{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T02:18:03Z","timestamp":1786673883596,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jep.2024.118123","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T17:52:15Z","timestamp":1711648335000},"page":"118123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Gigantol ameliorates DSS-induced colitis via suppressing \u03b22 integrin mediated adhesion and chemotaxis of macrophage"],"prefix":"10.1016","volume":"328","author":[{"given":"Weilai","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QingQing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-3458","authenticated-orcid":false,"given":"Haibin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118123_bib1","series-title":"Crohn's Disease and Ulcerative Colitis: from Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach","year":"2017"},{"key":"10.1016\/j.jep.2024.118123_bib2","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1136\/gutjnl-2012-303955","article-title":"Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation","volume":"62","author":"Cader","year":"2013","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.jep.2024.118123_bib5","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/np500015v","article-title":"Gigantol, a bibenzyl from Dendrobium draconis, inhibits the migratory behavior of non-small cell lung cancer cells","volume":"77","author":"Charoenrungruang","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2024.118123_bib6","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1021\/acs.jafc.1c07819","article-title":"Identification of adenylate kinase 5 as a protein target of ginsenosides in brain tissues using mass spectrometry-based drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA) techniques","volume":"70","author":"Chen","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2024.118123_bib7","first-page":"1","article-title":"Gigantol protects retinal pigment epithelial cells against high glucose-induced apoptosis, oxidative stress and inflammation by inhibiting MTDH-mediated NF-kB signaling pathway","author":"Chen","year":"2023","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jep.2024.118123_bib8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejcb.2013.10.009","article-title":"Integrating actin dynamics, mechanotransduction and integrin activation: the multiple functions of actin binding proteins in focal adhesions","volume":"92","author":"Ciobanasu","year":"2013","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jep.2024.118123_bib9","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.07.048","article-title":"Self-maintaining gut macrophages are essential for intestinal homeostasis","volume":"175","author":"De Schepper","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.118123_bib10","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/ibd\/izab029","article-title":"Human intestinal macrophages are involved in the pathology of both ulcerative colitis and crohn disease","volume":"27","author":"Dharmasiri","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jep.2024.118123_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jep.2015.06.034","article-title":"Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats","volume":"172","author":"Fang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094188","article-title":"The pro-inflammatory cytokine, interleukin-6, enhances the polarization of alternatively activated macrophages","volume":"9","author":"Fernando","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.118123_bib13","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvz039","article-title":"Intestinal barrier dysfunction, LPS translocation, and disease development","volume":"4","author":"Ghosh","year":"2020","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.jep.2024.118123_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102441","article-title":"Mo3Se4 nanoparticle with ROS scavenging and multi-enzyme activity for the treatment of DSS-induced colitis in mice","volume":"56","author":"Guo","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2024.118123_bib15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41575-023-00769-0","article-title":"Macrophages in intestinal homeostasis and inflammatory bowel disease","volume":"20","author":"Hegarty","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2024.118123_bib45","doi-asserted-by":"crossref","first-page":"154886","DOI":"10.1016\/j.phymed.2023.154886","article-title":"Gigantol restores the sensitivity of mcr carrying multidrug-resistant bacteria to colistin","volume":"117","author":"Huang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118123_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/14712598.2019.1666101","article-title":"Modern use of 5-aminosalicylic acid compounds for ulcerative colitis","volume":"20","author":"Le Berre","year":"2020","journal-title":"Expet Opin. Biol. Ther."},{"key":"10.1016\/j.jep.2024.118123_bib18","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2024.118123_bib20","article-title":"Monocyte and M1 macrophage-induced barrier defect contributes to chronic intestinal inflammation in IBD: inflamm","volume":"1","author":"Lissner","year":"2015","journal-title":"Bowel Dis."