{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:50:15Z","timestamp":1788501015966,"version":"build-2803163510"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.117209","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:52:25Z","timestamp":1695621145000},"page":"117209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"P2","title":["The anti-hepatocellular carcinoma effect of Aidi injection was related to the synergistic action of cantharidin, formononetin, and isofraxidin through BIRC5, FEN1, and EGFR"],"prefix":"10.1016","volume":"319","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9756-7198","authenticated-orcid":false,"given":"Shan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8120-8916","authenticated-orcid":false,"given":"Leiming","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-5936","authenticated-orcid":false,"given":"Antony","family":"Stalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongjun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-6110","authenticated-orcid":false,"given":"Jiarui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117209_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.721949","article-title":"A network-based methodology to identify subnetwork markers for diagnosis and prognosis of colorectal cancer","volume":"12","author":"Al-Harazi","year":"2021","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrc968","article-title":"Validating survivin as a cancer therapeutic target","volume":"3","author":"Altieri","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.jep.2023.117209_bib3","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.7150\/ijbs.68179","article-title":"Flap endonuclease 1 facilitated hepatocellular carcinoma progression by enhancing USP7\/MDM2-mediated P53 inactivation","volume":"18","author":"Bian","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2023.117209_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/hep.31394","article-title":"Genetics of hepatocellular carcinoma: approaches to explore molecular diversity","volume":"73","author":"Caruso","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1423-0127-20-43","article-title":"Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance","volume":"20","author":"Chang","year":"2013","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1124\/jpet.110.175786","article-title":"Activation of phosphatidylinositol 3-kinase\/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells","volume":"337","author":"Chen","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jep.2023.117209_bib7","article-title":"Efficacy and safety of aidi injection combined with transcatheter arterial chemoembolization on primary hepatic carcinoma: a systematic review and meta-analysis","volume":"2018","author":"Chen","year":"2018","journal-title":"Evid Based Compl. Alternat Med."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13046-022-02377-3","article-title":"TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K\/AKT pathway in bladder cancer","volume":"41","author":"Chi","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.jep.2023.117209_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.molcel.2010.02.031","article-title":"The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration","volume":"38","author":"Chin","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jep.2023.117209_bib10","article-title":"Effect of aidi injection plus TACE on hepatocellular carcinoma: a meta-analysis of randomized controlled trials","volume":"2018","author":"Dai","year":"2018","journal-title":"Evid Based Compl. Alternat Med."},{"issue":"5","key":"10.1016\/j.jep.2023.117209_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nrm.2016.177","article-title":"Control of structure-specific endonucleases to maintain genome stability","volume":"18","author":"Deh\u00e9","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.jep.2023.117209_bib12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nmeth.3485","article-title":"miRWalk2.0: a comprehensive atlas of microRNA-target interactions","volume":"12","author":"Dweep","year":"2015","journal-title":"Nat. Methods"},{"issue":"6","key":"10.1016\/j.jep.2023.117209_bib13","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/hep.32447","article-title":"Emerging immunotherapy for HCC: a guide for hepatologists","volume":"75","author":"Foerster","year":"2022","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.jep.2023.117209_bib14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41422-018-0079-6","article-title":"Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR\/PI3K\/AKT drives breast carcinogenesis","volume":"28","author":"He","year":"2018","journal-title":"Cell Res."},{"issue":"3","key":"10.1016\/j.jep.2023.117209_bib15","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jhep.2020.11.036","article-title":"Understanding tumour cell heterogeneity and its implication for immunotherapy in liver cancer using single-cell analysis","volume":"74","author":"Heinrich","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117209_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154984","article-title":"Compound Kushen Injection inhibits epithelial-mesenchymal transition of gastric carcinoma by regulating VCAM1 induced by the TNF signaling pathway","volume":"118","author":"Huang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117209_bib17","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.biopha.2017.10.043","article-title":"Ginsenoside Rg3 enhances the anti-proliferative activity of erlotinib in pancreatic cancer cell lines by downregulation of EGFR\/PI3K\/Akt signaling pathway","volume":"96","author":"Jiang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.jep.2023.117209_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cell.2015.02.043","article-title":"The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo","volume":"161","author":"Karreth","year":"2015","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jep.2023.117209_bib19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2011.09.032","article-title":"In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma","volume":"147","author":"Karreth","year":"2011","journal-title":"Cell"},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2023.117209_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/hep.31424","article-title":"Local