{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:41:16Z","timestamp":1792690876245,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104974"],"award-info":[{"award-number":["82104974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174471"],"award-info":[{"award-number":["82174471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005983","name":"Department of Trade and Industry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005983","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jep.2023.117620","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T21:45:41Z","timestamp":1703195141000},"page":"117620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Buyang Huanwu Decoction promotes neurovascular remodeling by modulating astrocyte and microglia polarization in ischemic stroke rats"],"prefix":"10.1016","volume":"323","author":[{"given":"Ming-cong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5040-9444","authenticated-orcid":false,"given":"Man-zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-yue","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ming","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-ting","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-yan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.117620_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27123659","article-title":"The ameliorative effect of empagliflozin in vigabatrin-induced cerebellar\/neurobehavioral deficits: targeting mTOR\/AMPK\/SIRT-1 signaling pathways","volume":"27","author":"Amer","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.117620_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1136070","article-title":"Effects of liraglutide on astrocyte polarization and neuroinflammation in Db\/Db mice: focus on iron overload and oxidative stress","volume":"17","author":"An","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2023.117620_bib3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jconrel.2023.11.002","article-title":"Astrocytes and microglia-targeted Danshensu liposomes enhance the therapeutic effects on cerebral ischemia-reperfusion injury","volume":"364","author":"Bai","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jep.2023.117620_bib4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.tins.2020.08.008","article-title":"Immunometabolism in the brain: how metabolism shapes microglial function","volume":"43","author":"Bernier","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jep.2023.117620_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112445","article-title":"Construction of a circRNA-miRNA-mRNA network revealed the potential mechanism of Buyang Huanwu Decoction in the treatment of cerebral ischemia","volume":"145","author":"Chen","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117620_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-021-02187-y","article-title":"Early glycolytic reprogramming controls microglial inflammatory activation","volume":"18","author":"Cheng","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2023.117620_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cells5010012","article-title":"The regulation of NF-kappaB subunits by phosphorylation","volume":"5","author":"Christian","year":"2016","journal-title":"Cells"},{"key":"10.1016\/j.jep.2023.117620_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120383","article-title":"Tyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs","volume":"294","author":"Dai","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2023.117620_bib9","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1159\/000494587","article-title":"Buyang Huanwu decoction attenuates infiltration of natural killer cells and protects against ischemic brain injury","volume":"50","author":"Dou","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2023.117620_bib10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12906-017-1847-4","article-title":"Effects of Bu Shen Yi sui capsule on NogoA\/NgR and its signaling pathways RhoA\/ROCK in mice with experimental autoimmune encephalomyelitis","volume":"17","author":"Fang","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.117620_bib11","article-title":"Magnetic resonance imaging investigation of neuroplasticity after ischemic stroke in tetramethylpyrazine-treated rats","volume":"13","author":"Feng","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1125412","article-title":"Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1\/A2 reactive astrocytes","volume":"17","author":"Feng","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2023.117620_bib13","article-title":"Buyang Huanwu Decoction alleviates blood stasis, platelet activation, and inflammation and regulates the HMGB1\/NF-kappaB pathway in rats with pulmonary fibrosis","volume":"319","author":"Feng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173552","article-title":"Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation","volume":"886","author":"Gan","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12955-021-01728-6","article-title":"Effect of Buyang Huanwu decoction for the rehabilitation of ischemic stroke patients: a meta-analysis of randomized controlled trials","volume":"19","author":"Gao","year":"2021","journal-title":"Health Qual. Life Outcome"},{"key":"10.1016\/j.jep.2023.117620_bib16","doi-asserted-by":"crossref","first-page":"7464","DOI":"10.1038\/s41598-021-86905-9","article-title":"Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease","volume":"11","author":"Grissi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.117620_bib17","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/stem.2628","article-title":"Brief report: Robo1 regulates the migration of human Subventricular zone neural progenitor cells during development","volume":"35","author":"Guerrero-Cazares","year":"2017","journal-title":"Stem Cell."