{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:38:45Z","timestamp":1793227125551,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013072","name":"Major Science and Technology Project of Hainan Province","doi-asserted-by":"publisher","award":["ZDXM20130060"],"award-info":[{"award-number":["ZDXM20130060"]}],"id":[{"id":"10.13039\/501100013072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jep.2024.118330","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T02:45:51Z","timestamp":1715395551000},"page":"118330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Evaluation of hemostatic, anti-inflammatory, wound healing, skin irritation and allergy, and antimicrobial properties of active fraction from the ethanol extract of Chromolaena odorata (L.) R.M. King & H. Rob"],"prefix":"10.1016","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-8272","authenticated-orcid":false,"given":"Hong-Fu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang-Chao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Long","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Qiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Chen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118330_bib1","first-page":"65","article-title":"Phytochemical and antimicrobial analyses of leaf extracts of Cerathoteca sesamoides and Chromolaena odorata","volume":"8","author":"Abubakar","year":"2020","journal-title":"Int. J. Res."},{"key":"10.1016\/j.jep.2024.118330_bib2","first-page":"8","article-title":"Pharmacological importance of Chromolaena odorata: a review","author":"Ajay","year":"2021","journal-title":"Int. J. Pharm. Drug Anal."},{"key":"10.1016\/j.jep.2024.118330_bib3","first-page":"191","article-title":"Phytochemicals constituents and antioxidant properties of extracts from the leaves of Chromolaena odorata","volume":"2","author":"Akinmoladun","year":"2007","journal-title":"Sci. Res. Essays"},{"key":"10.1016\/j.jep.2024.118330_bib4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.imr.2017.06.004","article-title":"Effect of ethanolic extract of Chromolaena odorata on the kidneys and intestines of healthy albino rats","volume":"6","author":"Anyanwu","year":"2017","journal-title":"Integr. Med. Res."},{"key":"10.1016\/j.jep.2024.118330_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4236\/aim.2013.31018","article-title":"Isolation and identification of two antibacterial agents from Chromolaena odorata L. active against four diarrheal strains","volume":"3","author":"Atindehou","year":"2013","journal-title":"Adv. Microbiol."},{"key":"10.1016\/j.jep.2024.118330_bib6","first-page":"590","article-title":"Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts","volume":"8","author":"Chen","year":"2014","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2024.118330_bib7","first-page":"151","article-title":"Bleeding time (BT) and clotting time (CT)","author":"Dg","year":"2016","journal-title":"BioSci. Pakistan"},{"key":"10.1016\/j.jep.2024.118330_bib8","first-page":"66","article-title":"Analysis of formulation and application of the common traditional Chinese medicine","volume":"13","author":"Duan","year":"2017","journal-title":"Asia-Pac. Tradit. Med."},{"key":"10.1016\/j.jep.2024.118330_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2006.09.030","article-title":"Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function","volume":"42","author":"Fialkow","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.jep.2024.118330_bib11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1021\/np400778m","article-title":"Identification of chromomoric acid C\u2013I as an Nrf2 activator in Chromolaena odorata","volume":"77","author":"Heiss","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2024.118330_bib12","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/biomedicines10040856","article-title":"The impact of prolonged inflammation on wound healing","volume":"10","author":"Holzer-Geissler","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2024.118330_bib13","first-page":"1001","article-title":"Antimicrobial activity of Chromolaena odorata against selected pyogenic pathogens. Int. J. Pharmacogn","volume":"9","author":"Hridhya","year":"2017","journal-title":"Phytochem. Res."},{"key":"10.1016\/j.jep.2024.118330_bib14","first-page":"262","article-title":"Phytotoxic potentials of cold and hot aqueous extracts of Chromolaena odorata against fungal deteriorating agents of yam tubers (Dioscorea rotundata, Poir) after harvest","author":"Ijato","year":"2015","journal-title":"J. Exp. Agric. Int."},{"key":"10.1016\/j.jep.2024.118330_bib15","first-page":"12","article-title":"Evaluation of the wound healing activity of a crude extract of Rubia cordifolia L. (Indian madder) in mice","volume":"2","author":"Karodi","year":"2003","journal-title":"Int. J. Appl. Res. Nat. Prod."