{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:08:08Z","timestamp":1784977688031,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.117170","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T15:35:43Z","timestamp":1694446543000},"page":"117170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"P1","title":["Phytochemical composition, toxicological profiling and effect on pup birth weight of Corchorus olitorius leaf extract in rats: Implications for fetal macrosomia control"],"prefix":"10.1016","volume":"319","author":[{"given":"Onyinye Mkpola","family":"Ukpai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon Nnah","family":"Ijioma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingsley","family":"Kanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Orieke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peace Amarachi","family":"Chinedu-Ndukwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingsley Chijioke","family":"Ugwuanyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3145-5473","authenticated-orcid":false,"given":"Eziuche Amadike","family":"Ugbogu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117170_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s12884-015-0790-y","article-title":"Prevalence of abnormal birth weight and related factors in Northern region, Ghana","volume":"15","author":"Abubakari","year":"2015","journal-title":"BMC Pregnancy Childbirth"},{"issue":"8","key":"10.1016\/j.jep.2023.117170_bib2","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/jgh.12229","article-title":"Gastroprotective effect of Corchorus olitorius leaf extract against ethanol-induced gastric mucosal hemorrhagic lesion in rats","volume":"28","author":"Al Batran","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.117170_bib3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/13510002.2022.2062947","article-title":"D-limonene (5 (one-methyl-four-[1-methylethenyl]) cyclohexane) diminishes CCl4-induced cardiac toxicity by alleviating oxidative stress, inflammatory and cardiac markers","volume":"27","author":"AlSaffar","year":"2022","journal-title":"Redox Rep."},{"issue":"12","key":"10.1016\/j.jep.2023.117170_bib4","article-title":"Review of the toxicity and phytochemistry of medicinal plant species used by herbalists in treating people living with HIV\/AIDS in Uganda","volume":"15","author":"Anywar","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2023.117170_bib5","doi-asserted-by":"crossref","first-page":"16153","DOI":"10.3390\/ijms150916153","article-title":"Maternal-fetal nutrient transport in pregnancy pathologies: the role of the placenta","volume":"15","author":"Brett","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117170_bib6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/bdr2.1035","article-title":"Animal embryotoxicity studies of key non-artemisinin antimalarials and use in women in the first trimester","volume":"109","author":"Clark","year":"2017","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.jep.2023.117170_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002290","article-title":"First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of observational studies","volume":"14","author":"Dellicour","year":"2017","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.jep.2023.117170_bib8","first-page":"8","article-title":"Anti-diabetic activity of ethanolic seed extract of Corchorus olitorius","volume":"12","author":"Egua","year":"2013","journal-title":"Int\u2019l J.Sci. Appl. Res."},{"key":"10.1016\/j.jep.2023.117170_bib9","article-title":"Levels and causes of maternal mortality and morbidity","volume":"vol. 2","author":"Filippi","year":"2016"},{"key":"10.1016\/j.jep.2023.117170_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/640291","article-title":"Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis","volume":"2014","author":"Gaudet","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.jep.2023.117170_bib11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: a guide for clinicians","volume":"172","author":"Giannini","year":"2005","journal-title":"CMAJ (Can. Med. Assoc. J.)"},{"issue":"2","key":"10.1016\/j.jep.2023.117170_bib12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/jphp.13032","article-title":"Amelioration of experimental metabolic syndrome induced in rats by orlistat and Corchorus olitorius leaf extract; role of adipo\/cytokines","volume":"71","author":"Gomaa","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2023.117170_bib13","first-page":"42","article-title":"Chemical compounds and biological activity of an extract from Bougainvillea buttiana (var. rose) HOLTTUM AND STANDL","volume":"9","author":"Guerrero","year":"2017","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2023.117170_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1034\/j.1600-0412.2002.810301.x","article-title":"Suspected big baby: a difficult clinical problem in obstetrics","volume":"81","author":"Haram","year":"2002","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.jep.2023.117170_bib15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/00016340801899289","article-title":"The macrosomic fetus: a challenge in current obstetrics","volume":"87","author":"Henriksen","year":"2008","journal-title":"Acta Obstet. Gynecol. Scand."