{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:43:12Z","timestamp":1788370992556,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jep.2023.117585","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T16:44:18Z","timestamp":1703781858000},"page":"117585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Impact of Codonopsis decoction on cerebral blood flow and cognitive function in rats with chronic cerebral ischemia"],"prefix":"10.1016","volume":"323","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5789-3135","authenticated-orcid":false,"given":"Junlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117585_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13020-022-00602-x","article-title":"Ludangshen oral liquid for treatment of convalescent COVID-19 patients: a randomized, double-blind, placebo-controlled multicenter trial","volume":"17","author":"An","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.117585_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s13659-020-00283-9","article-title":"Anticancer properties of lobetyolin, an essential component of Radix Codonopsis (dangshen)","volume":"11","author":"Bailly","year":"2021","journal-title":"Nat Prod Bioprospect"},{"key":"10.1016\/j.jep.2023.117585_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1142\/S0192415X10007907","article-title":"Dangshen (Codonopsis pilosula) activates IGF-I and FGF-2 pathways to induce proliferation and migration effects in RSC96 Schwann cells","volume":"38","author":"Chen","year":"2010","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2023.117585_bib4","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3233\/JAD-201165","article-title":"Deciphering alzheimer's disease pathogenic pathway: role of chronic brain hypoperfusion on p-tau and mTOR","volume":"79","author":"de la Torre","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.jep.2023.117585_bib5","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1364\/BOE.388856","article-title":"Multifunctional laser speckle imaging","volume":"11","author":"Du","year":"2020","journal-title":"Biomed. Opt Express"},{"key":"10.1016\/j.jep.2023.117585_bib6","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1042\/CS20160727","article-title":"Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia","volume":"131","author":"Duncombe","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.jep.2023.117585_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.trsl.2022.12.003","article-title":"Vascular contributions to Alzheimer's disease","volume":"254","author":"Eisenmenger","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.jep.2023.117585_bib8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/CM9.0000000000001918","article-title":"Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral \u03b2-amyloid deposition and brain atrophy","volume":"135","author":"Fan","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jep.2023.117585_bib9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/CM9.0000000000001918","article-title":"Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral \u03b2-amyloid deposition and brain atrophy","volume":"135","author":"Fan","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jep.2023.117585_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5392966","article-title":"Chronic cerebral hypoperfusion aggravates Parkinson's disease dementia-like symptoms and pathology in 6-OHDA-lesioned rat through interfering with sphingolipid metabolism","volume":"2022","author":"Fan","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2023.117585_bib11","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1007\/s12035-016-0268-6","article-title":"MicroRNA-181c ameliorates cognitive impairment induced by chronic cerebral hypoperfusion in rats","volume":"54","author":"Fang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2023.117585_bib12","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/jcbfm.2015.55","article-title":"Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment","volume":"35","author":"Jing","year":"2015","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.jep.2023.117585_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.580256","article-title":"Striate artery infarct after bilateral carotid artery ligation (BCAL) in a dog: a multimodal MRI Study","volume":"7","author":"Komornik","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.jep.2023.117585_bib14","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2147\/NDT.S205612","article-title":"Ginaton improves neurological function in ischemic stroke rats via inducing autophagy and maintaining mitochondrial homeostasis","volume":"15","author":"Li","year":"2019","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.jep.2023.117585_bib15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12974-021-02234-8","article-title":"Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function","volume":"18","author":"Liu","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2023.117585_bib17","first-page":"563","article-title":"Vascular reserve in chronic cerebral ischemia measured by the acetazolamide challenge test: comparison with positron emission tomography","volume":"16","author":"Nariai","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jep.2023.117585_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijscr.2015.01.021","article-title":"Bilateral external carotid artery ligation: a life saving procedure in severe maxillofacial trauma","volume":"8C","author":"Nasr","year":"2015","journal-title":"Int J Surg Case Rep"},{"key":"10.1016\/j.jep.2023.117585_bib19","article-title":"Morris water maze experiment","volume":"897","author":"Nunez","year":"2008","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jep.2023.117585_bib20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1538\/expanim.21-0120","article-title":"Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory","volume":"71","author":"Othman","year":"2022","journal-title":"Exp. Anim."