{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:17:42Z","timestamp":1790770662573,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jep.2024.118156","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T18:43:50Z","timestamp":1712342630000},"page":"118156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C\/EBP\u03b2"],"prefix":"10.1016","volume":"329","author":[{"given":"Yuanyuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xikun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weida","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanxi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-5795","authenticated-orcid":false,"given":"Sen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2024.118156_bib1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/ame2.12230","article-title":"A review: systematic research approach on toxicity model of liver and kidney in laboratory animals","volume":"5","author":"Abbasnezhad","year":"2022","journal-title":"Animal Model Exp Med"},{"key":"10.1016\/j.jep.2024.118156_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112104","article-title":"Effect of shenyan xiaobai granule on nephrin and podocin of adriamycin-induced renal injury: a randomised controlled trial","volume":"244","author":"Cao","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.118156_bib3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41401-021-00660-1","article-title":"Druggability of lipid metabolism modulation against renal fibrosis","volume":"43","author":"Chen","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.jep.2024.118156_bib4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mce.2010.08.014","article-title":"C\/EBP\u03b2 is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells","volume":"331","author":"Choudhury","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"issue":"10225","key":"10.1016\/j.jep.2024.118156_bib5","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(19)32977-0","article-title":"The global burden of chronic kidney disease","volume":"395","author":"Cockwell","year":"2020","journal-title":"Lancet"},{"issue":"17","key":"10.1016\/j.jep.2024.118156_bib6","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.1073\/pnas.0610068104","article-title":"Resveratrol stimulates AMP kinase activity in neurons","volume":"104","author":"Dasgupta","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"23","key":"10.1016\/j.jep.2024.118156_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233784","article-title":"Molecular cluster mining of adrenocortical carcinoma via multi-omics data analysis aids precise clinical therapy","volume":"11","author":"Guan","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jep.2024.118156_bib8","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1038\/ncomms8176","article-title":"AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation","volume":"6","author":"Herms","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2024.118156_bib9","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3389\/fphar.2017.00520","article-title":"Progression of tubulointerstitial fibrosis and the chronic kidney disease phenotype - role of risk factors and epigenetics","volume":"8","author":"Hewitson","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118156_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153739","article-title":"Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis","volume":"92","author":"Huang","year":"2021","journal-title":"Phytomedicine"},{"issue":"37","key":"10.1016\/j.jep.2024.118156_bib11","doi-asserted-by":"crossref","first-page":"32317","DOI":"10.1074\/jbc.M500801200","article-title":"Diet-induced obesity in C57BL\/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway","volume":"280","author":"Jiang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jep.2024.118156_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.jep.2024.118156_bib13","doi-asserted-by":"crossref","first-page":"F226","DOI":"10.1152\/ajprenal.00495.2014","article-title":"Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis","volume":"308","author":"Kim","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2024.118156_bib14","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/s41598-018-38250-7","article-title":"Attenuated lymphatic proliferation ameliorates diabetic nephropathy and high-fat diet-induced renal lipotoxicity","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jep.2024.118156_bib15","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1681\/ASN.2018010050","article-title":"Phosphorylation of acetyl-CoA carboxylase by AMPK reduces renal fibrosis and is essential for the anti-fibrotic effect of metformin","volume":"29","author":"Lee","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jep.2024.118156_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153274","article-title":"Uncovering the mechanism of Astragali Radix against nephrotic syndrome by intergrating lipidomics and network pharmacology","volume":"77","author":"Li","year":"2020","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2024.118156_bib17","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ame2.12221","article-title":"TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-\u03baB\/MAPK-TNF-\u03b1 pathway","volume":"5","author":"Li","year":"2022","journal-title":"Animal Model Exp Med"},{"key":"10.1016\/j.jep.2024.118156_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jare.2021.12.007","article-title":"Protective effects and mechanisms of psoralidin against adriamycin-induced cardiotoxicity","volume":"40","author":"Liang","year":"2022","journal-title":"J. Adv. Res."