{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:43:55Z","timestamp":1786992235879,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jep.2023.117567","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T19:07:25Z","timestamp":1702926445000},"page":"117567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Shexiang Tongxin dropping pills protect against ischemic stroke-induced cerebral microvascular dysfunction via suppressing TXNIP\/NLRP3 signaling pathway"],"prefix":"10.1016","volume":"322","author":[{"given":"Li","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Kai","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9386-5721","authenticated-orcid":false,"given":"Yong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2023.117567_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10557-019-06901-0","article-title":"Pathophysiology, diagnosis, and management of the No-reflow phenomenon","volume":"33","author":"Allencherril","year":"2019","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.jep.2023.117567_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.913399","article-title":"Efficacy of Shexiang Tongxin dropping pills in a swine model of slow flow","volume":"13","author":"Bai","year":"2022","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2023.117567_bib3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/glia.23232","article-title":"Selective knockout of astrocytic Na+\/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke","volume":"66","author":"Begum","year":"2018","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.jep.2023.117567_bib4","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00018-019-03030-7","article-title":"Tight junction proteins at the blood-brain barrier: far more than claudin-5","volume":"76","author":"Berndt","year":"2019","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"issue":"1","key":"10.1016\/j.jep.2023.117567_bib5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","article-title":"Ischaemic stroke","volume":"5","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"5","key":"10.1016\/j.jep.2023.117567_bib6","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Candelario-Jalil","year":"2022","journal-title":"Stroke"},{"issue":"9","key":"10.1016\/j.jep.2023.117567_bib7","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3390\/ijms17091418","article-title":"Ruscogenin attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP\/NLRP3 inflammasome activation and the MAPK pathway","volume":"17","author":"Cao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2023.117567_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000787","article-title":"A critical role for the vascular endothelium in functional neurovascular coupling in the brain","volume":"3","author":"Chen","year":"2014","journal-title":"J. Am. Heart Assoc."},{"issue":"10","key":"10.1016\/j.jep.2023.117567_bib9","doi-asserted-by":"crossref","first-page":"18597","DOI":"10.3390\/molecules201018597","article-title":"Qualitative and quantitative analysis of the major constituents in Shexiang Tongxin dropping pill by HPLC-Q-TOF-MS\/MS and UPLC-QqQ-MS\/MS","volume":"20","author":"Chen","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.117567_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172418","article-title":"Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K\/Akt\/mTOR signaling pathway in ischemic mice","volume":"856","author":"Chen","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.117567_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116742","article-title":"Shexiang Tongxin Dropping Pill alleviates M1 macrophage polarization-induced inflammation and endothelial dysfunction to reduce coronary microvascular dysfunction via the Dectin-1\/Syk\/IRF5 pathway","volume":"316","author":"Cui","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117567_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154131","article-title":"Berberine alleviates NLRP3 inflammasome induced endothelial junction dysfunction through Ca2+ signalling in inflammatory vascular injury","volume":"101","author":"Dai","year":"2022","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2023.117567_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/cns.12773","article-title":"Acupuncture inhibits TXNIP-associated oxidative stress and inflammation to attenuate cognitive impairment in vascular dementia rats","volume":"24","author":"Du","year":"2018","journal-title":"CNS Neurosci. Ther."},{"issue":"9","key":"10.1016\/j.jep.2023.117567_bib14","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.3390\/antiox9090864","article-title":"Oxidative stress in cardiovascular diseases","volume":"9","author":"Dubois-Deruy","year":"2020","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jep.2023.117567_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108260","article-title":"Neutrophils obstructing brain capillaries are a major cause of No-reflow in ischemic stroke","volume":"33","author":"El Amki","year":"2020","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.jep.2023.117567_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/17474930211065917","article-title":"World stroke organization (WSO): global stroke fact sheet 2022","volume":"17","author":"Feigin","year":"2022","journal-title":"Int. J. Stroke"},{"issue":"10","key":"10.1016\/j.jep.2023.117567_bib17","doi-asserted-by":"crossref","first-page":"5796","DOI":"10.3390\/ijms23105796","article-title":"The development of novel drug treatments for stroke patients: a review","volume":"23","author":"Frank","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117567_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbi.2020.12.009","article-title":"The NLRP3 inflammasome drives inflammation in ischemia\/reperfusion injury after transient middle cerebral artery occlusion in mice","volume":"92","author":"Franke","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jep.2023.117567_bib19","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1093\/eurheartj\/ehab371","article-title":"Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis","volume":"42","author":"Hinterdobler","year":"2021","journal-title":"Eur. Heart J."