{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:54:01Z","timestamp":1793379241384,"version":"4.5.0"},"reference-count":179,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903513"],"award-info":[{"award-number":["81903513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173713"],"award-info":[{"award-number":["82173713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M682599"],"award-info":[{"award-number":["2020M682599"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ40812"],"award-info":[{"award-number":["2021JJ40812"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ41000"],"award-info":[{"award-number":["2021JJ41000"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jep.2023.117353","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T02:22:29Z","timestamp":1698546149000},"page":"117353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"P3","title":["The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium"],"prefix":"10.1016","volume":"319","author":[{"given":"Yu-Fen","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Song","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Shan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-507X","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117353_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1615\/IntJMedMushr.v13.i1.50","article-title":"Potential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats","volume":"13","author":"Abdulla","year":"2011","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.jep.2023.117353_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/464238","article-title":"Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities","author":"Abdullah","year":"2012","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"10.1016\/j.jep.2023.117353_bib3","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1139\/m71-223","article-title":"Cyathin, a new antibiotic complex produced by Cyathus helenae","volume":"17","author":"Allbutt","year":"1971","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.jep.2023.117353_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1515\/znc-2002-3-411","article-title":"Studies on the biosynthesis of striatal-type diterpenoids and the biological activity of herical","volume":"57","author":"Anke","year":"2002","journal-title":"Z. Naturforsch., C: J. Biosci."},{"key":"10.1016\/j.jep.2023.117353_bib5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1021\/np50107a006","article-title":"Secondary mold metabolites: part 46. hericenes A\u2013C and erinapyrone C, new metabolites produced by the fungus Hericium erinaceus","volume":"57","author":"Arnone","year":"1994","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2023.117353_bib6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phytol.2019.04.017","article-title":"New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus","volume":"32","author":"Ashour","year":"2019","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.scienta.2021.109915","article-title":"The effect of different fruiting temperatures on the yield and nutritional parameters of some wild and hybrid Hericium isolates","volume":"280","author":"Atila","year":"2021","journal-title":"Sci. Hortic."},{"key":"10.1016\/j.jep.2023.117353_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.24326\/asphc.2019.6.10","article-title":"Comparative evaluation of the antioxidant potential of Hericium erinaceus, Hericium americanum and Hericium coralloides","volume":"18","author":"Atila","year":"2019","journal-title":"Acta Sci. Pol. Hortorum Cultus."},{"key":"10.1016\/j.jep.2023.117353_bib9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.scienta.2018.04.049","article-title":"The effect of some agro-industrial wastes on yield, nutritional characteristics and antioxidant activities of Hericium erinaceus isolates","volume":"238","author":"Atila","year":"2018","journal-title":"Sci. Hortic."},{"key":"10.1016\/j.jep.2023.117353_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104953","article-title":"Erinacine A and related cyathane diterpenoids: molecular diversity and mechanisms underlying their neuroprotection and anticancer activities","volume":"159","author":"Bailly","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2023.117353_bib11","first-page":"6","article-title":"Study on quality standard for Hericium erinaceus with solid cultures","volume":"32","author":"Bi","year":"2016","journal-title":"Journal of Guangdong Pharmaceutical University"},{"key":"10.1016\/j.jep.2023.117353_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.funeco.2010.10.001","article-title":"Ecology of Hericium cirrhatum, H. coralloides and H. erinaceus in the UK","volume":"4","author":"Boddy","year":"2011","journal-title":"Fungal Ecol"},{"key":"10.1016\/j.jep.2023.117353_bib13","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3390\/jof9050551","article-title":"Hericium erinaceus in neurodegenerative diseases: from bench to bedside and beyond, how far from the shoreline?","volume":"9","author":"Brandalise","year":"2023","journal-title":"J. Fungi."},{"key":"10.1016\/j.jep.2023.117353_bib14","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/dneu.20759","article-title":"Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease","volume":"70","author":"Calissano","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.jep.2023.117353_bib15","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1021\/acs.jnatprod.9b01251","article-title":"Total synthesis of isohericenone J via a stille coupling reaction","volume":"83","author":"Cao","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2023.117353_bib16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1055\/a-1146-8369","article-title":"Identification and alpha-glucosidase inhibitory activity of meroterpenoids from Hericium erinaceus","volume":"86","author":"Chen","year":"2020","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2023.117353_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2020.103456","article-title":"Isolation and determination of lipophilic mycochemicals from a New Zealand edible native mushroom Hericium novae-zealandiae","volume":"88","author":"Chen","year":"2020","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.jep.2023.117353_bib18","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.foodchem.2018.11.115","article-title":"Development and validation of an HPLC-DAD-MS method for determination of four nucleoside compounds in the New Zealand native mushroom Hericium sp","volume":"278","author":"Chen","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.117353_bib19","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1039\/C9FO01672D","article-title":"Characterization of the bioactivities of an ethanol extract and some of its constituents from the New Zealand native mushroom Hericium novae-zealandiae","volume":"10","author":"Chen","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.117353_bib20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.phytol.2018.07.006","article-title":"Hericinoids A\u2013C, cyathane diterpenoids from culture of mushroom Hericium erinaceus","volume":"27","author":"Chen","year":"2018","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib21","first-page":"1","article-title":"Secondary metabolites from higher fungi","volume":"106","author":"Chen","year":"2017","journal-title":"Prog. Chem. Org. Nat. Prod."