},{"key":"10.1016\/j.jep.2024.118330_bib16","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bcp.2005.12.031","article-title":"Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS stimulated RAW 264.7 cells","volume":"71","author":"Kim","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2024.118330_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mimet.2010.02.004","article-title":"Evaluation of diffusion and dilution methods to determine the antibacterial activity of plant extracts","volume":"2","author":"Klancnik","year":"2010","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.jep.2024.118330_bib18","series-title":"Invasive Plants: a Guide to the Identification of the Most Invasive Plants of Sri Lanka","first-page":"116","author":"Lalith","year":"2009"},{"key":"10.1016\/j.jep.2024.118330_bib19","first-page":"14","article-title":"Experimental study on skin irritation and allergy with compound Kushe cream","volume":"35","author":"Li","year":"2012","journal-title":"J. Chengdu Univ. TCM."},{"key":"10.1016\/j.jep.2024.118330_bib20","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1080\/14786419.2015.1062761","article-title":"Medicinal plants with anti-inflammatory activities","volume":"30","author":"Maione","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2024.118330_bib21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tcb.2005.09.002","article-title":"Inflammatory cells during wound repair: the good, the bad and the ugly","volume":"15","author":"Martin","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jep.2024.118330_bib22","first-page":"103","article-title":"Distribution and control of Chromolaena odorata (Asteraceae)","volume":"3","author":"Muniappan","year":"1991","journal-title":"Micronesica"},{"key":"10.1016\/j.jep.2024.118330_bib23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3923\/pjn.2009.521.524","article-title":"Chemical profile of Chromolaena odorata L. (King and Robinson) leaves","volume":"8","author":"Ngozi","year":"2009","journal-title":"Pakistan J. Nutr."},{"key":"10.1016\/j.jep.2024.118330_bib24","series-title":"Biomaterials for Threating Skin Loss","first-page":"25","article-title":"The pathophysiologic basis for wound healing and cutaneous regeneration","author":"Nguyen","year":"2009"},{"key":"10.1016\/j.jep.2024.118330_bib25","first-page":"89","article-title":"Haemostatic property of Chromolaena odorata leaf extracts: in vitro and in vivo evaluation in wistar rats","volume":"98","author":"Okoroiwu","year":"2016","journal-title":"J. Biol. Res. Boll. della Soc. Ital. di Biol. Sper."},{"key":"10.1016\/j.jep.2024.118330_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.sajb.2021.09.001","article-title":"Biological activities of Chromolaena odorata: a mechanistic review","volume":"144","author":"Olawale","year":"2022","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2024.118330_bib51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jep.2015.04.057","article-title":"Chromolaena odorata (L.) R.M. King & H. Rob. (Asteraceae) in sub-Saharan Africa: A synthesis and review of its medicinal potential","volume":"183","author":"Omokhua","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118330_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-020-03024-0","article-title":"Flavonoids isolated from the South African weed Chromolaena odorata (Asteraceae) have pharmacological activity against uropathogens","volume":"20","author":"Omokhua-Uyi","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jep.2024.118330_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40816-019-0115-1","article-title":"Anti-diabetic activities of Chromolaena odorata methanol root extract and its attenuation effect on diabetic induced hepatorenal impairments in rats","volume":"1","author":"Omonije","year":"2019","journal-title":"Clin. Phytosci."},{"key":"10.1016\/j.jep.2024.118330_bib29","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1163\/156856005774649386","article-title":"Anti-inflammatory activity of aqueous leaf extract of Chromolaena odorata","volume":"13","author":"Owoyele","year":"2005","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2024.118330_bib30","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s12272-001-2129-7","article-title":"Tectorigenin inhibits IFN-gamma\/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells","volume":"31","author":"Pan","year":"2008","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2024.118330_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/168269","article-title":"Hemostatic and wound healing properties of Chromolaena odorata leaf extract","volume":"2013","author":"Pandith","year":"2013","journal-title":"ISRN Dermatol."},{"key":"10.1016\/j.jep.2024.118330_bib32","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jep.2013.03.033","article-title":"Effect of siam weed extract and its bioactive component scutellarein tetramethyl ether on anti-inflammatory activity through NF-\u03baB pathway","volume":"147","author":"Pandith","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118330_bib33","first-page":"522","article-title":"Upregulation of adhesion complex proteins and fibronectin by human keratinocytes treated with an aqueous extract from the leaves of Chromolaena odorata (Eupolin)","volume":"10","author":"Phan","year":"2000","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.jep.2024.118330_bib34","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00006534-199803000-00027","article-title":"Enhanced proliferation of fibroblasts