{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:07:44Z","timestamp":1791925664387,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.117303","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:01:16Z","timestamp":1696986076000},"page":"117303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"P3","title":["DIA-based serum proteomics revealed the protective effect of modified siwu decoction against hypobaric hypoxia"],"prefix":"10.1016","volume":"319","author":[{"given":"Bodan","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5034-2146","authenticated-orcid":false,"given":"Yihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jep.2023.117303_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/biology10100986","article-title":"Effects of ibuprofen use on lymphocyte count and oxidative stress in elite paralympic powerlifting","volume":"10","author":"Aidar","year":"2021","journal-title":"Biology"},{"issue":"3","key":"10.1016\/j.jep.2023.117303_bib2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2337\/diab.31.3.212","article-title":"Effect of exercise (running) on serum glucose, insulin, glucagon, and chromium excretion","volume":"31","author":"Anderson","year":"1982","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2023.117303_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8033353","article-title":"Rebalance of the polyamine metabolism suppresses oxidative stress and delays senescence in nucleus pulposus cells","author":"Che","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.jep.2023.117303_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/MOH.0000000000000574","article-title":"Erythrocyte adaptive metabolic reprogramming under physiological and pathological hypoxia","volume":"27","author":"D'Alessandro","year":"2020","journal-title":"Curr. Opin. Hematol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2023.117303_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.clinbiochem.2012.09.007","article-title":"The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research","volume":"46","author":"Garelnabi","year":"2013","journal-title":"Clin. Biochem."},{"issue":"11","key":"10.1016\/j.jep.2023.117303_bib6","first-page":"499","article-title":"High altitude illness and related diseases - a review","volume":"105","author":"Gudbjartsson","year":"2019","journal-title":"Laeknabladid"},{"key":"10.1016\/j.jep.2023.117303_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/195835","article-title":"Protective effects of tao-Hong-si-Wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia","author":"Han","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"issue":"9","key":"10.1016\/j.jep.2023.117303_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091882","article-title":"Thirty minutes of hypobaric hypoxia provokes alterations of immune response, haemostasis, and metabolism proteins in human serum","volume":"18","author":"Hinkelbein","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117303_bib9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.archoralbio.2018.09.002","article-title":"Salivary proteome patterns of individuals exposed to High Altitude","volume":"96","author":"Jain","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jep.2023.117303_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2019.11.007","article-title":"Saliva panel of protein candidates: a comprehensive study for assessing high altitude acclimatization","volume":"95","author":"Jain","year":"2020","journal-title":"Nitric Oxide : biology and chemistry"},{"key":"10.1016\/j.jep.2023.117303_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.910217","article-title":"Neuroprotective effect of taohong siwu decoction on cerebral ischemia\/reperfusion injury via mitophagy-NLRP3 inflammasome pathway","volume":"13","author":"Ji","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2023.117303_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17050615","article-title":"TNFSF15 inhibits blood retinal barrier breakdown induced by diabetes","volume":"17","author":"Jiang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.jep.2023.117303_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.477","article-title":"Docosahexaenoic acid induces the degradation of HPV E6\/E7 oncoproteins by activating the ubiquitin\u2013proteasome system","volume":"5","author":"Jing","year":"2014","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.jep.2023.117303_bib14","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1152\/japplphysiol.00362.2013","article-title":"Exploratory proteomic analysis of hypobaric hypoxia and acute mountain sickness in humans","volume":"116","author":"Julian","year":"2014","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2023.117303_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10010113","article-title":"Astaxanthin-, beta-carotene-, and resveratrol-rich foods support resistance training-induced adaptation","volume":"10","author":"Kawamura","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2023.117303_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.903130","article-title":"Nitrate exposure reprograms hepatic amino acid and nutrient sensing pathways prior to exercise: a metabolomic and transcriptomic investigation in zebrafish (Danio rerio)","volume":"9","author":"Keller","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"14","key":"10.1016\/j.jep.2023.117303_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93367","article-title":"Red blood cell beta-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply","volume":"2","author":"Kim","year":"2017","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.jep.2023.117303_bib18","article-title":"The immediate effects of a single bout of aerobic exercise on oral glucose tolerance across the glucose tolerance continuum","volume":"2","author":"Knudsen","year":"2014","journal-title":"Phys. Rep."