{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:50:38Z","timestamp":1793879438169,"version":"4.7.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jep.2023.117570","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T11:59:40Z","timestamp":1702727980000},"page":"117570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Cistanche deserticola improves ovariectomized-induced osteoporosis mainly by regulating lipid metabolism: Insights from serum metabolomics using UPLC\/Q-TOF-MS"],"prefix":"10.1016","volume":"322","author":[{"given":"Jiashan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqian","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117570_bib1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/01.RES.0000216009.68958.e6","article-title":"N-3 atty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-\u03b3 pathways","volume":"98","author":"Abedin","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2023.117570_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101113","article-title":"Potential modulatory mechanisms of action by long-chain polyunsaturated fatty acids on bone cell and chondrocyte metabolism","volume":"83","author":"Abshirini","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jep.2023.117570_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","article-title":"10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension","volume":"5","author":"Bone","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jep.2023.117570_bib4","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2023.117570_bib5","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1073\/pnas.1533207100","article-title":"Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator","volume":"100","author":"Cenci","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jep.2023.117570_bib6","first-page":"2824","article-title":"Determination of the content of mineral elements in Cistanche tubulosa from different areas","volume":"32","author":"Du","year":"2012","journal-title":"Guang Pu Xue Yu Guang Pu Fen Xi"},{"key":"10.1016\/j.jep.2023.117570_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jep.2017.10.015","article-title":"Cistanches Herba: an overview of its chemistry, pharmacology, and pharmacokinetics property","volume":"219","author":"Fu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117570_bib8","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.7150\/ijms.77729","article-title":"DPA promotes hBMSCs osteogenic differentiation by miR-9-5p\/ERK\/ALP signaling pathway","volume":"19","author":"Gao","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.jep.2023.117570_bib9","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1359\/jbmr.2003.18.5.859","article-title":"The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation","volume":"18","author":"Garnero","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2023.117570_bib10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jbmr.5650110307","article-title":"Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis","volume":"11","author":"Garnero","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2023.117570_bib11","doi-asserted-by":"crossref","first-page":"e3159","DOI":"10.1210\/clinem\/dgab146","article-title":"Identification and functional characterization of metabolites for bone mass in peri- and postmenopausal Chinese women","volume":"106","author":"Gong","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jep.2023.117570_bib12","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1373\/clinchem.2016.259085","article-title":"Bone turnover markers in the iagnosis and monitoring of metabolic bone disease","volume":"63","author":"Greenblatt","year":"2017","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jep.2023.117570_bib13","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/jbmr.499","article-title":"Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study","volume":"26","author":"Hans","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2023.117570_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202100883","article-title":"Effects of calcium source, inulin, and lactose on gut\u2010bone associations in an ovarierectomized rat model","volume":"66","author":"He","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2023.117570_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12979-019-0155-x","article-title":"Inflammatory markers and bone health in postmenopausal women: a cross-sectional overview","volume":"16","author":"Ilesanmi-Oyelere","year":"2019","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.jep.2023.117570_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3390\/nu12010261","article-title":"Regulation of skeletal muscle function by amino acids","volume":"12","author":"Kamei","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2023.117570_bib17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/jcm10010108","article-title":"Development of p-coumaric acid analysis in human plasma and its clinical application to PK\/PD study","volume":"10","author":"Kim","year":"2020","journal-title":"JCM"},{"key":"10.1016\/j.jep.2023.117570_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/biof.5520220107","article-title":"Effect of dietary calcium: phosphorus ratio on bone mineralization and intestinal calcium absorption in ovariectomized rats","volume":"22","author":"Koshihara","year":"2004","journal-title":"Biofactors"},{"key":"10.1016\/j.jep.2023.117570_bib19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.phymed.2013.01.001","article-title":"Antiosteoporotic activity of echinacoside in ovariectomized rats","volume":"20","author":"Li","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117570_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cytogfr.2020.02.003","article-title":"The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis","volume":"52","author":"Li","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jep.2023.117570_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110747","article-title":"Beneficial