{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:11:49Z","timestamp":1791475909533,"version":"4.3.4"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jep.2024.118349","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T15:27:50Z","timestamp":1715873270000},"page":"118349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Alkaloids from Siparuna (Siparunaceae) are predicted as the inhibitors of proteolysis and plasma coagulation caused by snake venom and potentially counteract phospholipase A2 activity of Bothrops jararaca"],"prefix":"10.1016","volume":"332","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6120-761X","authenticated-orcid":false,"given":"Di\u00e9gina Ara\u00fajo","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-8695","authenticated-orcid":false,"given":"Brendo Araujo","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7195-1629","authenticated-orcid":false,"given":"Simony Carvalho","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8282-529X","authenticated-orcid":false,"given":"Camila de Castro","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-9345","authenticated-orcid":false,"given":"Eladio Oswaldo Flores","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-074X","authenticated-orcid":false,"given":"Suzana Guimar\u00e3es","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-5258","authenticated-orcid":false,"given":"Andr\u00e9 Lopes","family":"Fuly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-3993","authenticated-orcid":false,"given":"Gilda Guimar\u00e3es","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118349_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.842576","article-title":"Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations","volume":"13","author":"Adri\u00e3o","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118349_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0378-8741(86)90028-0","article-title":"Schumanniofoside, the Antisnake Venom principle from the stem bark of Schumanniophyton magnificum Harms","volume":"18","author":"Akunyili","year":"1986","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.biochi.2015.11.031","article-title":"A novel synthetic quinolinone inhibitor presents proteolytic and hemorrha gic inhibitory activities against snake venom metalloproteases","volume":"121","author":"Baraldi","year":"2016","journal-title":"Biochime"},{"key":"10.1016\/j.jep.2024.118349_bib4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jep.2012.10.056","article-title":"Characterization of the aqueous extract of the root of Aristolochia indica: evaluation of its traditional use as an antidote for snake bites","volume":"14","author":"Bhattacharjee","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2017.08.003","article-title":"Aristolochic acid and its derivatives as inhibitors of snake venom lamino acid oxidase","volume":"138","author":"Bhattacharjee","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2024.118349_bib6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1055\/s-2000-8577","article-title":"Inhibition of the lethal and myotoxic activities of Crotalus durissus terrificus venom by Tabernaemontana catharinensis: identification of one of the active components,\u201d","volume":"66","author":"Batina","year":"2000","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2024.118349_bib7","first-page":"13","article-title":"Profile of medicinal plants with anti-ophidian properties","volume":"1","author":"Binorkar","year":"2012","journal-title":"J. Pharmaceut. Sci. Innovat."},{"key":"10.1016\/j.jep.2024.118349_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.biochi.2022.10.011","article-title":"Structural and functional studies of a snake venom phospholipase A2- like protein complexed to an inhibitor from Tabernaemontana catharinensis","volume":"206","author":"Borges","year":"2023","journal-title":"Biochimie"},{"key":"10.1016\/j.jep.2024.118349_bib9","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1590\/0001-3765201820170257","article-title":"Chemical constituents of apolar fractions from fruit latex of twelve Clusia species (Clusiaceae)","volume":"90","author":"Camara","year":"2018","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.jep.2024.118349_bib10","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/toxins16040188","article-title":"Effect of seaweed-derived fucoidans from Undaria pinnatifida and Fucus vesiculosus on coagulant, proteolytic, and phospholipase A2 activities of snake Bothrops jararaca, B. jararacussu, and B. neuwiedi venom","volume":"12","author":"Castro-Pinheiro","year":"2024","journal-title":"Toxins"},{"key":"10.1016\/j.jep.2024.118349_bib11","first-page":"1","article-title":"Snake venom PLA2s inhibitors isolated from Brazilian plants: synthetic and natural molecules","volume":"153045","author":"Carvalho","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2024.118349_bib12","doi-asserted-by":"crossref","first-page":"10914","DOI":"10.1021\/bi0258593","article-title":"Structural basis of phospholipase A2 inhibition for the synthesis of prostaglandins by the plant alkaloid aristolochic acid from a 1.7 \u00c5 crystal structure","volume":"41","author":"Chandra","year":"2002","journal-title":"Biochem."