},{"key":"10.1016\/j.jep.2024.118123_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115084","article-title":"Potential activity of traditional Chinese medicine against ulcerative colitis: a review","volume":"289","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Molina","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jep.2024.118123_bib24","doi-asserted-by":"crossref","first-page":"R619","DOI":"10.1016\/j.cub.2021.01.036","article-title":"The cytoskeleton in phagocytosis and macropinocytosis","volume":"31","author":"Mylvaganam","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jep.2024.118123_bib25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2024.118123_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1080\/09546630902984596","article-title":"Efalizumab discontinuation: a practical strategy","volume":"20","author":"Pugashetti","year":"2009","journal-title":"J. Dermatol. Treat."},{"key":"10.1016\/j.jep.2024.118123_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/imr.12373","article-title":"The many faces of Mac\u20101 in autoimmune disease","volume":"269","author":"Rosetti","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jep.2024.118123_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2265028","article-title":"Current insights on the roles of gut microbiota in inflammatory bowel disease-associated extra-intestinal manifestations: pathophysiology and therapeutic targets","volume":"15","author":"Tie","year":"2023","journal-title":"Gut Microb."},{"key":"10.1016\/j.jep.2024.118123_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijbiomac.2016.04.062","article-title":"Characterization of a polysaccharide from Rosa davurica and inhibitory activity against neutrophil migration","volume":"89","author":"Tong","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2024.118123_bib31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1189\/jlb.1012487","article-title":"c-Abl tyrosine kinase plays a critical role in \u03b22 integrin-dependent neutrophil migration by regulating Vav1 activity","volume":"93","author":"Tong","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jep.2024.118123_bib32","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/00000478-200008000-00009","article-title":"Comparative studies of the colonic in situ expression of intercellular adhesion molecules (ICAM-1, -2, and -3), beta2 integrins (LFA-1, Mac-1, and p150,95), and PECAM-1 in ulcerative colitis and Crohn's disease","volume":"24","author":"Vainer","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.jep.2024.118123_bib33","article-title":"Analysis of trunk neural crest cell migration using a modified Zigmond chamber assay","volume":"3330","author":"Walheim","year":"2012","journal-title":"JoVE"},{"key":"10.1016\/j.jep.2024.118123_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jep.2012.12.013","article-title":"Naturally derived anti-inflammatory compounds from Chinese medicinal plants","volume":"146","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114368","article-title":"Traditional herbal medicine: therapeutic potential in rheumatoid arthritis","volume":"279","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113851","article-title":"Traditional uses, chemical constituents, pharmacological activities, and toxicological effects of Dendrobium leaves: a review","volume":"270","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115770","article-title":"Progress on the role of traditional Chinese medicine in therapeutic angiogenesis of heart failure","volume":"301","author":"Wu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jep.2017.01.026","article-title":"Gigantol from Dendrobium chrysotoxum Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: an in vitro mechanistic study","volume":"198","author":"Wu","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-79400-0","article-title":"Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK\/cPLA2\/12-LOX inflammatory pathway","volume":"10","author":"Xue","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.118123_bib40","article-title":"A role of kindlin-3 in integrin \u03b1M\u03b22 outside-in signaling and the Syk-Vav1-Rac1\/Cdc42 signaling axis","volume":"8","author":"Xue","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.118123_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115912","article-title":"Modern interpretation of the traditional application of Shihu - a comprehensive review on phytochemistry and pharmacology progress of Dendrobium officinale","volume":"302","author":"Yang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib43","article-title":"Dehydrocostus lactone suppresses dextran sulfate sodium-induced colitis by targeting the IKK\u03b1\/\u03b2-NF-\u03baB and Keap1-Nrf2 signalling pathways","volume":"13","author":"Yuan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118123_bib44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3390\/molecules23040818","article-title":"Extraction and analysis of gigantol from Dendrobium officinale with response surface methodology","volume":"23","author":"Zheng","year":"2018","journal-title":"Molecules"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124004227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124004227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T03:18:33Z","timestamp":1725506313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124004227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S0378874124004227"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118123","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gigantol ameliorates DSS-induced colitis via suppressing \u03b22 integrin mediated adhesion and chemotaxis of macrophage","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118123"}}