{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:58:27Z","timestamp":1792706307812,"version":"4.5.0"},"reference-count":179,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003024","name":"Shanghai Education Development Foundation","doi-asserted-by":"publisher","award":["20CG50"],"award-info":[{"award-number":["20CG50"]}],"id":[{"id":"10.13039\/501100003024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010574","name":"China Academy of Space Technology","doi-asserted-by":"publisher","award":["2020QNRC001"],"award-info":[{"award-number":["2020QNRC001"]}],"id":[{"id":"10.13039\/501100010574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130120"],"award-info":[{"award-number":["82130120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20516"],"award-info":[{"award-number":["U23A20516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jep.2023.117514","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T19:10:15Z","timestamp":1701371415000},"page":"117514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Recent progress on the application of compound formulas of traditional Chinese medicine in clinical trials and basic research in vivo for chronic liver disease"],"prefix":"10.1016","volume":"321","author":[{"given":"Feipeng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117514_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coph.2021.11.003","article-title":"Emerging drugs for the treatment of primary sclerosing cholangitis","volume":"62","author":"Abbas","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.777500","article-title":"Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation","volume":"12","author":"Abdalla","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27228082","article-title":"Effects of sorafenib and quercetin alone or in combination in treating hepatocellular carcinoma: in vitro and in vivo approaches","volume":"27","author":"Abdu","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.117514_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11091645","article-title":"Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma: in vivo & in vitro insights","volume":"11","author":"Abdu","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2023.117514_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.etp.2007.10.008","article-title":"Ketoconazole-induced testicular damage in rats reduced by Gentiana extract","volume":"59","author":"Amin","year":"2008","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.jep.2023.117514_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4236\/jdm.2011.13006","article-title":"Pancreas-protective effects of chlorella in STZ-induced diabetic animal model: insights into the mechanism","volume":"1","author":"Amin","year":"2011","journal-title":"J. Diabetes Mellitus"},{"key":"10.1016\/j.jep.2023.117514_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15164063","article-title":"Combining crocin and sorafenib improves their tumor-inhibiting effects in a rat model of diethylnitrosamine-induced cirrhotic-hepatocellular carcinoma","volume":"15","author":"Awad","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2023.117514_bib9","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jhep.2015.06.031","article-title":"Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'","volume":"63","author":"Beuers","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib10","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.jhep.2011.04.012","article-title":"A major step towards effective treatment evaluation in primary biliary cirrhosis","volume":"55","author":"Beuers","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15153900","article-title":"Steroidal saponins: naturally occurring compounds as inhibitors of the hallmarks of cancer","volume":"15","author":"Bouabdallah","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2023.117514_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13020-021-00559-3","article-title":"Traditional Chinese medicine Lingguizhugan decoction ameliorate HFD-induced hepatic-lipid deposition in mice by inhibiting STING-mediated inflammation in macrophages","volume":"17","author":"Cao","year":"2022","journal-title":"Chin. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2023.117514_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1440-1746.2010.06544.x","article-title":"Chronic hepatitis B in Asia-new insights from the past decade","volume":"26","author":"Chan","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2016.12.013","article-title":"Clinical efficacy of Rong-Yang-Jyh-Gan-Tang on patients with chronic hepatitis C: a double-blinded randomized placebo-controlled crossover study","volume":"196","author":"Chen","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib15","article-title":"Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.117514_bib16","first-page":"23","article-title":"Clinical study on effect of bushen granule combined with marine injection in treating chronic hepatitis B of Gan-shen deficiency with damp-heat syndrome type","volume":"26","author":"Chen","year":"2006","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib17","first-page":"136","article-title":"Efficacy and safety of yanggan jian in hepatitis B virus-related decompensated cirrhosis: a randomized, double-blind, controlled trial","volume":"11","author":"Chen","year":"2023","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.jep.2023.117514_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105849","article-title":"Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis","volume":"172","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2023.117514_bib19","first-page":"276","article-title":"Effects of hypoxia on expression and activity of matrix metalloproteinase-2 in hepatic stellate cell","volume":"8","author":"Chen","year":"2000","journal-title":"Chin. J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib20","article-title":"Dynamical regulation analysis identifies molecular mechanisms of fuzheng-huayu formula against hepatitis B-caused liver cirrhosis","author":"Chen","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib21","article-title":"Efficacy of erzhu jiedu recipe on hepatitis B cirrhosis with hyperalphafetoproteinemia: a