},{"key":"10.1016\/j.jep.2024.118349_bib13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.bbapap.2011.03.002","article-title":"Identification of a novel and potent inhibitor of phospholipase A2 in a medicinal plant: crystal structure at 1.93 \u00c5 and surface plasmon resonance analysis of phospholipase A2 complexed with berberine","volume":"1814","author":"Chandra","year":"2011","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"10.1016\/j.jep.2024.118349_bib14","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1002\/jssc.201201054","article-title":"Changes in the mobile phase composition on a stepwise counter-current chromatography elution for the isolation of flavonoids from Siparuna glycycarpa","volume":"36","author":"Costa","year":"2013","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jep.2024.118349_bib15","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.2174\/1568026619666190724160711","article-title":"Utilization of the plant Clusia Fluminensis Planch & Triana against some toxic activities of the venom of Bothrops jararaca and B. jararacussu snake venom toxic activities","volume":"19","author":"da Silva","year":"2019","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jep.2024.118349_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115038","article-title":"Chemical profiling and unraveling of anti-COVID-19 biomarkers of red sage (Lantana Camara L.) cultivars using UPLC-MS\/MS coupled to chemometric analysis, in vitro study and molecular docking","volume":"291","author":"Darwish","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib17","series-title":"Utilisation and Management of Medicinal Plants","first-page":"1","article-title":"Anti-venom activity of medicinal plants from South America","author":"Dellacassa","year":"2014"},{"key":"10.1016\/j.jep.2024.118349_bib18","article-title":"In vitro and in vivo antimalarial activity, cytotoxicity and phytochemical HRMS2 profile of plants from the Western Par\u00e1 State, Brazilian Amazonia","author":"Dos Santos","year":"2023","journal-title":"Chem. Biodiversity"},{"key":"10.1016\/j.jep.2024.118349_bib86","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.toxicon.2016.09.010","article-title":"Neutralization of toxicological activities of medically-relevant Bothrops snake venoms and relevant toxins by two polyvalent bothropic antivenoms produced in Peru and Brazil","volume":"122","author":"Estevao-Costa","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2024.118349_bib19","doi-asserted-by":"crossref","DOI":"10.1590\/0001-3765202320211605","article-title":"The bioprospecting potential of Clusia fluminensis Planch. & Triana: a scoping review","volume":"95","author":"Faria","year":"2023","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.jep.2024.118349_bib20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jprot.2017.12.008","article-title":"Functional and proteomic comparison of Bothrops jararaca venom from captive specimens and the Brazilian Bothropic Reference venom","volume":"174","author":"Farias","year":"2018","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.jep.2024.118349_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1590\/0037-8682-0105-2013","article-title":"Snakebites as a largely neglected problem in the Brazilian Amazon: highlights of the epidemiological trends in the State of Amazonas","volume":"48","author":"Feitosa","year":"2015","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.jep.2024.118349_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/5748256","article-title":"Medicinal plants for the treatment of local tissue damage induced by snake venoms: an overview from traditional use to pharmacological evidence","author":"F\u00e9lix-Silva","year":"2017","journal-title":"Evidence Based Complem. Alternative Med."},{"key":"10.1016\/j.jep.2024.118349_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0133370","article-title":"Structural basis for the inhibition of a phospholipase A2-like toxin by caffeic and aristolochic acids","volume":"10","author":"Fernandes","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.118349_bib24","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.3390\/molecules23112784","article-title":"New sulphated flavonoids and larvicidal of Helicteres velutina K. Schum (Sterculiaceae)","volume":"23","author":"Fernandes","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118349_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0003-9861(78)80015-0","article-title":"Purification and characterization of a sulfhydryl-dependent protease from Rhodinius prolixus midgut","volume":"188","author":"Garcia","year":"1978","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2024.118349_bib26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jep.2017.02.011","article-title":"Medicinal plants used to treat snakebite in Central America: review and assessment of scientific evidence","volume":"199","author":"Giovannini","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib27","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1080\/07391102.2021.1905554","article-title":"Network pharmacology based high throughput screening for identification of multi targeted anti-diabetic compound from traditionally used plants","volume":"40","author":"Gogoi","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jep.2024.118349_bib28","first-page":"865","article-title":"Herbs and herbal constituents are active against snake bites","volume":"48","author":"Gomes","year":"2010","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.jep.2024.118349_bib29","first-page":"1","article-title":"Structure of leaf galls in Clusia fluminensis Planch. and Triana (Clusiaceae): sex-biased development in a dioecious host plant","volume":"10","author":"Guimar\u00e3es","year":"2021","journal-title":"Plants"},{"issue":"12","key":"10.1016\/j.jep.2024.118349_bib31","first-page":"1","article-title":"In vitro screening and evaluation of antivenom phytochemicals from Azima tetracantha Lam. leaves against Bungarus caeruleus and Vipera russelli. J. Venomous Animals Toxins including Trop","volume":"20","author":"Janardhan","year":"2014","journal-title":"Dis."