{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:45:49Z","timestamp":1788630349890,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jep.2024.118227","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:34:37Z","timestamp":1714264477000},"page":"118227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1016","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-5295","authenticated-orcid":false,"given":"Hangjie","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0118-2491","authenticated-orcid":false,"given":"Qiehao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.jep.2024.118227_bib1","doi-asserted-by":"crossref","first-page":"16620","DOI":"10.1021\/acsomega.2c07254","article-title":"Chitosan-coated niosomes loaded with ellagic acid present antiaging activity in a skin cell line","volume":"8","author":"Abd-Elghany","year":"2023","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.jep.2024.118227_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jaad.2017.02.054","article-title":"The effectiveness of treatments for androgenetic alopecia: a systematic review and meta-analysis","volume":"77","author":"Adil","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"7","key":"10.1016\/j.jep.2024.118227_bib3","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/00006534-199412000-00018","article-title":"Involvement of lipid peroxidation in necrosis of skin flaps and its suppression by ellagic acid","volume":"94","author":"Ashoori","year":"1994","journal-title":"Plast. Reconstr. Surg."},{"issue":"8","key":"10.1016\/j.jep.2024.118227_bib4","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1111\/j.1600-0625.2009.01044.x","article-title":"Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation","volume":"19","author":"Bae","year":"2010","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jep.2024.118227_bib5","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3389\/fphar.2019.01528","article-title":"Dihydrotestosterone regulates hair growth through the wnt\/beta-catenin pathway in C57bl\/6 mice and in vitro organ culture","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2024.118227_bib6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s40265-023-01880-x","article-title":"Androgenetic alopecia: therapy update","volume":"83","author":"Devjani","year":"2023","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.jep.2024.118227_bib7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s10103-018-2455-3","article-title":"Activation of Wnt\/beta-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED in in vitro culture model","volume":"33","author":"Han","year":"2018","journal-title":"Laser Med. Sci."},{"issue":"2","key":"10.1016\/j.jep.2024.118227_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.jep.2024.118227_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab067","article-title":"Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome","volume":"27","author":"Hu","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jep.2024.118227_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176237","article-title":"Cyanidin-3-O-glucoside and its derivative vitisin A alleviate androgenetic alopecia by exerting anti-androgen effect and inhibiting dermal papilla cell apoptosis","volume":"963","author":"Hu","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2024.118227_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","article-title":"beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin","volume":"105","author":"Huelsken","year":"2001","journal-title":"Cell"},{"issue":"7142","key":"10.1016\/j.jep.2024.118227_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature05766","article-title":"Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding","volume":"447","author":"Ito","year":"2007","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jep.2024.118227_bib13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.jep.2024.118227_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12929-022-00800-7","article-title":"Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts","volume":"29","author":"Jung","year":"2022","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.jep.2024.118227_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00430-022-00754-5","article-title":"In vitro and in vivo therapeutic antileishmanial potential of ellagic acid against Leishmania donovani in murine model","volume":"212","author":"Keshav","year":"2023","journal-title":"Med. Microbiol. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2024.118227_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00403-021-02195-1","article-title":"Physcion, a novel inhibitor of 5alpha-reductase that promotes hair growth in vitro and in vivo","volume":"314","author":"Lao","year":"2022","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jep.2024.118227_bib39","article-title":"Shikonin Induces Ferroptosis in Multiple Myeloma via GOT1-mediated Ferritinophagy","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jep.2024.118227_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102435","article-title":"Ferroportin-dependent ferroptosis induced by ellagic acid retards liver fibrosis by impairing the SNARE complexes formation","volume":"56","author":"Li","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2024.118227_bib18","article-title":"Ethanol extract of eclipta prostrata induces multiple myeloma ferroptosis via keap1\/nrf2\/HO-1 Axis","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118227_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115132","article-title":"The multifaceted mechanisms of ellagic acid in the treatment of tumors: state-of-the-art","volume":"165","author":"Lu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118227_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jphotobiol.2017.11.004","article-title":"Consumption of ellagic acid and dihydromyricetin synergistically protects against UV-B induced photoaging, possibly by activating both TGF-beta1 and wnt signaling pathways","volume":"178","author":"Moon","year":"2018","journal-title":"J. Photochem. Photobiol., B"},{"issue":"6","key":"10.1016\/j.jep.2024.118227_bib21","first-page":"725","article-title":"Lipid peroxides induce early onset of catagen phase in murine hair cycles","volume":"22","author":"Naito","year":"2008","journal-title":"Int. J. Mol. Med."