{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:45:20Z","timestamp":1790023520635,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jep.2023.117516","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T20:15:52Z","timestamp":1701375352000},"page":"117516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Tianhuang formula ameliorates liver fibrosis by inhibiting CCL2-CCR2 axis and MAPK\/NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"321","author":[{"given":"Tian","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4140-8315","authenticated-orcid":false,"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5671-2460","authenticated-orcid":false,"given":"Xianzhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanle","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duosheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglu","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/hep.26783","article-title":"Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice","volume":"59","author":"Baeck","year":"2014","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/hep.26351","article-title":"C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice","volume":"58","author":"Chu","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117516_bib3","unstructured":"Dan-Zhuo)With integrated Chinese and western medicine. World Chin. Med. 14(3), 771-782.."},{"issue":"6","key":"10.1016\/j.jep.2023.117516_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib5","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jep.2011.09.032","article-title":"Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats","volume":"138","author":"Feng","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2023.117516_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071764","article-title":"Hypoxia, hypoxia-inducible factors and liver fibrosis","volume":"10","author":"Foglia","year":"2021","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.jep.2023.117516_bib7","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.jep.2023.117516_bib8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1142\/S0192415X22500197","article-title":"Notoginsenoside R1, an active compound from Panax notoginseng, inhibits hepatic stellate cell activation and liver fibrosis via MAPK signaling pathway","volume":"50","author":"Gong","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2023.117516_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/534960","article-title":"A randomized controlled study of fuzheng huayu capsule for prevention of esophageal variceal bleeding in patients with liver cirrhosis","volume":"2013","author":"Gu","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"6","key":"10.1016\/j.jep.2023.117516_bib10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11655-017-2811-3","article-title":"Research progress on prevention and treatment of glucolipid metabolic disease with integrated traditional Chinese and Western medicine","volume":"23","author":"Guo","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117516_bib11","series-title":"Specification of Diagnosis and Treatment of Glucolipid Metabolic Disorders","author":"Guo","year":"2019"},{"key":"10.1016\/j.jep.2023.117516_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4494099","article-title":"Efficacy and safety of a botanical formula fuzheng huayu for hepatic fibrosis in patients with CHC: results of a Phase 2 clinical trial","volume":"2022","author":"Hassanein","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2023.117516_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jep.2023.117516_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-\u03baB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1172\/JCI30542","article-title":"Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ","volume":"117","author":"Iredale","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"46","key":"10.1016\/j.jep.2023.117516_bib17","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.3748\/wjg.v12.i46.7413","article-title":"Role of Kupffer cells in the pathogenesis of liver disease","volume":"12","author":"Kolios","year":"2006","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib18","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.29885","article-title":"Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2","volume":"68","author":"Lan","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2023.117516_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.864703","article-title":"Fufang Zhenzhu Tiaozhi capsule prevents intestinal inflammation and barrier disruption in mice with non-alcoholic steatohepatitis","volume":"13","author":"Lan","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2023.117516_bib20","article-title":"Tian-Huang formula, a traditional Chinese medicinal prescription, improves hepatosteatosis and glucose intolerance targeting AKT-SREBP nexus in diet-induced obese rats","volume":"2021","author":"Li","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2023.117516_bib21","article-title":"Traditional Chinese medicine: an important source for discovering candidate agents against hepatic fibrosis","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2023.117516_bib22","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s11655-012-1030-1","article-title":"Fuzheng huayu capsule in the treatment of liver fibrosis: clinical evidence and mechanism of action","volume":"18","author":"Liu","year":"2012","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117516_bib23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1749-8546-4-12","article-title":"Effect of Fuzheng Huayu formula and its actions against liver