{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:12:51Z","timestamp":1792977171516,"version":"4.5.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jep.2024.117787","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T01:18:34Z","timestamp":1705799914000},"page":"117787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Inhibition of ferroptosis: A new direction in the treatment of ulcerative colitis by traditional Chinese medicine"],"prefix":"10.1016","volume":"324","author":[{"given":"Meitong","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5688-3174","authenticated-orcid":false,"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.117787_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1127931","article-title":"Kumatakenin inhibited iron-ferroptosis in epithelial cells from colitis mice by regulating the Eno3-IRP1-axis","volume":"14","author":"Arenbaoligao","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.117787_bib2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41591-020-01183-8","article-title":"Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals","volume":"27","author":"Asnicar","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2024.117787_bib3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.117787_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2024.117787_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000504092","article-title":"Treatment Algorithm for mild and moderate-to-severe ulcerative colitis: an Update","volume":"101","author":"Burri","year":"2020","journal-title":"Digestion"},{"key":"10.1016\/j.jep.2024.117787_bib6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00384-005-0011-7","article-title":"Exacerbation of dextran sulfate sodium-induced colitis by dietary iron supplementation: role of NF-\u03baB","volume":"21","author":"Carrier","year":"2006","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.jep.2024.117787_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2020.06.005","article-title":"Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2\/HO-1 signaling pathway","volume":"225","author":"Chen","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jep.2024.117787_bib8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jep.2024.117787_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174518","article-title":"Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2\/HO-1 pathway","volume":"911","author":"Chen","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2024.117787_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(04)00130-8","article-title":"Structure of the human transferrin receptor-transferrin complex","volume":"116","author":"Cheng","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.117787_bib11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1158\/1940-6207.CAPR-09-0117","article-title":"Resveratrol Suppresses colitis and colon cancer associated with colitis","volume":"3","author":"Cui","year":"2010","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.jep.2024.117787_bib12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1572-0241.2006.00943.x","article-title":"Inflammation and Coagulation in inflammatory bowel disease: the Clot Thickens","volume":"102","author":"Danese","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jep.2024.117787_bib13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.117787_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2024.117787_bib15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.117787_bib16","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.dld.2021.02.011","article-title":"Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway","volume":"53","author":"Dong","year":"2021","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.jep.2024.117787_bib17","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and pathogenesis of ulcerative colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.jep.2024.117787_bib18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/08923973.2015.1021357","article-title":"Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats","volume":"37","author":"El Morsy","year":"2015","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2024.117787_bib19","first-page":"107","article-title":"Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia","volume":"22","author":"Fujii","year":"2003","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jep.2024.117787_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-022-01004-z","article-title":"ACSL4, PUFA, and ferroptosis: new arsenal in anti-tumor immunity","volume":"7","author":"Gan","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2024.117787_bib21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.redox.2015.08.010","article-title":"Calcium and ROS: a mutual interplay","volume":"6","author":"G\u00f6rlach","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2024.117787_bib22","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3390\/ijms21030993","article-title":"Contributions of myosin light chain kinase to regulation of epithelial paracellular permeability and mucosal homeostasis","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.117787_bib23","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2024.117787_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131374","article-title":"Probiotic intervention mitigates the metabolic disturbances of perfluorobutanesulfonate along the gut-liver axis of zebrafish","volume":"284","author":"Hu","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jep.2024.117787_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105444","article-title":"Baicalin and the liver-gut system: pharmacological bases explaining its therapeutic