and regional therapies for hepatocellular carcinoma","volume":"73","author":"Kloeckner","year":"2021","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jep.2023.117209_bib21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1053\/j.gastro.2018.08.065","article-title":"Epidemiology and management of hepatocellular carcinoma","volume":"156","author":"Kulik","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2023.117209_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114073","article-title":"Aidi injection induces apoptosis of hepatocellular carcinoma cells through the mitochondrial pathway","volume":"274","author":"Lan","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"15","key":"10.1016\/j.jep.2023.117209_bib23","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.18632\/aging.102140","article-title":"TGF\u03b21- miR-140-5p axis mediated up-regulation of Flap Endonuclease 1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma","volume":"11","author":"Li","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"6711","key":"10.1016\/j.jep.2023.117209_bib24","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/25141","article-title":"Control of apoptosis and mitotic spindle checkpoint by survivin","volume":"396","author":"Li","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jep.2023.117209_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cca.2017.06.007","article-title":"Droplet digital PCR improved the EGFR mutation diagnosis with pleural fluid samples in non-small-cell lung cancer patients","volume":"471","author":"Li","year":"2017","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.jep.2023.117209_bib26","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20204457","article-title":"Aidi injection, a traditional Chinese biomedical preparation for gynecologic tumors: a systematic review and PRISMA-compliant meta-analysis","volume":"41","author":"Li","year":"2021","journal-title":"Biosci. Rep."},{"issue":"3","key":"10.1016\/j.jep.2023.117209_bib27","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.gendis.2019.10.016","article-title":"Traditional Chinese medicine as supportive care for the management of liver cancer: past, present, and future","volume":"7","author":"Liao","year":"2020","journal-title":"Genes Dis."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41392-021-00741-x","article-title":"Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial","volume":"6","author":"Liu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"10","key":"10.1016\/j.jep.2023.117209_bib29","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s11655-017-2426-8","article-title":"Effects of aidi injection with western medical therapies on quality of life for patients with primary liver cancer: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2019","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117209_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/wjtcm.wjtcm_86_20","article-title":"Quantitative evaluation of the compatibility effects of aidi injection on the treatment of hepatocellular carcinoma using targeted metabolomics: a new strategy on the mechanism study of an anticancer compound in traditional Chinese medicine","volume":"7","author":"Liu","year":"2021","journal-title":"World J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"5","key":"10.1016\/j.jep.2023.117209_bib32","first-page":"393","article-title":"[Clinical study on treatment of primary liver cancer by Aidi injection combined with cool-tip radiofrequency ablation]","volume":"27","author":"Lou","year":"2007","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2023.117209_bib33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/hep.31310","article-title":"Role of the mammalian target of rapamycin pathway in liver cancer: from molecular genetics to targeted therapies","volume":"73","author":"Lu","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13046-021-01968-w","article-title":"Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets","volume":"40","author":"Luo","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"28","key":"10.1016\/j.jep.2023.117209_bib35","article-title":"Identification of novel biomarkers correlated with prostate cancer progression by an integrated bioinformatic analysis","volume":"99","author":"Ma","year":"2020","journal-title":"Medicine (Baltim.)"},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2023.117209_bib36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/hep.31288","article-title":"Epidemiology of hepatocellular carcinoma","volume":"73","author":"McGlynn","year":"2021","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.jep.2023.117209_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13081768","article-title":"Systematic analysis of the transcriptome profiles and Co-expression networks of tumour endothelial cells identifies several tumour-associated modules and potential therapeutic targets in hepatocellular carcinoma","volume":"13","author":"Mohr","year":"2021","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.gene.2005.10.018","article-title":"Epidermal growth factor receptor (EGFR) signaling in cancer","volume":"366","author":"Normanno","year":"2006","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12935-021-01792-4","article-title":"Identification of a prognostic and therapeutic immune signature associated with hepatocellular carcinoma","volume":"21","author":"Peng","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib40","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1080\/10717544.2017.1386729","article-title":"GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K\/AKT and Ras\/Raf\/MEK\/ERK pathways","volume":"24","author":"Pi","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jep.2023.117209_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.578816","article-title":"IGF2BP2 promotes liver cancer growth through an m6A-FEN1-dependent mechanism","volume":"10","author":"Pu","year":"2020","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib42","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12967-022-03416-5","article-title":"VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K\/AKT\/mTOR