{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:05:16Z","timestamp":1791255916862,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of The Peoples Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jep.2024.117988","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T12:18:15Z","timestamp":1709122695000},"page":"117988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Xianglian Pill combined with 5-fluorouracil enhances antitumor activity and reduces gastrointestinal toxicity in gastric cancer by regulating the p38 MAPK\/NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"326","author":[{"given":"Lei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-yuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-fang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.jep.2024.117988_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0248-4900(01)01124-8","article-title":"Cell cycle regulation by p38 MAP kinases","volume":"93","author":"Ambrosino","year":"2001","journal-title":"Biol. Cell."},{"issue":"8","key":"10.1016\/j.jep.2024.117988_bib2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ni.2060","article-title":"Inflammation meets cancer, with NF-\u03baB as the matchmaker","volume":"12","author":"Ben-Neriah","year":"2011","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.jep.2024.117988_bib3","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1111\/cas.14532","article-title":"5-Fluorouracil resistance mechanisms in colorectal cancer: from classical pathways to promising processes","volume":"111","author":"Blondy","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jep.2024.117988_bib4","article-title":"p38 MAP kinase's emerging role as a tumor suppressor","volume":"92","author":"Bulavin","year":"2004","journal-title":"Adv. Cancer Res."},{"issue":"10","key":"10.1016\/j.jep.2024.117988_bib5","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1002\/jcb.25994","article-title":"Dehydrocostus lactone suppresses proliferation of human chronic myeloid leukemia cells through Bcr\/Abl-JAK\/STAT signaling pathways","volume":"118","author":"Cai","year":"2017","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.jep.2024.117988_bib6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.molcel.2019.05.036","article-title":"IKKalpha kinase regulates the DNA damage response and Drives chemo-resistance in cancer","volume":"75","author":"Colomer","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jep.2024.117988_bib7","series-title":"Pharmacopoeia of the People's Republic of China","author":"Committee","year":"2020"},{"issue":"8","key":"10.1016\/j.jep.2024.117988_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.molmed.2009.06.005","article-title":"p38(MAPK): stress responses from molecular mechanisms to therapeutics","volume":"15","author":"Coulthard","year":"2009","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.117988_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa055531","article-title":"Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer","volume":"355","author":"Cunningham","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2024.117988_bib10","article-title":"Xianglian Pill attenuates ulcerative colitis through TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"300","author":"Dai","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2024.117988_bib11","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/onc.2011.321","article-title":"P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance","volume":"31","author":"de la Cruz-Morcillo","year":"2012","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.jep.2024.117988_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1600-065X.2012.01099.x","article-title":"NF-\u03baB and the link between inflammation and cancer","volume":"246","author":"DiDonato","year":"2012","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.jep.2024.117988_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13046-021-02229-6","article-title":"ROS\/PI3K\/Akt and Wnt\/beta-catenin signalings activate HIF-1alpha-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer","volume":"41","author":"Dong","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jep.2024.117988_bib14","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.2147\/IJN.S257700","article-title":"Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer","volume":"15","author":"Entezar-Almahdi","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"8","key":"10.1016\/j.jep.2024.117988_bib15","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tibs.2007.06.007","article-title":"The pathways to tumor suppression via route p38","volume":"32","author":"Han","year":"2007","journal-title":"Trends Biochem. Sci."},{"issue":"7","key":"10.1016\/j.jep.2024.117988_bib16","first-page":"973","article-title":"Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells","volume":"15","author":"Hudita","year":"2021","journal-title":"Nanotoxicology"},{"issue":"7","key":"10.1016\/j.jep.2024.117988_bib17","first-page":"973","article-title":"Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells in vitro","volume":"15","author":"Hudita","year":"2021","journal-title":"Nanotoxicology"},{"issue":"5600","key":"10.1016\/j.jep.2024.117988_bib18","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.jep.2024.117988_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13101627","article-title":"Induction of apoptosis by isoalantolactone in human hepatocellular carcinoma Hep3B cells through activation of the ROS-dependent JNK signaling pathway","volume":"13","author":"Kim","year":"2021","journal-title":"Pharmaceutics"},{"issue":"9","key":"10.1016\/j.jep.2024.117988_bib20","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrd1177","article-title":"p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases","volume":"2","author":"Kumar","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.jep.2024.117988_bib21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00280-003-0682-0","article-title":"Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infusion","volume":"52","author":"Kurita","year":"2003","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2024.117988_bib22","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/physrev.2001.81.2.807","article-title":"Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation","volume":"81","author":"Kyriakis","year":"2001","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.jep.2024.117988_bib23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.jep.2024.117988_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/13880209.2020.1865407","article-title":"Berberine regulates the Notch1\/PTEN\/PI3K\/AKT\/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells","volume":"59","author":"Li","year":"2021","journal-title":"Pharm. Biol."},{"issue":"6","key":"10.1016\/j.jep.2024.117988_bib25","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.3892\/ol.2013.1592","article-title":"Sinomenine sensitizes gastric cancer cells to 5-fluorouracil in vitro and in vivo","volume":"6","author":"Liao","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2024.117988_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejca.2020.01.002","article-title":"Poor clinical outcomes of intratumoral dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin-positive macrophages associated with immune evasion in gastric cancer","volume":"128","author":"Liu","year":"2020","journal-title":"Eur. J. Cancer"},{"issue":"2","key":"10.1016\/j.jep.2024.117988_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00280-008-0732-8","article-title":"Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?","volume":"63","author":"Logan","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.117988_bib28","doi-asserted-by":"crossref","first-page":"765","DOI":"10.5114\/aoms.2018.73128","article-title":"Dehydrocostus lactone inhibits gastrinoma cancer cell growth through apoptosis induction, sub-G1 cell cycle arrest, DNA damage and loss of mitochondrial membrane potential","volume":"15","author":"Long","year":"2019","journal-title":"Arch. Med. Sci."