effects","volume":"165","author":"Hu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.117787_bib26","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/jpp\/rgad047","article-title":"Shaoyao Gancao Decoction protects against dextran sulfate sodium-induced ulcerative colitis by down-regulating ferroptosis","volume":"75","author":"Hu","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2024.117787_bib27","first-page":"1","article-title":"Inhibiting ferroptosis: a novel approach for ulcerative colitis therapeutics","volume":"2022","author":"Huang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2024.117787_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214195","article-title":"The impacts of iron overload and ferroptosis on intestinal mucosal homeostasis and inflammation","volume":"23","author":"Huo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.117787_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106013","article-title":"p53: a double-edged sword in tumor ferroptosis","volume":"177","author":"Ji","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.117787_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/9419085","article-title":"Anticolitic effect of berberine in rat experimental model: impact of PGE2\/p38 MAPK pathways","volume":"2020","author":"Jia","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2024.117787_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.117787_bib32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2024.117787_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2018.05.074","article-title":"The tumor suppressor protein p53 and the ferroptosis network","volume":"133","author":"Kang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2024.117787_bib34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10787-016-0305-0","article-title":"Implication of Nrf2\/HO-1 pathway in the coloprotective effect of coenzyme Q10 against experimentally induced ulcerative colitis","volume":"25","author":"Khodir","year":"2017","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2024.117787_bib35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.biopha.2018.11.133","article-title":"Targeting Nrf2\/HO-1 signaling by crocin: role in attenuation of AA-induced ulcerative colitis in rats","volume":"110","author":"Khodir","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.117787_bib36","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3390\/ijms18061284","article-title":"p53 expression as a diagnostic biomarker in ulcerative colitis-associated cancer","volume":"18","author":"Kobayashi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.117787_bib37","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/jgh.14642","article-title":"Association between dietary iron and zinc intake and development of ulcerative colitis: a case\u2013control study in Japan","volume":"34","author":"Kobayashi","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2024.117787_bib38","series-title":"Experimental Study on the Effect of Fenfendrine on Ulcerative Colitis in Rats","author":"Li","year":"2012"},{"key":"10.1016\/j.jep.2024.117787_bib39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.intimp.2016.08.020","article-title":"Luteolin ameliorates dextran sulfate sodium-induced colitis in mice possibly through activation of the Nrf2 signaling pathway","volume":"40","author":"Li","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.117787_bib40","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","article-title":"Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion","volume":"26","author":"Li","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.117787_bib41","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13020-022-00652-1","article-title":"Therapeutic material basis and underling mechanisms of Shaoyao Decoction-exerted alleviation effects of colitis based on GPX4-regulated ferroptosis in epithelial cells","volume":"17","author":"Li","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2024.117787_bib42","first-page":"3865","article-title":"Mechanistic study on iron death-mitochondrial dynamics imbalance in mucosal cells of ulcerative colitis intervened by Radix et Rhizoma Ginseng via PI3K\/Akt","volume":"54","author":"Li","year":"2023","journal-title":"Chinese Herbal Medicine"},{"key":"10.1016\/j.jep.2024.117787_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904197","article-title":"Recent progress in ferroptosis inducers for cancer therapy","volume":"31","author":"Liang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jep.2024.117787_bib45","first-page":"234","article-title":"Effect of coix aconite sauce powder combined with western medicine based on Nrf2 pathway on dextran sulfate sodium salt-induced mucosal repair in colitis in mice","volume":"29","author":"Liang","year":"2021","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine on Digestion"},{"key":"10.1016\/j.jep.2024.117787_bib46","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","article-title":"p53 in ferroptosis regulation: the new weapon for the old guardian","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.117787_bib47","first-page":"214","article-title":"Antioxidant and anti-inflammatory effects of Dendrobium officinale extract on DSS-induced ulcerative colitis in mice","volume":"28","author":"Liu","year":"2019","journal-title":"Chinese Journal of New Drugs"},{"key":"10.1016\/j.jep.2024.117787_bib48","doi-asserted-by":"crossref","first-page":"9470","DOI":"10.1039\/D2FO00945E","article-title":"Prdx6-induced inhibition of ferroptosis in epithelial cells contributes to liquiritin-exerted alleviation of colitis","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2024.117787_bib49","first-page":"4893","article-title":"Research progress in clinical application and pharmacologicaleffect of Yiyi Fuzi Baijiang