randomized, double-blind, placebo-controlled clinical trial","volume":"100","author":"Chen","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.jep.2023.117514_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3322\/caac.21338","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jep.2023.117514_bib23","first-page":"283","article-title":"Antiviral Therapeutic Effects of Bushen Qingtou Prescription to Hepatitis B Virus Carriers with Positive e Antigen","volume":"19","author":"Chen","year":"2013","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.117514_bib24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2023.117514_bib25","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.hbpd.2022.03.007","article-title":"Impact of Fuzheng Huayu tablet on antiviral effect of entecavir in patients with hepatitis B cirrhosis","volume":"21","author":"Cheng","year":"2022","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.jep.2023.117514_bib26","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/imj.14844","article-title":"Erzhu Qinggan Jiedu Recipe improves the clinical outcome of hepatocellular cancer after surgical resection: a case-control retrospective study","volume":"51","author":"Cheng","year":"2021","journal-title":"Intern. Med. J."},{"key":"10.1016\/j.jep.2023.117514_bib27","article-title":"The traditional Chinese formulae Ling-gui-zhu-gan decoction alleviated non-alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules","volume":"19","author":"Dang","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.117514_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jep.2011.04.008","article-title":"A single arm phase II study of a Far-Eastern traditional herbal formulation (sho-sai-ko-to or xiao-chai-hu-tang) in chronic hepatitis C patients","volume":"136","author":"Deng","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jep.2016.06.041","article-title":"Effect of leaf digestion and artemisinin solubility for use in oral consumption of dried Artemisia annua leaves to treat malaria","volume":"190","author":"Desrosiers","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib30","first-page":"921","article-title":"Study on therapeutic mechanisms of Danshen injection in intrahepatic cholestasis of pregnancy","volume":"31","author":"Du","year":"2006","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2023.117514_bib31","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/S0140-6736(18)30300-3","article-title":"Primary sclerosing cholangitis","volume":"391","author":"Dyson","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2023.117514_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116838","article-title":"Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats","volume":"317","author":"Fang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib33","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1080\/17461391.2019.1571114","article-title":"Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): roles of oxidative stress and inflammation","volume":"19","author":"Farzanegi","year":"2019","journal-title":"Eur. J. Sport Sci."},{"key":"10.1016\/j.jep.2023.117514_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11655-010-0019-x","article-title":"Effect of Chinese medicine therapy for strengthening-Pi and nourishing-Shen in preventing lamivudine induced YMDD mutation and its immunologic mechanism","volume":"16","author":"Feng","year":"2010","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117514_bib35","first-page":"290","article-title":"Treatment of early and mid-term primary biliary cirrhosis by Qingying Huoxue Decoction Combined ursodeoxycholic acid: a clinical observation","volume":"35","author":"Fu","year":"2015","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.771459","article-title":"The potential application of Chinese medicine in liver diseases: a new opportunity","volume":"12","author":"Fu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib37","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hep.32314","article-title":"Getting to HBV cure: the promising paths forward","volume":"76","author":"Fung","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117514_bib38","first-page":"2367","article-title":"Prospective randomized controlled study on advanced primary hepatic cancer treated by ganfule prescription","volume":"39","author":"Gao","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2023.117514_bib39","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1046\/j.1432-1033.2003.03952.x","article-title":"Beta-oxidation of fatty acids. A century of discovery","volume":"271","author":"Ghisla","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jep.2023.117514_bib40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.32163","article-title":"Population screening for liver fibrosis: toward early diagnosis and intervention for chronic liver diseases","volume":"75","author":"Gines","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117514_bib41","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gines","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2023.117514_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/534960","article-title":"A randomized controlled study of fuzheng huayu capsule for prevention of esophageal variceal bleeding in patients with liver cirrhosis","author":"Gu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6178358","article-title":"Yinchen Linggui zhugan decoction ameliorates nonalcoholic fatty liver disease in rats by regulating the Nrf2\/ARE signaling pathway","author":"Guo","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib44","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s40265-021-01545-7","article-title":"Cholestatic liver disease: current treatment strategies and new therapeutic agents","volume":"81","author":"Hasegawa","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.jep.2023.117514_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4494099","article-title":"Efficacy and safety of a botanical formula fuzheng huayu for hepatic fibrosis in patients with CHC: results of a phase 2 clinical trial","volume":"2022","author":"Hassanein","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib164","first-page":"246","article-title":"A randomized double-blind placebo-controlled