},{"key":"10.1016\/j.jep.2023.117620_bib18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12974-021-02284-y","article-title":"Astrocytic A1\/A2 paradigm participates in glycogen mobilization mediated neuroprotection on reperfusion injury after ischemic stroke","volume":"18","author":"Guo","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2023.117620_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.833431","article-title":"The important double-edged role of astrocytes in neurovascular unit after ischemic stroke","volume":"14","author":"Han","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jep.2023.117620_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/biom12070883","article-title":"Exosomes derived from Bone marrow mesenchymal stem cells promote angiogenesis in ischemic stroke mice via upregulation of MiR-21-5p","volume":"12","author":"Hu","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2023.117620_bib21","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","article-title":"Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia","volume":"43","author":"Hu","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2023.117620_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.589582","article-title":"Lactate transporters mediate Glia-neuron metabolic crosstalk in homeostasis and disease","volume":"14","author":"Jha","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2023.117620_bib23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1073858418783959","article-title":"Microglia-astrocyte crosstalk: an intimate molecular conversation","volume":"25","author":"Jha","year":"2019","journal-title":"Neuroscientist"},{"key":"10.1016\/j.jep.2023.117620_bib24","first-page":"2006","article-title":"Modulators of microglia activation and polarization in ischemic stroke (Review)","volume":"21","author":"Jiang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2023.117620_bib25","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.7150\/thno.25674","article-title":"AMPK: potential therapeutic target for ischemic stroke","volume":"8","author":"Jiang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2023.117620_bib26","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11655-018-2917-7","article-title":"Buyang Huanwu decoction attenuates glial scar by downregulating the expression of leukemia inhibitory factor in intracerebral hemorrhagic rats","volume":"25","author":"Kang","year":"2019","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.117620_bib27","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00424-020-02441-x","article-title":"Glucose transporters in brain in health and disease","volume":"472","author":"Koepsell","year":"2020","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.jep.2023.117620_bib28","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.1007\/s12035-022-03051-7","article-title":"Transcranial direct-current stimulation regulates MCT1-PPA-PTEN-LONP1 signaling to confer neuroprotection after rat cerebral ischemia-reperfusion injury","volume":"59","author":"Kong","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2023.117620_bib29","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.1007\/s12035-018-0933-z","article-title":"Regulatory effects of neuroinflammatory responses through brain-derived neurotrophic factor signaling in microglial cells","volume":"55","author":"Lai","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2023.117620_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107335","article-title":"Astragaloside IV promotes microglia\/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARgamma pathway after cerebral ischemia\/reperfusion injury in rats","volume":"92","author":"Li","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2023.117620_bib31","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3389\/fphys.2019.01528","article-title":"MRI evaluation of axonal remodeling after combination treatment with Xiaoshuan enteric-coated capsule and enriched environment in rats after ischemic stroke","volume":"10","author":"Li","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jep.2023.117620_bib32","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.biopha.2018.04.125","article-title":"Investigation of Ginkgo biloba extract (EGb 761) promotes neurovascular restoration and axonal remodeling after embolic stroke in rat using magnetic resonance imaging and histopathological analysis","volume":"103","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117620_bib33","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3389\/fneur.2018.00581","article-title":"Ultrastructural characteristics of neuronal death and white matter injury in mouse brain tissues after intracerebral hemorrhage: coexistence of ferroptosis, autophagy, and necrosis","volume":"9","author":"Li","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jep.2023.117620_bib34","doi-asserted-by":"crossref","first-page":"10948","DOI":"10.1096\/fj.202000377R","article-title":"Identification of a new functional domain of Nogo-A that promotes inflammatory pain and inhibits neurite growth through binding to NgR1","volume":"34","author":"Liu","year":"2020","journal-title":"Faseb. J."