{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:41:41Z","timestamp":1768714901531,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006345","name":"Nicolaus Copernicus University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jep.2024.117847","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T21:55:39Z","timestamp":1706824539000},"page":"117847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The Eleutherococcus senticosus fruits' intractum affects changes in the transepithelial electric potential in the distal section of the rabbit's large intestine and inhibits hyaluronidase"],"prefix":"10.1016","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-9338","authenticated-orcid":false,"given":"Filip","family":"Graczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"G\u0119balski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-4993","authenticated-orcid":false,"given":"El\u017cbieta","family":"Piskorska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Ma\u0142kowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"S\u0142omka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Gawenda-Kempczy\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Kondrzycka-D\u0105da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Olszewska-S\u0142onina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Styczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orazio","family":"Taglialatela-Scafati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-1424","authenticated-orcid":false,"given":"Rob","family":"Verpoorte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Za\u0142uski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.117847_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-10-499","article-title":"Involvement of hyaluronidases in colorectal cancer","volume":"10","author":"Bouga","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jep.2024.117847_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.imr.2018.04.002","article-title":"Study of the effect of the herbal composition SR2004 on hemoglobin A1c, fasting blood glucose, and lipids in patients with type 2 diabetes mellitus","volume":"7","author":"Chatterji","year":"2018","journal-title":"Integr. Med. Res."},{"key":"10.1016\/j.jep.2024.117847_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejps.2010.06.010","article-title":"Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate","volume":"41","author":"Dube","year":"2010","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2024.117847_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/1476-9255-3-5","article-title":"Changes in ion transport in inflammatory disease","volume":"3","author":"Eisenhut","year":"2006","journal-title":"J. Inflamm."},{"key":"10.1016\/j.jep.2024.117847_bib5","first-page":"327","article-title":"A critical review to identify the domains used to measure the effect and outcome of adaptogenic herbal medicines","volume":"93","author":"Gerontakos","year":"2020","journal-title":"YJBM"},{"key":"10.1016\/j.jep.2024.117847_bib6","article-title":"Phenolic profile, antioxidant, anti-enzymatic and cytotoxic activity of the fruits and roots of Eleutherococcus senticosus","volume":"27","author":"Graczyk","year":"2022","journal-title":"Rupr. et Maxim.) Maxim. Molecules"},{"key":"10.1016\/j.jep.2024.117847_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113636","article-title":"The intractum from the Eleutherococcus senticosus fruits affects the innate immunity in human leukocytes: from the ethnomedicinal use to contemporary evidence-based research","volume":"268","author":"Graczyk","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.117847_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112939","article-title":"The impact of Morus alba L. leaf extract on intestinal ion transport. An in vitro study","volume":"150","author":"Gryn-Rynko","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.117847_bib9","first-page":"967","article-title":"Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation","volume":"36","author":"Heldin","year":"2003","journal-title":"BJMBR"},{"key":"10.1016\/j.jep.2024.117847_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-33690-2","article-title":"Nickel ions influence the transepithelial sodium transport in the trachea, intestine and skin","volume":"13","author":"Ho\u0142y\u0144ska-Iwan","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.117847_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75275-3","article-title":"Analysis of changes in sodium and chloride ion transport in the skin","volume":"10","author":"Ho\u0142y\u0144ska-Iwan","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jep.2024.117847_bib12","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.3390\/ijms22063204","article-title":"Hyaluronidase in human diseases","volume":"22","author":"Kaul","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.117847_bib13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.17219\/acem\/155111","article-title":"Reduced sodium absorption in the colon under serotonin is a potential factor aggravating secretory diarrhea","volume":"32","author":"Koza","year":"2023","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.jep.2024.117847_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.eururo.2009.03.057","article-title":"HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer","volume":"57","author":"Kramer","year":"2010","journal-title":"Eur. Urol."},{"key":"10.1016\/j.jep.2024.117847_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00026.2001","article-title":"Electrolyte transport in the mammalian colon: mechanisms and implications for disease","volume":"82","author":"Kunzelmann","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2024.117847_bib16","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1158\/0008-5472.CAN-04-2805","article-title":"HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion","volume":"65","author":"Lokeshwar","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2024.117847_bib17","doi-asserted-by":"crossref","first-page":"11922","DOI":"10.1074\/jbc.M008432200","article-title":"Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer","volume":"276","author":"Lokeshwar","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2024.117847_bib18","first-page":"489","article-title":"Effects of amiloride and bumetanide on hyperpolarization after movement across the distal colon epithelium","volume":"57","author":"M\u0142odzik-Danielewicz","year":"2005","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jep.2024.117847_bib19","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/0006-2952(91)90127-Q","article-title":"Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols","volume":"41","author":"Nguyen","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2024.117847_bib20","article-title":"Myths and facts in herbal medicines: Eleutherococcus senticosus (Siberian ginseng) and its contraindication in hypertensive patients","volume":"27","author":"Schmidt","year":"2014","journal-title":"Botanics"},{"key":"10.1016\/j.jep.2024.117847_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113685","article-title":"Medicinal Plants of the 14th edition of the Russian Pharmacopoeia; recent updates","volume":"268","author":"Shikov","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.117847_bib22","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jep.2014.04.007","article-title":"Medicinal Plants of the Russian Pharmacopoeia; their history and applications","volume":"154","author":"Shikov","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"Suppl. 5","key":"10.1016\/j.jep.2024.117847_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.phymed.2006.03.015","article-title":"STW 5 (Iberogast) and its individual herbal components modulate intestinal electrophysiology of mice","volume":"13","author":"Sibaev","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.117847_bib24","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1021\/cr050247k","article-title":"Hyaluronidases: their genomics, structures, and mechanisms of action","volume":"106","author":"Stern","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jep.2024.117847_bib25","first-page":"17","article-title":"Effect of the flavonol quercetin on ion transport in the isolated intestine of the eel, Anguilla anguilla","volume":"143","author":"Trischitta","year":"2006","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.jep.2024.117847_bib26","article-title":"HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro","volume":"3","author":"Wang","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.117847_bib27","first-page":"493","article-title":"Effect of aqueous extract of Anacardium occidentale (L) stem bark on sodium and chloride transport in the rabbit colon","volume":"3","author":"Yusuf","year":"2009","journal-title":"JMPR"},{"key":"10.1016\/j.jep.2024.117847_bib28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1556\/AChrom.22.2010.4.7","article-title":"TLC screening for eleutherosides B, E, and E1, and isofraxidin in the roots of six Eleutherococcus species cultivated in Poland","volume":"22","author":"Za\u0142uski","year":"2010","journal-title":"Acta Chromatogr."},{"key":"10.1016\/j.jep.2024.117847_bib29","first-page":"1","article-title":"Phytochemical content and pharma-nutrition study on Eleutherococcus senticosus fruits intractum","author":"Za\u0142uski","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2024.117847_bib30","series-title":"National Red List Database","year":"2022"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124001466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124001466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:43:44Z","timestamp":1759945424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124001466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":30,"alternative-id":["S0378874124001466"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.117847","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Eleutherococcus senticosus fruits' intractum affects changes in the transepithelial electric potential in the distal section of the rabbit's large intestine and inhibits hyaluronidase","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.117847","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117847"}}