},{"key":"10.1016\/j.jep.2023.117353_bib22","article-title":"Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.117353_bib23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.fitote.2017.08.017","article-title":"Isoindolinone-containing meroterpenoids with alpha-glucosidase inhibitory activity from mushroom Hericium caput-medusae","volume":"122","author":"Chen","year":"2017","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2023.117353_bib24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1021\/acs.jnatprod.5b00474","article-title":"Erinacine S, a rare sesterterpene from the mycelia of Hericium erinaceus","volume":"79","author":"Chen","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2023.117353_bib25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jep.2005.02.037","article-title":"Inhibitory effect on proliferation of vascular smooth muscle cells and protective effect on CCl4 -induced hepatic damage of HEAI extract","volume":"100","author":"Choi","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117353_bib26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3390\/ijms21010163","article-title":"Therapeutic potential of Hericium erinaceus for depressive disorder","volume":"21","author":"Chong","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117353_bib27","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.3390\/antiox10111664","article-title":"Key mechanisms and potential implications of Hericium erinaceus in NLRP3 inflammasome activation by reactive oxygen species during Alzheimer's Disease","volume":"10","author":"Cordaro","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2023.117353_bib28","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.procbio.2014.04.008","article-title":"Purification and partial characterization of a novel hemagglutinating glycoprotein from the cultured mycelia of Hericium erinaceus","volume":"49","author":"Cui","year":"2014","journal-title":"Process Biochem."},{"key":"10.1016\/j.jep.2023.117353_bib29","first-page":"801","article-title":"A revised checklist of medicinal fungi in China","volume":"27","author":"Dai","year":"2008","journal-title":"Mycosystema"},{"key":"10.1016\/j.jep.2023.117353_bib30","doi-asserted-by":"crossref","first-page":"85838","DOI":"10.18632\/oncotarget.20689","article-title":"Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota","volume":"8","author":"Diling","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2023.117353_bib31","first-page":"116","article-title":"Effect of Hericium caput-medusae oligosaccharide on immunity function of tumor mice","volume":"11","author":"Du","year":"2013","journal-title":"J. Fungal Res."},{"key":"10.1016\/j.jep.2023.117353_bib32","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1039\/b811227b","article-title":"Synthetic efforts toward cyathane diterpenoid natural products","volume":"26","author":"Enquist","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jep.2023.117353_bib33","series-title":"Chinese Materia Medica","year":"1999"},{"key":"10.1016\/j.jep.2023.117353_bib34","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1021\/acs.jafc.5b02914","article-title":"Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (Lion's Mane) mushroom fruiting bodies and mycelia and their bioactive compounds","volume":"63","author":"Friedman","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.117353_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1745-4522.2002.tb00206.x","article-title":"Antioxidant and free radical scavenging activities of edible mushrooms","volume":"9","author":"Fui","year":"2002","journal-title":"J. Food Lipids"},{"key":"10.1016\/j.jep.2023.117353_bib36","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1139\/b85-215","article-title":"Hericium in North America: cultural characteristics and mating behavior","volume":"63","author":"Ginns","year":"2011","journal-title":"Can. J. Bot.-Rev. Can. Bot."},{"key":"10.1016\/j.jep.2023.117353_bib37","doi-asserted-by":"crossref","DOI":"10.1007\/s11557-022-01829-6","article-title":"Optimal conditions for mycelial growth of medicinal mushrooms belonging to the genus Hericium","volume":"21","author":"Gonkhom","year":"2022","journal-title":"Mycol. Prog."},{"key":"10.1016\/j.jep.2023.117353_bib38","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10457-015-9790-1","article-title":"Production of Hericium sp. (Lion's Mane) mushrooms on totem logs in a forest farming system","volume":"89","author":"Grace","year":"2015","journal-title":"Agrofor. Syst."},{"key":"10.1016\/j.jep.2023.117353_bib39","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijbiomac.2017.01.040","article-title":"Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: a review","volume":"97","author":"He","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.117353_bib40","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3390\/nu12051339","article-title":"Antitumor, anti-inflammatory and antiallergic effects of Agaricus blazei mushroom extract and the related medicinal basidiomycetes mushrooms, Hericium erinaceus and Grifola frondosa: a review of preclinical and clinical studies","volume":"12","author":"Hetland","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2023.117353_bib41","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1271\/bbb.100130","article-title":"Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet","volume":"74","author":"Hiwatashi","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2023.117353_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131896","article-title":"Structural characterization of two Hericium erinaceus polysaccharides and their protective effects on the alcohol-induced gastric mucosal