pathway","volume":"20","author":"Pu","year":"2022","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.jep.2023.117209_bib43","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/bib\/bbz006","article-title":"Decoding competing endogenous RNA networks for cancer biomarker discovery","volume":"21","author":"Qi","year":"2020","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.jep.2023.117209_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2014.12.004","article-title":"Natural inhibitors of PI3K\/AKT signaling in breast cancer: emphasis on newly-discovered molecular mechanisms of action","volume":"93","author":"Safdari","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.jep.2023.117209_bib45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jep.2023.117209_bib46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13045-015-0129-1","article-title":"Competing endogenous RNA networks: tying the essential knots for cancer biology and therapeutics","volume":"8","author":"Sanchez-Mejias","year":"2015","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jep.2023.117209_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.868726","article-title":"Exosomes from cancer-associated mesenchymal stem cells transmit TMBIM6 to promote the malignant behavior of hepatocellular carcinoma via activating PI3K\/AKT pathway","volume":"12","author":"Shang","year":"2022","journal-title":"Front. Oncol."},{"issue":"5","key":"10.1016\/j.jep.2023.117209_bib48","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0254-6272(17)30310-2","article-title":"Effect of Aidi injection plus transarterial chemoembolization on primary hepatic carcinoma: a systematic review and Meta-analysis","volume":"37","author":"Shen","year":"2017","journal-title":"J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jpha.2021.01.005","article-title":"Identifying the molecular basis of Jinhong tablets against chronic superficial gastritis via chemical profile identification and symptom-guided network pharmacology analysis","volume":"12","author":"Shi","year":"2022","journal-title":"J. Pharm. Anal."},{"issue":"2","key":"10.1016\/j.jep.2023.117209_bib50","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.canlet.2015.06.016","article-title":"Survivin in survival of hepatocellular carcinoma","volume":"379","author":"Su","year":"2016","journal-title":"Cancer Lett."},{"issue":"11","key":"10.1016\/j.jep.2023.117209_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9111639","article-title":"Targeting the PI3K\/Akt\/mTOR pathway in hepatocellular carcinoma","volume":"9","author":"Sun","year":"2021","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.jep.2023.117209_bib52","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2011.09.029","article-title":"Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs","volume":"147","author":"Tay","year":"2011","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jep.2023.117209_bib53","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg.2016.20","article-title":"Endogenous microRNA sponges: evidence and controversy","volume":"17","author":"Thomson","year":"2016","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.jep.2023.117209_bib54","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/hep.32613","article-title":"Hepatocellular carcinoma down-staging for liver transplantation in the era of systemic combined therapy with anti-VEGF\/TKI and immunotherapy","volume":"76","author":"Tran","year":"2022","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"6352","key":"10.1016\/j.jep.2023.117209_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2507","article-title":"A pathology atlas of the human cancer transcriptome","volume":"357","author":"Uhlen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jep.2023.117209_bib56","doi-asserted-by":"crossref","first-page":"W498","DOI":"10.1093\/nar\/gks494","article-title":"DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways","volume":"40","author":"Vlachos","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2023.117209_bib57","article-title":"The optimal adjuvant strategy of aidi injection with gemcitabine and cisplatin in advanced non-small cell lung cancer: a meta-analysis of 70 randomized controlled trials","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib58","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13020-023-00710-2","article-title":"Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments","volume":"18","author":"Wang","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.117209_bib59","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0074-7696(05)47002-3","article-title":"Survivin: a protein with dual roles in mitosis and apoptosis","volume":"247","author":"Wheatley","year":"2005","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.jep.2023.117209_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.567950","article-title":"Identification of an immune-related prognostic predictor in hepatocellular carcinoma","volume":"7","author":"Wu","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jep.2023.117209_bib61","article-title":"Identification of Flap endonuclease 1 with diagnostic and prognostic value in breast cancer","volume":"11","author":"Wu","year":"2021","journal-title":"Front. Oncol."},{"issue":"9","key":"10.1016\/j.jep.2023.117209_bib62","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.7150\/ijbs.70546","article-title":"HTR1D functions as a key target of HOXA10-AS\/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway","volume":"18","author":"Wu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2023.117209_bib63","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1002\/jcp.30015","article-title":"A novel prognostic index of hepatocellular carcinoma based on immunogenomic landscape analysis","volume":"236","author":"Xiao","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2023.117209_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104637","article-title":"Clinical efficacy and safety of aidi injection combination with vinorelbine and cisplatin for advanced non-small-cell lung carcinoma: a systematic review and meta-analysis of 54 randomized controlled trials","volume":"153","author":"Xiao","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2023.117209_bib65","doi-asserted-by":"crossref","DOI":"10.1177\/1534735418810799","article-title":"Aidi injection, a traditional Chinese medicine injection, could Be used as an adjuvant drug to improve quality of life of cancer patients receiving chemotherapy: a propensity score matching analysis","volume":"18","author":"Xie","year":"2019","journal-title":"Integr. Cancer Ther."