powder","volume":"48","author":"Liuyi","year":"2023","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2024.117787_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121272","article-title":"ACSF2-mediated ferroptosis is involved in ulcerative colitis","volume":"313","author":"Luo","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2024.117787_bib52","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/ars.2007.1893","article-title":"Intracellular iron transport and storage: from molecular mechanisms to health implications","volume":"10","author":"Mackenzie","year":"2008","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2024.117787_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/1061186X.2017.1339196","article-title":"Targeted-mitochondria antioxidants therapeutic implications in inflammatory bowel disease","volume":"26","author":"Matondo","year":"2018","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jep.2024.117787_bib54","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00060-18","article-title":"Escherichia coli pathobionts associated with inflammatory bowel disease","volume":"32","author":"Mirsepasi-Lauridsen","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jep.2024.117787_bib55","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.3748\/wjg.v27.i23.3317","article-title":"Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?","volume":"27","author":"Nishida","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2024.117787_bib56","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/ng1658","article-title":"Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells","volume":"37","author":"Ohgami","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jep.2024.117787_bib57","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2024.117787_bib58","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1607152113","article-title":"Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses","volume":"113","author":"Ou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jep.2024.117787_bib59","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2024.117787_bib60","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1080\/10408398.2016.1203286","article-title":"Short chain and polyunsaturated fatty acids in host gut health and foodborne bacterial pathogen inhibition","volume":"57","author":"Peng","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2024.117787_bib61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2024.117787_bib62","first-page":"646","article-title":"Effect of fenfencaine regulating Nrf2\/HO-1\/NLRP3 signaling pathway on neuronal injury in depressed rats","volume":"22","author":"Qiu","year":"2023","journal-title":"Journal of Intractable Diseases"},{"key":"10.1016\/j.jep.2024.117787_bib63","article-title":"Low serum Hepcidin levels in patients with ulcerative colitis \u2013 implications for treatment of Co-existent iron-deficiency anemia","author":"Ramasamy","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2024.117787_bib64","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.117787_bib65","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.4049\/jimmunol.1400278","article-title":"Intestinal inflammation modulates expression of the iron-regulating hormone Hepcidin depending on erythropoietic activity and the commensal microbiota","volume":"193","author":"Shanmugam","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2024.117787_bib66","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.biopha.2018.12.033","article-title":"Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-\u03baB and NLRP3 inflammasome","volume":"110","author":"Shen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.117787_bib67","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s11030-018-9878-4","article-title":"A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer's and Parkinson's diseases","volume":"23","author":"Singh","year":"2019","journal-title":"Mol. Divers."},{"key":"10.1016\/j.jep.2024.117787_bib68","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1111\/jam.15504","article-title":"Balancing reactive oxygen species generation by rebooting gut microbiota","volume":"132","author":"Singh","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.jep.2024.117787_bib69","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system Xc\u2013 activity","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jep.2024.117787_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00838","article-title":"The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces","volume":"8","author":"Statovci","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.117787_bib71","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.117787_bib72","first-page":"1","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2024.117787_bib73","first-page":"314","article-title":"Zileuton ameliorates neuronal ferroptosis and functional recovery after spinal cord injury","volume":"29","author":"Sun","year":"2023","journal-title":"Alternative Ther. Health Med."