injury","volume":"375","author":"Hou","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.117353_bib43","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4489\/MYCO.2008.36.2.088","article-title":"Vegetative growth of four strains of Hericium erinaceus collected from different habitats","volume":"36","author":"Imtiaj","year":"2008","journal-title":"MYCOBIOLOGY"},{"key":"10.1016\/j.jep.2023.117353_bib44","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3390\/ijms20040859","article-title":"The neuroprotective effect of Hericium erinaceus extracts in mouse hippocampus after pilocarpine-induced status epilepticus","volume":"20","author":"Jang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117353_bib45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3892\/etm.2016.3279","article-title":"Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities","volume":"12","author":"Jiang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2023.117353_bib46","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1007\/s00253-014-5955-5","article-title":"Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals","volume":"98","author":"Jiang","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jep.2023.117353_bib47","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1016\/j.tet.2006.06.091","article-title":"Erinacines J and K from the mycelia of Hericium erinaceum","volume":"62","author":"Kawagishi","year":"2006","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2023.117353_bib48","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.1016\/0040-4039(96)01687-5","article-title":"Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum","volume":"37","author":"Kawagishi","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2023.117353_bib49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1515\/HC.1996.2.1.51","article-title":"Erinacine D, a stimulator of NGF-synthesis, from the mycelia of Hericium erinaceum","volume":"2","author":"Kawagishi","year":"1996","journal-title":"Heterocycl. Commun."},{"key":"10.1016\/j.jep.2023.117353_bib50","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0040-4039(00)76760-8","article-title":"Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum","volume":"35","author":"Kawagishi","year":"1994","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2023.117353_bib51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0031-9422(92)80127-Z","article-title":"Chromans, hericenone F, hericenone G and hericenone H from the mushroom Hericium-erinaceum","volume":"32","author":"Kawagishi","year":"1993","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2023.117353_bib52","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1246\/cl.1992.2475","article-title":"Erinapyrone A and erinapyrone B from the cultured mycelia of Hericium erinaceum","volume":"12","author":"Kawagishi","year":"1992","journal-title":"Chem. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib53","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1016\/0040-4039(91)80039-9","article-title":"Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum","volume":"32","author":"Kawagishi","year":"1991","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2023.117353_bib54","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0040-4039(00)94558-1","article-title":"Hericenone A and B as cytotoxic principles from the mushroom Hericium erinaceum","volume":"31","author":"Kawagishi","year":"1990","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2023.117353_bib55","first-page":"1329","article-title":"A novel fatty acid from the mushroom Hericium erinaceum","volume":"54","author":"Kawagishi","year":"1990","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib56","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1271\/bbb.68.1786","article-title":"Erinacol (cyatha-3,12-dien-14 beta-ol) and 11-O-acetylcyathin A3, new cyathane metabolites from an erinacine Q-producing Hericium erinaceum","volume":"68","author":"Kenmoku","year":"2004","journal-title":"Biosci. Biotech. Bioch."},{"key":"10.1016\/j.jep.2023.117353_bib57","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1271\/bbb.66.571","article-title":"Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete","volume":"66","author":"Kenmoku","year":"2002","journal-title":"Biosci. Biotech. Bioch."},{"key":"10.1016\/j.jep.2023.117353_bib58","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1016\/S0040-4039(01)01550-7","article-title":"Isolation of (-)-cyatha-3,12-diene, a common biosynthetic intermediate of cyathane diterpenoids, from an erinacine-producing basidiomycete, Hericium erinaceum, and its formation in a cell-free system","volume":"42","author":"Kenmoku","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2023.117353_bib59","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1016\/S0040-4039(00)00601-8","article-title":"Isolation of erinacine P, a new parental metabolite of cyathane-xylosides, from Hericium erinaceum and its biomimetic conversion into erinacines A and B","volume":"41","author":"Kenmoku","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2023.117353_bib60","first-page":"253","article-title":"Hericium erinaceus: an edible mushroom with medicinal values","volume":"10","author":"Khan","year":"2013","journal-title":"J. Compl. Integr. Med."},{"key":"10.1016\/j.jep.2023.117353_bib61","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41429-018-0067-6","article-title":"New antioxidants from the culture broth of Hericium coralloides","volume":"71","author":"Kim","year":"2018","journal-title":"J. Antibiot."},{"key":"10.1016\/j.jep.2023.117353_bib62","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.ijbiomac.2017.10.018","article-title":"A novel core 1 O-linked glycan-specific binding lectin from the fruiting body of Hericium erinaceus","volume":"107","author":"Kim","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.117353_bib63","series-title":"Sialic Acid-specific Binding Affinity Lectin from the Mushroom Hericium Erinaceum","author":"Kim","year":"2018"},{"key":"10.1016\/j.jep.2023.117353_bib64","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1021\/jf400916c","article-title":"Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice","volume":"61","author":"Kim","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.117353_bib65","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ja.2012.65","article-title":"Isohericenone, a new cytotoxic isoindolinone alkaloid from Hericium erinaceum","volume":"65","author":"Kim","year":"2012","journal-title":"J. Antibiot."