fibrosis","volume":"4","author":"Liu","year":"2009","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.117516_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13020-019-0270-9","article-title":"Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine","volume":"14","author":"Luo","year":"2019","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.117516_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.984019","article-title":"Tianhuang formula reduces the oxidative stress response of NAFLD by regulating the gut microbiome in mice","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12906-023-04009-5","article-title":"Tianhuang formula regulates adipocyte mitochondrial function by AMPK\/MICU1 pathway in HFD\/STZ-induced T2DM mice","volume":"23","author":"Luo","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"issue":"36","key":"10.1016\/j.jep.2023.117516_bib27","doi-asserted-by":"crossref","first-page":"12956","DOI":"10.3748\/wjg.v20.i36.12956","article-title":"Non-alcoholic fatty liver disease: what the clinician needs to know","volume":"20","author":"Machado","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib28","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2014.06.043","article-title":"Roles for chemokines in liver disease","volume":"147","author":"Marra","year":"2014","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-0040-1708876","article-title":"Hepatic stellate cell-macrophage crosstalk in liver fibrosis and carcinogenesis","volume":"40","author":"Matsuda","year":"2020","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.jep.2023.117516_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108934","article-title":"CD30L is involved in the regulation of the inflammatory response through inducing homing and differentiation of monocytes via CCL2\/CCR2 axis and NF-\u03baB pathway in mice with colitis","volume":"110","author":"Mei","year":"2022","journal-title":"Int. Immunopharm."},{"issue":"5","key":"10.1016\/j.jep.2023.117516_bib31","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.2353\/ajpath.2009.080632","article-title":"Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice","volume":"174","author":"Mitchell","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.jep.2023.117516_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0968-0004(00)01595-4","article-title":"p38 MAP kinases: beyond the stress response","volume":"25","author":"Nebreda","year":"2000","journal-title":"Trends Biochem. Sci."},{"issue":"442","key":"10.1016\/j.jep.2023.117516_bib33","doi-asserted-by":"crossref","first-page":"ra85","DOI":"10.1126\/scisignal.aab2820","article-title":"Negative regulation of NF-\u03baB p65 activity by serine 536 phosphorylation","volume":"9","author":"Prad\u00e8re","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jep.2023.117516_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116419","article-title":"A herbal product inhibits carbon tetrachloride-induced liver fibrosis by suppressing the epidermal growth factor receptor signaling pathway","volume":"311","author":"Qi","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2023.117516_bib35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s13659-018-0176-8","article-title":"Research of Panax spp. in Kunming Institute of botany, CAS","volume":"8","author":"Qiao","year":"2018","journal-title":"Nat. Prod. Bioprospect."},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3748\/wjg.v27.i1.107","article-title":"Correction to \"Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults\"","volume":"27","author":"Rahayu","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2023.117516_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109772","article-title":"Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-\u03baB p65 and MAPK signaling pathways in septic AKI mice","volume":"122","author":"Ren","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2023.117516_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"issue":"1 Suppl. l","key":"10.1016\/j.jep.2023.117516_bib39","article-title":"The carbon tetrachloride model in mice","volume":"49","author":"Scholten","year":"2015","journal-title":"Lab. Anim."},{"issue":"7","key":"10.1016\/j.jep.2023.117516_bib40","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of fibrosis development in nonalcoholic steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib41","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27332","article-title":"Hepatic inflammation and fibrosis: functional links and key pathways","volume":"61","author":"Seki","year":"2015","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib42","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.22952","article-title":"CCR2 promotes hepatic fibrosis in mice","volume":"50","author":"Seki","year":"2009","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jep.2023.117516_bib43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jhep.2019.09.033","article-title":"PSMP\/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target","volume":"72","author":"She","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117516_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8826091","article-title":"Adjuvant fuzheng huayu capsule reduces the incidence of hepatocellular carcinoma in patients with hepatitis B-caused cirrhosis","volume":"2020","author":"Shi","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2023.117516_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111343","article-title":"The traditional Chinese medicine formula Fufang-Zhenzhu-Tiaozhi protects myocardia from injury in diabetic minipigs with coronary heart disease","volume":"137","author":"Song","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.jep.2023.117516_bib46","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2023.117516_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.651664","article-title":"Bergenin monohydrate attenuates inflammatory response via MAPK and NF-\u03baB pathways against Klebsiella pneumonia infection","volume":"12","author":"Tang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2023.117516_bib48","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/hep.26174","article-title":"Liver-specific p38\u03b1 deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice","volume":"57","author":"Tormos","year":"2013","journal-title":"Hepatology"},{"issue":"1 Suppl. l","key":"10.1016\/j.jep.2023.117516_bib49","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.jhep.2015.02.039","article-title":"Hepatic fibrosis: concept to treatment","volume":"62","author":"Trautwein","year":"2015","journal-title":"J. Hepatol."