{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:19:07Z","timestamp":1782587947117,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jep.2024.118039","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T02:01:00Z","timestamp":1710208860000},"page":"118039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Epiberberine inhibits bone metastatic breast cancer-induced osteolysis"],"prefix":"10.1016","volume":"327","author":[{"given":"Chengming","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meina","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8537-1959","authenticated-orcid":false,"given":"Fuming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yu","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118039_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111824","article-title":"New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities","volume":"141","author":"Ashrafizadeh","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2024.118039_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/njms.NJMS_236_20","article-title":"Medication-related osteonecrosis of the jaw: an update","volume":"13","author":"Bansal","year":"2022","journal-title":"Natl. J. Maxillofac. Surg."},{"issue":"4","key":"10.1016\/j.jep.2024.118039_bib3","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3390\/cancers7040897","article-title":"Paclitaxel through the ages of anticancer therapy: exploring its role in chemoresistance and radiation therapy","volume":"7","author":"Barbuti","year":"2015","journal-title":"Cancers"},{"issue":"42","key":"10.1016\/j.jep.2024.118039_bib4","doi-asserted-by":"crossref","first-page":"30399","DOI":"10.1074\/jbc.M113.469973","article-title":"Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis","volume":"288","author":"Cao","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.jep.2024.118039_bib5","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1158\/2326-6066.CIR-21-0232","article-title":"Effective treatment of established bone metastases can Be achieved by combinatorial osteoclast blockade and depletion of granulocytic subsets","volume":"9","author":"Capietto","year":"2021","journal-title":"Cancer Immunol. Res."},{"issue":"9","key":"10.1016\/j.jep.2024.118039_bib6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41419-023-06107-1","article-title":"Dlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.jep.2024.118039_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/03008207.2017.1290085","article-title":"Osteoblast-osteoclast interactions","volume":"59","author":"Chen","year":"2018","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.jep.2024.118039_bib8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jep.2015.05.020","article-title":"Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies","volume":"171","author":"Choi","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2024.118039_bib9","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s12272-015-0626-3","article-title":"Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf\/MEK1\/2\/ERK1\/2 and AMPK\u03b1\/Akt pathways","volume":"38","author":"Choi","year":"2015","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"15","key":"10.1016\/j.jep.2024.118039_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14153640","article-title":"Bone-targeted agents and metastasis prevention","volume":"14","author":"Coleman","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2024.118039_bib11","article-title":"Metastatic bone disease: pathogenesis and therapeutic options: up-date on bone metastasis management","volume":"15","author":"D'Oronzo","year":"2018","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.jep.2024.118039_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153551","article-title":"Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells","volume":"85","author":"Du","year":"2021","journal-title":"Phytomedicine: Int. J. Phytother. Phytopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118039_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jir.2014.0026","article-title":"The role of cytokines in breast cancer development and progression","volume":"35","author":"Esquivel-Vel\u00e1zquez","year":"2015","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.jep.2024.118039_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41413-020-0083-6","article-title":"Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion","volume":"8","author":"Fan","year":"2020","journal-title":"Bone Res."},{"issue":"21","key":"10.1016\/j.jep.2024.118039_bib15","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1101\/gad.187900","article-title":"Fra-1 replaces c-Fos-dependent functions in mice","volume":"14","author":"Fleischmann","year":"2000","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.jep.2024.118039_bib16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/03639045.2021.1879840","article-title":"Docetaxel\/dimethyl-\u03b2-cyclodextrin inclusion complexes: preparation, in vitro evaluation and physicochemical characterization","volume":"47","author":"Giri","year":"2021","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"4","key":"10.1016\/j.jep.2024.118039_bib17","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s12276-020-0427-8","article-title":"Spi-C positively regulates RANKL-mediated osteoclast differentiation and function","volume":"52","author":"Go","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jep.2024.118039_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/mc.23545","article-title":"Withaferin A inhibits breast cancer-induced osteoclast differentiation","author":"Hahm","year":"2023","journal-title":"Mol. Carcinog."