{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:53:55Z","timestamp":1789268035882,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8181101216"],"award-info":[{"award-number":["8181101216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jep.2024.117886","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T02:04:11Z","timestamp":1707703451000},"page":"117886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["PolyphyllinVI alleviates the spared nerve injury-induced neuropathic pain based on P2X3 receptor-mediated the release of inflammatory mediators"],"prefix":"10.1016","volume":"325","author":[{"given":"Mengqin","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-7353","authenticated-orcid":false,"given":"Hekun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-4260","authenticated-orcid":false,"given":"Hong","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2024.117886_bib1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.2174\/1874467213666200611142438","article-title":"Pain perception and management: where do we stand?","volume":"14","author":"Afridi","year":"2021","journal-title":"Curr. Mol. Pharmacol."},{"issue":"18","key":"10.1016\/j.jep.2024.117886_bib2","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.22-18-08139.2002","article-title":"Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain","volume":"22","author":"Barclay","year":"2002","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.jep.2024.117886_bib3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","article-title":"Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment","volume":"9","author":"Baron","year":"2010","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.jep.2024.117886_bib4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/14728222.2017.1328057","article-title":"Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain","volume":"21","author":"Berta","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"issue":"1\u20132","key":"10.1016\/j.jep.2024.117886_bib5","article-title":"Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse","volume":"122","author":"Bourquin","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.jep.2024.117886_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/bs.apha.2015.09.001","article-title":"Purinergic mechanisms and pain","volume":"75","author":"Burnstock","year":"2016","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.jep.2024.117886_bib7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neures.2020.08.004","article-title":"Neferine alleviates P2X3 receptor in rat dorsal root ganglia mediated neuropathic pain","volume":"170","author":"Dan","year":"2021","journal-title":"Neurosci. Res."},{"issue":"10","key":"10.1016\/j.jep.2024.117886_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13461","article-title":"Bone marrow-derived mesenchymal stem cells attenuate complete Freund's adjuvant-induced inflammatory pain by inhibiting the expression of P2X3","volume":"56","author":"Deng","year":"2023","journal-title":"Cell Prolif."},{"issue":"3","key":"10.1016\/j.jep.2024.117886_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.spen.2016.10.003","article-title":"Pathogenesis of pain","volume":"23","author":"Dinakar","year":"2016","journal-title":"Semin. Pediatr. Neurol."},{"key":"10.1016\/j.jep.2024.117886_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113029","article-title":"Association between P2X3 receptors and neuropathic pain: as a potential therapeutic target for therapy","volume":"150","author":"Dong","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.117886_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116762","article-title":"The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor","volume":"317","author":"Gao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.117886_bib12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejphar.2015.11.023","article-title":"Involvement of AMPK\/SIRT1 pathway in anti-allodynic effect of troxerutin in CCI-induced neuropathic pain","volume":"769","author":"Gui","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2024.117886_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13041-015-0139-5","article-title":"Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice","volume":"8","author":"Guida","year":"2015","journal-title":"Mol. Brain"},{"issue":"3","key":"10.1016\/j.jep.2024.117886_bib14","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1113\/jphysiol.1959.sp006157","article-title":"The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves","volume":"145","author":"Holton","year":"1959","journal-title":"J. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2024.117886_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0304-3959(02)00032-5","article-title":"Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats","volume":"99","author":"Honore","year":"2002","journal-title":"Pain"},{"issue":"11","key":"10.1016\/j.jep.2024.117886_bib16","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jep.2024.117886_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104686","article-title":"Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal rats","volume":"135","author":"Hsieh","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2024.117886_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114309","article-title":"Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors","volume":"187","author":"Inoue","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2024.117886_bib19","article-title":"Analgesic alkaloids derived from traditional Chinese medicine in pain management","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2024.117886_bib20","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1007\/s00424-021-02599-y","article-title":"Common and discrete mechanisms underlying chronic pain and itch: peripheral and central