and endothelial cells treated with an extract of the leaves of Chromolaena odorata (Eupolin), an herbal remedy for treating wounds","volume":"101","author":"Phan","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.jep.2024.118330_bib35","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1248\/bpb.24.1373","article-title":"Phenolic compounds of Chromolaena odorata protect cultured skin cells from oxidative damage: implication for cutaneous wound healing","volume":"24","author":"Phan","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2024.118330_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/S0890037X00042524","article-title":"Genetic diversity and origin of siam weed (Chromolaena odorata) in Australia","volume":"12","author":"Scott","year":"1998","journal-title":"Weed Technol."},{"key":"10.1016\/j.jep.2024.118330_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/phrev.phrev_53_16","article-title":"Wound healing property review of siam weed, Chromolaena odorata","volume":"11","author":"Sirinthipaporn","year":"2017","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.jep.2024.118330_bib38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/BF02980123","article-title":"Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata","volume":"27","author":"Suksamrarn","year":"2004","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2024.118330_bib39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0305-4179(00)00137-6","article-title":"Anti-oxidant effects of the extracts from the leaves of Chromolaena odorata on human dermal fibroblasts and epidermal keratinocytes against hydrogen peroxide and hypoxanthine-xanthine oxidase induced damage","volume":"27","author":"Thang","year":"2001","journal-title":"Burns"},{"key":"10.1016\/j.jep.2024.118330_bib40","first-page":"947","article-title":"Chemical and biological activity of leaf extracts of Chromolaena leivensis","volume":"6","author":"Torrenegra","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2024.118330_bib41","first-page":"283","article-title":"Effect of Eupatorium odoratum on blood coagulation","volume":"74","author":"Triratana","year":"1991","journal-title":"J. Med. Assoc. Thail."},{"key":"10.1016\/j.jep.2024.118330_bib42","first-page":"80","article-title":"The invasive weed with healing properties: a review on chromolaena odorata","volume":"3","author":"Vaisakh","year":"2012","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.jep.2024.118330_bib43","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3892\/mmr.2017.6133","article-title":"Chromolaena odorata: a neglected weed with a wide spectrum of pharmacological activities","volume":"15","author":"Vijayaraghavan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2024.118330_bib44","doi-asserted-by":"crossref","first-page":"565","DOI":"10.17221\/161\/2016-VETMED","article-title":"Efficacy of Chromolaena odorata leaf extracts for the healing of rat excision wounds","volume":"62","author":"Vijayaraghavan","year":"2017","journal-title":"Vet. Med. (Praha)."},{"key":"10.1016\/j.jep.2024.118330_bib45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bcab.2018.05.014","article-title":"Phytochemical screening, free radical scavenging and antimicrobial potential of chromolaena odorata leaf extracts against pathogenic bacterium in wound infections\u2015a multispectrum perspective","volume":"15","author":"Vijayaraghavan","year":"2018","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"10.1016\/j.jep.2024.118330_bib46","first-page":"9","article-title":"Eupatorium odoratum Linn: an enhancer of hemostasis","volume":"17","author":"Wongkrajang","year":"1990","journal-title":"Mahidol J. Pharm. Sci."},{"key":"10.1016\/j.jep.2024.118330_bib47","series-title":"Methodology of Pharmacological Experiments","first-page":"1016","author":"Xu","year":"1991"},{"key":"10.1016\/j.jep.2024.118330_bib48","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3923\/rjphyto.2014.64.73","article-title":"Biofilm killing effects of Chromolaena odorata extracts against Pseudomonas aeruginosa","volume":"8","author":"Yahya","year":"2014","journal-title":"Res. J. Phytochem."},{"key":"10.1016\/j.jep.2024.118330_bib49","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1021\/np300386d","article-title":"PPAR\u03b3 agonist from Chromolaena odorata","volume":"75","author":"Zhang","year":"2012","journal-title":"J. Nat. Prod."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124006299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124006299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:44:35Z","timestamp":1777571075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124006299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":49,"alternative-id":["S0378874124006299"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118330","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of hemostatic, anti-inflammatory, wound healing, skin irritation and allergy, and antimicrobial properties of active fraction from the ethanol extract of Chromolaena odorata (L.) R.M. King & H. Rob","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118330","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118330"}}