},{"issue":"5","key":"10.1016\/j.jep.2023.117303_bib19","doi-asserted-by":"crossref","first-page":"13622","DOI":"10.1080\/21655979.2022.2081755","article-title":"Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1alpha\/vascular endothelial growth factor\/STAT3 pathway","volume":"13","author":"Kong","year":"2022","journal-title":"Bioengineered"},{"issue":"12","key":"10.1016\/j.jep.2023.117303_bib20","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1172\/JCI105948","article-title":"Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels","volume":"47","author":"Lenfant","year":"1968","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.jep.2023.117303_bib21","article-title":"Effect of tao-hong-Si-Wu-tang, a traditional Chinese herbal medicine formula, on physical fatigue in mice","volume":"10","author":"Li","year":"2012","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.jep.2023.117303_bib22","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.rmed.2018.11.004","article-title":"Research advances in pathogenesis and prophylactic measures of acute high altitude illness","volume":"145","author":"Li","year":"2018","journal-title":"Respir. Med."},{"issue":"10","key":"10.1016\/j.jep.2023.117303_bib23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1139\/cjpp-2019-0690","article-title":"Mechanism and effects of fructose diphosphate on anti-hypoxia fatigue and learning memory ability","volume":"98","author":"Liu","year":"2020","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2023.117303_bib24","first-page":"814","article-title":"Siwu series decoctions for treating primary dysmenorrea of gynecology blood stasis syndrome--research progress of Taohong Siwu decoction","volume":"40","author":"Liu","year":"2015","journal-title":"China J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.jep.2023.117303_bib25","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1080\/13880209.2023.2220360","article-title":"Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt\/\u03b2-catenin pathway","volume":"61","author":"Liu","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2023.117303_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.853225","article-title":"Lonicera caerulea berry polyphenols extract alleviates exercise fatigue in mice by reducing oxidative stress, inflammation, skeletal muscle cell apoptosis, and by increasing cell proliferation","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2023.117303_bib27","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/s41598-018-19818-9","article-title":"Plasma proteomic study of acute mountain sickness susceptible and resistant individuals","volume":"8","author":"Lu","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jep.2023.117303_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4144","article-title":"Effects of Tao-Hong-Si-Wu decoction on acute blood stasis in rats based on a LC-Q\/TOF-MS metabolomics and network approach","volume":"32","author":"Ma","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2023.117303_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2018.03.042","article-title":"Hypoxia, oxidative stress and inflammation","volume":"125","author":"McGarry","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2023.117303_bib30","article-title":"Ferulic acid grafted into \u03b2-cyclodextrin nanosponges ameliorates Paraquat-induced human MRC-5 fibroblast injury","author":"Meamar","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"8","key":"10.1016\/j.jep.2023.117303_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12080681","article-title":"Margaritaria nobilis L.F. (Phyllanthaceae): ethnopharmacology and application of computational tools in the annotation of bioactive molecules","volume":"12","author":"Santiago","year":"2022","journal-title":"Metabolites"},{"issue":"7","key":"10.1016\/j.jep.2023.117303_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073909","article-title":"Influence of 30 and 60 min of hypobaric hypoxia in simulated altitude of 15,000 ft on human proteome profile","volume":"23","author":"Schmitz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117303_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.816347","article-title":"Effects and mechanisms of taohong siwu decoction on the prevention and treatment of myocardial injury","volume":"13","author":"Shao","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2023.117303_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5114\/biolsport.2021.102930","article-title":"Higher evening metabolic responses contribute to diurnal variation of self-paced cycling performance","volume":"39","author":"Souissi","year":"2022","journal-title":"Biol. Sport"},{"key":"10.1016\/j.jep.2023.117303_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12086","article-title":"Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia","volume":"7","author":"Sun","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2023.117303_bib36","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3389\/fmicb.2018.01078","article-title":"Effects of 1,8-cineole on carbohydrate metabolism related cell structure changes of