{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:00:35Z","timestamp":1780434035013,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.117049","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T05:52:51Z","timestamp":1692078771000},"page":"117049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"PB","title":["Akebia saponin D from Dipsacus asper wall. Ex C.B. Clarke ameliorates skeletal muscle insulin resistance through activation of IGF1R\/AMPK signaling pathway"],"prefix":"10.1016","volume":"318","author":[{"given":"Yue","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-5842","authenticated-orcid":false,"given":"Chun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117049_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/476279","article-title":"Pathogenesis of insulin resistance in skeletal muscle","volume":"2010","author":"Abdul-Ghani","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"issue":"3","key":"10.1016\/j.jep.2023.117049_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1071-3581(03)00520-8","article-title":"Metabolic and molecular basis of insulin resistance","volume":"10","author":"Bajaj","year":"2003","journal-title":"J. Nucl. Cardiol."},{"issue":"2","key":"10.1016\/j.jep.2023.117049_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/1573399054022785","article-title":"Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes","volume":"1","author":"Bouzakri","year":"2005","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.jep.2023.117049_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bone.2015.02.010","article-title":"Bone and muscle: interactions beyond mechanical","volume":"80","author":"Brotto","year":"2015","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.jep.2023.117049_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1172\/JCI7535","article-title":"Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle","volume":"105","author":"Cusi","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.jep.2023.117049_bib6","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2337\/diab.37.6.667","article-title":"Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM","volume":"37","author":"DeFronzo","year":"1988","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.jep.2023.117049_bib7","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2337\/db09-9028","article-title":"Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus","volume":"58","author":"Defronzo","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2023.117049_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.reth.2019.03.007","article-title":"Asperosaponin VI stimulates osteogenic differentiation of rat adipose-derived stem cells","volume":"11","author":"Ding","year":"2019","journal-title":"Regen Ther"},{"key":"10.1016\/j.jep.2023.117049_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112563","article-title":"AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation","volume":"146","author":"Entezari","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.jep.2023.117049_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001485","article-title":"Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass","volume":"11","author":"Girousse","year":"2013","journal-title":"PLoS Biol."},{"issue":"4","key":"10.1016\/j.jep.2023.117049_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jphs.2017.11.007","article-title":"Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy","volume":"136","author":"Gong","year":"2018","journal-title":"J. Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.jep.2023.117049_bib12","doi-asserted-by":"crossref","first-page":"10852","DOI":"10.1039\/D0FO01909G","article-title":"Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2\/HO-1\/NF-kappaB axis and ameliorates osteoarthritis in mice","volume":"11","author":"Gu","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.117049_bib13","series-title":"Etiology and Morphogenesis of Congenital Heart Disease: from Gene Function and Cellular Interaction to Morphology","first-page":"127","article-title":"Myogenic progenitor cell differentiation is dependent on modulation of mitochondrial biogenesis through autophagy","author":"Hiraumi","year":"2016"},{"issue":"2\u20133","key":"10.1016\/j.jep.2023.117049_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12013-007-0030-9","article-title":"Insulin signaling and glucose transport in insulin resistant human skeletal muscle","volume":"48","author":"Karlsson","year":"2007","journal-title":"Cell Biochem. Biophys."},{"issue":"9","key":"10.1016\/j.jep.2023.117049_bib15","doi-asserted-by":"crossref","first-page":"14262","DOI":"10.1002\/jcb.28946","article-title":"Muscle-bone crosstalk and potential therapies for sarco-osteoporosis","volume":"120","author":"Li","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"14 Suppl. l","key":"10.1016\/j.jep.2023.117049_bib16","doi-asserted-by":"crossref","first-page":"E94","DOI":"10.2527\/jas.2007-0462","article-title":"Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes","volume":"86","author":"Lorenzo","year":"2008","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.jep.2023.117049_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154010","article-title":"Asperosaponin VI protects mice from sepsis by regulating Hippo and Rho signaling pathway","volume":"99","author":"Pang","year":"2022","journal-title":"Phytomedicine"},{"issue":"31","key":"10.1016\/j.jep.2023.117049_bib18","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1073\/pnas.0705408104","article-title":"The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome","volume":"104","author":"Petersen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.jep.2023.117049_bib19","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2023.117049_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112912","article-title":"Traditional uses, processing methods, phytochemistry, pharmacology and quality control of Dipsacus asper Wall. ex C.B. Clarke: a review","volume":"258","author":"Tao","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2023.117049_bib21","doi-asserted-by":"crossref","first-page":"E141","DOI":"10.1152\/ajpendo.00712.2009","article-title":"Glucose transporters in the 21st century","volume":"298","author":"Thorens","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.jep.2023.117049_bib22","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.cmet.2017.09.024","article-title":"Dietary restriction and AMPK increase lifespan via mitochondrial network and peroxisome remodeling","volume":"26","author":"Weir","year":"2017","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.jep.2023.117049_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1172\/JCI88880","article-title":"Skeletal muscle inflammation and insulin resistance in obesity","volume":"127","author":"Wu","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2023.117049_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115078","article-title":"Comparative analysis of anti-osteoporosis efficacy in Radix Dipsaci before and after processing with salt based on spectrum-effect relationship","volume":"221","author":"Wu","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"9","key":"10.1016\/j.jep.2023.117049_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091970","article-title":"Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy","volume":"9","author":"Yoshida","year":"2020","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.jep.2023.117049_bib26","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/jssc.201901186","article-title":"Comprehensive separation of iridoid glycosides and triterpenoid saponins from Dipsacus asper with salt-containing solvent by high-speed countercurrent chromatography coupled with recycling mode","volume":"43","author":"Yu","year":"2020","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jep.2023.117049_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111468","article-title":"Effect and mechanism of berberine against polycystic ovary syndrome","volume":"138","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2023.117049_bib28","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1093\/advances\/nmaa161","article-title":"Impacts of selected dietary nutrient intakes on skeletal muscle insulin sensitivity and applications to early prevention of type 2 diabetes","volume":"12","author":"Zhang","year":"2021","journal-title":"Adv. Nutr."},{"issue":"11","key":"10.1016\/j.jep.2023.117049_bib29","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","article-title":"New opportunities and challenges of natural products research: when target identification meets single-cell multiomics","volume":"12","author":"Zhu","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"6865","key":"10.1016\/j.jep.2023.117049_bib30","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123009170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123009170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:09:14Z","timestamp":1736402954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123009170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":30,"alternative-id":["S0378874123009170"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117049","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Akebia saponin D from Dipsacus asper wall. Ex C.B. Clarke ameliorates skeletal muscle insulin resistance through activation of IGF1R\/AMPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117049"}}