},{"key":"10.1016\/j.jep.2023.117353_bib66","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.1021\/jf300897w","article-title":"Hericium erinaceus mushroom extracts protect infected mice against salmonella typhimurium-induced liver damage and mortality by stimulation of innate immune cells","volume":"60","author":"Kim","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.117353_bib67","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3109\/08923973.2011.633527","article-title":"Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages","volume":"34","author":"Kim","year":"2012","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2023.117353_bib68","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1039\/c1fo10030k","article-title":"Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells","volume":"2","author":"Kim","year":"2011","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.117353_bib69","doi-asserted-by":"crossref","first-page":"9861","DOI":"10.1021\/jf201944n","article-title":"Composition and mechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice","volume":"59","author":"Kim","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.117353_bib70","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/12298093.2000.12015719","article-title":"Isolation of antimicrobial substances from Hericium erinaceum","volume":"28","author":"Kim","year":"2000","journal-title":"MYCOBIOLOGY"},{"key":"10.1016\/j.jep.2023.117353_bib71","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.biortech.2004.12.009","article-title":"Comparative study of mycelial growth and basidiomata formation in seven different species of the edible mushroom genus Hericium","volume":"96","author":"Ko","year":"2005","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jep.2023.117353_bib72","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.joc.0c02681","article-title":"Total synthesis, structure revision, and neuroprotective effect of hericenones C\u2013H and their derivatives","volume":"86","author":"Kobayashi","year":"2021","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib73","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.tetlet.2018.03.065","article-title":"Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A\u2013C and their derivatives","volume":"59","author":"Kobayashi","year":"2018","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2023.117353_bib74","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1021\/jo500795z","article-title":"Divergent synthesis of bioactive resorcinols isolated from the fruiting bodies of Hericium erinaceum: total syntheses of hericenones A, B, and I, hericenols B\u2013D, and erinacerins A and B","volume":"79","author":"Kobayashi","year":"2014","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib75","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1021\/jo300719m","article-title":"Total synthesis and structural revision of hericerin","volume":"77","author":"Kobayashi","year":"2012","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib76","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/elsc.201000084","article-title":"Erinacine A biosynthesis in submerged cultivation of Hericium erinaceum: quantification and improved cultivation","volume":"10","author":"Krzyczkowski","year":"2010","journal-title":"Eng. Life Sci."},{"key":"10.1016\/j.jep.2023.117353_bib77","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.funeco.2016.12.002","article-title":"Habitat preferences of Hericium erinaceus in Slovakia","volume":"27","author":"Kunca","year":"2017","journal-title":"Fungal Ecol"},{"key":"10.1016\/j.jep.2023.117353_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.funeco.2020.101035","article-title":"Distribution and ecological traits of a rare and threatened fungus Hericium flagellum in Poland with the prediction of its potential occurrence in Europe","volume":"50","author":"Kujawska","year":"2021","journal-title":"Fungal Ecol"},{"key":"10.1016\/j.jep.2023.117353_bib79","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3390\/antiox8080261","article-title":"Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. suppresses H2O2-induced oxidative damage and LPS-induced inflammation in HT22 hippocampal neurons and BV2 nicroglia","volume":"8","author":"Kushairi","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2023.117353_bib80","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1271\/bbb.56.1417","article-title":"Synthesis and absolute configuration of a cytotoxic fatty acid isolated from the mushroom","volume":"56","author":"Kuwahara","year":"1992","journal-title":"Hericium erinaceum. Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2023.117353_bib81","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3390\/ijms23020810","article-title":"Erinacine A prevents lipopolysaccharide-mediated glial cell activation to protect dopaminergic neurons against inflammatory factor-induced cell death in vitro and in vivo","volume":"23","author":"Lee","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117353_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113197","article-title":"Characterization of alpha-glucosidase inhibitory constituents of the fruiting body of Lion's Mane mushroom (Hericium erinaceus)","volume":"262","author":"Lee","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117353_bib83","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3389\/fphar.2019.01174","article-title":"Induction apoptosis of erinacine A in human colorectal cancer cells involving the expression of TNFR, fas, and fas ligand via the JNK\/p300\/p50 signaling pathway with histone acetylation","volume":"10","author":"Lee","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117353_bib84","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1016\/j.bmcl.2015.10.092","article-title":"A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment","volume":"25","author":"Lee","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib85","doi-asserted-by":"crossref","first-page":"15073","DOI":"10.3390\/ijms150915073","article-title":"Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS\/p38 MAPK and nitrotyrosine","volume":"15","author":"Lee","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117353_bib87","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1271\/bbb.64.2402","article-title":"Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum","volume":"64","author":"Lee","year":"2000","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2023.117353_bib88","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1590\/fst.09919","article-title":"Antioxidant-mediated protective role of Hericium erinaceus (Bull.: Fr.) Pers. against oxidative damage in fibroblasts from Friedreich's ataxia patient","volume":"40","author":"Lew","year":"2020","journal-title":"Food Sci. Tech-Brazil."