{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:43:55Z","timestamp":1786992235227,"version":"build-2736575974"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002418","name":"China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.117121","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T04:56:33Z","timestamp":1693716993000},"page":"117121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"P1","title":["Anti-hypertension effect of Wuwei Jiangya decoction via ACE2\/Ang1-7\/MAS signaling pathway in SHR based on network degree-distribution analysis"],"prefix":"10.1016","volume":"319","author":[{"given":"Pengqian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danli","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjiang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9970","key":"10.1016\/j.jep.2023.117121_bib1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(14)62256-X","article-title":"A public health approach to global management of hypertension","volume":"385","author":"Angell","year":"2015","journal-title":"Lancet (London, England)"},{"issue":"6","key":"10.1016\/j.jep.2023.117121_bib2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1161\/HYP.0b013e318293645f","article-title":"Beyond medications and diet: alternative approaches to lowering blood pressure: a scientific statement from the american heart association","volume":"61","author":"Brook","year":"2013","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jep.2010.09.013","article-title":"Antihypertensive effect of total flavone extracts from Puerariae Radix","volume":"133","author":"Cai","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117121_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105919","article-title":"The antihypertensive potential of flavonoids from Chinese Herbal Medicine: a review","volume":"174","author":"Cao","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12906-017-1677-4","article-title":"Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study","volume":"17","author":"Chen","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.117121_bib6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.biopha.2018.12.061","article-title":"Vasorelaxant and antihypertensive effects of Tianshu Capsule on rats: an in vitro and in vivo approach","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2023.117121_bib7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/HCO.0000000000000189","article-title":"Antihypertensive therapy causes erectile dysfunction","volume":"30","author":"Chrysant","year":"2015","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.jep.2023.117121_bib8","unstructured":"Copyright 1996 by the National Academy of Sciences. All rights reserved., Washington (DC) ."},{"key":"10.1016\/j.jep.2023.117121_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101295","article-title":"Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: role of renin-angiotensin system","volume":"26","author":"Cui","year":"2019","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.jep.2023.117121_bib10","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1139\/cjpp-2016-0407","article-title":"Vasodilatory effects and underlying mechanisms of the ethyl acetate extracts from Gastrodia elata","volume":"95","author":"Dai","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jep.2023.117121_bib11","article-title":"Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti-hypertension effect","volume":"145","author":"Deng","year":"2022","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.hfc.2019.09.001","article-title":"Hypertension and heart failure: prevention, targets, and treatment","volume":"16","author":"Di Palo","year":"2020","journal-title":"Heart Fail. Clin."},{"issue":"2","key":"10.1016\/j.jep.2023.117121_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ccl.2021.12.011","article-title":"Hypertension and heart failure: prevention, targets, and treatment","volume":"40","author":"Di Palo","year":"2022","journal-title":"Cardiol. Clin."},{"issue":"2 Pt 2","key":"10.1016\/j.jep.2023.117121_bib14","doi-asserted-by":"crossref","first-page":"103s","DOI":"10.1093\/ajh\/4.2.103S","article-title":"Hypertension and vascular disease","volume":"4","author":"Doyle","year":"1991","journal-title":"Am. J. Hypertens."},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/sj.bjp.0704064","article-title":"Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats","volume":"133","author":"Duarte","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2023.117121_bib16","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1161\/HYPERTENSIONAHA.111.177485","article-title":"Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor","volume":"59","author":"Flores-Munoz","year":"2012","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.jep.2023.117121_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S1674-8301(12)60018-9","article-title":"Quercetin attenuates the progression of monocrotaline-induced pulmonary hypertension in rats","volume":"26","author":"Gao","year":"2012","journal-title":"Journal of biomedical research"},{"key":"10.1016\/j.jep.2023.117121_bib18","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3389\/fphar.2019.00989","article-title":"Effects of tianshu capsule on spontaneously hypertensive rats as revealed by (1)H-NMR-Based metabolic profiling","volume":"10","author":"Gao","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2023.117121_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11010-005-4503-0","article-title":"Effects of chronic quercetin treatment in