},{"key":"10.1016\/j.jep.2024.118349_bib32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxicon.2016.11.249","article-title":"Differences between renal effects of venom from two Bothrops jararaca populations from southeastern and southern Brazil","volume":"125","author":"Jorge","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2024.118349_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110774","article-title":"Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism","volume":"131","author":"Khan","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.jep.2024.118349_bib34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3390\/toxins13080519","article-title":"Bothrops Jararaca snake venom modulates key cancer-related proteins in breast tumor cell lines","volume":"13","author":"Kisaki","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.jep.2024.118349_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.toxicon.2022.08.002","article-title":"The potential of Brazilian native plant species used in the therapy for snakebites: a literature review","volume":"217","author":"Konrath","year":"2022","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2024.118349_bib36","doi-asserted-by":"crossref","unstructured":"Kusar, S., Saddiqe, Z., Asad, M.H.H.B., Ali, F., Kirmani, F. 2024 Phytochemical characterization and phospholipase A2 inhibitory effect of Vitex negundo L. root extracts. J. Ethnopharmacol.. 323, 117671. https:\/\/doi.org\/10.1016\/j.jep.2023.117671.","DOI":"10.1016\/j.jep.2023.117671"},{"key":"10.1016\/j.jep.2024.118349_bib37","article-title":"Amazonian Siparuna extracts as potential anti-influenza agents: metabolic fingerprinting","volume":"270","author":"Leal","year":"2021","journal-title":"J. Etnhopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib38","first-page":"658","article-title":"Flavonoids from Siparuna cristata as potential inhibitors of SARS-CoV-2 replication","volume":"31","author":"Leal","year":"2021","journal-title":"Braz. J. Pharmacog."},{"key":"10.1016\/j.jep.2024.118349_bib39","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/molecules27020399","article-title":"Bioassay-guided fractionation of Siparuna glycycarpa n-butanol extract with inhibitory activity against influenza A(H1N1)pdm09 virus by Centrifugal Partition Chromatography (CPC)","volume":"27","author":"Leal","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118349_bib40","first-page":"377","article-title":"Constituents of some Aegiphila species and neutralization of Crotalus durissus terrificus venom by Aegiphila lhotzkyana","volume":"67","author":"Leit\u00e3o","year":"1996","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2024.118349_bib41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0378-8741(98)00233-5","article-title":"Chemistry and pharmacology of monimiaceae: a special focus on Siparuna and Mollinedia","volume":"65","author":"Leit\u00e3o","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib42","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0031-9422(00)00222-3","article-title":"Kaempferol glycosides from Siparuna apiosyce","volume":"55","author":"Leit\u00e3o","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2024.118349_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/s2175-97902022e191124","article-title":"Anti-snake venom properties of medicinal plants: a comprehensive systematic review of literature","volume":"58","author":"Liaqat","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2024.118349_bib44","first-page":"79","article-title":"Integrative approach based on leaf spray mass spectrometry, HPLC-DAD-MS\/MS, and NMR for comprehensive characterization of isoquinoline-derived alkaloids in leaves of Onychopetalum amazonicum R. E. Fr","volume":"31","author":"Lima","year":"2020","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.jep.2024.118349_bib45","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.toxicon.2009.03.015","article-title":"Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: contributions to understanding snakebite envenomings and their treatment","volume":"54","author":"Lomonte","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2024.118349_bib46","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1055\/s-2006-961021","article-title":"Alkaloids of Siparuna tonduziana","volume":"56","author":"Lopez","year":"1990","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2024.118349_bib47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jprot.2015.04.029","article-title":"Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest","volume":"135","author":"Machado","year":"2016","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.jep.2024.118349_bib48","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2174\/156802607780487614","article-title":"Snake venom phospholipase A2 inhibitors: medicinal chemistry and therapeutic potential","volume":"7","author":"Marcussi","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jep.2024.118349_bib49","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0005-2760(65)90152-9","article-title":"The action of phospholipase A2 on lipoproteins","volume":"98","author":"Marinetti","year":"1965","journal-title":"Biochim. Biophys. Acta Lipids Lipid. Metabol."