},{"key":"10.1016\/j.jep.2024.117787_bib74","doi-asserted-by":"crossref","first-page":"R1292","DOI":"10.1016\/j.cub.2020.09.068","article-title":"Ferroptosis","volume":"30","author":"Tang","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jep.2024.117787_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119617","article-title":"Oxymatrine loaded nitric oxide-releasing liposomes for the treatment of ulcerative colitis","volume":"586","author":"Tang","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jep.2024.117787_bib76","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.freeradbiomed.2021.06.012","article-title":"Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis","volume":"172","author":"Tang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2024.117787_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/4535194","article-title":"Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies","volume":"2017","author":"Tian","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2024.117787_bib78","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1128\/IAI.00659-16","article-title":"Iron homeostasis regulates the genotoxicity of Escherichia coli that produces colibactin","volume":"84","author":"Tronnet","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jep.2024.117787_bib79","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2024.117787_bib80","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","article-title":"ATF3 promotes erastin-induced ferroptosis by suppressing system Xc","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.117787_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118356","article-title":"Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4","volume":"259","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2024.117787_bib82","doi-asserted-by":"crossref","first-page":"16630","DOI":"10.1021\/acs.jafc.3c05339","article-title":"Phenolics from Dendrobium officinale leaf ameliorate dextran sulfate sodium-induced chronic colitis by regulating gut microbiota and intestinal barrier","volume":"71","author":"Wang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2024.117787_bib83","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13020-023-00819-4","article-title":"Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids","volume":"18","author":"Wang","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2024.117787_bib84","first-page":"17","article-title":"Effects of Scutellaria baicalensis soup on oxidative stress and iron death-related indexes GSH-Px4,P53,SLC7A11 in ulcerative colitis mice","volume":"27","author":"Wu","year":"2021","journal-title":"Chinese Journal of Experimental Formulas"},{"key":"10.1016\/j.jep.2024.117787_bib85","series-title":"Exploring the Mechanism of Curcumin in the Treatment of Ulcerative Colitis Based on Iron Death-Related Signaling Pathway","author":"Xiang","year":"2023"},{"key":"10.1016\/j.jep.2024.117787_bib86","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.117787_bib87","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41419-020-2299-1","article-title":"Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2024.117787_bib88","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.3390\/foods12203800","article-title":"Inhibition of IEC-6 cell proliferation and the mechanism of ulcerative colitis in C57BL\/6 mice by dandelion root polysaccharides","volume":"12","author":"Yan","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.jep.2024.117787_bib89","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.117787_bib90","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.21037\/apm-20-279","article-title":"Geniposide attenuates dextran sulfate sodium-induced colitis in mice via Nrf-2\/HO-1\/NF-\u03baB pathway","volume":"9","author":"Yang","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.jep.2024.117787_bib91","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.3390\/molecules28093775","article-title":"Protocatechuic acid alleviates dextran-sulfate-sodium-induced ulcerative colitis in mice via the regulation of intestinal flora and ferroptosis","volume":"28","author":"Yang","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.117787_bib92","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2263210","article-title":"The influence of microbiota on ferroptosis in intestinal diseases","volume":"15","author":"Yao","year":"2023","journal-title":"Gut Microb."},{"key":"10.1016\/j.jep.2024.117787_bib93","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","article-title":"Identification of ACSL4 as a biomarker and contributor of ferroptosis","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2024.117787_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.01354","article-title":"Huang-lian-jie-du decoction ameliorates acute ulcerative colitis in mice via regulating NF-\u03baB and Nrf2 signaling pathways and enhancing intestinal barrier function","volume":"10","author":"Yuan","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.117787_bib95","first-page":"3585","article-title":"Expert consensus opinion on the diagnosis and treatment of ulcerative colitis in traditional Chinese medicine","volume":"32","author":"Zhang","year":"2017","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"10.1016\/j.jep.2024.117787_bib96","first-page":"671","article-title":"Experimental study of resveratrol inhibiting ulcerative colitis-associated colon cancer in mice by regulating iron death pathway","volume":"52","author":"Zhang","year":"2023","journal-title":"Shaanxi Medical Journal"},{"key":"10.1016\/j.jep.2024.117787_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165678","article-title":"Probiotics ameliorate benzene-induced systemic inflammation and hematopoietic toxicity by inhibiting Bacteroidaceae-mediated ferroptosis","volume":"899","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124000862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124000862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:51:23Z","timestamp":1759945883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124000862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":95,"alternative-id":["S0378874124000862"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.117787","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of ferroptosis: A new direction in the treatment of ulcerative colitis by traditional Chinese medicine","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.117787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117787"}}