},{"issue":"5","key":"10.1016\/j.jep.2024.117988_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.jep.2024.117988_bib30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1470-2045(20)30012-7","article-title":"Chemotherapy for resectable microsatellite instability-high gastric cancer?","volume":"21","author":"Lordick","year":"2020","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.jep.2024.117988_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4770","article-title":"Pharmacokinetics and tissue distribution of four major bioactive components in rats after oral administration of Xianglian pill","volume":"34","author":"Lu","year":"2020","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2024.117988_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.taap.2018.05.026","article-title":"Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells","volume":"352","author":"Lu","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2024.117988_bib33","first-page":"144","article-title":"Integrative oncology: addressing the global challenges of cancer prevention and treatment","volume":"72","author":"Mao","year":"2022","journal-title":"CA A Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.jep.2024.117988_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/1097-0142(19930701)72:1<37::AID-CNCR2820720109>3.0.CO;2-P","article-title":"Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer","volume":"72","author":"Murad","year":"1993","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.jep.2024.117988_bib35","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.4049\/jimmunol.169.9.5260","article-title":"Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase","volume":"169","author":"Nick","year":"2002","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2024.117988_bib36","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/s41392-022-01110-y","article-title":"Regulated cell death (RCD) in cancer: key pathways and targeted therapies","volume":"7","author":"Peng","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"3","key":"10.1016\/j.jep.2024.117988_bib37","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2010.06.133","article-title":"MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress","volume":"399","author":"Preta","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.jep.2024.117988_bib38","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.it.2013.03.008","article-title":"MyD88 and its divergent toll in carcinogenesis","volume":"34","author":"Salcedo","year":"2013","journal-title":"Trends Immunol."},{"issue":"33","key":"10.1016\/j.jep.2024.117988_bib39","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1200\/JCO.2011.36.5908","article-title":"Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer","volume":"29","author":"Sasako","year":"2011","journal-title":"J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.jep.2024.117988_bib40","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nrc1503","article-title":"Targeting the mitogen-activated protein kinase cascade to treat cancer","volume":"4","author":"Sebolt-Leopold","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jep.2024.117988_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111285","article-title":"5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: implication of DNA repair inhibition","volume":"137","author":"Sethy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.117988_bib42","article-title":"Berberine mediates tumor cell death by skewing tumor-associated immunosuppressive macrophages to inflammatory macrophages","volume":"99","author":"Shah","year":"2021","journal-title":"Phytomedicine"},{"issue":"10251","key":"10.1016\/j.jep.2024.117988_bib43","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.jep.2024.117988_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077969","article-title":"Tissue distribution of berberine and its metabolites after oral administration in rats","volume":"8","author":"Tan","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jep.2024.117988_bib45","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cgh.2019.07.045","article-title":"Burden of gastric cancer","volume":"18","author":"Thrift","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2024.117988_bib46","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4161\/cc.4.1.1342","article-title":"A subtle change in p38 MAPK activity is sufficient to suppress in vivo tumorigenesis","volume":"4","author":"Timofeev","year":"2005","journal-title":"Cell Cycle"},{"issue":"8","key":"10.1016\/j.jep.2024.117988_bib47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2694","article-title":"Signal integration by JNK and p38 MAPK pathways in cancer development","volume":"9","author":"Wagner","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.jep.2024.117988_bib48","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nrclinonc.2014.51","article-title":"Standing the test of time: targeting thymidylate biosynthesis in cancer therapy","volume":"11","author":"Wilson","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jep.2024.117988_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113377","article-title":"Xianglian Pill ameliorates antibiotic-associated diarrhea by restoring intestinal microbiota and attenuating mucosal damage","volume":"264","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"13","key":"10.1016\/j.jep.2024.117988_bib50","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1200\/JCO.2010.33.0597","article-title":"Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial","volume":"29","author":"Ychou","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jep.2024.117988_bib51","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.2147\/DDDT.S326328","article-title":"The anticancer potential of maslinic acid and its derivatives: a review","volume":"ume 15","author":"Yu","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"issue":"11","key":"10.1016\/j.jep.2024.117988_bib52","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1111\/jcmm.15131","article-title":"Dehydrocostus lactone inhibits cell proliferation and induces apoptosis by PI3K\/Akt\/Bad and ERS signalling pathway in human laryngeal carcinoma","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124002873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124002873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:54:14Z","timestamp":1759946054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124002873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":52,"alternative-id":["S0378874124002873"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.117988","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xianglian Pill combined with 5-fluorouracil enhances antitumor activity and reduces gastrointestinal toxicity in gastric cancer by regulating the p38 MAPK\/NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.117988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117988"}}