clinical trial on a Chinese herbal formula (invigorating the kidney and the spleen gelatin capsule) in the treatment of chronic hepatitis B virus carriers","volume":"16","author":"He","year":"2010","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.117514_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/961926","article-title":"Efficacy and safety of a Chinese herbal formula (invigorating kidney and strengthening spleen) in chronic hepatitis B virus carrier: results from a multicenter, randomized, double-blind, and placebo-controlled trial","author":"He","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"EASL Clinical Practice Guidelines: the diagnosis and management of patients with primary biliary cholangitis","volume":"67","author":"Hirschfield","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib48","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1136\/gutjnl-2017-315259","article-title":"The British Society of Gastroenterology\/UK-PBC primary biliary cholangitis treatment and management guidelines","volume":"67","author":"Hirschfield","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.jep.2023.117514_bib49","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.11569\/wcjd.v19.i21.2279","article-title":"Influences of liver-soothing and spleen-strengthening traditional Chinese medicine on efficacy and safety of telbivudine in treatment of HBeAg-positive chronic hepatitis B patients","volume":"19","author":"Hu","year":"2011","journal-title":"World Chin. J. Dig."},{"key":"10.1016\/j.jep.2023.117514_bib50","first-page":"93","article-title":"Influences of warming kidney prescription on antiviral therapeutic efficacy and creatine kinase in telbivudine-treated HBeAg-positive chronic hepatitis B patients","volume":"20","author":"Hu","year":"2012","journal-title":"Chin. J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib51","first-page":"530","article-title":"Effect of telbivudine tablet combined jianpi bushen recipe on HBV specific cytotoxic T lymphocyte and HBeAg seroconversion in patients with HBeAg positive chronic hepatitis B","volume":"36","author":"Hua","year":"2016","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib52","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13071-020-04121-2","article-title":"Xiaochaihu decorction relieves liver fibrosis caused by Schistosoma japonicum infection via the HSP47\/TGF-beta pathway","volume":"13","author":"Huang","year":"2020","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.jep.2023.117514_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9030225","article-title":"Complex cell type-specific roles of autophagy in liver fibrosis and cirrhosis","volume":"9","author":"Hung","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.jep.2023.117514_bib54","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.jhep.2022.07.018","article-title":"Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B","volume":"77","author":"Ji","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib55","first-page":"13","article-title":"Clinical study on treatment of alcoholic liver disease by qinggan huoxue recipe","volume":"24","author":"Ji","year":"2004","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8983903","article-title":"Immunomodulatory effects of combination therapy with bushen formula plus entecavir for chronic hepatitis B patients","author":"Ji","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jep.2023.117514_bib57","article-title":"Protective effects and mechanisms of yinchen Linggui zhugan decoction in HFD-induced nonalcoholic fatty liver disease rats based on network pharmacology and experimental verification","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib58","first-page":"1178","article-title":"Clinical observation of Kangshi Daoshui Fuling Decoction in the treatment of water dampness stagnation type alcoholic cirrhosis during decompensation","volume":"37","author":"Kang","year":"2022","journal-title":"China J Tradit Chin Med and Pharmacy"},{"key":"10.1016\/j.jep.2023.117514_bib59","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cld.2018.06.005","article-title":"Autoimmune hepatitis, sclerosing cholangitis, and autoimmune sclerosing cholangitis or overlap syndrome","volume":"22","author":"Kerkar","year":"2018","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.jep.2023.117514_bib60","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib61","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3350\/cmh.2020.0189","article-title":"Recent updates on the management of autoimmune hepatitis","volume":"27","author":"Komori","year":"2021","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib62","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.4254\/wjh.v7.i8.1030","article-title":"Current and future antiviral drug therapies of hepatitis B chronic infection","volume":"7","author":"Koumbi","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113869","article-title":"Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jep.2023.117514_bib64","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jep.2006.07.042","article-title":"Herb medicine Yin-Chen-Hao-Tang ameliorates hepatic fibrosis in bile duct ligation rats","volume":"109","author":"Lee","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib65","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1211\/jpp.59.4.0014","article-title":"Yin-Chen-Hao-Tang ameliorates obstruction-induced hepatic apoptosis in rats","volume":"59","author":"Lee","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.967623","article-title":"Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: a network pharmacology study and in vivo experimental validation","volume":"13","author":"Lei","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112442","article-title":"Advances in anti hepatic fibrotic therapy with Traditional Chinese Medicine herbal formula","volume":"251","author":"Li","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib68","first-page":"1511","article-title":"Diwu Yanggan capsule improving liver histological response for patients with HBeAg-negative chronic hepatitis B: a randomized controlled clinical