{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:06:08Z","timestamp":1772449568165,"version":"3.50.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jep.2024.117807","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T06:50:08Z","timestamp":1706251808000},"page":"117807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["An investigation into the HIF-dependent intestinal barrier protective mechanism of Qingchang Wenzhong decoction in ulcerative colitis management"],"prefix":"10.1016","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0574-0179","authenticated-orcid":false,"given":"Meng-juan","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-nuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1089-3653","authenticated-orcid":false,"given":"Jing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.117807_bib1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3390\/antiox11071323","article-title":"Role of heme oxygenase in gastrointestinal epithelial cells","volume":"11","author":"Akagi","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2024.117807_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1165\/rcmb.2006-0340TR","article-title":"How Many transcription factors Does it Take to turn on the heme oxygenase-1 gene?","volume":"36","author":"Alam","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jep.2024.117807_bib3","article-title":"Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions","volume":"0","author":"Alizadeh","year":"2021","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.jep.2024.117807_bib4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-020-00491-x","article-title":"Regulation of inflammation by the antioxidant haem oxygenase 1","volume":"21","author":"Campbell","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2024.117807_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153132","article-title":"Effects of chlorogenic acid on thermal stress tolerance in C. elegans via HIF-1, HSF-1 and autophagy","volume":"66","author":"Carranza","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.117807_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2022.100145","article-title":"Efficacy of integrated traditional Chinese and Western medicine on ulcerative colitis: a systematic review and meta-analysis","volume":"4","author":"Chen","year":"2022","journal-title":"Pharmacological Research - Modern Chinese Medicine"},{"key":"10.1016\/j.jep.2024.117807_bib7","series-title":"Clinical Effect of Qingchang Wenzhong on the Treatment of Ulcerative Colitis (Master's Thesis)","author":"Cheng","year":"2015"},{"key":"10.1016\/j.jep.2024.117807_bib8","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2147\/JIR.S402395","article-title":"Protective effect of Qingchang Wenzhong decoction on colitis and colitis-related carcinogenesis by regulating inflammation and intestinal Fibrosis","volume":"16","author":"Cheng","year":"2023","journal-title":"JIR"},{"key":"10.1016\/j.jep.2024.117807_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/986075","article-title":"Elevation of HO-1 expression mitigates intestinal ischemia-reperfusion injury and restores tight junction function in a rat Liver Transplantation model","volume":"2015","author":"Chi","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2024.117807_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152864","article-title":"The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-\u03baB and MAPK\/p38 pathways","volume":"58","author":"Fan","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.117807_bib11","doi-asserted-by":"crossref","first-page":"7695","DOI":"10.1002\/jcp.27767","article-title":"Roles of Nrf2\/HO-1 and HIF-1\u03b1\/VEGF in lung tissue injury and repair following cerebral ischemia\/reperfusion injury","volume":"234","author":"Fan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2024.117807_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s13287-022-02945-6","article-title":"FG-4592 protects the intestine from irradiation-induced injury by targeting the TLR4 signaling pathway","volume":"13","author":"Feng","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jep.2024.117807_bib13","doi-asserted-by":"crossref","first-page":"S233","DOI":"10.1513\/AnnalsATS.201608-610MG","article-title":"Epithelial barrier regulation by hypoxia-inducible factor","volume":"14","author":"Glover","year":"2017","journal-title":"Annals ATS"},{"key":"10.1016\/j.jep.2024.117807_bib14","first-page":"192","article-title":"Prolyl hydroxylase inhibition mitigates Pouchitis","volume":"26","author":"Harnoss","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jep.2024.117807_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00109-012-0880-5","article-title":"Nitric oxide signaling in hypoxia","volume":"90","author":"Ho","year":"2012","journal-title":"J Mol Med"},{"key":"10.1016\/j.jep.2024.117807_bib16","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2024.117807_bib17","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI200421086","article-title":"Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis","volume":"114","author":"Karhausen","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2024.117807_bib18","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.chom.2015.03.005","article-title":"Crosstalk between microbiota-derived Short-Chain fatty acids and intestinal epithelial HIF Augments tissue barrier function","volume":"17","author":"Kelly","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jep.2024.117807_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jep.2024.117807_bib20","article-title":"Network pharmacology mechanisms and experimental verification of licorice in the treatment of ulcerative colitis","volume":"117691","author":"Kong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.117807_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910701","article-title":"Chronic and cycling hypoxia: Drivers of cancer chronic inflammation through HIF-1 and NF-\u03baB activation: a review of the molecular mechanisms","volume":"22","author":"Korbecki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.117807_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/2645465","article-title":"Tight junction in the intestinal epithelium: its association with diseases and regulation by Phytochemicals","volume":"2018","author":"Lee","year":"2018","journal-title":"Journal of Immunology Research"},{"key":"10.1016\/j.jep.2024.117807_bib23","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1074\/jbc.272.9.5375","article-title":"Hypoxia-inducible factor-1 Mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia","volume":"272","author":"Lee","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2024.117807_bib24","article-title":"In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin","author":"Li","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2024.117807_bib25","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.foodres.2011.04.010","article-title":"Isolation of quinone reductase (QR) inducing agents from ginger rhizome and their in vitro anti-inflammatory activity","volume":"44","author":"Li","year":"2011","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2024.117807_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.freeradbiomed.2016.03.019","article-title":"Luteolin inhibits viral-induced inflammatory response in RAW264.7 cells via suppression of STAT1\/3 dependent NF-\u03baB and activation of HO-1","volume":"95","author":"Liu","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2024.117807_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111436","article-title":"Luteolin alleviates ochratoxin A induced oxidative stress by regulating Nrf2 and HIF-1\u03b1 pathways in NRK-52E rat kidney cells","volume":"141","author":"Liu","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2024.117807_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115084","article-title":"Potential activity of traditional Chinese medicine against ulcerative colitis: a review","volume":"289","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.117807_bib29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jcmgh.2017.02.004","article-title":"Hypoxia inducible factor (HIF) hydroxylases as regulators of intestinal epithelial barrier function","volume":"3","author":"Manresa","year":"2017","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.jep.2024.117807_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4312538","article-title":"Qingchang Wenzhong decoction ameliorates dextran sulphate sodium-induced ulcerative colitis in rats by Downregulating the IP10\/CXCR3 axis-mediated inflammatory response","volume":"2016","author":"Mao","year":"2016","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2024.117807_bib31","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1172\/JCI126744","article-title":"Epithelial HIF-1\u03b1\/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis","volume":"129","author":"Masterson","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2024.117807_bib32","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/ars.2012.5116","article-title":"The Crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and Endotoxin-Shocked mice","volume":"20","author":"Mo","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2024.117807_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097901","article-title":"Luteolin and Quercetin Affect the Cholesterol absorption mediated by epithelial Cholesterol Transporter Niemann\u2013Pick C1-like 1 in caco-2 cells and rats","volume":"9","author":"Nekohashi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.117807_bib34","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1089\/ars.2007.1683","article-title":"Regulated function of the prolyl-4-hydroxylase domain (PHD) oxygen sensor proteins","volume":"9","author":"Nytko","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jep.2024.117807_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/cmi.2014.89","article-title":"NADPH oxidases: an overview from structure to innate immunity-associated pathologies","volume":"12","author":"Panday","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jep.2024.117807_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117316","article-title":"Kuijie decoction ameliorates ulcerative colitis by affecting intestinal barrier functions, gut microbiota, metabolic pathways and Treg\/Th17 balance in mice","volume":"319","author":"Peng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.117807_bib37","article-title":"Qingchang Wenzhong decoction Prevents the occurrence of intestinal Tumors by regulating intestinal microbiota and Gasdermin","volume":"13","author":"Ren","year":"2022","journal-title":"E. Front. Physiol."},{"key":"10.1016\/j.jep.2024.117807_bib38","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.3390\/ijerph18052262","article-title":"Indol-3-Carbinol and Quercetin ameliorate chronic DSS-induced colitis in C57BL\/6 mice by AhR-mediated anti-inflammatory mechanisms","volume":"18","author":"Riemschneider","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.jep.2024.117807_bib39","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1091\/mbc.E14-07-1194","article-title":"HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity","volume":"26","author":"Saeedi","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jep.2024.117807_bib40","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ibd.21403","article-title":"Importance of disrupted intestinal barrier in inflammatory bowel diseases","volume":"17","author":"Salim","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jep.2024.117807_bib41","doi-asserted-by":"crossref","first-page":"9979","DOI":"10.1002\/jcb.28280","article-title":"The inhibitory effects of Qingchang Wenzhong granule on the interactive network of inflammation, oxidative stress, and apoptosis in rats with dextran sulfate sodium-induced colitis","volume":"120","author":"Shi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2024.117807_bib42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.foodchem.2014.06.100","article-title":"Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL\/6 mice","volume":"168","author":"Shin","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2024.117807_bib43","doi-asserted-by":"crossref","first-page":"682","DOI":"10.5009\/gnl18221","article-title":"Effects of 17beta;-Estradiol on colonic permeability and inflammation in an Azoxymethane\/dextran sulfate sodium-induced colitis mouse model","volume":"12","author":"Song","year":"2018","journal-title":"Gut and Liver"},{"key":"10.1016\/j.jep.2024.117807_bib44","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.3748\/wjg.15.3916","article-title":"Soluble intercellular adhesion molecule-1, D-lactate and diamine oxidase in patients with inflammatory bowel disease","volume":"15","author":"Song","year":"2009","journal-title":"WJG"},{"key":"10.1016\/j.jep.2024.117807_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17980\/2016.1","article-title":"Mechanistic roles of epithelial and immune cell signaling during the development of colitis-associated cancer","volume":"2","author":"Subramaniam","year":"2016","journal-title":"Cancer Res Front"},{"key":"10.1016\/j.jep.2024.117807_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.738152","article-title":"Qingchang Wenzhong decoction Accelerates intestinal mucosal Healing through modulation of Dysregulated gut Microbiome, intestinal