},{"key":"10.1016\/j.jep.2023.117585_bib21","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1538\/expanim.21-0120","article-title":"Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory","volume":"71","author":"Othman","year":"2022","journal-title":"Exp. Anim."},{"key":"10.1016\/j.jep.2023.117585_bib22","article-title":"Testing spatial and nonspatial learning using a morris water maze","author":"Paul","year":"2007","journal-title":"CSH Protoc"},{"key":"10.1016\/j.jep.2023.117585_bib23","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2744","article-title":"Barnes maze procedure for spatial learning and memory in mice","volume":"8","author":"Pitts","year":"2018","journal-title":"Bio Protoc"},{"key":"10.1016\/j.jep.2023.117585_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115410","article-title":"Effects of Dangshen Yuanzhi Powder on learning ability and gut microflora in rats with memory disorder","volume":"296","author":"Ren","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117585_bib25","doi-asserted-by":"crossref","DOI":"10.3791\/51194-v","article-title":"Barnes maze testing strategies with small and large rodent models","author":"Rosenfeld","year":"2014","journal-title":"J Vis Exp e51194"},{"key":"10.1016\/j.jep.2023.117585_bib26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.5455\/OVJ.2022.v12.i4.7","article-title":"Bilateral asymptomatic common carotid artery stenosis: mouse model for stroke research","volume":"12","author":"Sani","year":"2022","journal-title":"Open Vet. J."},{"key":"10.1016\/j.jep.2023.117585_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0022-510X(02)00302-7","article-title":"Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models","volume":"204","author":"Sarti","year":"2002","journal-title":"J Neurol Sci 203\u2013"},{"key":"10.1016\/j.jep.2023.117585_bib28","first-page":"17235","article-title":"Gingko biloba extract (Ginaton) ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in mice via reducing IL-6\/STAT3 and IL-23\/IL-17","volume":"8","author":"Sun","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.jep.2023.117585_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12987-021-00255-2","article-title":"Reduction in pericyte coverage leads to blood-brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion","volume":"18","author":"Sun","year":"2021","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.jep.2023.117585_bib30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jmri.20686","article-title":"Significance of the perfusion-diffusion mismatch in chronic cerebral ischemia","volume":"24","author":"Surikova","year":"2006","journal-title":"J. Magn. Reson. Imag."},{"key":"10.1016\/j.jep.2023.117585_bib31","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.3390\/ijms20246176","article-title":"Animal models of chronic cerebral hypoperfusion: from mouse to primate","volume":"20","author":"Washida","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117585_bib32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fgene.2014.00088","article-title":"Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models","volume":"5","author":"Webster","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.jep.2023.117585_bib33","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s12264-013-1345-8","article-title":"Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain","volume":"29","author":"Wu","year":"2013","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.jep.2023.117585_bib34","doi-asserted-by":"crossref","first-page":"9522","DOI":"10.18632\/aging.202555","article-title":"EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment","volume":"13","author":"Yao","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jep.2023.117585_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10571-014-0127-9","article-title":"From chronic cerebral hypoperfusion to Alzheimer-like brain pathology and neurodegeneration","volume":"35","author":"Zhao","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jep.2023.117585_bib36","first-page":"1","article-title":"Laser speckle contrast imaging system using nanosecond pulse laser source","volume":"25","author":"Zhao","year":"2020","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.jep.2023.117585_bib37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.sjbs.2015.08.009","article-title":"Comparative pharmacokinetics of a proliposome formulation of Ginkgo biloba extract and Ginaton in rats by a sensitive ultra performance liquid chromatography-tandem mass spectrometry method","volume":"23","author":"Zheng","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.jep.2023.117585_bib38","article-title":"Dangshen erling decoction ameliorates myocardial hypertrophy via inhibiting myocardial inflammation","volume":"12","author":"Zhong","year":"2021","journal-title":"Front. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.jep.2024.118682","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123014551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123014551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T15:32:26Z","timestamp":1725377546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123014551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":37,"alternative-id":["S0378874123014551"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117585","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jep.2024.118682","asserted-by":"object"}]},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of Codonopsis decoction on cerebral blood flow and cognitive function in rats with chronic cerebral ischemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117585","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117585"}}