},{"issue":"8","key":"10.1016\/j.jep.2024.118039_bib19","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.ajpath.2016.04.003","article-title":"Effects of IL-8 up-regulation on cell survival and osteoclastogenesis in multiple myeloma","volume":"186","author":"Herrero","year":"2016","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.jep.2024.118039_bib20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13046-018-1001-2","article-title":"RANKL\/RANK\/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives","volume":"38","author":"Infante","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.jep.2024.118039_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.chembiol.2023.01.001","article-title":"Investigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagents","volume":"30","author":"Janiszewski","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jep.2024.118039_bib22","article-title":"Echinacoside inhibits osteoclast function by down-regulating PI3K\/Akt\/C-fos to alleviate osteolysis caused by periprosthetic joint infection","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"26","key":"10.1016\/j.jep.2024.118039_bib23","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1073\/pnas.1202810109","article-title":"Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death","volume":"109","author":"Jo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.jep.2024.118039_bib24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2174\/1389557520666201005143818","article-title":"Biological role of AKT and regulation of AKT signaling pathway by thymoquinone: perspectives in cancer therapeutics","volume":"21","author":"Junaid","year":"2021","journal-title":"Mini Rev. Med. Chem."},{"issue":"8","key":"10.1016\/j.jep.2024.118039_bib25","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1248\/bpb.32.1433","article-title":"Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids","volume":"32","author":"Jung","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2024.118039_bib26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.phymed.2018.06.020","article-title":"Icariin abrogates osteoclast formation through the regulation of the RANKL-mediated TRAF6\/NF-\u03baB\/ERK signaling pathway in Raw264.7 cells","volume":"51","author":"Kim","year":"2018","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.jep.2024.118039_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-osteoclast communication and bone homeostasis","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jep.2024.118039_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2052180","article-title":"Antioxidant and anti-inflammatory effects of rhei rhizoma and coptidis rhizoma mixture on reflux esophagitis in rats","volume":"2016","author":"Kwon","year":"2016","journal-title":"Evid Based Complement Alternat. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118039_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10549-006-9438-y","article-title":"RANKL-dependent and RANKL-independent mechanisms of macrophage-osteoclast differentiation in breast cancer","volume":"105","author":"Lau","year":"2007","journal-title":"Breast Cancer Res. Treat."},{"issue":"7","key":"10.1016\/j.jep.2024.118039_bib30","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/chromsci\/bmu175","article-title":"Seasonal variation of alkaloid contents and anti-inflammatory activity of rhizoma coptidis based on fingerprints combined with chemometrics methods","volume":"53","author":"Li","year":"2015","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jep.2024.118039_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104771","article-title":"Multifunctional epiberberine mediates multi-therapeutic effects","volume":"147","author":"Liu","year":"2020","journal-title":"Fitoterapia"},{"issue":"4","key":"10.1016\/j.jep.2024.118039_bib32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ddr.21302","article-title":"Antihyperglycemia and antihyperlipidemia effect of protoberberine alkaloids from rhizoma coptidis in HepG2 cell and diabetic KK-ay mice","volume":"77","author":"Ma","year":"2016","journal-title":"Drug Dev. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118039_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41598-019-57282-1","article-title":"BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis","volume":"10","author":"Mann","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.118039_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-4939-8997-3_5","article-title":"2D and 3D in vitro Co-culture for cancer and bone cell interaction studies","volume":"1914","author":"Marino","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"10","key":"10.1016\/j.jep.2024.118039_bib35","doi-asserted-by":"crossref","first-page":"11589","DOI":"10.1002\/cam4.5784","article-title":"Characterization of immune cell populations in syngeneic murine tumor models","volume":"12","author":"Snipstad","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.jep.2024.118039_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejca.2022.01.026","article-title":"Denosumab