experimental renovascular hypertension","volume":"270","author":"Garc\u00eda-Saura","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jep.2023.117121_bib20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bcp.2018.08.045","article-title":"Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension","volume":"156","author":"Gonzalez","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2023.117121_bib21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000064341","article-title":"Inhibition of angiotesin-converting enzyme by quercetin alters the vascular response to brandykinin and angiotensin I","volume":"65","author":"H\u00e4ckl","year":"2002","journal-title":"Pharmacology"},{"issue":"3","key":"10.1016\/j.jep.2023.117121_bib22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrd2195","article-title":"A robustness-based approach to systems-oriented drug design","volume":"6","author":"Hiroaki","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"14","key":"10.1016\/j.jep.2023.117121_bib23","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.lfs.2004.05.005","article-title":"Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide","volume":"75","author":"Hou","year":"2004","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.jep.2023.117121_bib24","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3892\/etm.2020.9400","article-title":"Puerarin protects vascular smooth muscle cells from oxidized low-density lipoprotein-induced reductions in viability via inhibition of the p38 MAPK and JNK signaling pathways","volume":"20","author":"Hu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2023.117121_bib25","article-title":"Gastrodia elata ameliorates high-fructose diet-induced lipid metabolism and endothelial dysfunction","volume":"2014","author":"Kho","year":"2014","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"issue":"3","key":"10.1016\/j.jep.2023.117121_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.121.007923","article-title":"Efficacy and safety of Chinese herbal medicine compared with losartan for mild essential hypertension: a randomized, multicenter, double-blind, noninferiority trial. Circulation","volume":"15","author":"Lai","year":"2022","journal-title":"Cardiovascular quality and outcomes"},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/ph3010237","article-title":"Quercetin: a treatment for hypertension?-A review of efficacy and mechanisms","volume":"3","author":"Larson","year":"2010","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3945\/an.111.001271","article-title":"Therapeutic potential of quercetin to decrease blood pressure: review of effcacy and mechanisms","volume":"3","author":"Larson","year":"2012","journal-title":"Adv. Nutr."},{"issue":"4","key":"10.1016\/j.jep.2023.117121_bib29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jamainternmed.2016.0190","article-title":"The burden of hypertension and associated risk for cardiovascular mortality in China","volume":"176","author":"Lewington","year":"2016","journal-title":"JAMA Intern. Med."},{"issue":"10","key":"10.1016\/j.jep.2023.117121_bib30","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.3390\/ijms131013501","article-title":"A systems biology approach to understanding the mechanisms of action of Chinese herbs for treatment of cardiovascular disease","volume":"13","author":"Li","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13020-021-00507-1","article-title":"A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model","volume":"16","author":"Li","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.117121_bib32","article-title":"Gastrodin reduces blood pressure by intervening with RAAS and PPAR\u03b3 in SHRs","volume":"2015","author":"Liu","year":"2015","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib33","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41598-017-18764-2","article-title":"Systems pharmacology analysis of synergy of TCM: an example using saffron formula","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jep.2023.117121_bib34","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3892\/etm.2020.8746","article-title":"Radix Puerariae rebalances vasomotor factors and improves left ventricular diastolic dysfunction in patients with essential hypertension","volume":"20","author":"Liu","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.jep.2023.117121_bib35","first-page":"403","article-title":"[Analysis of medication laws for Chinese medicine treating hypertension patients with yin defi- ciency Yang hyperactivity syndrome based on literatures]","volume":"36","author":"Ma","year":"2016","journal-title":"Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine"},{"issue":"3","key":"10.1016\/j.jep.2023.117121_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/FJC.0b013e318162011f","article-title":"The antihypertensive effects of quercetin in a salt-sensitive model of hypertension","volume":"51","author":"Mackraj","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2023.117121_bib37","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1097\/HJH.0b013e3283472643","article-title":"Peripheral edema associated with calcium channel blockers: incidence and withdrawal rate--a meta-analysis of randomized trials","volume":"29","author":"Makani","year":"2011","journal-title":"J. Hypertens."