trial","volume":"10","author":"Li","year":"2018","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.jep.2023.117514_bib69","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/j.gastro.2022.09.027","article-title":"Hepatocyte adenosine kinase promotes excessive fat deposition and liver inflammation","volume":"164","author":"Li","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2023.117514_bib70","first-page":"15","article-title":"Treatment of nonalcoholic steatohepatitis by Jianpi Shugan Recipe: a multi-center, randomized, controlled clinical trial","volume":"34","author":"Li","year":"2014","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib71","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11655-010-0023-1","article-title":"Treatment of non-alcoholic fatty liver disease by Qianggan Capsule","volume":"16","author":"Li","year":"2010","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117514_bib72","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jep.2013.01.038","article-title":"Beneficial therapeutic effect of Chinese herbal Bushen formula on CHB patients with mildly elevated alanine aminotransferase by down-regulating CD4+CD25+T cells","volume":"146","author":"Li","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib73","first-page":"1","article-title":"Burden of cirrhosis and other chronic liver diseases caused by specific etiologies in China, 1990-2016: findings from the global burden of disease study 2016","volume":"33","author":"Li","year":"2020","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.jep.2023.117514_bib74","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1159\/000491891","article-title":"Beneficial effects of bushen formula combined with enticavir on chronic hepatitis B patients with suboptimal response to enticavir by regulating B-cell differentiation","volume":"48","author":"Li","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2023.117514_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152948","article-title":"Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury by inhibiting bile acid-stimulated inflammation in DDC-induced mice","volume":"62","author":"Li","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117514_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114801","article-title":"Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms","volume":"284","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib77","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s12072-020-10097-z","article-title":"Entecavir combining Chinese herbal medicine for HBeAg-positive chronic hepatitis B patients: a randomized, controlled trial","volume":"14","author":"Li","year":"2020","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jep.2023.117514_bib78","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s11655-020-3250-0","article-title":"Adefovir dipivoxil plus Chinese medicine in HBeAg-positive chronic hepatitis B patients: a randomized controlled 48-week trial","volume":"26","author":"Li","year":"2020","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117514_bib79","article-title":"Identifying hepatoprotective mechanism and effective components of Yinchenzhufu decoction in chronic cholestatic liver injury using a comprehensive strategy based on metabolomics, molecular biology, pharmacokinetics, and cytology","volume":"319","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib80","first-page":"666","article-title":"Treatment of HBeAg positive chronic hepatitis B by xiaoyao powder combined with interferon-alpha: a clinical observation","volume":"34","author":"Liang","year":"2014","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib81","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hep.30145","article-title":"Primary biliary cholangitis: 2018 practice guidance from the American association for the study of liver diseases","volume":"69","author":"Lindor","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117514_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114913","article-title":"Anti-hepatocellular carcinoma efficacy of Fuzheng Xiaozheng prescription and its interventional mechanism studies","volume":"285","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib83","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.biopha.2018.06.134","article-title":"Protective effects of Kangxian ruangan capsule against nonalcoholic fatty liver disease fibrosis in rats induced by MCD diet","volume":"108","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117514_bib84","article-title":"Antifibrotic effects of kangxian ruangan capsule on rats with nonalcoholic fatty liver fibrosis and hepatic stellate cells through regulation of TGF-beta and TLR4 signaling pathways","volume":"2021","author":"Liu","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib85","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1089\/acm.2019.0334","article-title":"Fufang Banmao capsule, a traditional Chinese medicinal formulation, enhances the survival of patients with hepatocellular carcinoma and vp3-4 portal vein tumor thrombosis undergoing supportive treatment","volume":"26","author":"Liu","year":"2020","journal-title":"J. Alternative Compl. Med."},{"key":"10.1016\/j.jep.2023.117514_bib86","first-page":"853","article-title":"Experimental study on inhibitory effect of xiaochaihu decoction on duck hepatitis B virus","volume":"20","author":"Liu","year":"2000","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib88","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41571-018-0073-4","article-title":"Molecular therapies and precision medicine for hepatocellular carcinoma","volume":"15","author":"Llovet","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jep.2023.117514_bib89","first-page":"5610","article-title":"Study on protective effect of Chaihu Shugan Powder against liver injury in rats with intrahepatic cholestasis by regulating FXR\/Nrf2\/ARE pathway","volume":"47","author":"Lou","year":"2022","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2023.117514_bib90","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2023.117514_bib91","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/jgh.15329","article-title":"Regional variation and temporal trend of primary biliary cholangitis epidemiology: a systematic review and