},{"issue":"8","key":"10.1016\/j.jep.2023.117567_bib20","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1007\/s12035-021-02384-z","article-title":"Verapamil as an adjunct therapy to reduce tPA toxicity in hyperglycemic stroke: implication of TXNIP\/NLRP3 inflammasome","volume":"58","author":"Ismael","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.jep.2023.117567_bib21","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/s41423-019-0318-x","article-title":"Jagged1-mediated myeloid Notch1 signaling activates HSF1\/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury","volume":"17","author":"Jin","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jep.2023.117567_bib22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.redox.2014.05.006","article-title":"Mitochondrial reactive oxygen species: a double edged sword in ischemia\/reperfusion vs preconditioning","volume":"2","author":"Kalogeris","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2023.117567_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12987-020-00182-8","article-title":"Autophagy-mediated occludin degradation contributes to blood-brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models","volume":"17","author":"Kim","year":"2020","journal-title":"Fluids Barriers CNS"},{"issue":"1","key":"10.1016\/j.jep.2023.117567_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12974-020-01942-x","article-title":"Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury","volume":"17","author":"Li","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2023.117567_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113302","article-title":"Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK\/GSK-3 beta","volume":"329","author":"Liu","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2023.117567_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107094","article-title":"Z-Guggulsterone alleviated oxidative stress and inflammation through inhibiting the TXNIP\/NLRP3 axis in ischemic stroke","volume":"89","author":"Liu","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2023.117567_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116731","article-title":"Mailuoning oral liquid attenuates convalescent cerebral ischemia by inhibiting AMPK\/mTOR-associated apoptosis and promoting CREB\/BDNF-mediated neuroprotection","volume":"317","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2023.117567_bib28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00395-014-0415-z","article-title":"TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia\/reperfusion injury","volume":"109","author":"Liu","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.jep.2023.117567_bib29","article-title":"Shexiang Tongxin Dropping Pills promote macrophage Polarization-Induced angiogenesis against coronary microvascular dysfunction via PI3K\/Akt\/mTORC1 Pathway","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"38","key":"10.1016\/j.jep.2023.117567_bib30","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000022126","article-title":"Effect of Shexiang Tongxin dropping pill on stable coronary artery disease patients with normal fractional flow reserve and coronary microvascular disease A study protocol","volume":"99","author":"Lu","year":"2020","journal-title":"Medicine"},{"issue":"3","key":"10.1016\/j.jep.2023.117567_bib31","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.200940168","article-title":"Signaling by ROS drives inflammasome activation","volume":"40","author":"Martinon","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jep.2023.117567_bib32","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1093\/eurheartj\/ehaa857","article-title":"Assessment and pathophysiology of microvascular disease: recent progress and clinical implications","volume":"42","author":"Masi","year":"2021","journal-title":"Eur. Heart J."},{"issue":"8","key":"10.1016\/j.jep.2023.117567_bib33","doi-asserted-by":"crossref","first-page":"E790","DOI":"10.1212\/WNL.0000000000013210","article-title":"Prevalence and significance of impaired microvascular tissue reperfusion despite macrovascular angiographic reperfusion (No-Reflow)","volume":"98","author":"Ng","year":"2022","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.jep.2023.117567_bib34","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jep.2023.117567_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9154295","article-title":"Biomarkers of oxidative stress tethered to cardiovascular diseases","volume":"2022","author":"Panda","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"14","key":"10.1016\/j.jep.2023.117567_bib36","doi-asserted-by":"crossref","first-page":"776","DOI":"10.21037\/atm-22-2770","article-title":"Interleukin-35 attenuates blood-brain barrier dysfunction caused by cerebral ischemia-reperfusion injury through