},{"key":"10.1016\/j.jep.2023.117353_bib89","first-page":"185","article-title":"Studies on quality standard of Hericium erinaceus extracts","volume":"24","author":"Li","year":"2021","journal-title":"Modern Food"},{"key":"10.1016\/j.jep.2023.117353_bib90","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/10286020.2018.1483346","article-title":"Chemical constituents from the culture of the fungus Hericium alpestre","volume":"21","author":"Li","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.117353_bib91","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5802634","article-title":"Neurohealth properties of Hericium erinaceus mycelia enriched with erinacines","author":"Li","year":"2018","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.jep.2023.117353_bib92","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1021\/acs.molpharmaceut.8b00525","article-title":"Discovery and characterization of 4-hydroxy-2-pyridone derivative sambutoxin as a potent and promising anticancer drug candidate: activity and molecular mechanism","volume":"15","author":"Li","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jep.2023.117353_bib93","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1080\/10286020.2017.1307185","article-title":"Two new isobenzofuranone derivatives from the fruiting bodies of Hericium erinaceus","volume":"19","author":"Li","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.117353_bib94","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bse.2016.12.011","article-title":"Sterols, aromatic compounds, and cerebrosides from the Hericium erinaceus fruiting body","volume":"70","author":"Li","year":"2017","journal-title":"Biochem. Systemat. Ecol."},{"key":"10.1016\/j.jep.2023.117353_bib95","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.phytochem.2015.02.021","article-title":"Sterols from Hericium erinaceum and their inhibition of TNF-\u03b1 and NO production in lipopolysaccharide-induced RAW 264.7 cells","volume":"115","author":"Li","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2023.117353_bib96","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.foodchem.2014.08.078","article-title":"Isolation and identification of aromatic compounds in Lion's Mane mushroom and their anticancer activities","volume":"170","author":"Li","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.117353_bib97","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1016\/j.tetlet.2014.05.117","article-title":"Hericirine, a novel anti-inflammatory alkaloid from Hericium erinaceum","volume":"55","author":"Li","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2023.117353_bib98","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1021\/np500234f","article-title":"Sterol fatty acid esters from the mushroom Hericium erinaceum and their PPAR transactivational effects","volume":"77","author":"Li","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2023.117353_bib99","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jep.2014.03.003","article-title":"Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers","volume":"153","author":"Li","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117353_bib100","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/716515","article-title":"A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum","author":"Li","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.jep.2023.117353_bib101","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/antiox9030234","article-title":"Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea","volume":"9","author":"Limanaqi","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2023.117353_bib102","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1039\/C8OB02774A","article-title":"Biosynthesis of bioactive natural products from Basidiomycota","volume":"17","author":"Lin","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib103","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.phytol.2018.05.017","article-title":"A xanthurenate and an isoindolinone from the mycelia of Hericium erinaceum","volume":"26","author":"Lin","year":"2018","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib104","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jff.2015.12.031","article-title":"Inhibitory effect of erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21","volume":"21","author":"Lu","year":"2016","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.jep.2023.117353_bib105","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1080\/14786419.2014.898145","article-title":"Bioactive metabolites from the mycelia of the basidiomycete Hericium erinaceum","volume":"28","author":"Lu","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.117353_bib107","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1016\/j.apsb.2021.04.014","article-title":"Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new \"non-natural\" analogues","volume":"11","author":"Ma","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2023.117353_bib108","first-page":"363","article-title":"Hericenone L, a new aromatic compound from the fruiting bodies of Hericium erinaceums","volume":"10","author":"Ma","year":"2012","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2023.117353_bib109","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/ja.2010.112","article-title":"Cytotoxic aromatic compounds from Hericium erinaceum","volume":"63","author":"Ma","year":"2010","journal-title":"J. Antibiot."},{"key":"10.1016\/j.jep.2023.117353_bib110","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1515\/znb-2008-1017","article-title":"A new cyathane-xyloside from the mycelia of Hericium erinaceum","volume":"63","author":"Ma","year":"2008","journal-title":"Z. Naturforsch."},{"key":"10.1016\/j.jep.2023.117353_bib111","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/B978-0-444-63602-7.00005-9","article-title":"7-6-5 Tricarbocyclic diterpenes: valparanes, mulinanes, cyathanes, homoverrucosanes, and related ones","volume":"48","author":"Marcos","year":"2016","journal-title":"Stud. Nat. Prod. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib112","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.tet.2011.11.068","article-title":"Two new aromatic compounds and a new D-arabinitol ester from the mushroom Hericium erinaceum","volume":"68","author":"Miyazawa","year":"2012","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2023.117353_bib113","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.phymed.2010.05.004","article-title":"Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation","volume":"17","author":"Mori","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117353_bib115","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1248\/bpb.31.1727","article-title":"Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells","volume":"31","author":"Mori","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2023.117353_bib116","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1021\/acs.joc.7b00920","article-title":"Total synthesis of isohericerin, isohericenone, and erinacerin A: development of a copper-catalyzed methylboronation of terminal alkynes","volume":"82","author":"Mun","year":"2017","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib117","series-title":"The National Compilation of Chinese 29 Herbal Medicine","year":"1975"},{"key":"10.1016\/j.jep.2023.117353_bib118","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/08923973.2014.947036","article-title":"Benzyl alcohol derivatives from the mushroom Hericium erinaceum attenuate LPS-stimulated inflammatory response through the regulation of NF-kappa B and AP-1 activity","volume":"36","author":"Noh","year":"2014","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2023.117353_bib119","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1358\/dnp.2002.15.5.840042","article-title":"The signaling pathway of neurotrophic factor biosynthesis","volume":"15","author":"Obara","year":"2002","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.jep.2023.117353_bib120","first-page":"522","article-title":"Isolation and identification of two new pyrone compounds from the culture of Herictum erinaceus","volume":"25","author":"Qian","year":"1990","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.jep.2023.117353_bib121","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1615\/IntJMedMushrooms.v18.i3.50","article-title":"Anti-inflammatory effects of ethanol extract of Lion's Mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), in mice with ulcerative colitis","volume":"18","author":"Qin","year":"2016","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.jep.2023.117353_bib122","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3390\/nu14061177","article-title":"Searching for a longevity food, we bump into Hericium erinaceus primordium rich in ergothioneine: the \"longevity vitamin\" improves locomotor performances during aging","volume":"14","author":"Roda","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2023.117353_bib123","first-page":"24","article-title":"Study on prepararation technique and quality standard optimization of compound Houtou granules","volume":"17","author":"Ru","year":"2017","journal-title":"Jiangsu Science & Technology Information"},{"key":"10.1016\/j.jep.2023.117353_bib124","first-page":"760","article-title":"Two new cyathane diterpenoids from mycelial cultures of the medicinal mushroom Hericium erinaceus and the rare species","volume":"19","author":"Rupcic","year":"2018","journal-title":"Hericium flagellum. Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117353_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2020.127714","article-title":"Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus","volume":"31","author":"Ryu","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib126","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/2225-4110.106549","article-title":"Neuronal health \u2013 can culinary and medicinal mushrooms help?","volume":"3","author":"Sabaratnam","year":"2013","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jep.2023.117353_bib127","doi-asserted-by":"crossref","first-page":"983","DOI":"10.7164\/antibiotics.51.983","article-title":"Erinacine E as a kappa opioid receptor agonist and its new analogs from a basidiomycete, Hericium ramosum","volume":"51","author":"Saito","year":"1998","journal-title":"J. Antibiot."},{"key":"10.1016\/j.jep.2023.117353_bib129","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12979-017-0108-1","article-title":"Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer's disease and Alzheimer- linked pathologies: modulation by nutritional mushrooms","volume":"15","author":"Salinaro","year":"2018","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.jep.2023.117353_bib130","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jobm.200800102","article-title":"Diterpenoids of macromycetes","volume":"49","author":"Shen","year":"2009","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.jep.2023.117353_bib131","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1021\/jo9804700","article-title":"Synthesis of (\u00b1)-allocyathin B and (+)-erinacine A","volume":"63","author":"Snider","year":"1998","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib132","doi-asserted-by":"crossref","DOI":"10.5586\/am.1069","article-title":"Biology, cultivation, and medicinal functions of the mushroom Hericium erinaceum","volume":"50","author":"Sok\u00f3\u0142","year":"2016","journal-title":"Acta Mycol."},{"key":"10.1016\/j.jep.2023.117353_bib133","volume":"vol. I","author":"State Pharmacopoeia Committee","year":"2020"},{"key":"10.1016\/j.jep.2023.117353_bib134","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1021\/ol0059753","article-title":"Synthesis of the tricyclic skeleton of cyathins using Brook rearrangement-mediated 3+4 annulation","volume":"2","author":"Takeda","year":"2000","journal-title":"Org. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib135","series-title":"Study on Chemical Constituents of Hericium erinaceus Grown in Sichuan","author":"Tang","year":"2021"},{"key":"10.1016\/j.jep.2023.117353_bib136","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11557-015-1105-4","article-title":"Hericium erinaceus, an amazing medicinal mushroom","volume":"14","author":"Thongbai","year":"2015","journal-title":"Mycol. Prog."