{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:08:50Z","timestamp":1736485730208,"version":"3.32.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jep.2023.117332","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T15:53:35Z","timestamp":1697558015000},"page":"117332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Safety evaluation of standardized Ayurvedic formulation-Panchvalkala, by subacute toxicity study"],"prefix":"10.1016","volume":"321","author":[{"given":"Shama","family":"Aphale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjiri","family":"Karandikar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-4048","authenticated-orcid":false,"given":"Vijaya A.","family":"Pandit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.N.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-1038","authenticated-orcid":false,"given":"Ruchika","family":"Kaul-Ghanekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2023.117332_bib1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jep.2005.11.027","article-title":"Preliminary toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats","volume":"105","author":"Adeneye","year":"2006","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2023.117332_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/ptr.835","article-title":"Investigation into the toxicological effects of Catha edulis leaves: a short term study in animals","volume":"16","author":"Al-Mamary","year":"2002","journal-title":"Phytother Res."},{"issue":"3","key":"10.1016\/j.jep.2023.117332_bib3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jep.2007.12.008","article-title":"Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals","volume":"116","author":"Amresh","year":"2008","journal-title":"J. Ethnopharmacol."},{"issue":"58","key":"10.1016\/j.jep.2023.117332_bib4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4103\/pm.pm_252_18","article-title":"Phytochemical standardization of panchavalkala: an ayurvedic formulation and evaluation of its anticancer activity in cervical cancer cell lines","volume":"14","author":"Aphale","year":"2018","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.jep.2023.117332_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114405","article-title":"Panchvalkala, a traditional Ayurvedic formulation, exhibits antineoplastic and immunomodulatory activity in cervical cancer cells and C57BL\/6 mouse papilloma model","volume":"280","author":"Aphale","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117332_bib6","series-title":"Department of Indian System of Medicine and Homeopathy. Part I","first-page":"353","article-title":"Ministry of health and family welfare","year":"2003"},{"key":"10.1016\/j.jep.2023.117332_bib7","first-page":"1","article-title":"Quality control of the traditional herbs and herbal products: a review","volume":"6","author":"Balekundri","year":"2020","journal-title":"Future J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.117332_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/0974-8520.146216","article-title":"A clinical study on the efficacy of Panchavalkala cream in Vrana Shodhana wsr to its action on microbial load and wound infection","volume":"35","author":"Bhat","year":"2014","journal-title":"Ayu"},{"issue":"1","key":"10.1016\/j.jep.2023.117332_bib9","first-page":"6","article-title":"Acute & subchronic toxicity studies and pharmacological evaluation of Ficus bengalensis L. (Family: moraceae) on scopolamine-induced memory impairment in experimental animals","volume":"1","author":"Chandra","year":"2013","journal-title":"Indian J. Drugs"},{"issue":"4","key":"10.1016\/j.jep.2023.117332_bib10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/0975-9476.90769","article-title":"Contribution of world health organization in the global acceptance of Ayurveda","volume":"2","author":"Chaudhary","year":"2011","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.jep.2023.117332_bib11","series-title":"Bhavaprakash Nighantu","first-page":"519","author":"Chunekar","year":"1999"},{"key":"10.1016\/j.jep.2023.117332_bib12","series-title":"Glucose Intake and Utilization in Pre-diabetes and Diabetes","first-page":"229","article-title":"Myoinositol supplementation on insulin resistance in gestational diabetes","author":"Corrado","year":"2015"},{"key":"10.1016\/j.jep.2023.117332_bib13","unstructured":"Dhanavantari, N., Varg, M., 1600. National Institute of Indian Medical Heritage,."},{"year":"2019","series-title":"A Comparative Clinical Study on Panchavalkala Ointment and Zinc Oxide Ointment in the Management of Ahiputana Wsr to Napkin Rash in Children","author":"Dhanke","key":"10.1016\/j.jep.2023.117332_bib14"},{"issue":"3","key":"10.1016\/j.jep.2023.117332_bib15","first-page":"73","article-title":"Leucorrhoea in ayurvedic literature-a review","volume":"3","author":"Dhiman","year":"2014","journal-title":"Ayurpharm. Int. J. Ayur. Alli Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.117332_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3844\/ajptsp.2012.62.67","article-title":"Toxicological evaluation of Murraya paniculata (L.) leaves extract on rodents","volume":"7","author":"Gautam","year":"2012","journal-title":"Am. J. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2023.117332_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/0970-9371.238251","article-title":"Use of cervical cytology, vaginal pH & colposcopy, adjuvant to clinical evaluation of ayurvedic vaginal douche, panchvalkal in leucorrhoea","volume":"21","author":"Joshi","year":"2004","journal-title":"J. Cytol."},{"key":"10.1016\/j.jep.2023.117332_bib19","series-title":"Panchvalkala: A Monograph, Experimental & Clinical Studies on the Use of Modified Panchavalkal (An Ayurvedic Formulation) in Leucorrhoea","first-page":"1","author":"Joshi J","year":"2013"},{"key":"10.1016\/j.jep.2023.117332_bib21","first-page":"1","article-title":"Therapeutic uses of Panchvalkal in different forms\u2013A review","volume":"2","author":"Khadkutkar","year":"2014","journal-title":"Ayurlog. Nat. J. Res. Ayurveda Sci."