meta-analysis","volume":"36","author":"Lv","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113834","article-title":"Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment","volume":"155","author":"Ma","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117514_bib93","first-page":"537","article-title":"Sustained efficacy of alpha-interferon therapy combined with Yixuesheng Capsule in treatment of chronic hepatitis B","volume":"37","author":"Mao","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2023.117514_bib94","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/hep.32792","article-title":"Steatosis, HBV-related HCC, cirrhosis, and HBsAg seroclearance: a systematic review and meta-analysis","volume":"77","author":"Mao","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117514_bib95","first-page":"219","article-title":"Effects of lipid based Multiple Micronutrients Supplement on the birth outcome of underweight pre-eclamptic women: a randomized clinical trial","volume":"38","author":"Mohammad","year":"2022","journal-title":"Pakistan J. Med. Sci."},{"key":"10.1016\/j.jep.2023.117514_bib96","doi-asserted-by":"crossref","first-page":"7062","DOI":"10.1038\/s41598-021-86391-z","article-title":"Camel whey protein hydrolysates induced G2\/M cellcycle arrest in human colorectal carcinoma","volume":"11","author":"Murali","year":"2021","journal-title":"Sci. Rep."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2023.117514_bib97","doi-asserted-by":"crossref","first-page":"i59","DOI":"10.1136\/gutjnl-2012-302076","article-title":"Management of HBV- and HCV-induced end stage liver disease","volume":"61","author":"Mutimer","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jep.2023.117514_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11061125","article-title":"Molecular mechanisms behind safranal's toxicity to HepG2 cells from dual omics","volume":"11","author":"Nelson","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2023.117514_bib99","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.2147\/DMSO.S370492","article-title":"Lingguizhugan decoction targets intestinal microbiota and metabolites to reduce insulin resistance in high-fat diet rats","volume":"15","author":"Ning","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.jep.2023.117514_bib100","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12072-017-9799-9","article-title":"Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update","volume":"11","author":"Omata","year":"2017","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jep.2023.117514_bib101","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/hep.31173","article-title":"Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD","volume":"72","author":"Paik","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117514_bib102","first-page":"29","article-title":"Clinical study of qinggan huatan huoxue recipe on the treatment of non-alcoholic steatohepatitis","volume":"32","author":"Pei","year":"2012","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib103","first-page":"176","article-title":"Clinical study on Baihua Xianglian detoxification recipe combined with adefovir dipivoxil in treating HBeAg positive chronic hepatitis","volume":"32","author":"Qiu","year":"2012","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113658","article-title":"Metabolomics analysis delineates the therapeutic effects of Huangqi decoction and astragalosides on alpha-naphthylisothiocyanate (ANIT) -induced cholestasis in rats","volume":"268","author":"Qiu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib105","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00281-022-00940-w","article-title":"Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease","volume":"44","author":"Richardson","year":"2022","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jep.2023.117514_bib106","article-title":"A multi-society Delphi consensus statement on new fatty liver disease nomenclature","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib107","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000000323","article-title":"AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117514_bib108","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/infdis\/jiaa266","article-title":"Synergistic effect of biejia-ruangan on fibrosis regression in patients with chronic hepatitis B treated with entecavir: a multicenter, randomized, double-blind, placebo-controlled trial","volume":"225","author":"Rong","year":"2022","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jep.2023.117514_bib109","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/S0140-6736(15)61412-X","article-title":"Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013","volume":"386","author":"Schweitzer","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2023.117514_bib110","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0140-6736(10)61965-4","article-title":"Primary biliary cirrhosis","volume":"377","author":"Selmi","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2023.117514_bib111","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/jama.2020.2298","article-title":"Nonalcoholic steatohepatitis: a review","volume":"323","author":"Sheka","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jep.2023.117514_bib112","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF02835740","article-title":"Two-year observation of the clinical efficacy in treating chronic hepatitis B Patients with Ganxian recipe and lamivudine","volume":"11","author":"Shen","year":"2005","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117514_bib113","first-page":"116","article-title":"Observation on effect of danxiaoling in supplementary treatment of intrahepatic cholestasis in pregnancy","volume":"22","author":"Shi","year":"2002","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib114","first-page":"1660","article-title":"Clinical observation on xixian erhuang decoction combined with ursodeoxycholic acid for 40 cases of primary biliary cirrhosis","volume":"55","author":"Shi","year":"2014","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2023.117514_bib115","first-page":"181","article-title":"Efficacy of qinggan Qushi huoxue decoction in treatment of nonalcoholic fatty