effect of 2\u2019-acetylacteoside on ovariectomized mice via modulating the function of bone resorption","volume":"131","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117570_bib22","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgab492","article-title":"The association of gut microbiota with osteoporosis is mediated by amino acid metabolism: multiomics in a large cohort","volume":"106","author":"Ling","year":"2021","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.jep.2023.117570_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154399","article-title":"Integration of pharmacodynamics and metabolomics reveals the therapeutic effects of 6-acetylacteoside on ovariectomy-induced osteoporosis mice","volume":"106","author":"Liu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117570_bib24","article-title":"Role of essential amino acids in age-induced bone loss","volume":"23","author":"Lv","year":"2022","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.jep.2023.117570_bib25","article-title":"Metabolomic profiles delineate signature metabolic shifts during estrogen deficiency-induced bone loss in rat by GC-TOF\/MS","volume":"8","author":"Ma","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2023.117570_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41574-020-0339-7","article-title":"A broader strategy for osteoporosis interventions","volume":"16","author":"Reid","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jep.2023.117570_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13333","article-title":"Omega-3 fatty acids in pathological calcification and bone health","volume":"44","author":"Sharma","year":"2020","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.jep.2023.117570_bib28","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/med.21768","article-title":"Cistanches Herba, from an endangered species to a big brand of Chinese medicine","volume":"41","author":"Song","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jep.2023.117570_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prostaglandins.2016.02.001","article-title":"Promotion of adipogenesis by 15-(S)-hydroxyeicosatetraenoic acid","volume":"123","author":"Song","year":"2016","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.jep.2023.117570_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11306-022-01937-0","article-title":"Feature selection approaches identify potential plasma metabolites in postmenopausal osteoporosis patients","volume":"18","author":"Wang","year":"2022","journal-title":"Metabolomics"},{"key":"10.1016\/j.jep.2023.117570_bib31","doi-asserted-by":"crossref","first-page":"5814","DOI":"10.3390\/ijms24065814","article-title":"Hormone-related and drug-induced osteoporosis: a cellular and molecular overview","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117570_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154020","article-title":"Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation","volume":"99","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117570_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104464","article-title":"Cistanche deserticola polysaccharide inhibits OVX-induced bone loss in mice and RANKL-induced osteoclastogenesis","volume":"81","author":"Xiao","year":"2021","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.jep.2023.117570_bib34","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.3390\/ijms20122974","article-title":"Protective effect of acteoside on ovariectomy-induced bone loss in mice","volume":"20","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117570_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijsu.2019.03.004","article-title":"Teriparatide versus bisphosphonates for treatment of postmenopausal osteoporosis: a meta-analysis","volume":"66","author":"Yuan","year":"2019","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.jep.2023.117570_bib36","first-page":"4129","article-title":"Network analysis and experimental verification of Qingyan Formula in treatment of perimenopausal anxiety disorder","volume":"45","author":"Yuan","year":"2020","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2023.117570_bib37","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/jcp.24435","article-title":"BK C a and h E ag1 channels regulate cell proliferation and differentiation in human bone marrow\u2010 D erived mesenchymal stem cells","volume":"229","author":"Zhang","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2023.117570_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113644","article-title":"QingYan formula extracts protect against postmenopausal osteoporosis in ovariectomized rat model via active ER-dependent MEK\/ERK and PI3K\/Akt signal pathways","volume":"268","author":"Zhao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117570_bib39","article-title":"Estrogenic effect of the extract of QingYan formula on reproductive tissues in immature mice","volume":"1\u20138","author":"Zhao","year":"2019","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.117570_bib40","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3109\/09513590.2010.487615","article-title":"Metabolomics in serum of ovariectomised rats and those exposed to 17\u03b2-oestradiol and genistein","volume":"26","author":"Zhu","year":"2010","journal-title":"Gynecol. Endocrinol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412301440X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412301440X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T08:38:45Z","timestamp":1736325525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412301440X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":40,"alternative-id":["S037887412301440X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117570","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cistanche deserticola improves ovariectomized-induced osteoporosis mainly by regulating lipid metabolism: Insights from serum metabolomics using UPLC\/Q-TOF-MS","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117570"}}