},{"key":"10.1016\/j.jep.2023.117332_bib22","series-title":"Protocol for Testing Ayurvedic, Siddha and Unani Medicines","first-page":"17","author":"Lohar","year":"2007"},{"issue":"5","key":"10.1016\/j.jep.2023.117332_bib23","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/01926230701595292","article-title":"Evaluation of organ weights for rodent and non-rodent toxicity studies: a review of regulatory guidelines and a survey of current practices","volume":"35","author":"Michael","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.jep.2023.117332_bib24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jep.2007.02.011","article-title":"Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents","volume":"112","author":"Mukinda","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117332_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/804086","article-title":"Underestimating the toxicological challenges associated with the use of herbal medicinal products in developing countries","author":"Neergheen-Bhujun","year":"2013","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.jep.2023.117332_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/rtph.2000.1399","article-title":"Concordance of the toxicity of pharmaceuticals in humans and in animals","volume":"32","author":"Olson","year":"2000","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2023.117332_bib27","first-page":"1343","article-title":"A clinical round up of the female infertility therapy amongst Indians","volume":"6","author":"Palatty","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"issue":"30","key":"10.1016\/j.jep.2023.117332_bib28","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221413120","article-title":"The human milk component myo-inositol promotes neuronal connectivity","volume":"120","author":"Paquette","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.jep.2023.117332_bib29","first-page":"316","article-title":"Shodhana effect of Panchavalkala kvatha prakshalana in the management of pittaja dushta vrana","volume":"5","author":"Patil","year":"2017","journal-title":"Int. Ayurvedic Med. J."},{"issue":"3","key":"10.1016\/j.jep.2023.117332_bib30","first-page":"84","article-title":"Toxicological studies of Ficus virens in wistar albino rats","author":"Pattar J","year":"2012","journal-title":"Int. Res. J. Pharm."},{"issue":"3S","key":"10.1016\/j.jep.2023.117332_bib31","first-page":"301","article-title":"Evaluating the protective role and phytotoxic effect of Ficus virens in wistar albino rats","volume":"7","author":"Pattar","year":"2018","journal-title":"J. Pharmacogn. Phytochem."},{"issue":"5","key":"10.1016\/j.jep.2023.117332_bib32","first-page":"33","article-title":"Toward the integration and advancement of herbal medicine: a focus on Traditional Indian medicine","author":"Sen","year":"2015","journal-title":"Botanics"},{"key":"10.1016\/j.jep.2023.117332_bib33","first-page":"1","article-title":"Clinical biochemistry of hepatotoxicity","volume":"4","author":"Singh","year":"2011","journal-title":"J. Clin. Toxicol."},{"issue":"7","key":"10.1016\/j.jep.2023.117332_bib34","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.20959\/wjpr20177-8892","article-title":"Effect of Panchavalkala kvatha prakshalana and Ropana ghrita in management of dushta vrana","volume":"6","author":"Singh","year":"2017","journal-title":"World J. Pharmaceut. Res."},{"issue":"1","key":"10.1016\/j.jep.2023.117332_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/0253-7613.106437","article-title":"Biochemical and histopathological effects on liver due to acute oral toxicity of aqueous leaf extract of Eclipta alba on female Swiss albino mice","volume":"45","author":"Singh","year":"2013","journal-title":"Indian J. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2023.117332_bib36","first-page":"110","article-title":"Evaluation of acute and sub-acute toxicity of a standardized polyherbal formulation (HC9): an in vivo study","volume":"7","author":"Suryavanshi","year":"2015","journal-title":"Int. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.jep.2023.117332_bib37","doi-asserted-by":"crossref","DOI":"10.5530\/pj.2014.2.2","article-title":"Standardization of a polyherbal formulation (HC9) and comparative analysis of its cytotoxic activity with the individual herbs present in the composition in breast cancer cell lines","volume":"6","author":"Suryavanshi","year":"2014","journal-title":"Pharmacogn. J."},{"issue":"3","key":"10.1016\/j.jep.2023.117332_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaim.2022.100594","article-title":"Wound healing activity of topical herbal aerosol sprays on diabetic and varicose ulcers: a randomized, controlled, open labelled, multi-centric clinical trial","volume":"13","author":"Tamoli","year":"2022","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.jep.2023.117332_bib41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.yrtph.2018.11.010","article-title":"Acute and 28-days repeated dose sub-acute toxicity study of gallic acid in albino mice","volume":"101","author":"Variya","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2023.117332_bib39","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1021\/jf011066w","article-title":"90-day oral toxicity study of a grape seed extract (IH636) in rats","volume":"50","author":"Wren","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.117332_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2012.12.042","article-title":"The hepatoprotection of caffeic acid and rosmarinic acid, major compounds of Perilla frutescens, against t-BHP-induced oxidative liver damage","volume":"55","author":"Yang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.117332_fur1","doi-asserted-by":"crossref","unstructured":"Evacuasiany, E., Ratnawati, H., Liana, L.K., Widowati, W., Maesaroh, M., Mozef, T., Risdian, C., 2014. Cytotoxic and antioxidant activities of catechins in inhibiting the malignancy of breast cancer. Oxid. Antioxid. Med. Sci. 3 (2), 141 6 doi:10.5455\/oams.240614.or.066.","DOI":"10.5455\/oams.240614.or.066"},{"issue":"1","key":"10.1016\/j.jep.2023.117332_fur2","article-title":"An ayurvedic management of vulvovaginitis during pregnancy","volume":"28","author":"Joshi","year":"2007","journal-title":"AYU"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123012023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123012023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:18:22Z","timestamp":1736403502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123012023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":41,"alternative-id":["S0378874123012023"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117332","relation":{},"ISSN":["0378-8741"],"issn-type":[{"type":"print","value":"0378-8741"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety evaluation of standardized Ayurvedic formulation-Panchvalkala, by subacute toxicity study","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117332","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117332"}}