},{"key":"10.1016\/j.jep.2023.117620_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113302","article-title":"Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK\/GSK-3beta","volume":"329","author":"Liu","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2023.117620_bib36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3389\/fimmu.2020.01024","article-title":"Interaction of microglia and astrocytes in the neurovascular Unit","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2023.117620_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.1036380","article-title":"Buyang Huanwu decoction affects gut microbiota and lipid metabolism in a ZDF rat model of co-morbid type 2 diabetes mellitus and obesity: an integrated metabolomics analysis","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.jep.2023.117620_bib38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2023.117620_bib39","article-title":"Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1\/M2 polarization and JAK1\/STAT3 pathway","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib40","article-title":"Combination of fMRI and PET reveals the beneficial effect of three-phase enriched environment on post-stroke memory deficits by enhancing plasticity of brain connectivity between hippocampus and peri-hippocampal cortex","author":"Lu","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jep.2023.117620_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114238","article-title":"Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK\/Akt\/CREB\/BDNF signaling cascades","volume":"159","author":"Mahmoud","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.117620_bib42","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1111\/febs.16151","article-title":"AMPK in the brain: its roles in glucose and neural metabolism","volume":"289","author":"Muraleedharan","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.jep.2023.117620_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108092","article-title":"AMPK-regulated astrocytic lactate shuttle plays a non-cell-autonomous role in neuronal survival","volume":"32","author":"Muraleedharan","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2023.117620_bib44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuropharm.2019.03.026","article-title":"Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression","volume":"150","author":"Odaira","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2023.117620_bib45","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.freeradbiomed.2021.01.015","article-title":"NQO1 mediates the anti-inflammatory effects of nootkatone in lipopolysaccharide-induced neuroinflammation by modulating the AMPK signaling pathway","volume":"164","author":"Park","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2023.117620_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678744","article-title":"Immune cells in the BBB disruption after Acute ischemic stroke: targets for Immune Therapy?","volume":"12","author":"Qiu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2023.117620_bib47","doi-asserted-by":"crossref","first-page":"34538","DOI":"10.1074\/jbc.M504943200","article-title":"Phosphorylation of RelA\/p65 on serine 536 defines an IkappaBalpha-independent NF-kappaB pathway","volume":"280","author":"Sasaki","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2023.117620_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154312","article-title":"An evidence-based evaluation of Buyang Huanwu decoction for the treatment of the sequelae of stroke: a PRISMA-compliant systematic review and meta-analysis of randomized controlled trials","volume":"104","author":"Shao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117620_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113614","article-title":"AMP-activated protein kinase: an energy sensor and survival mechanism in the reinstatement of metabolic homeostasis","volume":"428","author":"Sharma","year":"2023","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2023.117620_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11092587","article-title":"NF-kappaB pathway and its inhibitors: a promising Frontier in the Management of Alzheimer's disease","volume":"11","author":"Sivamaruthi","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2023.117620_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115140","article-title":"Metformin alleviates the cognitive impairment caused by aluminum by improving energy metabolism disorders in mice","volume":"202","author":"Song","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib52","article-title":"Integrating network pharmacology and bioinformatics to explore and experimentally verify the regulatory effect of Buyang Huanwu decoction on glycolysis and angiogenesis after cerebral infarction","volume":"319","author":"Tian","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib53","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1161\/ATVBAHA.122.318559","article-title":"Hypoxia-preconditioned Bone marrow mesenchymal stem cells improved cerebral collateral circulation and stroke outcome in mice","volume":"43","author":"Tian","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jep.2023.117620_bib54","article-title":"Icariin improves learning and memory function in Abeta(1-42)-induced AD mice through regulation of the BDNF-TrkappaB signaling pathway","author":"Wan","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib55","article-title":"Selective targeting of Class I HDAC reduces microglial inflammation in the Entorhinal cortex of Young APP\/PS1 mice","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.117620_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113870","article-title":"Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis","volume":"347","author":"Wang","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2023.117620_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154966","article-title":"Dan-Deng-Tong-Nao