{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:06:13Z","timestamp":1791770773890,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305204"],"award-info":[{"award-number":["82305204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2022E012XB"],"award-info":[{"award-number":["CI2022E012XB"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["2022s481"],"award-info":[{"award-number":["2022s481"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZZ16-YQ-021"],"award-info":[{"award-number":["ZZ16-YQ-021"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005893","name":"China Academy of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jep.2023.117371","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:42:04Z","timestamp":1700250124000},"page":"117371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["Zishen Tongyang Huoxue decoction (TYHX) alleviates sinoatrial node cell ischemia\/reperfusion injury by directing mitochondrial quality control via the VDAC1\u2013\u03b2-tubulin signaling axis"],"prefix":"10.1016","volume":"320","author":[{"given":"Xing","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanke","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaomin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117371_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100940","article-title":"Mitochondria in the signaling pathways that control longevity and health span","volume":"54","author":"Akbari","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jep.2023.117371_bib2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.1136985","article-title":"An ATP gate controls tubulin binding by the tethered head of kinesin-1","volume":"316","author":"Alonso","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jep.2023.117371_bib3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s13045-020-00993-0","article-title":"Blocking of Transient Receptor Potential Vanilloid 1 (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein response","volume":"13","author":"Beider","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jep.2023.117371_bib4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1089\/ars.2022.0126","article-title":"Long COVID-19 and the heart: is cardiac mitochondria the missing link?","volume":"38","author":"Chang","year":"2023","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2023.117371_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155313","article-title":"Mitochondrial quality control mechanisms as molecular targets in diabetic heart","volume":"137","author":"Chang","year":"2022","journal-title":"Metabolism"},{"key":"10.1016\/j.jep.2023.117371_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154502","article-title":"ss-tubulin contributes to Tongyang Huoxue decoction-induced protection against hypoxia\/reoxygenation-induced injury of sinoatrial node cells through SIRT1-mediated regulation of mitochondrial quality surveillance","volume":"108","author":"Chang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117371_bib7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.7150\/ijbs.76223","article-title":"Molecular mechanisms of mitochondrial quality control in ischemic cardiomyopathy","volume":"19","author":"Chang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2023.117371_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104260","article-title":"Therapeutic strategies in ischemic cardiomyopathy: focus on mitochondrial quality surveillance","volume":"84","author":"Chang","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jep.2023.117371_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3154501","article-title":"Tongyang Huoxue decoction (TYHX) ameliorating hypoxia\/reoxygenation-induced disequilibrium of calcium homeostasis and redox imbalance via regulating mitochondrial quality control in sinoatrial node cells","volume":"2021","author":"Chang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2023.117371_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5529913","article-title":"Quercetin improves cardiomyocyte vulnerability to hypoxia by regulating SIRT1\/TMBIM6-related mitophagy and endoplasmic reticulum stress","volume":"2021","author":"Chang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2023.117371_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5876841","article-title":"SIRT5-Related desuccinylation modification contributes to quercetin-induced protection against heart failure and high-glucose-prompted cardiomyocytes injured through regulation of mitochondrial quality surveillance","volume":"2021","author":"Chang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2023.117371_bib12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41419-022-04755-3","article-title":"VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway","volume":"13","author":"de Sousa","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2023.117371_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153933","article-title":"Perfluorooctane sulfonate induces mitochondrial calcium overload and early hepatic insulin resistance via autophagy\/detyrosinated alpha-tubulin-regulated IP3R2-VDAC1-MICU1 interaction","volume":"825","author":"Dong","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jep.2023.117371_bib14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jacc.2014.05.029","article-title":"Sick sinus syndrome: synopsis","volume":"64","author":"Ewy","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2023.117371_bib15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jep.2023.117371_bib16","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1016\/j.cell.2022.11.014","article-title":"Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC\/CCT","volume":"185","author":"Gestaut","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jep.2023.117371_bib17","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s42003-022-03848-1","article-title":"Mitochondrial Ca(2+) uptake by the MCU facilitates pyramidal neuron excitability and metabolism during action potential firing","volume":"5","author":"Groten","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jep.2023.117371_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/cells11193174","article-title":"Mitochondrial VDAC1: a potential therapeutic target of inflammation-related diseases and clinical