liver","volume":"22","author":"Shi","year":"2016","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.117514_bib116","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1136\/jnnp-2021-326123","article-title":"Wilson's disease: update on pathogenesis, biomarkers and treatments","volume":"92","author":"Shribman","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jep.2023.117514_bib117","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cbi.2011.02.021","article-title":"Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease","volume":"192","author":"Smathers","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2023.117514_bib118","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/709305","article-title":"Therapeutic efficacy of fuzheng-huayu tablet based traditional Chinese medicine syndrome differentiation on hepatitis-B-caused cirrhosis: a multicenter double-blind randomized controlled trail","author":"Song","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib119","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2023.117514_bib120","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5063088","article-title":"Effect of modified xianglian pingwei powder plus glutathione and levofloxacin hydrochloride on patients with liver cirrhosis and positive small intestinal bacterial overgrowth","volume":"2022","author":"Su","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib121","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/453503","article-title":"Metabonomic evaluation of ZHENG differentiation and treatment by fuzhenghuayu tablet in hepatitis-B-caused cirrhosis","author":"Sun","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib122","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib123","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S2468-1253(20)30307-1","article-title":"Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis","volume":"6","author":"Tan","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jep.2023.117514_bib124","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.cgh.2022.06.029","article-title":"Comparative burden of metabolic dysfunction in lean NAFLD vs non-lean NAFLD - a systematic review and meta-analysis","volume":"21","author":"Tang","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib125","first-page":"823","article-title":"Curative effect of Yidu Recipe in treating chronic hepatitis B patients of gan-shen yin-deficiency and damp-heat syndrome type and its influence of T-cell subsets","volume":"30","author":"Tang","year":"2010","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib126","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1177\/147323000903700308","article-title":"Clinical and experimental effectiveness of astragali compound in the treatment of chronic viral hepatitis B","volume":"37","author":"Tang","year":"2009","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.jep.2023.117514_bib127","doi-asserted-by":"crossref","DOI":"10.3390\/nu9090981","article-title":"Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease","volume":"9","author":"Ter Horst","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2023.117514_bib128","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1136\/gutjnl-2020-322362","article-title":"Recent advances in clinical practice: epidemiology of autoimmune liver diseases","volume":"70","author":"Trivedi","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jep.2023.117514_bib129","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bbadis.2017.11.022","article-title":"The pathophysiology of human obstructive cholestasis is mimicked in cholestatic Gold Syrian hamsters","volume":"1864","author":"van Golen","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.jep.2023.117514_bib130","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jhep.2016.09.012","article-title":"Personalized treatment of patients with very early hepatocellular carcinoma","volume":"66","author":"Vitale","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib131","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev-pharmtox-010818-021059","article-title":"Drug therapies for chronic cholestatic liver diseases","volume":"60","author":"Wagner","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2023.117514_bib132","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12944-022-01689-9","article-title":"Danshao Shugan Granule therapy for non-alcoholic fatty liver disease","volume":"21","author":"Wang","year":"2022","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jep.2023.117514_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116053","article-title":"Effects and mechanisms of Xiaochaihu Tang against liver fibrosis: an integration of network pharmacology, molecular docking and experimental validation","volume":"303","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib134","first-page":"121","article-title":"Clinical study of Jiawei xiaochaihutang combined with microwave ablation in treatment of primary hepatocellular carcinoma","volume":"28","author":"Wang","year":"2022","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.117514_bib135","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1210\/er.2019-00034","article-title":"The liver as an endocrine organ-linking NAFLD and insulin resistance","volume":"40","author":"Watt","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jep.2023.117514_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115550","article-title":"Promising traditional Chinese medicine for the treatment of cholestatic liver disease process (cholestasis, hepatitis, liver fibrosis, liver cirrhosis)","volume":"297","author":"Wei","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib137","first-page":"981","article-title":"Mechanism of Gandou Fumu decoction in treating liver fibrosis mice with wilson's disease based on network pharmacology and experimental proof","volume":"41","author":"Wei","year":"2021","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib138","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3748\/wjg.v3.i3.177","article-title":"Analysis of fibronectin, fibronectin receptor and interleukin-1 in patients with cirrhosis treated by the Yanggan Jieyu decoction","volume":"3","author":"Wu","year":"1997","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2023.117514_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112827","article-title":"Rapid