softgel capsule promotes angiogenesis of cerebral microvasculature to protect cerebral ischemia reperfusion injury via activating HIF-1alpha-VEGFA-Notch1 signaling pathway","volume":"118","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.117620_bib58","article-title":"Efficacy evaluation of Buyang Huanwu Decoction in the treatment of ischemic stroke in the recovery period: a systematic review of randomized controlled trials","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.980722","article-title":"Microglia-mediated neuroinflammation and neuroplasticity after stroke","volume":"16","author":"Wang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jep.2023.117620_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18429","article-title":"Upregulation of EphA4 deteriorate brain damage by shifting microglia M1-polarization via NF-kappaB signaling after focal cerebral ischemia in rats","volume":"9","author":"Wei","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2023.117620_bib61","article-title":"Gypenoside Pretreatment alleviates the cerebral ischemia injury via inhibiting the microglia-mediated neuroinflammation","author":"Xia","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2023.117620_bib62","article-title":"Buyang Huanwu Decoction alleviates cerebral ischemic injury through modulating caveolin-1-mediated mitochondrial quality control","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib73","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jep.2018.09.028","article-title":"Buyang huanwu decoction combined with BMSCs transplantation promotes recovery after spinal cord injury by rescuing axotomized red nucleus neurons","volume":"228","author":"Yang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114358","article-title":"Trillium tschonoskii rhizomes' saponins induces oligodendrogenesis and axonal reorganization for ischemic stroke recovery in rats","volume":"279","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib64","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1007\/s11064-023-03966-0","article-title":"Astrocyte-neuronal Communication and its role in stroke","volume":"48","author":"Yao","year":"2023","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2023.117620_bib65","article-title":"Experimental evidence of Buyang Huanwu decoction and related modern preparations (Naoxintong capsule and Yangyin Tongnao Granule) in treating cerebral ischemia: Intestinal Microorganisms and Transcriptomics in rats","volume":"2022","author":"Yin","year":"2022","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.117620_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115953","article-title":"Buyang Huanwu decoction alleviates oxidative injury of cerebral ischemia-reperfusion through PKCepsilon\/Nrf2 signaling pathway","volume":"303","author":"Yin","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.117620_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105091","article-title":"The three-phase enriched environment paradigm promotes neurovascular restorative and prevents learning impairment after ischemic stroke in rats","volume":"146","author":"Zhan","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jep.2023.117620_bib68","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3389\/fnins.2019.00701","article-title":"An MRI study of neurovascular restorative after Combination treatment with Xiaoshuan enteric-coated capsule and enriched environment in rats after stroke","volume":"13","author":"Zhan","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jep.2023.117620_bib69","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1177\/0963689718802755","article-title":"Effects of Xiaoshuan enteric-coated capsule on white and Gray Matter injury evaluated by diffusion tensor imaging in ischemic stroke","volume":"28","author":"Zhang","year":"2019","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jep.2023.117620_bib70","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12906-016-1184-z","article-title":"Effects of Xiaoshuan enteric-coated capsule on neurovascular functions assessed by quantitative multiparametric MRI in a rat model of permanent cerebral ischemia","volume":"16","author":"Zhang","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2023.117620_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102089","article-title":"Glucose metabolic crosstalk and regulation in brain function and diseases","volume":"204","author":"Zhang","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jep.2023.117620_bib72","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuint.2014.03.007","article-title":"Cerebral glucose transporter: the possible therapeutic target for ischemic stroke","volume":"70","author":"Zhang","year":"2014","journal-title":"Neurochem. Int."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123014903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123014903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:43:38Z","timestamp":1759945418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123014903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":73,"alternative-id":["S0378874123014903"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.117620","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Buyang Huanwu Decoction promotes neurovascular remodeling by modulating astrocyte and microglia polarization in ischemic stroke rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.117620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117620"}}