},{"issue":"12","key":"10.1016\/j.jep.2024.118156_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124359","article-title":"Nifedipine exacerbates lipogenesis in the kidney via KIM-1, CD36, and SREBP upregulation: implications from an animal model for human study","volume":"21","author":"Lin","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118156_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2022.10.014","article-title":"Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS\/STING signaling dependent on LKB1\/AMPK\/ULK1-mediated autophagy","volume":"51","author":"Lu","year":"2023","journal-title":"J. Adv. Res."},{"issue":"7","key":"10.1016\/j.jep.2024.118156_bib21","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1007\/s00262-021-03116-x","article-title":"Metformin inhibits human non-small cell lung cancer by regulating AMPK-CEBPB-PDL1 signaling pathway","volume":"71","author":"Lu","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"issue":"3","key":"10.1016\/j.jep.2024.118156_bib22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbalip.2009.09.017","article-title":"Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome","volume":"1801","author":"Prieur","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.jep.2024.118156_bib23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nefro.2019.06.009","article-title":"Melatonin ameliorates the drug induced nephrotoxicity: molecular insights","volume":"40","author":"Raza","year":"2020","journal-title":"Nefrologia"},{"issue":"4","key":"10.1016\/j.jep.2024.118156_bib27","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3109\/0886022X.2014.882737","article-title":"The restoration of kidney mitochondria function by inhibition of angiotensin-II production in rats with acute adriamycin-induced nephrotoxicity","volume":"36","author":"Taskin","year":"2014","journal-title":"Ren. Fail."},{"issue":"7","key":"10.1016\/j.jep.2024.118156_bib28","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1248\/bpb.b17-00724","article-title":"AMPK-mediated regulation of lipid metabolism by phosphorylation","volume":"41","author":"Wang","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2024.118156_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153886","article-title":"Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis","volume":"96","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2024.118156_bib30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/ckj\/sfx093","article-title":"Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis","volume":"11","author":"Wilson","year":"2018","journal-title":"Clin Kidney J"},{"issue":"1","key":"10.1016\/j.jep.2024.118156_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tips.2022.10.003","article-title":"Mitochondrial quality control mechanisms as therapeutic targets in doxorubicin-induced cardiotoxicity","volume":"44","author":"Wu","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2024.118156_bib32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/ame2.12194","article-title":"Folic acid-induced animal model of kidney disease","volume":"4","author":"Yan","year":"2021","journal-title":"Animal Model Exp Med"},{"issue":"5","key":"10.1016\/j.jep.2024.118156_bib33","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.ymthe.2023.02.016","article-title":"Delivery of mitochondria confers cardioprotection through mitochondria replenishment and metabolic compliance","volume":"31","author":"Zhang","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jep.2024.118156_bib34","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3389\/fphar.2017.00872","article-title":"Total coumarins from Hydrangea paniculata show renal protective effects in lipopolysaccharide-induced acute kidney injury via anti-inflammatory and antioxidant activities","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118156_bib35","first-page":"115","article-title":"Nicousamide protects kidney podocyte by inhibiting the TGFbeta receptor II phosphorylation and AGE-RAGE signaling","volume":"9","author":"Zhang","year":"2017","journal-title":"Am J Transl Res"},{"issue":"138","key":"10.1016\/j.jep.2024.118156_bib36","article-title":"Seeking for correlative genes and signaling pathways with bone metastasis from breast cancer by integrated analysis","volume":"9","author":"Zhang","year":"2019","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.jep.2024.118156_bib37","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s12935-021-02068-7","article-title":"New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis","volume":"21","author":"Zhang","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.jep.2024.118156_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115004","article-title":"Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway","volume":"288","author":"Zhang","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1\u20133","key":"10.1016\/j.jep.2024.118156_bib40","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejphar.2012.05.017","article-title":"Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats","volume":"692","author":"Zhang","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"43","key":"10.1016\/j.jep.2024.118156_bib39","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.3748\/wjg.v23.i43.7705","article-title":"Palmitate induces fat accumulation by activating C\/EBP\u03b2-mediated G0S2 expression in HepG2 cells","volume":"23","author":"Zhao","year":"2017","journal-title":"World J. Gastroenterol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124004550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124004550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T17:59:09Z","timestamp":1716227949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124004550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":37,"alternative-id":["S0378874124004550"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118156","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C\/EBP\u03b2","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118156"}}