opportunities","volume":"11","author":"Hu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jep.2023.117371_bib19","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1080\/15548627.2020.1841953","article-title":"Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein","volume":"17","author":"Hwang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2023.117371_bib20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1080\/15548627.2022.2069437","article-title":"Autophagy in age-related macular degeneration","volume":"19","author":"Kaarniranta","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2023.117371_bib21","article-title":"betaIII-tubulin overexpression in cancer: causes, consequences, and potential therapies","volume":"1876","author":"Kanakkanthara","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"key":"10.1016\/j.jep.2023.117371_bib22","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nrc2803","article-title":"Microtubules and resistance to tubulin-binding agents","volume":"10","author":"Kavallaris","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jep.2023.117371_bib23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/15548627.2018.1509818","article-title":"Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations","volume":"15","author":"Li","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2023.117371_bib24","article-title":"The role of mitochondrial quality control in anthracycline-induced cardiotoxicity: from bench to bedside","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2023.117371_bib25","article-title":"Effects of yiqi Tongyang on HCN4 protein phosphorylation in damaged rabbit sinoatrial node cells","volume":"2016","author":"Liu","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2023.117371_bib26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Martinez-Reyes","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2023.117371_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tcb.2018.08.003","article-title":"The tubulin detyrosination cycle: function and enzymes","volume":"29","author":"Nieuwenhuis","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jep.2023.117371_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101679","article-title":"Complex interplay between autophagy and oxidative stress in the development of pulmonary disease","volume":"36","author":"Ornatowski","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2023.117371_bib29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41569-018-0059-z","article-title":"Mitochondrial quality control mechanisms as molecular targets in cardiac ageing","volume":"15","author":"Picca","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jep.2023.117371_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells8030239","article-title":"Tubulin betaII and betaIII isoforms as the regulators of VDAC channel permeability in health and disease","volume":"8","author":"Puurand","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jep.2023.117371_bib31","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41569-022-00703-y","article-title":"The role of mitochondrial fission in cardiovascular health and disease","volume":"19","author":"Quiles","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jep.2023.117371_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molmed.2020.08.001","article-title":"Mitochondria as therapeutic targets in transplantation","volume":"27","author":"Saeb-Parsy","year":"2021","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jep.2023.117371_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/biom10111485","article-title":"VDAC1 at the intersection of cell metabolism, apoptosis, and diseases","volume":"10","author":"Shoshan-Barmatz","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2023.117371_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13663","article-title":"A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model","volume":"21","author":"Vijayan","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.jep.2023.117371_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101604","article-title":"MCU (mitochondrial Ca(2+) uniporter) makes the calcium go round","volume":"298","author":"Walters","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2023.117371_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abh1121","article-title":"DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury","volume":"15","author":"Wang","year":"2022","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jep.2023.117371_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102049","article-title":"Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury","volume":"45","author":"Wang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2023.117371_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4114817","article-title":"The effect of the Tongyang Huoxue recipe (TYHX) on the I (to)\/I (Kur) in ischemia\/reperfusion sinoatrial node cells","volume":"2022","author":"Wang","year":"2022","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.jep.2023.117371_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108640","article-title":"VDAC1 regulates mitophagy in NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions","volume":"209","author":"Xie","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jep.2023.117371_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101777","article-title":"Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control","volume":"38","author":"Zhu","year":"2021","journal-title":"Redox Biol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123012412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123012412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:44:07Z","timestamp":1777571047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123012412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":40,"alternative-id":["S0378874123012412"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117371","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zishen Tongyang Huoxue decoction (TYHX) alleviates sinoatrial node cell ischemia\/reperfusion injury by directing mitochondrial quality control via the VDAC1\u2013\u03b2-tubulin signaling axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117371","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117371"}}