},{"issue":"12","key":"10.1016\/j.jep.2024.118227_bib22","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/exd.14213","article-title":"Clues that mitochondria are involved in the hair cycle clock: MPZL3 regulates entry into and progression of murine hair follicle cycling","volume":"29","author":"Nicu","year":"2020","journal-title":"Exp. Dermatol."},{"issue":"7","key":"10.1016\/j.jep.2024.118227_bib23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/10715762.2014.976213","article-title":"Lipid oxidation in the skin","volume":"49","author":"Niki","year":"2015","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118227_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pathophys.2017.12.001","article-title":"Oral phenytoin protects against experimental cyclophosphamide-chemotherapy induced hair loss","volume":"25","author":"Onaolapo","year":"2018","journal-title":"Pathophysiology"},{"key":"10.1016\/j.jep.2024.118227_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67437","article-title":"Quantitative mapping of human hair greying and reversal in relation to life stress","volume":"10","author":"Rosenberg","year":"2021","journal-title":"Elife"},{"issue":"7","key":"10.1016\/j.jep.2024.118227_bib26","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1038\/jid.2013.52","article-title":"Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2","volume":"133","author":"Sengupta","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.jep.2024.118227_bib27","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/ptr.5324","article-title":"The androgenic alopecia protective effects of forsythiaside-A and the molecular regulation in a mouse model","volume":"29","author":"Shin","year":"2015","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2024.118227_bib28","article-title":"Targeted deletion of Crif1 in mouse epidermis impairs skin homeostasis and hair morphogenesis","volume":"7","author":"Shin","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jep.2024.118227_bib29","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol."},{"issue":"22","key":"10.1016\/j.jep.2024.118227_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223580","article-title":"Targeting wnt\/beta-catenin signaling exacerbates ferroptosis and increases the efficacy of melanoma immunotherapy via the regulation of MITF","volume":"11","author":"Wang","year":"2022","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.jep.2024.118227_bib31","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1038\/s41418-022-01008-w","article-title":"Wnt\/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.118227_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110788","article-title":"Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice","volume":"386","author":"Weng","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2024.118227_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114454","article-title":"The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated alpha-MSH pathways via Nrf2 activation in keratinocytes","volume":"185","author":"Yang","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2024.118227_bib34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/14656566.2020.1721463","article-title":"A review of the treatment of male pattern hair loss","volume":"21","author":"York","year":"2020","journal-title":"Expet Opin. Pharmacother."},{"issue":"11","key":"10.1016\/j.jep.2024.118227_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ph14111128","article-title":"Alleviation of androgenetic alopecia with aqueous Paeonia lactiflora and poria cocos extract intake through suppressing the steroid hormone and inflammatory pathway","volume":"14","author":"Zhang","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2024.118227_bib36","article-title":"Transcriptome analysis reveals an inhibitory effect of dihydrotestosterone-treated 2D- and 3D-cultured dermal papilla cells on hair follicle growth","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.jep.2024.118227_bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1530\/JOE-20-0155","article-title":"Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats","volume":"246","author":"Zhang","year":"2020","journal-title":"J. Endocrinol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124005269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124005269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T08:08:04Z","timestamp":1715242084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124005269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":38,"alternative-id":["S0378874124005269"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118227","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt\/\u03b2-catenin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118227","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118227"}}