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib66","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1186\/s12885-021-08390-7","article-title":"Identification of prognostic markers for hepatocellular carcinoma based on the epithelial-mesenchymal transition-related gene BIRC5","volume":"21","author":"Xu","year":"2021","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib67","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12943-019-0954-x","article-title":"Targeting PI3K in cancer: mechanisms and advances in clinical trials","volume":"18","author":"Yang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.jep.2023.117209_bib68","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.117209_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114656","article-title":"Chinese patent medicine Aidi injection for cancer care: an overview of systematic reviews and meta-analyses","volume":"282","author":"Yang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117209_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.690206","article-title":"Angiogenesis-related immune signatures correlate with prognosis, tumor microenvironment, and therapeutic sensitivity in hepatocellular carcinoma","volume":"8","author":"Yang","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"1","key":"10.1016\/j.jep.2023.117209_bib71","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s41392-020-00251-2","article-title":"Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth","volume":"5","author":"Yao","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"5","key":"10.1016\/j.jep.2023.117209_bib72","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"9","key":"10.1016\/j.jep.2023.117209_bib73","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/07357900802017553","article-title":"Survivin expression in renal cell carcinoma","volume":"26","author":"Zamparese","year":"2008","journal-title":"Cancer Invest."},{"key":"10.1016\/j.jep.2023.117209_bib74","doi-asserted-by":"crossref","DOI":"10.1177\/09636897211008874","article-title":"CircANKRD52 promotes the tumorigenesis of hepatocellular carcinoma by sponging miR-497-5p and upregulating BIRC5 expression","volume":"30","author":"Zhang","year":"2021","journal-title":"Cell Transplant."},{"issue":"12","key":"10.1016\/j.jep.2023.117209_bib75","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1158\/1078-0432.CCR-18-2548","article-title":"A novel mTORC1\/2 inhibitor (MTI-31) inhibits tumor growth, epithelial-mesenchymal transition, metastases, and improves antitumor immunity in preclinical models of lung cancer","volume":"25","author":"Zhang","year":"2019","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.jep.2023.117209_bib76","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.7150\/ijbs.66184","article-title":"Exosome-depleted MiR-148a-3p derived from hepatic stellate cells promotes tumor progression via ITGA5\/PI3K\/akt Axis in hepatocellular carcinoma","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2023.117209_bib77","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2514090","article-title":"Upregulation of FEN1 is associated with the tumor progression and prognosis of hepatocellular carcinoma","volume":"2020","author":"Zhang","year":"2020","journal-title":"Dis. Markers"},{"key":"10.1016\/j.jep.2023.117209_bib78","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4103\/wjtcm.wjtcm_81_20","article-title":"An exploration in the potential substance basis and mechanism of chuanxiong rhizoma and angelicae dahuricae Radix on analgesia based on network pharmacology and molecular docking","volume":"7","author":"Zhao","year":"2021","journal-title":"World J. Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2023.117209_bib79","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12424","article-title":"Combined Erlotinib and PF-03084014 treatment contributes to synthetic lethality in head and neck squamous cell carcinoma","volume":"51","author":"Zheng","year":"2018","journal-title":"Cell Prolif."},{"key":"10.1016\/j.jep.2023.117209_bib80","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.biopha.2016.11.100","article-title":"miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K\/Akt signaling pathway and inhibites cell migration via targeting ZEB1","volume":"85","author":"Zhou","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117209_bib81","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.RA120.002384","article-title":"Proteomic analyses identify differentially expressed proteins and pathways between low-risk and high-risk subtypes of early-stage lung adenocarcinoma and their prognostic impacts","volume":"20","author":"Zhou","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jep.2023.117209_bib82","article-title":"An advanced systems pharmacology strategy reveals AKR1B1, MMP2, PTGER3 as key genes in the competing endogenous RNA network of compound kushen injection treating gastric carcinoma by integrated bioinformatics and experimental verification","volume":"9","author":"Zhou","year":"2021","journal-title":"Front. Cell Dev. Biol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123010796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123010796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:15:03Z","timestamp":1736403303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123010796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":82,"alternative-id":["S0378874123010796"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117209","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The anti-hepatocellular carcinoma effect of Aidi injection was related to the synergistic action of cantharidin, formononetin, and isofraxidin through BIRC5, FEN1, and EGFR","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117209"}}