},{"key":"10.1016\/j.jep.2023.117353_bib137","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1271\/bbb.90279","article-title":"Endoplasmic reticulum (ER) stress-suppressive compounds from scrap cultivation beds of the mushroom Hericium erinaceum","volume":"73","author":"Ueda","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2023.117353_bib138","doi-asserted-by":"crossref","first-page":"9467","DOI":"10.1016\/j.bmc.2008.09.044","article-title":"An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum","volume":"16","author":"Ueda","year":"2008","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib139","series-title":"New Derivatives of Phthalaldehyde, Process for Their Preparation and Their Use","author":"V\u00e9rtesy Laszlo","year":"1998"},{"key":"10.1016\/j.jep.2023.117353_bib140","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1021\/acs.joc.2c01096","article-title":"Total synthesis of isohericerinol A and its analogues to access their potential neurotrophic effects","volume":"87","author":"Vishwanath","year":"2022","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib141","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.3390\/molecules24183317","article-title":"Anti-inflammatory effect of erinacine C on no production through down-regulation of NF-\u03baB and activation of Nrf2-mediated HO-1 in BV2 microglial cells treated with LPS","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.117353_bib142","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1080\/10408398.2018.1521370","article-title":"Recent developments in Hericium erinaceus polysaccharides: extraction, purification, structural characteristics and biological activities","volume":"59","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2023.117353_bib143","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/10286020.2016.1183653","article-title":"Three new isobenzofuranone derivatives from the fruiting bodies of Hericium erinaceus","volume":"19","author":"Wang","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.jep.2023.117353_bib144","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.fitote.2016.04.010","article-title":"New isoindolinones from the fruiting bodies of Hericium erinaceum","volume":"111","author":"Wang","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2023.117353_bib145","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.1016\/j.tet.2015.10.068","article-title":"Eight new alkaloids with PTP1B and alpha-glucosidase inhibitory activities from the medicinal mushroom Hericium erinaceus","volume":"71","author":"Wang","year":"2015","journal-title":"Tetrahedron"},{"key":"10.1016\/j.jep.2023.117353_bib146","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/np5004388","article-title":"Erinacerins C\u2013L, isoindolin-1-ones with alpha-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus","volume":"78","author":"Wang","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2023.117353_bib147","first-page":"553","article-title":"A review of research on the active secondary metabolites of Hericium species","volume":"34","author":"Wang","year":"2015","journal-title":"Mycosystema"},{"key":"10.1016\/j.jep.2023.117353_bib148","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1039\/C4FO00511B","article-title":"Hericium erinaceus (Yamabushitake): a unique resource for developing functional foods and medicines","volume":"5","author":"Wang","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.117353_bib149","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbrc.2004.07.075","article-title":"A new laccase from dried fruiting bodies of the monkey head mushroom Hericium erinaceum","volume":"322","author":"Wang","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2023.117353_bib150","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1021\/ja7102795","article-title":"Biomimetic total synthesis of (-)-erinacine","volume":"130","author":"Watanabe","year":"2008","journal-title":"E. J. Am. Chem. Soc."},{"key":"10.1016\/j.jep.2023.117353_bib151","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1021\/ol0628816","article-title":"Enantioselective total synthesis of (-)-erinacine","volume":"9","author":"Watanabe","year":"2007","journal-title":"B. Org. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/acph-2021-0007","article-title":"The use of Hericium erinaceus and trametes versicolor extracts in supportive treatment in oncology","volume":"71","author":"Winder","year":"2021","journal-title":"Acta Pharm."},{"key":"10.1016\/j.jep.2023.117353_bib153","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1021\/acs.jnatprod.6b00371","article-title":"Corallocins A\u2013C, nerve growth and brain-derived neurotrophic factor inducing metabolites from the mushroom Hericium coralloides","volume":"79","author":"Wittstein","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2023.117353_bib154","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1615\/IntJMedMushr.v14.i5.10","article-title":"Neuroregenerative potential of Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher basidiomycetes), in the treatment of peripheral nerve injury","volume":"14","author":"Wong","year":"2012","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.jep.2023.117353_bib155","doi-asserted-by":"crossref","DOI":"10.1093\/ecam\/neq062","article-title":"Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)","author":"Wong","year":"2011","journal-title":"Evid. Based Complementary Altern. Med."},{"key":"10.1016\/j.jep.2023.117353_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.12.005","article-title":"The protective effect of erinacine A-enriched Hericium erinaceus mycelium ethanol extract on oxidative Stress-Induced neurotoxicity in cell and Drosophila models of spinocerebellar ataxia type 3","volume":"195","author":"Wu","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2023.117353_bib157","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1021\/acs.jafc.8b06050","article-title":"Erinachromanes A and B and erinaphenol A from the culture broth of Hericium erinaceus","volume":"67","author":"Wu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.117353_bib158","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1021\/np500623s","article-title":"Erinaceolactones A to C, from the culture broth of Hericium erinaceus","volume":"78","author":"Wu","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2023.117353_bib159","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.3390\/molecules27072157","article-title":"Secondary metabolites from Hericium erinaceus and their anti-inflammatory activities","volume":"27","author":"Xie","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.117353_bib160","article-title":"Flavonoids intake and risk of type 2 diabetes mellitus: a meta-analysis of prospective cohort studies","volume":"97","author":"Xu","year":"2018","journal-title":"Medicine"},{"key":"10.1016\/j.jep.2023.117353_bib161","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1021\/ol401187b","article-title":"Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans","volume":"15","author":"Yaegashi","year":"2013","journal-title":"Org. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib162","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.3390\/nu14183721","article-title":"Polysaccharides from Hericium erinaceus fruiting bodies: structural characterization, immunomodulatory activity and mechanism","volume":"14","author":"Yang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2023.117353_bib163","first-page":"1","article-title":"Rapid identification of chemical constituents in Hericium erinaceus based on LC-MS\/MS metabolomics","author":"Yang","year":"2021","journal-title":"J. Food Qual."},{"key":"10.1016\/j.jep.2023.117353_bib164","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1002\/anie.201700565","article-title":"Discovery and characterization of a new family of diterpene cyclases in bacteria and fungi","volume":"56","author":"Yang","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jep.2023.117353_bib165","first-page":"85","article-title":"Structural properties of polysaccharides for the mycelium of Hericium caput-medusae","volume":"11","author":"Yang","year":"2013","journal-title":"J. Fungal Res."},{"key":"10.1016\/j.jep.2023.117353_bib166","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1271\/bbb.67.1292","article-title":"Hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus","volume":"67","author":"Yang","year":"2003","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2023.117353_bib167","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.3390\/cells11152284","article-title":"The monkey head mushroom and memory enhancement in Alzheimer's disease","volume":"11","author":"Yanshree","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jep.2023.117353_bib168","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1615\/IntJMedMushrooms.2021037646","article-title":"Evaluation of in vitro antioxidant and antihyperglycemic activities of extracts from the Lion's Mane medicinal mushroom, Hericium erinaceus (Agaricomycetes)","volume":"23","author":"Yao","year":"2021","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.jep.2023.117353_bib169","first-page":"1202","article-title":"Two new aromatic compounds from Hericium erinaceum","volume":"53","author":"Yaoita","year":"2005","journal-title":"Bull. (Arch. Am. Art): FR.) PERS. Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.jep.2023.117353_bib170","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1745-7254.2007.00577.x","article-title":"Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes","volume":"28","author":"Yim","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2023.117353_bib171","first-page":"111","article-title":"Study on chemical constituents of Hericium erinaceus culture","volume":"12","author":"Yu","year":"2014","journal-title":"J. fungal Res."},{"key":"10.1016\/j.jep.2023.117353_bib172","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.ijbiomac.2018.05.169","article-title":"Structural characterization of a novel glycoprotein in wheat germ and its physicochemical properties","volume":"117","author":"Yun","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.117353_bib173","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijbiomac.2015.01.060","article-title":"Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis","volume":"76","author":"Zan","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.117353_bib174","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.2174\/1871520620666200804104243","article-title":"Erinacerins, Novel glioma inhibitors from Hericium erinaceus, induce apoptosis of u87 cells through Bax\/Capase-2 pathway","volume":"20","author":"Zhang","year":"2020","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.jep.2023.117353_bib175","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41429-018-0065-8","article-title":"Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus","volume":"71","author":"Zhang","year":"2018","journal-title":"J. Antibiot."},{"key":"10.1016\/j.jep.2023.117353_bib176","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3390\/ijms18081659","article-title":"Chemical constituents from Hericium erinaceus promote neuronal survival and potentiate neurite outgrowth via the TrkA\/Erk1\/2 pathway","volume":"18","author":"Zhang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117353_bib177","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.3390\/ijms17111810","article-title":"The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 Cells and an Alzheimer's disease mouse model","volume":"17","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117353_bib178","series-title":"Chemical Constituents of Hericium erinaceus","author":"Zhang","year":"2016"},{"key":"10.1016\/j.jep.2023.117353_bib179","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1016\/j.bmcl.2015.10.016","article-title":"Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells","volume":"25","author":"Zhang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib180","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phytol.2014.12.011","article-title":"A new diterpene from the fungal mycelia of Hericium erinaceus","volume":"11","author":"Zhang","year":"2015","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2023.117353_bib181","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.ijbiomac.2012.09.002","article-title":"Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey","volume":"51","author":"Zhang","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.117353_bib182","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41429-020-0303-8","article-title":"A concise total synthesis and PPAR activation activity of hericerin from Hericium erinaceum","volume":"73","author":"Zheng","year":"2020","journal-title":"J. Antibiot."},{"key":"10.1016\/j.jep.2023.117353_bib183","first-page":"1703","article-title":"Chemical components from surface liquid fermented Hericium erinaceus with cytotoxity investigations","volume":"24","author":"Zheng","year":"2012","journal-title":"Nat. Prod. Res. Dev."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123012230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123012230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:46:29Z","timestamp":1759945589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123012230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":179,"alternative-id":["S0378874123012230"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117353","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117353"}}