action of mechanism investigation of Yixin Ningshen tablet in treating depression by combinatorial use of systems biology and bioinformatics tools","volume":"257","author":"Wu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib140","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3892\/etm.2014.1740","article-title":"Chinese medicinal formula, Qinggan Huoxue Recipe protects rats from alcoholic liver disease via the lipopolysaccharide-Kupffer cell signal conduction pathway","volume":"8","author":"Wu","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2023.117514_bib141","first-page":"1477","article-title":"Clinical observation on the safety and efficacy of ursodeoxycholic acid and fuzheng huayu capsule in the treatment of primary biliary cirrhosis","volume":"32","author":"Wu","year":"2012","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154769","article-title":"beta, beta-Dimethylacrylshikonin potentiates paclitaxel activity, suppresses immune evasion and triple negative breast cancer progression via STAT3Y705 phosphorylation inhibition based on network pharmacology and transcriptomics analysis","volume":"114","author":"Wu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117514_bib143","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0254-6272(17)30076-6","article-title":"Colon hydrotherapy plus Traditional Chinese Medicine to treat non-alcoholic fatty liver disease: a pilot study","volume":"37","author":"Xiao","year":"2017","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2023.117514_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115210","article-title":"Efficacy and safety of AnluoHuaxian pills on chronic hepatitis B with normal or minimally elevated alanine transaminase and early liver fibrosis: a randomized controlled trial","volume":"293","author":"Xiao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2019.03.004","article-title":"Global liver disease burdens and research trends: analysis from a Chinese perspective","volume":"71","author":"Xiao","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib146","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1080\/10717544.2021.1977422","article-title":"Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery","volume":"28","author":"Xie","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jep.2023.117514_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106737","article-title":"Chinese herbal formula ruangan granule enhances the efficacy of entecavir to reverse advanced liver fibrosis\/early cirrhosis in patients with chronic HBV infection: a multicenter, randomized clinical trial","volume":"190","author":"Xing","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2023.117514_bib148","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.3748\/wjg.v26.i30.4501","article-title":"Efficacy of a Chinese herbal formula on hepatitis B e antigen-positive chronic hepatitis B patients","volume":"26","author":"Xing","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2023.117514_bib149","article-title":"Chinese herbal medicine (Chaihu-Huaji decoction) alleviates postembolization syndrome following transcatheter arterial chemoembolization and improves survival in unresectable hepatocellular cancer: a retrospective study","author":"Xu","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib150","first-page":"785","article-title":"Effect of Gandou Decoction IV combined with short-term decoppering therapy with sodium dimercapto-sulphonate on serum indexes of hepatic fibrosis in patients with Wilson' s disease","volume":"27","author":"Xue","year":"2007","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib151","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/cs0990421","article-title":"Effects of the Japanese herbal medicine 'Inchinko-to' (TJ-135) on concanavalin A-induced hepatitis in mice","volume":"99","author":"Yamashiki","year":"2000","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.jep.2023.117514_bib152","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1038\/s41598-017-04536-5","article-title":"Herbal medicine Yinchenhaotang protects against alpha-naphthylisothiocyanate-induced cholestasis in rats","volume":"7","author":"Yan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.117514_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154217","article-title":"Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora","volume":"102","author":"Yan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117514_bib154","first-page":"1632","article-title":"Clinical observation of cholestatic liver disease caused by cytomegalovirus infection treated by lidan mixture: a case report of 120 infants","volume":"32","author":"Yan","year":"2012","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib155","article-title":"Evaluation of the mechanism of modified lingguizhugan decoction in the treatment of nonalcoholic fatty liver disease","volume":"2022","author":"Yang","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib156","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12906-015-0627-2","article-title":"Chlorpromazine-induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin-Chen-Hao-Tang","volume":"15","author":"Yang","year":"2015","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.117514_bib157","first-page":"157","article-title":"Huazhi rougan granule in treating damp-heat accumulation type non-alcoholic fatty liver disease","volume":"21","author":"Yang","year":"2015","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.117514_bib158","doi-asserted-by":"crossref","DOI":"10.1007\/s11655-016-2519-9","article-title":"Effect of Shuanghu Qinggan Granule (1) and Yigan Yiqi Jieyu Granule (1) plus lamivudine on chronic hepatitis B patients: a randomized double-blind placebo-controlled trial","author":"Ye","year":"2016","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117514_bib159","first-page":"3875","article-title":"Clinical analysis of modified Chaiping decoction in treating HBeAg-negative chronic hepatitis B","volume":"41","author":"Ye","year":"2016","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2023.117514_bib160","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3389\/fphar.2018.00510","article-title":"Yinchenhao