inhibiting brain endothelial cell injury","volume":"10","author":"Qian","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"9","key":"10.1016\/j.jep.2023.117567_bib37","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s41593-021-00904-7","article-title":"Revisiting the neurovascular unit","volume":"24","author":"Schaeffer","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jep.2023.117567_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109572","article-title":"Pelargonic acid vanillylamide and rosuvastatin protect against oxidized low-density lipoprotein-induced endothelial dysfunction by inhibiting the NF-KB\/NLRP3 pathway and improving cell-cell junctions","volume":"345","author":"Sivasinprasasn","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2023.117567_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.641848","article-title":"Tanshinone IIA protects against cerebral ischemia reperfusion injury by regulating microglial activation and polarization via NF-kappa B pathway","volume":"12","author":"Song","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2023.117567_bib40","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s12974-020-01988-x","article-title":"Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia\/reperfusion injury","volume":"17","author":"Sun","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.jep.2023.117567_bib41","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2023.117567_bib42","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ejheart.2006.11.001","article-title":"Cognitive impairment in heart failure: a systematic review of the literature","volume":"9","author":"Vogels","year":"2007","journal-title":"Eur. J. Heart Fail."},{"issue":"3","key":"10.1016\/j.jep.2023.117567_bib43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1474-4422(18)30443-5","article-title":"Global, regional, and national burden of multiple sclerosis 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Wallin","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jep.2023.117567_bib44","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","article-title":"Small vessel disease: mechanisms and clinical implications","volume":"18","author":"Wardlaw","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jep.2023.117567_bib45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jep.2014.11.013","article-title":"Shexiang Tongxin dropping pill attenuates atherosclerotic lesions in ApoE deficient mouse model","volume":"159","author":"Xiong","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117567_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4717258","article-title":"Ezetimibe attenuates oxidative stress and neuroinflammation via the AMPK\/Nrf2\/TXNIP Pathway after MCAO in rats","volume":"2020","author":"Yu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2023.117567_bib47","article-title":"Shexiang Tongxin Dropping Pill protects against chronic heart failure in mice via inhibiting the ERK\/MAPK and TGF-\u03b2 signaling pathways","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117567_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172795","article-title":"Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction","volume":"865","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2023.117567_bib49","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/JLB.3MA0520-582R","article-title":"Aloe emodin relieves Ang II-induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation","volume":"108","author":"Zhang","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jep.2023.117567_bib50","doi-asserted-by":"crossref","first-page":"abn6598","DOI":"10.1126\/science.abn6598","article-title":"Heart-brain connections: phenotypic and genetic insights from magnetic resonance images","volume":"380","author":"Zhao","year":"2023","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jep.2023.117567_bib51","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2023.117567_bib52","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.apsb.2019.02.008","article-title":"Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury","volume":"9","author":"Zhou","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2023.117567_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8868941","article-title":"Classical active ingredients and extracts of Chinese herbal medicines: pharmacokinetics, pharmacodynamics, and molecular mechanisms for ischemic stroke","volume":"2021","author":"Zhu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.jep.2023.117567_bib54","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12951-021-01137-3","article-title":"Hepatic small extracellular vesicles promote microvascular endothelial hyperpermeability during NAFLD via novel-miRNA-7","volume":"19","author":"Zuo","year":"2021","journal-title":"J. Nanobiotechnol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412301437X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412301437X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T03:38:52Z","timestamp":1736307532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412301437X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":54,"alternative-id":["S037887412301437X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117567","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shexiang Tongxin dropping pills protect against ischemic stroke-induced cerebral microvascular dysfunction via suppressing TXNIP\/NLRP3 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117567"}}