},{"issue":"2","key":"10.1016\/j.jep.2023.117121_bib38","first-page":"219","article-title":"Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities","volume":"3","author":"Manavalan","year":"2012","journal-title":"International journal of biochemistry and molecular biology"},{"issue":"2","key":"10.1016\/j.jep.2023.117121_bib39","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/HYPERTENSIONAHA.112.191445","article-title":"Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats","volume":"60","author":"Matori","year":"2012","journal-title":"Hypertension"},{"issue":"9587","key":"10.1016\/j.jep.2023.117121_bib40","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0140-6736(07)61299-9","article-title":"Essential hypertension","volume":"370","author":"Messerli","year":"2007","journal-title":"Lancet (London, England)"},{"issue":"12","key":"10.1016\/j.jep.2023.117121_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114492","article-title":"The flavonoid quercetin reverses pulmonary hypertension in rats","volume":"9","author":"Morales-Cano","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2023.117121_bib42","series-title":"Guide for the Care and Use of Laboratory Animals","year":"1996"},{"key":"10.1016\/j.jep.2023.117121_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115183","article-title":"Angiotensin-(1-9) in hypertension","volume":"203","author":"Norambuena-Soto","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2023.117121_bib44","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1111\/j.1755-5922.2010.00258.x","article-title":"Hyperkalemia associated with use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers","volume":"30","author":"Raebel","year":"2012","journal-title":"Cardiovascular therapeutics"},{"key":"10.1016\/j.jep.2023.117121_bib45","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.freeradbiomed.2021.02.040","article-title":"Oxidative stress in cardiac hypertrophy: from molecular mechanisms to novel therapeutic targets","volume":"166","author":"Ramachandra","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.jep.2023.117121_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002713","article-title":"Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials","volume":"5","author":"Serban","year":"2016","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.jep.2023.117121_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1142\/S0192415X19500022","article-title":"Puerarin reduces blood pressure in spontaneously hypertensive rats by targeting eNOS","volume":"47","author":"Shi","year":"2019","journal-title":"Am. J. Chin. Med."},{"issue":"7","key":"10.1016\/j.jep.2023.117121_bib48","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1210\/en.2012-1076","article-title":"Phytoestrogen genistein up-regulates endothelial nitric oxide synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells","volume":"153","author":"Si","year":"2012","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.jep.2023.117121_bib49","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3109\/10641963.2015.1116543","article-title":"Molecular genetics of essential hypertension","volume":"38","author":"Singh","year":"2016","journal-title":"Clin. Exp. Hypertens."},{"issue":"21","key":"10.1016\/j.jep.2023.117121_bib50","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.3390\/cells11213336","article-title":"Angiotensin II-induced signal transduction mechanisms for cardiac hypertrophy","volume":"11","author":"Sukhwinder","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jep.2023.117121_bib51","article-title":"Mining important herb combinations of traditional Chinese medicine against hypertension based on the symptom-herb network combined with network pharmacology","volume":"2022","author":"Sun","year":"2022","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"issue":"6","key":"10.1016\/j.jep.2023.117121_bib52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1142\/S0192415X17500641","article-title":"Puerarin improves vascular insulin resistance and cardiovascular remodeling in salt-sensitive hypertension","volume":"45","author":"Tan","year":"2017","journal-title":"Am. J. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2023.117121_bib53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.21010\/ajtcam.v14i4.32","article-title":"IN VIVO effect of guiding-herb radix PLATYCODONIS and radix cyathulae on paeoniflorin pharmacokinetics of xuefu zhuyu tang in rats","volume":"14","author":"Tang","year":"2017","journal-title":"Afr. J. Tradit., Complementary Altern. Med. : AJTCAM"},{"key":"10.1016\/j.jep.2023.117121_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104523","article-title":"Chuanxiongdiolides R4 and R5, phthalide dimers with a complex polycyclic skeleton from the aerial parts of Ligusticum chuanxiong and their vasodilator activity","volume":"107","author":"Tang","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2023.117121_bib55","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.jep.2014.07.047","article-title":"Prescription pattern of Chinese herbal products for hypertension in Taiwan: a population-based study","volume":"155","author":"Tsai","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117121_bib56","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1006\/jmcc.2002.2075","article-title":"Cardiac renin\u2013angiotensin aldosterone system local cardiac renin\u2013angiotensin system: hypertension and cardiac failure","volume":"34","author":"Varagic","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2023.117121_bib57","article-title":"Control strategy on hypertension in Chinese medicine","volume":"2012","author":"Wang","year":"2012","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"key":"10.1016\/j.jep.2023.117121_bib58","article-title":"Evidence-based Chinese medicine for