},{"issue":"9930","key":"10.1016\/j.jep.2023.117516_bib50","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.jep.2023.117516_bib51","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib52","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/13880209.2019.1577466","article-title":"Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology","volume":"57","author":"Wang","year":"2019","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2023.117516_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114056","article-title":"Molecular mechanism of Fufang Zhenzhu Tiaozhi capsule in the treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease based on network pharmacology and validation in minipigs","volume":"274","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2023.117516_bib54","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2174\/1871530320666200910105612","article-title":"Berberine as a potential multi-target agent for metabolic diseases: a review of investigations for berberine","volume":"21","author":"Wang","year":"2021","journal-title":"Endocr., Metab. Immune Disord.: Drug Targets"},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1124\/pr.111.005074","article-title":"CC chemokine receptors and chronic inflammation-therapeutic opportunities and pharmacological challenges","volume":"65","author":"White","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jep.2023.117516_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.907921","article-title":"Fuzheng Huayu Recipe and its active compounds inhibited HBeAg production by promoting TOMM34 gene expression in HBV-infected hepatocytes","volume":"13","author":"Xing","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117516_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114545","article-title":"Metaflammation in glucolipid metabolic disorders: pathogenesis and treatment","volume":"161","author":"Xiong","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.jep.2023.117516_bib58","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1142\/S0192415X18500519","article-title":"Panax notoginseng for inflammation-related chronic diseases: a review on the modulations of multiple pathways","volume":"46","author":"Xu","year":"2018","journal-title":"Am. J. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2023.117516_bib59","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12072-021-10138-1","article-title":"Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease","volume":"15","author":"Xu","year":"2021","journal-title":"Hepatol. Int."},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13880209.2019.1687527","article-title":"Effects of Fuzheng Huayu recipe on entecavir pharmacokinetics in normal and dimethylnitrosamine-induced hepatic fibrosis rats","volume":"58","author":"Yang","year":"2020","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib61","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10585-019-09993-y","article-title":"CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway","volume":"37","author":"Yasui","year":"2020","journal-title":"Clin. Exp. Metastasis"},{"issue":"1","key":"10.1016\/j.jep.2023.117516_bib62","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jhep.2014.03.009","article-title":"Traditional Chinese Medicine (TCM) for fibrotic liver disease: hope and hype","volume":"61","author":"Zhang","year":"2014","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.jep.2023.117516_bib63","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jpha.2020.10.001","article-title":"Transformation of berberine to its demethylated metabolites by the CYP51 enzyme in the gut microbiota","volume":"11","author":"Zhang","year":"2021","journal-title":"J. Pharm. Anal."},{"issue":"4","key":"10.1016\/j.jep.2023.117516_bib64","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41419-022-04802-z","article-title":"MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2023.117516_bib65","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.biopha.2018.04.175","article-title":"Hepatoprotective effects of berberine on acetaminophen-induced hepatotoxicity in mice","volume":"103","author":"Zhao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117516_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115599","article-title":"Efficacy and safety of Fuzheng Huayu tablet on persistent advanced liver fibrosis following 2 years entecavir treatment: a single arm clinical objective performance criteria trial","volume":"298","author":"Zhao","year":"2022","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123013867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123013867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:20:35Z","timestamp":1736385635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123013867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":66,"alternative-id":["S0378874123013867"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117516","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tianhuang formula ameliorates liver fibrosis by inhibiting CCL2-CCR2 axis and MAPK\/NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117516"}}