},{"key":"10.1016\/j.jep.2024.118349_bib50","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.3390\/molecules18033018","article-title":"Natural aristolactams and aporphine alkaloids as inhibitors of CDK1\/Cyclin B and DYRK1A","volume":"18","author":"Marti","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118349_bib51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.21577\/1984-6835.20190002","article-title":"Determination of bioactive compounds in Clusia fluminensis Planch. & Triana fruit's arils","volume":"11","author":"Mazza","year":"2019","journal-title":"Rev Virtual Qu\u00edmica"},{"key":"10.1016\/j.jep.2024.118349_bib52","article-title":"Apoptosis-inducing anti-proliferative and quantitative phytochemical profiling with in silico study of antioxidant-rich Leea aequata L. leaves","volume":"10","author":"Mostofa","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2024.118349_bib53","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jep.2014.12.020","article-title":"Plants used to treat snake bites in Santar\u00e9m, western Par\u00e1, Brazil: an assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom","volume":"161","author":"Moura","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib54","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/ph17010022","article-title":"Computer-Aided Drug design and Drug discovery: a prospective analysis","volume":"17","author":"Niazi","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2024.118349_bib55","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3390\/molecules14031072","article-title":"Anti-hemorrhagic activity of four Brazilian vegetable species against Bothrops jararaca venom","volume":"14","author":"Nishijima","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118349_bib56","first-page":"1","article-title":"Inhibitory effect of plant Manilkara subsericea against biological activities of Lachesis muta snake venom","volume":"408068","author":"Oliveira","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2024.118349_bib57","first-page":"1","article-title":"Protective effect of the plant extracts of Erythroxylum sp. against toxic effects induced by the venom of Lachesis muta snake","volume":"21","author":"Oliveira","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118349_bib58","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0378-8741(00)00321-4","article-title":"Snakebites and ethnobotany in the northwest region of Colombia part III: neutralization of the hemorrhagic of Bothrops atrox venom","volume":"73","author":"Otero","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib59","first-page":"1168","article-title":"Redes Moleculares: uma an\u00e1lise sobre anota\u00e7\u00f5es e descoberta de novos ativos","volume":"44","author":"Pilon","year":"2021","journal-title":"Quim. Nova"},{"key":"10.1016\/j.jep.2024.118349_bib60","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/md20050320","article-title":"Application of MS-based metabolomic approaches in analysis of starfish and sea cucumber bioactive compounds","volume":"20","author":"Popov","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.jep.2024.118349_bib61","first-page":"202","article-title":"New species of Siparuna (Siparunaceae) IV. A new subcanopy tree from white-sand areas in Brazil and Venezuela","volume":"15","author":"Renner","year":"2005","journal-title":"Novon"},{"key":"10.1016\/j.jep.2024.118349_bib62","article-title":"Medicinal plants used to treat snakebites by people in the neighborhood watersheds Platinum and Amazon, Brazil. Plant","volume":"79","author":"Rieder","year":"2013","journal-title":"Med."},{"key":"10.1016\/j.jep.2024.118349_bib63","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1590\/0037-8682-0489-2017","article-title":"Epidemiological study os snakebite cases on Brazilian Western Amazonia","volume":"51","author":"Roriz","year":"2018","journal-title":"Rev. Soc. Bras. Trop."},{"key":"10.1016\/j.jep.2024.118349_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.828269","article-title":"The bioflavonoids rutin and rutin succinate neutralize the toxins of B. jararaca venom and inhibit its lethality","volume":"13","author":"Sachetto","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib65","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/138955713804484730","article-title":"Snake venom induced local toxicities: plant secondary metabolites as an auxiliary therapy","volume":"13","author":"Santhosh","year":"2013","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.jep.2024.118349_bib66","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1007\/s43440-023-00543-8","article-title":"Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors","volume":"75","author":"Sampat","year":"2023","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.jep.2024.118349_bib67","doi-asserted-by":"crossref","first-page":"48","DOI":"10.6026\/97320630008048","article-title":"Therapeutic application of natural inhibitors against snake venom phospholipase A2","volume":"8","author":"Samy","year":"2012","journal-title":"Bioinformation"},{"key":"10.1016\/j.jep.2024.118349_bib68","first-page":"1","article-title":"Overview of snakebite in Brazil: possible drivers and toll for risk mapping","volume":"15","author":"Scheneider","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.jep.2024.118349_bib69","doi-asserted-by":"crossref","first-page":"9365","DOI":"10.3390\/ijerph18179365","article-title":"Snakebites in rural areas of Brazil by race: indigenous the most exposed group","volume":"18","author":"Scheneider","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.jep.2024.118349_bib70","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jep.2013.03.022","article-title":"Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle","volume":"147","author":"Shenoy","year":"2013","journal-title":"J. Etnhopharmcol."