},{"issue":"3 Pt 2","key":"10.1016\/j.jep.2023.117170_bib16","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.ajog.2005.06.030","article-title":"Treatment of suspected fetal macrosomia: a cost-effectiveness analysis","volume":"193","author":"Herbst","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.jep.2023.117170_bib17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jdermsci.2013.10.010","article-title":"Anti-bacterial and anti-inflammatory properties of capric acid against Propionibacterium acnes: a comparative study with lauric acid","volume":"73","author":"Huang","year":"2014","journal-title":"J. Dermatol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2023.117170_bib18","first-page":"295","article-title":"Anaemia in pregnancy: a survey of pregnant women in Abeokuta, Nigeria","volume":"5","author":"Idowu","year":"2005","journal-title":"Afr. Health Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.117170_bib19","first-page":"165","article-title":"Effect of aqueous extract of alligator pepper (Zingiberaceae aframomum melegueta) on gestational weight gain","volume":"24","author":"Inegbenebor","year":"2009","journal-title":"Niger. J. Physiol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.117170_bib20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/0976-500X.81896","article-title":"Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats","volume":"2","author":"Jindal","year":"2011","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"1\u20133","key":"10.1016\/j.jep.2023.117170_bib21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejphar.2013.06.022","article-title":"Preventive and ameliorating effects of citrus D-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity","volume":"715","author":"Jing","year":"2013","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2023.117170_bib22","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1309\/LM920SBNZPJRJGUT","article-title":"Overview of urea and creatinine","volume":"45","author":"Jose","year":"2014","journal-title":"Lab. Med."},{"issue":"6","key":"10.1016\/j.jep.2023.117170_bib23","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00404-008-0780-7","volume":"279","author":"Kamanu","year":"2009","journal-title":"Archives Gynaecol. Obstet."},{"issue":"28","key":"10.1016\/j.jep.2023.117170_bib24","article-title":"Haematological, biochemical and antioxidant changes in wistar rats exposed to a dichlorvos based insecticide formulation used in southeast Nigeria","volume":"4","author":"Kanu","year":"2016","journal-title":"Toxics"},{"key":"10.1016\/j.jep.2023.117170_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.24.012003.132306","article-title":"New insights into erythropoiesis: the roles of folate, vitamin B12, and iron","volume":"24","author":"Koury","year":"2004","journal-title":"Annu. Rev. Nutr."},{"issue":"2\u20134","key":"10.1016\/j.jep.2023.117170_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/10937404.2010.483176","article-title":"Toxicity testing in the 21st century: a vision and a strategy","volume":"13","author":"Krewski","year":"2010","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.jep.2023.117170_bib27","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/B978-0-12-814823-5.00051-9","article-title":"Obesity\/Perinatal origins of obesity","author":"Kwok","year":"2020","journal-title":"Maternal Fetal Neonatal Endocrinol."},{"key":"10.1016\/j.jep.2023.117170_bib28","article-title":"Acute and subacute toxicity of methanol extract of syzygium guineense leaves on the histology of the liver and kidney and biochemical compositions of blood in rats","volume":"2019","author":"Loha","year":"2019","journal-title":"Evid. base Compl. Alternative Med."},{"issue":"9745","key":"10.1016\/j.jep.2023.117170_bib29","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/S0140-6736(10)60751-9","article-title":"The association between pregnancy weight gain and birth weight: a within-family comparison","volume":"376","author":"Ludwig","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2023.117170_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.675775","article-title":"The association between high birth weight and long-term outcomes-implications for assisted reproductive technologies: a systematic review and meta-analysis","volume":"9","author":"Magnusson","year":"2021","journal-title":"Front. Pediatr."},{"issue":"3","key":"10.1016\/j.jep.2023.117170_bib31","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/0253-7613.81519","article-title":"In vitro and in vivo antioxidant activities of the aqueous extract of Celosia argentea leaves","volume":"43","author":"Malomo","year":"2011","journal-title":"Indian J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2023.117170_bib32","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.toxrep.2014.09.006","article-title":"In vivo toxicity evaluation of a standardized extract of Syzygium aqueum leaf","volume":"21","author":"Manaharan","year":"2014","journal-title":"Toxicol Rep"},{"issue":"4","key":"10.1016\/j.jep.2023.117170_bib33","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/antiox9040282","article-title":"Bioactive variability and in vitro and in vivo antioxidant activity of unprocessed and processed flour of nine cultivars of Australian lupin species: a comprehensive substantiation","volume":"9","author":"Mazumder","year":"2020","journal-title":"Antioxidants"},{"issue":"6","key":"10.1016\/j.jep.2023.117170_bib34","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181253","article-title":"Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs","volume":"38","author":"Mukhtar","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jep.2023.117170_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1376817","article-title":"Phytochemical analysis, acute toxicity, as well as antihyperglycemic and antidiabetic activities of Corchorus olitorius L. leaf extracts","volume":"2022","author":"Nakaziba","year":"2022","journal-title":"Sci. World J."