decoction ameliorates alpha-naphthylisothiocyanate induced intrahepatic cholestasis in rats by regulating phase II metabolic enzymes and transporters","volume":"9","author":"Yi","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib161","first-page":"292","article-title":"Effect of zimian formula combined with ursodeoxycholic acid in treatment of primary biliary cholangitis patients with Gan-shen yin deficiency syndrome: a randomized controlled trial","author":"You","year":"2023","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib162","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117514_bib163","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hep.30254","article-title":"Burden of illness and economic model for patients with nonalcoholic steatohepatitis in the United States","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2023.117514_bib165","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/jgh.12207","article-title":"Bermuda Triangle for the liver: alcohol, obesity, and viral hepatitis","volume":"28","author":"Zakhari","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.117514_bib166","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s12072-019-09984-x","article-title":"Epidemiology and clinical course of primary biliary cholangitis in the Asia-Pacific region: a systematic review and meta-analysis","volume":"13","author":"Zeng","year":"2019","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jep.2023.117514_bib167","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1080\/13880209.2020.1855212","article-title":"Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells","volume":"58","author":"Zhang","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2023.117514_bib168","article-title":"Bushen jianpi formula combined with entecavir for the treatment of HBeAg-negative chronic hepatitis B: a multicenter, randomized, double-blind, placebo-controlled trial","volume":"2022","author":"Zhang","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib169","first-page":"180","article-title":"Effects of entecavir and Shenxian Yiganling combination therapy on patients with HBeAg-positive chronic hepatitis B for 48 weeks","volume":"32","author":"Zhang","year":"2012","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib170","first-page":"123","article-title":"Clinical efficacy of gandouling combined with short-term decoppering on hepatic fibrosis of wilson's disease based on transient elastography","volume":"28","author":"Zhang","year":"2022","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.117514_bib171","article-title":"Effect of WSP, a Chinese herbal formula, on Th17\/treg ratio and HBeAg seroconversion in telbivudine-treated HBeAg-positive chronic hepatitis B patients with high baseline ALT levels (20-30 times the ULN)","author":"Zhang","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib172","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11655-009-0060-6","article-title":"Influence of TCM therapy for supplementing Pi and nourishing Shen on dendritic cell function in patients with chronic hepatitis B treated by lamivudine","volume":"15","author":"Zhang","year":"2009","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117514_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115599","article-title":"Efficacy and safety of Fuzheng Huayu tablet on persistent advanced liver fibrosis following 2 years entecavir treatment: a single arm clinical objective performance criteria trial","volume":"298","author":"Zhao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117514_bib174","first-page":"284","article-title":"Effect of gansu granule on patients with chronic hepatitis B","volume":"19","author":"Zhen","year":"2013","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2023.117514_bib175","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep.31150","article-title":"Epidemiological features of NAFLD from 1999 to 2018 in China","volume":"71","author":"Zhou","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117514_bib176","first-page":"1220","article-title":"Study of xiaozhang recipe combined with lamivudine in treatment of 84 chronic viral hepatitis B patients with compensated liver cirrhosis","volume":"31","author":"Zhou","year":"2011","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib177","doi-asserted-by":"crossref","first-page":"82621","DOI":"10.18632\/oncotarget.19734","article-title":"Lingguizhugan decoction improves non-alcoholic fatty liver disease by altering insulin resistance and lipid metabolism related genes: a whole trancriptome study by RNA-Seq","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2023.117514_bib178","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/620230","article-title":"Lingmao formula combined with entecavir for HBeAg-positive chronic hepatitis B patients with mildly elevated alanine aminotransferase: a multicenter, randomized, double-blind, placebo-controlled trial","author":"Zhu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.117514_bib179","first-page":"1178","article-title":"Effect of compound qizhu granule on cellular immunity of chronic hepatitis B patients","volume":"34","author":"Zhu","year":"2014","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2023.117514_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113544","article-title":"Hepatoprotective effects of Huangqi decoction (Astragali Radix and Glycyrrhizae Radix et Rhizoma) on cholestatic liver injury in mice: involvement of alleviating intestinal microbiota dysbiosis","volume":"267","author":"Zou","year":"2021","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123013843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123013843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:21:05Z","timestamp":1736385665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123013843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":179,"alternative-id":["S0378874123013843"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117514","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent progress on the application of compound formulas of traditional Chinese medicine in clinical trials and basic research in vivo for chronic liver disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117514"}}