related osteonecrosis of the jaw: unusual pattern with periosteal reaction","volume":"166","author":"Tagliamento","year":"2022","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jep.2024.118039_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-030-20301-6_7","article-title":"Bone metastasis of breast cancer","volume":"1152","author":"Tahara","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.jep.2024.118039_bib38","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/jbmr.3031","article-title":"TRAF6 mediates suppression of osteoclastogenesis and prevention of ovariectomy-induced bone loss by a novel prenylflavonoid","volume":"32","author":"Tan","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2024.118039_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejps.2017.02.004","article-title":"Epiberberine, a natural protoberberine alkaloid, inhibits urease of Helicobacter pylori and jack bean: susceptibility and mechanism","volume":"110","author":"Tan","year":"2017","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"1","key":"10.1016\/j.jep.2024.118039_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jep.2009.08.009","article-title":"Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations","volume":"126","author":"Tang","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2024.118039_bib41","doi-asserted-by":"crossref","first-page":"917","DOI":"10.4065\/82.8.917","article-title":"The semiquantitative bone scintigraphy index correlates with serum tartrate-resistant acid phosphatase activity in breast cancer patients with bone metastasis","volume":"82","author":"Tsai","year":"2007","journal-title":"Mayo Clin. Proc."},{"issue":"7","key":"10.1016\/j.jep.2024.118039_bib42","doi-asserted-by":"crossref","first-page":"R421","DOI":"10.1530\/ERC-17-0309","article-title":"The role of IL-1B in breast cancer bone metastasis","volume":"25","author":"Tulotta","year":"2018","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.jep.2024.118039_bib43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-pathmechdis-031521-040919","article-title":"Osteoclasts, master sculptors of bone","volume":"18","author":"Veis","year":"2023","journal-title":"Ann. Rev. Pathol."},{"key":"10.1016\/j.jep.2024.118039_bib44","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3389\/fphar.2020.01175","article-title":"Schisandrin B inhibits osteoclastogenesis and protects against ovariectomy-induced bone loss","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118039_bib45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jep.2015.10.028","article-title":"Berberine and Coptidis Rhizoma as potential anticancer agents: recent updates and future perspectives","volume":"176","author":"Wang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118039_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106400","article-title":"Alpinetin ameliorates bone loss in LPS-induced inflammation osteolysis via ROS mediated P38\/PI3K signaling pathway","volume":"184","author":"Wei","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"7578","key":"10.1016\/j.jep.2024.118039_bib47","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1038\/527S101a","article-title":"Breast cancer","volume":"527","author":"Woolston","year":"2015","journal-title":"Natur"},{"issue":"1","key":"10.1016\/j.jep.2024.118039_bib48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00774-020-01175-1","article-title":"Discovery of the RANKL\/RANK\/OPG system","volume":"39","author":"Yasuda","year":"2021","journal-title":"J. Bone Miner. Metabol."},{"issue":"8","key":"10.1016\/j.jep.2024.118039_bib49","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s12272-019-01163-8","article-title":"Idelalisib inhibits osteoclast differentiation and pre-osteoclast migration by blocking the PI3K\u03b4-Akt-c-Fos\/NFATc1 signaling cascade","volume":"42","author":"Yeon","year":"2019","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"1","key":"10.1016\/j.jep.2024.118039_bib50","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jep.2012.10.062","article-title":"Safety evaluation of main alkaloids from Rhizoma Coptidis","volume":"145","author":"Yi","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118039_bib51","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.phrs.2019.02.015","article-title":"Sinomenine inhibits osteolysis in breast cancer by reducing IL-8\/CXCR1 and c-Fos\/NFATc1 signaling","volume":"142","author":"Zhang","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.jep.2024.118039_bib52","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41419-023-05819-8","article-title":"A novel microRNA-182\/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death Dis."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124003386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124003386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T09:17:54Z","timestamp":1716110274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124003386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":52,"alternative-id":["S0378874124003386"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118039","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epiberberine inhibits bone metastatic breast cancer-induced osteolysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118039"}}