},{"key":"10.1016\/j.jep.2024.118349_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40409-015-0002-2","article-title":"The red seaweed Plocamium brasiliense shows anti-snake venom toxic effects","volume":"21","author":"Silva","year":"2015","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.jep.2024.118349_bib72","article-title":"Chemical profile of Stachytarpheta schottiana by LC-HRMS\/MS dereplication and molecular networking","volume":"72","author":"Silva","year":"2021","journal-title":"Rodriguesia"},{"key":"10.1016\/j.jep.2024.118349_bib73","first-page":"168","article-title":"Siparuna Aublet genus (Siparunaceae): from folk medicine to chemical composition and biological activity","volume":"5","author":"Silva","year":"2021","journal-title":"Trends Phytochem. Res"},{"key":"10.1016\/j.jep.2024.118349_bib74","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1023\/A:1005672017673","article-title":"Chemical ecological characteristics of herbivory of Siparuna guianensis seeds by Buffy-Headed Marmosets (Callithrix flaviceps) in the Atlantic forest of Southeastern Brazil","volume":"27","author":"Simas","year":"2001","journal-title":"J. Chem. Ecol."},{"key":"10.1016\/j.jep.2024.118349_bib75","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3831\/KPI.2017.20.020","article-title":"A review on venom enzymes neutralizing ability of secondary metabolites from medicinal plants","volume":"20","author":"Singh","year":"2017","journal-title":"J. Pharmacopuncture"},{"key":"10.1016\/j.jep.2024.118349_bib76","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/rcm.1343","article-title":"Key fragmentation patterns of aporphine alkaloids by electrospray ionization with multistage mass spectrometry","volume":"18","author":"St\u00e9vigny","year":"2004","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jep.2024.118349_bib77","article-title":"Antimicrobial alkaloids from marine-derived fungi as Drug leads versus COVID-19 infection: a computational approach to explore their anti-COVID-19 activity and ADMET properties","volume":"8","author":"Sweilam","year":"2022","journal-title":"Evid Based Comp. Alternat Med."},{"key":"10.1016\/j.jep.2024.118349_bib78","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1021\/np200479a","article-title":"Antiophidic solanidane steroidal alkaloids from Solanum campaniforme","volume":"74","author":"Torres","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2024.118349_bib79","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.phytochem.2013.09.007","article-title":"Solanidane and iminosolanidane alkaloids from Solanum campaniforme","volume":"96","author":"Torres","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2024.118349_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115889","article-title":"The anti-snake activity of Nectandra angustifolia flavonoids on phospholipase A2: In vitro and in silico evaluation","volume":"302","author":"Torres","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib81","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jep.2012.12.043","article-title":"Snakebites and ethnobotany in the Eastern region of Antioquia, Colombia - the traditional use of plants","volume":"146","author":"V\u00e1squez","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib82","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jep.2015.04.059","article-title":"Main plants used in traditional medicine for the treatment of snake bites in the regions of the department of Antioquia, Colombia","volume":"170","author":"V\u00e1squez","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118349_bib83","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.3390\/antibiotics11081014","article-title":"Interactions between medical plant-derived bioactive compounds: focus on antimicrobial combination effects","volume":"11","author":"Vaou","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2024.118349_bib84","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0041-0101(87)90155-3","article-title":"Interaction of aristolochic acid with Vipera russelli phospholipase A2: its effect on enzymatic and pathological activities","volume":"25","author":"Vishwanath","year":"1987","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2024.118349_bib85","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1021\/np400413s","article-title":"Molecular networking as a dereplication strategy","volume":"76","author":"Yang","year":"2013","journal-title":"J. Nat. Prod."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124006482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124006482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T22:13:03Z","timestamp":1717971183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124006482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":85,"alternative-id":["S0378874124006482"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118349","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alkaloids from Siparuna (Siparunaceae) are predicted as the inhibitors of proteolysis and plasma coagulation caused by snake venom and potentially counteract phospholipase A2 activity of Bothrops jararaca","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118349","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118349"}}