barrier and immune responses in mice","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.117807_bib47","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2024.117807_bib48","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbrc.2006.10.025","article-title":"Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase","volume":"351","author":"Tsukiyama","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2024.117807_bib49","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2024.117807_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142481","article-title":"Evolution of Costs of inflammatory bowel disease over two Years of Follow-up","volume":"11","author":"van der Valk","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.117807_bib51","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/path.4861","article-title":"Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis: Haematopoietic Phd1 deficiency protects against colitis","volume":"241","author":"Van Welden","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.jep.2024.117807_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104808","article-title":"Chlorogenic acid supplementation alleviates dextran sulfate sodium (DSS)-induced colitis via inhibiting inflammatory responses and oxidative stress, improving gut barrier integrity and Nrf-2\/HO-1 pathway","volume":"87","author":"Wan","year":"2021","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.jep.2024.117807_bib53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10753-019-01099-7","article-title":"Luteolin Alters macrophage polarization to Inhibit inflammation","volume":"43","author":"Wang","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2024.117807_bib54","series-title":"Clinical Research on the Treatment of Ulcerative Colitis with QingchangWenzhong Decoction (Master's Thesis)","author":"Wei","year":"2014"},{"key":"10.1016\/j.jep.2024.117807_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153743","article-title":"Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1\/NF-\u03baB pathway","volume":"92","author":"Wei","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.117807_bib56","first-page":"802","article-title":"Role of NF-kB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expression","volume":"6","author":"Wijayanti","year":"2004","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2024.117807_bib57","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.117807_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154460","article-title":"Qingchang Wenzhong Decoction reduce ulcerative colitis in mice by inhibiting Th17 lymphocyte differentiation","volume":"107","author":"Xia","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.117807_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106999","article-title":"Network pharmacology based research into the effect and potential mechanism of Portulaca oleracea L. polysaccharide against ulcerative colitis","volume":"161","author":"Yang","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.jep.2024.117807_bib60","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/cbin.11712","article-title":"The role of hypoxia-inducible factor 1-alpha in inflammatory bowel disease","volume":"46","author":"Yin","year":"2022","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.jep.2024.117807_bib61","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/cbin.11336","article-title":"Mutual regulation between butyrate and hypoxia-inducible factor-1\u03b1 in epithelial cell promotes expression of tight junction proteins","volume":"44","author":"Yin","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.jep.2024.117807_bib62","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/cbin.11336","article-title":"Mutual regulation between butyrate and hypoxia\u2010inducible factor\u20101\u03b1 in epithelial cell promotes expression of tight junction proteins","volume":"44","author":"Yin","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.jep.2024.117807_bib63","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1142\/S0192415X16500518","article-title":"Berberine Preconditioning protects Neurons against ischemia via Sphingosine-1-Phosphate and hypoxia-inducible factor-1\u03b1","volume":"44","author":"Zhang","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2024.117807_bib64","first-page":"28","article-title":"The clinical effect of Qingchang Wenzhong Fang in the treatment of ulcerative colitis, as well its impact on patients' intestinal mucosa\u2019 s barrier function","author":"Zhang","year":"2023","journal-title":"Chinese Journal of Coloproctology"},{"key":"10.1016\/j.jep.2024.117807_bib65","article-title":"Qingchang Wenzhong Decoction ameliorates intestinal inflammation and intestinal barrier dysfunction in ulcerative colitis via the GC-C signaling pathway","author":"Zhang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.117807_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2022.994036","article-title":"Integrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activation","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2024.117807_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153519","article-title":"Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17\/Treg cell homeostasis via suppressing IL-6\/JAK2\/STAT3 signaling","volume":"84","author":"Zhao","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.117807_bib68","doi-asserted-by":"crossref","first-page":"26291","DOI":"10.18632\/oncotarget.4657","article-title":"GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK\/FOXO3a pathway","volume":"6","author":"Zhao","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2024.117807_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110075","article-title":"Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: involvement of the Nrf2\/HO-1 signaling and anti-apoptosis role","volume":"126","author":"Zhou","year":"2020","journal-title":"Biomed. Pharmacother."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124001065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124001065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:50:48Z","timestamp":1759945848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124001065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":69,"alternative-id":["S0378874124001065"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.117807","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An investigation into the HIF-dependent intestinal barrier protective mechanism of Qingchang Wenzhong decoction in ulcerative colitis management","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.117807","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117807"}}