hypertension","volume":"2013","author":"Wang","year":"2013","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"key":"10.1016\/j.jep.2023.117121_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114214","article-title":"Applying cooperative module pair analysis to uncover compatibility mechanism of Fangjis: an example of Wenxin Keli decoction","volume":"278","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117121_bib60","article-title":"Network pharmacology prediction and pharmacological verification mechanism of yeju Jiangya decoction on hypertension","volume":"2021","author":"Wang","year":"2021","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"key":"10.1016\/j.jep.2023.117121_bib61","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/132912","article-title":"Cardiovascular protective effects of adjunctive alternative medicine (salvia miltiorrhiza and pueraria lobata) in high-risk hypertension","author":"Woo","year":"2013","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"key":"10.1016\/j.jep.2023.117121_bib62","article-title":"Trends in the treatment of hypertension from the perspective of traditional Chinese medicine","volume":"2013","author":"Xiong","year":"2013","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"issue":"7","key":"10.1016\/j.jep.2023.117121_bib63","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/hr.2013.18","article-title":"Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science","volume":"36","author":"Xiong","year":"2013","journal-title":"Hypertens. Res. : official journal of the Japanese Society of Hypertension"},{"issue":"9","key":"10.1016\/j.jep.2023.117121_bib64","first-page":"1831","article-title":"The effects of red yeast rice dietary supplement on blood pressure, lipid profile, and C-reactive protein in hypertension: a systematic review","volume":"57","author":"Xiong","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2023.117121_bib65","article-title":"Traditional Chinese medicine suppresses left ventricular hypertrophy by targeting extracellular signal-regulated kinases signaling pathway in spontaneously hypertensive rats","volume":"7","author":"Xiong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.117121_bib66","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.phrs.2019.01.018","article-title":"Efficacy and safety of Chinese herbal medicine for patients with postmenopausal hypertension: a systematic review and meta-analysis","volume":"141","author":"Xiong","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.jep.2023.117121_bib67","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1271\/bbb.70.933","article-title":"Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet","volume":"70","author":"Yamamoto","year":"2006","journal-title":"Biosc. Biotech. Biochem."},{"issue":"12","key":"10.1016\/j.jep.2023.117121_bib68","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/ars.2016.6950","article-title":"ACE2 and the homolog collectrin in the modulation of nitric oxide and oxidative stress in blood pressure homeostasis and vascular injury","volume":"26","author":"Yang","year":"2017","journal-title":"Antioxidants Redox Signal."},{"issue":"19","key":"10.1016\/j.jep.2023.117121_bib69","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/CIRCULATIONAHA.120.046685","article-title":"Treatment of masked hypertension with a Chinese herbal formula: a randomized, placebo-controlled trial","volume":"142","author":"Zhang","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2023.117121_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1098725","article-title":"Role of inflammation, immunity, and oxidative stress in hypertension: new insights and potential therapeutic targets","volume":"13","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2023.117121_bib71","first-page":"5395","article-title":"Radix Cyathula officinalis Kuan inhibits arterial remodeling in spontaneously hypertensive rats","volume":"14","author":"Zhao","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2023.117121_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104817","article-title":"Tetramethylpyrazine alleviates iron overload damage in vascular endothelium via upregulating DDAHII expression","volume":"65","author":"Zhou","year":"2020","journal-title":"Toxicol. Vitro : an international journal published in association with BIBRA"},{"issue":"11","key":"10.1016\/j.jep.2023.117121_bib73","doi-asserted-by":"crossref","first-page":"10137","DOI":"10.1039\/D0FO02356F","article-title":"Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels","volume":"11","author":"Zhou","year":"2020","journal-title":"Food Funct."},{"issue":"11","key":"10.1016\/j.jep.2023.117121_bib74","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41569-021-00559-8","article-title":"Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension","volume":"18","author":"Zhou","year":"2021","journal-title":"Nat. Rev. Cardiol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123009893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123009893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:12:07Z","timestamp":1736385127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123009893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":74,"alternative-id":["S0378874123009893"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117121","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-hypertension effect of Wuwei Jiangya decoction via ACE2\/Ang1-7\/MAS signaling pathway in SHR based on network degree-distribution analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117121"}}