Salmonella","volume":"9","author":"Sun","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2023.117303_bib37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s11658-018-0074-4","article-title":"Arsenic trioxide induces apoptosis and the formation of reactive oxygen species in rat glioma cells","volume":"23","author":"Sun","year":"2018","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"8","key":"10.1016\/j.jep.2023.117303_bib38","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s11655-019-3028-4","article-title":"Efficacy and safety evaluation of taohong siwu decoction (vvvv) for patients with angina pectoris: a meta-analysis of randomized controlled trials","volume":"27","author":"Tao","year":"2021","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117303_bib39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fphar.2015.00072","article-title":"Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps","volume":"6","author":"Teschke","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117303_bib40","article-title":"Hydrogen sulfide is a regulator of hemoglobin oxygen-carrying capacity via controlling 2,3-BPG production in erythrocytes","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2023.117303_bib41","doi-asserted-by":"crossref","first-page":"7943","DOI":"10.2147\/IJN.S335438","article-title":"Extracellular vesicles from HIF-1alpha-Overexpressing adipose-derived stem cells restore diabetic wounds through accelerated fibroblast proliferation and migration","volume":"16","author":"Wang","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"7","key":"10.1016\/j.jep.2023.117303_bib42","first-page":"499","article-title":"Siwu decoction attenuates oxonate-induced hyperuricemia and kidney inflammation in mice","volume":"14","author":"Wang","year":"2016","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.jep.2023.117303_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010555","article-title":"IL-17 pathway members as potential biomarkers of effective systemic treatment and cardiovascular disease in patients with moderate-to-severe psoriasis","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.jep.2023.117303_bib44","doi-asserted-by":"crossref","first-page":"11465","DOI":"10.3390\/ijms160511465","article-title":"Gene expression signature in endemic osteoarthritis by microarray analysis","volume":"16","author":"Wang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117303_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113249","article-title":"Research progress on classical traditional Chinese medicine Taohong Siwu decoction in the treatment of coronary heart disease","volume":"152","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117303_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/803015","article-title":"Neuroprotection by the traditional Chinese medicine, tao-hong-Si-Wu-tang, against middle cerebral artery occlusion-induced cerebral ischemia in rats","author":"Wu","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.jep.2023.117303_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/CIRCRESAHA.120.318805","article-title":"Immunometabolic endothelial phenotypes: integrating inflammation and glucose metabolism","volume":"129","author":"Xiao","year":"2021","journal-title":"Circ. Res."},{"issue":"4\u20135","key":"10.1016\/j.jep.2023.117303_bib48","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1360\/TB-2020-1034","article-title":"Traditional Chinese Medicine (TCM) safety evaluation and pharmacovigilance","volume":"66","author":"Xiao","year":"2021","journal-title":"Chin. Sci. Bull."},{"issue":"10","key":"10.1016\/j.jep.2023.117303_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9100230","article-title":"Alterations in exercise-induced plasma adenosine triphosphate concentration in highly trained athletes in a one-year training cycle","volume":"9","author":"Zarebska","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.jep.2023.117303_bib50","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2022.03.011","article-title":"Amygdalin protects against acetaminophen-induced acute liver failure by reducing inflammatory response and inhibiting hepatocyte death","volume":"602","author":"Zhang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2023.117303_bib51","article-title":"Hepatotoxicity comparison of crude and licorice-processed euodiae fructus in rats with stomach excess-cold syndrome","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2023.117303_bib52","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/emboj.2013.38","article-title":"Fine-tuning BMP7 signalling in adipogenesis by UBE2O\/E2-230K-mediated monoubiquitination of SMAD6","volume":"32","author":"Zhang","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.jep.2023.117303_bib53","article-title":"Uterine metabolomics reveals protection of taohong siwu decoction against abnormal uterine bleeding","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412301173X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412301173X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:41:29Z","timestamp":1759945289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412301173X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":53,"alternative-id":["S037887412301173X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117303","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DIA-based serum proteomics revealed the protective effect of modified siwu decoction against hypobaric hypoxia","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117303"}}