023.117007_bib10","first-page":"2417","article-title":"Assessment of the Worldwide antimalarial resistance network standardized procedure for in vitro malaria drug sensitivity testing using SYBR green assay for field samples with various initial parasitemia levels","volume":"60","author":"Cheruiyot","year":"2016","journal-title":"Chem"},{"key":"10.1016\/j.jep.2023.117007_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s12936-021-03935-4","article-title":"Efficacy of artesunate-amodiaquine and artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria in Madagascar, 2018","volume":"20","author":"Dentinger","year":"2021","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2023.117007_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21010\/ajtcam.v14i4.1","article-title":"Randomized anticancer and cytotoxicity activities of Guibourtia Coleosperma and Diospyros Chamaethamnus","volume":"14","author":"Dushimemaria","year":"2017","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.jep.2023.117007_bib13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrmicro.2017.161","article-title":"Drug resistance in Plasmodium","volume":"16","author":"Haldar","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jep.2023.117007_bib14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1473-3099(17)30048-8","article-title":"The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study","volume":"17","author":"Imwong","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jep.2023.117007_bib15","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1248\/bpb.29.1050","article-title":"Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship","volume":"29","author":"Kalauni","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2023.117007_bib16","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/JCM.00276-11","article-title":"Development of a highly sensitive genus-specific quantitative reverse transcriptase real-time PCR assay for detection and quantitation of Plasmodium by amplifying RNA and DNA of the 18S rRNA genes","volume":"49","author":"Kamau","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jep.2023.117007_bib17","first-page":"346","article-title":"Plant derived antimalarial agents","volume":"5","author":"Kaur","year":"2017","journal-title":"J. Med. Plants Stud."},{"key":"10.1016\/j.jep.2023.117007_bib44","series-title":"Medicinal Plants of East Africa","author":"Kokwaro","year":"2009"},{"key":"10.1016\/j.jep.2023.117007_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-8741(00)00367-6","article-title":"Antimalarial activity of Ajuga remota Benth (Labiatae) and Caesalpinia volkensii harms (Caesalpiniaceae): In vitro confirmation of ethnopharmacological use","volume":"74","author":"Kuria","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117007_bib19","first-page":"1","article-title":"Treatment-seeking behavior and practices among caregivers of children aged <\/=5 yrs with presumed malaria in rural Uganda","volume":"00","author":"Lee","year":"2019","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jep.2023.117007_bib20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.fitote.2014.04.001","article-title":"Antimalarial diterpene alkaloids from the seeds of Caesalpinia minax","volume":"95","author":"Ma","year":"2014","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2023.117007_bib21","doi-asserted-by":"crossref","first-page":"14319","DOI":"10.1016\/j.ijhydene.2022.02.175","article-title":"Green synthesis of DyBa2Fe3O7.988\/DyFeO3 nanocomposites using almond extract with dual eco-friendly applications: photocatalytic and antibacterial activities","volume":"47","author":"Mahdi","year":"2022","journal-title":"Int. J. Hydrogen Energy"},{"key":"10.1016\/j.jep.2023.117007_bib47","first-page":"1","article-title":"Diversity and utilization of antimalarial ethnophytotherapeutic remedies among the Kikuyus (Central Kenya)","volume":"2","author":"Njoroge","year":"2006","journal-title":"J. Ethnobiol.\u00a0Ethnomed."},{"key":"10.1016\/j.jep.2023.117007_bib23","first-page":"1","article-title":"Medicinal plants used by \u2018root doctors\u2019, local traditional healers in Bi\u00e9 province, Angola","volume":"19","author":"Novotna","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117007_bib24","first-page":"1","article-title":"A new benzophenone , and the antiplasmodial activities of the constituents of Securidaca longipedunculata fresen (Polygalaceae)","volume":"0","author":"Ochora","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.117007_bib25","first-page":"1","article-title":"Synergism in antiplasmodial activities of artemether and lumefantrine in combination with Securidaca longipedunculata","volume":"11","author":"Ochora","year":"2022","journal-title":"MDPI Plants"},{"key":"10.1016\/j.jep.2023.117007_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.26538\/tjnpr\/v2i4.5","article-title":"Antiplasmodial and acute toxicity studies of fractions and cassane-type diterpenoids from the stem bark of Caesalpinia pulcherrima (L.) Sw","volume":"24","author":"Ogbeide","year":"2018","journal-title":"Trop. J. Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.117007_bib28","first-page":"22","article-title":"Study of acute toxicity of Caesalpinia decapetala","volume":"7","author":"Pingale","year":"2018","journal-title":"Int. J. Chem. Phys. Sci."},{"key":"10.1016\/j.jep.2023.117007_bib29","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2307\/3283540","article-title":"Taxonomic revision of the genus Trichinella","volume":"78","author":"Pozio","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1016\/j.jep.2023.117007_bib30","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.3389\/fphar.2021.678535","article-title":"Pharmacological assessment of antiprotozoal activity, cytotoxicity and genotoxicity of medicinal plants used in treatment of malaria in the Greater Mpigi Region in Uganda","volume":"12","author":"Schultz","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117007_bib31","first-page":"253","article-title":"Phytotherapy among the rural women of district Abbotabad","volume":"45","author":"Shah","year":"2013","journal-title":"Pakistan J. Bot."},{"key":"10.1016\/j.jep.2023.117007_bib32","first-page":"1421","article-title":"Antimicrobial evaluation of Caesalpinia decapetala","volume":"9","author":"Sharma","year":"2018","journal-title":"Int. J. Pharmacogn. Phytochem. Res."},{"issue":"1","key":"10.1016\/j.jep.2023.117007_bib33","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s41182-023-00526-8","article-title":"Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda","volume":"51","author":"Tabuti","year":"2023","journal-title":"Trop. Med. Health"},{"key":"10.1016\/j.jep.2023.117007_bib34","first-page":"98","article-title":"Phytochemical screening and extraction: a review","volume":"1","author":"Tiwari","year":"2011","journal-title":"Int. Pharm. Sci."},{"issue":"20","key":"10.1016\/j.jep.2023.117007_bib35","first-page":"1","article-title":"Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of North-West Himalaya","volume":"10","author":"Verma","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2023.117007_bib36","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1186\/s12916-022-02652-2","article-title":"Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs","volume":"20","author":"Wakoli","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.jep.2023.117007_bib38","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3390\/molecules18011325","article-title":"Chemical constituents of Caesalpinia decapetala (Roth) alston","volume":"18","author":"Wei","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.117007_bib39","series-title":"World Health Organization, Malaria Report","author":"WHO","year":"2020"},{"key":"10.1016\/j.jep.2023.117007_bib40","series-title":"WHO Guidelines for Malaria - 16 February 2021","author":"WHO","year":"2021"},{"key":"10.1016\/j.jep.2023.117007_bib41","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.actatropica.2012.04.011","article-title":"The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii","volume":"123","author":"Yenesew","year":"2012","journal-title":"Acta Trop."},{"key":"10.1016\/j.jep.2023.117007_bib42","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1111\/jace.17696","article-title":"Dy2BaCuO5\/Ba4DyCu3O9.09 S-scheme heterojunction nanocomposite with enhanced photocatalytic and antibacterial activities","volume":"104","author":"Yousefi","year":"2021","journal-title":"Am. Ceram. Soc."},{"key":"10.1016\/j.jep.2023.117007_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules21050559","article-title":"The traditional medicine and modern medicine from natural products","volume":"21","author":"Yuan","year":"2016","journal-title":"Molecules"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123008759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:08:01Z","timestamp":1736402881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123008759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":42,"alternative-id":["S0378874123008759"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117007","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ex vivo and in vitro antiplasmodial activity and toxicity of Caesalpinia decapetala (Roth) Alston (Fabaceae)","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117007"}}