sensitization","volume":"473","author":"Li","year":"2021","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"2","key":"10.1016\/j.jep.2024.117886_bib21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.117886_bib22","first-page":"28","article-title":"Compounds of traditional Chinese medicine and neuropathic pain","volume":"18","author":"Li","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2024.117886_bib23","article-title":"Polyphyllin VI screened from Chonglou by cell membrane immobilized chromatography relieves inflammatory pain by inhibiting inflammation and normalizing the expression of P2X(3) purinoceptor","volume":"14","author":"Luo","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2024.117886_bib24","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/sj.bjp.0705574","article-title":"Effects of A-317491, a novel and selective P2X3\/P2X2\/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration","volume":"140","author":"McGaraughty","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.117886_bib25","first-page":"265","article-title":"Peripheral neuropathic pain","volume":"47","author":"Murphy","year":"2020","journal-title":"NeuroRehabilitation"},{"issue":"5","key":"10.1016\/j.jep.2024.117886_bib26","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/0022034513483770","article-title":"Interaction of IL-1beta and P2X(3) receptor in pathologic masseter muscle pain","volume":"92","author":"Noma","year":"2013","journal-title":"J. Dent. Res."},{"issue":"10","key":"10.1016\/j.jep.2024.117886_bib27","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/00007632-200405150-00006","article-title":"TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord","volume":"29","author":"Ohtori","year":"2004","journal-title":"Spine"},{"issue":"1","key":"10.1016\/j.jep.2024.117886_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12933-022-01610-9","article-title":"Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy","volume":"21","author":"Pan","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.jep.2024.117886_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1072629","article-title":"Neuropathic pain: mechanisms and therapeutic strategies","volume":"11","author":"Petroianu","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.jep.2024.117886_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"10.1016\/j.jep.2024.117886_bib31","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1007\/s12035-016-0146-2","article-title":"P2X3 and P2X2\/3 receptors play a crucial role in articular hyperalgesia development through inflammatory mechanisms in the knee joint experimental synovitis","volume":"54","author":"Teixeira","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2024.117886_bib32","series-title":"Translational Pain Research: from Mouse to Man","article-title":"On the role of ATP-gated P2X receptors in acute, inflammatory and neuropathic pain","author":"Toulme","year":"2010"},{"key":"10.1016\/j.jep.2024.117886_bib33","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.3389\/fimmu.2018.02091","article-title":"Polyphyllin I ameliorates collagen-induced arthritis by suppressing the inflammation response in macrophages through the NF-kappaB pathway","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.jep.2024.117886_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/life11080836","article-title":"Roles of AMPK and its downstream signals in pain regulation","volume":"11","author":"Wang","year":"2021","journal-title":"Life"},{"issue":"1","key":"10.1016\/j.jep.2024.117886_bib35","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s00383-023-05425-x","article-title":"Polyphyllin D induces necroptosis in neuroblastoma cells (IMR-32 and LA-N-2) in mice","volume":"39","author":"Watanabe","year":"2023","journal-title":"Pediatr. Surg. Int."},{"issue":"1","key":"10.1016\/j.jep.2024.117886_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12974-019-1411-x","article-title":"AMPK activation attenuates inflammatory pain through inhibiting NF-kappaB activation and IL-1beta expression","volume":"16","author":"Xiang","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.jep.2024.117886_bib37","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/neup.12653","article-title":"Red nucleus IL-6 mediates the maintenance of neuropathic pain by inducing the productions of TNF-alpha and IL-1beta through the JAK2\/STAT3 and ERK signaling pathways","volume":"40","author":"Yang","year":"2020","journal-title":"Neuropathology"},{"key":"10.1016\/j.jep.2024.117886_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainresbull.2017.01.002","article-title":"A317491 relieved HIV gp120-associated neuropathic pain involved in P2X3 receptor in dorsal root ganglia","volume":"130","author":"Yi","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jep.2024.117886_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/17448069211011315","article-title":"The interaction between P2X3 and TRPV1 in the dorsal root ganglia of adult rats with different pathological pains","volume":"17","author":"Yu","year":"2021","journal-title":"Mol. Pain"},{"key":"10.1016\/j.jep.2024.117886_bib40","first-page":"2535","article-title":"Rhizoma paridis saponins induces cell cycle arrest and apoptosis in non-small cell lung carcinoma A549 cells","volume":"21","author":"Zhang","year":"2015","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124001855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124001855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:49:49Z","timestamp":1759945789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124001855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":40,"alternative-id":["S0378874124001855"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.117886","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PolyphyllinVI alleviates the spared nerve injury-induced neuropathic pain based on P2X3 receptor-mediated the release of inflammatory mediators","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.117886","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117886"}}