},{"key":"10.1016\/j.jep.2023.117170_bib36","series-title":"Guideline for the Testing of Chemicals, No.420, Acute Oral Toxicity\u2014Fixed Dose Procedure","year":"2001"},{"key":"10.1016\/j.jep.2023.117170_bib37","series-title":"Guidelines forTesting of Chemicals, No.407, Repeated Dose Oral Toxicity Test Method","year":"2008"},{"issue":"2","key":"10.1016\/j.jep.2023.117170_bib38","first-page":"114","article-title":"High birth weight babies: incidence and foetal outcome in a Mission Hospital in Benin City, Nigeria","volume":"9","author":"Onyiriuka","year":"2006","journal-title":"Niger. J. Clin. Pract."},{"issue":"6","key":"10.1016\/j.jep.2023.117170_bib39","first-page":"551","article-title":"Semen quality, hormone profile and histological changes in male albino rats treated with Corchorus olitorius leaf extract","volume":"9","author":"Orieke","year":"2019","journal-title":"Avicenna J. Phytomed."},{"key":"10.1016\/j.jep.2023.117170_bib40","article-title":"Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of Corchorus olitorius leaf extract in laboratory animal models","volume":"247","author":"Orieke","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2023.117170_bib41","first-page":"1","article-title":"Acute and sub-acute evaluations of methanolic leaf extract of Corchorus olitorius in experimental animal models","volume":"2","author":"Orieke","year":"2018","journal-title":"Asian J. Res. Anim. Vet. Sci."},{"key":"10.1016\/j.jep.2023.117170_bib42","first-page":"227","article-title":"Comparative Effects of Methanol and Aqueous Extracts of Corchorus olitorius plant on haematology and some reproductive indices of male wistar rats","volume":"36","author":"Oyeyemi","year":"2021","journal-title":"Niger. J. Physiol. Sci."},{"key":"10.1016\/j.jep.2023.117170_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112728","article-title":"Maternal-fetal repercussions of Phyllanthus niruri L. treatment during rat pregnancy","volume":"254","author":"Paula","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2023.117170_bib44","first-page":"536","article-title":"Obesity and the western diet: how we got here","volume":"117","author":"Rakhra","year":"2020","journal-title":"Mo. Med."},{"issue":"3","key":"10.1016\/j.jep.2023.117170_bib45","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/nu11030557","article-title":"The effects of vegetarian and vegan diet during pregnancy on the health of mothers and offspring","volume":"11","author":"Sebastiani","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2023.117170_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111543","article-title":"Liposomal drug delivery of Corchorus olitorius leaf extract containing phytol using design of experiment (DoE): in-vitro anticancer and in-vivo anti-inflammatory studies","volume":"199","author":"Shariare","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"2","key":"10.1016\/j.jep.2023.117170_bib47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3803\/EnM.2021.105","article-title":"Food preferences and obesity","volume":"36","author":"Spinelli","year":"2021","journal-title":"Endocrinol. Metab. (Seoul)"},{"issue":"6","key":"10.1016\/j.jep.2023.117170_bib48","first-page":"19","article-title":"Evaluation of the iron content of the genus Corchorus species encountered in Cote d\u2019Ivoire","volume":"9","author":"Ta Bi","year":"2020","journal-title":"J. Pharmacogn. Phytochem."},{"key":"10.1016\/j.jep.2023.117170_bib56","article-title":"Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence","volume":"344","author":"Thangaratinam","year":"2012","journal-title":"BMJ (Clinical research ed.)"},{"issue":"6","key":"10.1016\/j.jep.2023.117170_bib50","first-page":"478","article-title":"Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats","volume":"8","author":"Ugbogu","year":"2018","journal-title":"Avicenna J. Phytomed."},{"issue":"4","key":"10.1016\/j.jep.2023.117170_bib51","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbrc.2017.05.160","article-title":"Phytol increases adipocyte number and glucose tolerance through activation of PI3K\/Akt signaling pathway in mice fed high-fat and high-fructose diet","volume":"489","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2023.117170_bib52","series-title":"Perinatal Epidemiology","first-page":"442","author":"Wingate","year":"2017"},{"key":"10.1016\/j.jep.2023.117170_bib53","doi-asserted-by":"crossref","DOI":"10.1177\/2050312119827096","article-title":"Effect of nutritional status of pregnant women on birth weight of newborns at Butajira referral hospital, Butajira, Ethiopia","volume":"7","author":"Woldeamanuel","year":"2019","journal-title":"SAGE Open Med"},{"key":"10.1016\/j.jep.2023.117170_bib54","series-title":"Guidelines for the Treatment of Malaria","year":"2015"},{"issue":"1","key":"10.1016\/j.jep.2023.117170_bib55","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/mnfr.201500428","article-title":"Mechanisms of body weight reduction and metabolic syndrome alleviation by tea","volume":"60","author":"Yang","year":"2016","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123010401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123010401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:13:47Z","timestamp":1736403227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123010401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":55,"alternative-id":["S0378874123010401"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117170","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phytochemical composition, toxicological profiling and effect on pup birth weight of Corchorus olitorius leaf extract in rats: Implications for fetal macrosomia control","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117170"}}