{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:40:42Z","timestamp":1792723242311,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jep.2024.118362","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:37:41Z","timestamp":1716046661000},"page":"118362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Investigating the effects of rare ginsenosides on hyperuricemia and associated sperm damage via nontargeted metabolomics and gut microbiota"],"prefix":"10.1016","volume":"332","author":[{"given":"Xueying","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2024.118362_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/106002809302700317","article-title":"Allopurinol hypersensitivity syndrome: a review","volume":"27","author":"Arellano","year":"1993","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.jep.2024.118362_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.926926","article-title":"Composition and diversity of gut microbiota in diabetic retinopathy","volume":"13","author":"Bai","year":"2022","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.jep.2024.118362_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/biom8030065","article-title":"Role of uric acid in semen","volume":"8","author":"Banihani","year":"2018","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.jep.2024.118362_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41579-021-00621-9","article-title":"Mass spectrometry-based metabolomics in microbiome investigations","volume":"20","author":"Bauermeister","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"issue":"10","key":"10.1016\/j.jep.2024.118362_bib5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","article-title":"Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2024.118362_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109195","article-title":"Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice","volume":"118","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2024.118362_bib7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/medicina57010058","article-title":"Therapeutic strategies for the treatment of chronic hyperuricemia: an evidence-based update","volume":"57","author":"Cicero","year":"2021","journal-title":"Medicina"},{"issue":"10287","key":"10.1016\/j.jep.2024.118362_bib8","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Gout. Lancet"},{"key":"10.1016\/j.jep.2024.118362_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118998","article-title":"Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance","volume":"268","author":"Dhouibi","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2024.118362_bib10","series-title":"Functional Metabolomics Reveals the Mechanism of Pyrimidines'Benefits to Obesity","author":"Feng","year":"2022"},{"issue":"14","key":"10.1016\/j.jep.2024.118362_bib11","first-page":"1897","article-title":"Study on mechanism of fermentation of Astragalus membranaceus on serum metabonomics in hyperuricemia based on UHPLC-HRMS","volume":"40","author":"Ge","year":"2023","journal-title":"Chi. J Mod Appl Pharm."},{"issue":"8","key":"10.1016\/j.jep.2024.118362_bib12","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1002\/jsfa.12383","article-title":"Spatial distribution of gut microbiota in mice during the occurrence and remission of hyperuricemia","volume":"103","author":"Han","year":"2023","journal-title":"J. Sci. Food Agric."},{"issue":"10","key":"10.1016\/j.jep.2024.118362_bib13","doi-asserted-by":"crossref","DOI":"10.1099\/jmm.0.001435","article-title":"The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis","volume":"70","author":"Hasani","year":"2021","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jep.2024.118362_bib14","first-page":"1","article-title":"Shugan Bushen Yulin Decoction can improve sperm quality of Liver Depression and Kidney Deficiency Type oligasthenospermia mice by regulating Keap1\/Nrf2\/GPX4 pathway to inhibit ferroptosis of testicular cells","author":"Jiang","year":"2023","journal-title":"Chin Arch Tradit Chin Med"},{"issue":"3","key":"10.1016\/j.jep.2024.118362_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3349\/ymj.2022.63.3.241","article-title":"Distinct gut microbiota in patients with asymptomatic hyperuricemia: a potential protector against gout development","volume":"63","author":"Kim","year":"2022","journal-title":"Yonsei Med. J."},{"issue":"1","key":"10.1016\/j.jep.2024.118362_bib16","first-page":"104","article-title":"Research progress of classical Chinese medicine formulas for the treatment of gout, pharmacol clin","volume":"39","author":"Lang","year":"2023","journal-title":"Chin Mater Med."},{"issue":"4","key":"10.1016\/j.jep.2024.118362_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.jep.2024.118362_bib18","doi-asserted-by":"crossref","DOI":"10.4161\/spmg.26391","article-title":"Ginseng and male reproductive function","volume":"3","author":"Leung","year":"2013","journal-title":"Spermatogenesis"},{"issue":"9","key":"10.1016\/j.jep.2024.118362_bib19","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/nu8090566","article-title":"Ginsenoside Rg5 ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress, and apoptosis","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"issue":"50","key":"10.1016\/j.jep.2024.118362_bib20","doi-asserted-by":"crossref","first-page":"15804","DOI":"10.1021\/acs.jafc.2c06377","article-title":"Ginsenoside Rk1 prevents UVB irradiation-mediated oxidative stress, inflammatory response, and collagen degradation via the PI3K\/AKT\/NF-\u03baB pathway in vitro and in vivo","volume":"70","author":"Liu","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.jep.2024.118362_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/and.14184","article-title":"Differentially expressed microRNA in testicular tissues of hyperuricaemia rats","volume":"53","author":"Ma","year":"2021","journal-title":"Andrologia"},{"issue":"3","key":"10.1016\/j.jep.2024.118362_bib22","article-title":"Effects of high serum uric acid levels on oxidative stress levels and semen parameters in male infertile patients","volume":"101","author":"Ma","year":"2022","journal-title":"Medicine (Baltim.)"},{"issue":"7503","key":"10.1016\/j.jep.2024.118362_bib23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.jep.2024.118362_bib24","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1039\/D1FO00198A","article-title":"Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism","volume":"12","author":"Ni","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2024.118362_bib25","first-page":"119","article-title":"Lactobacillus: host-microbe relationships","volume":"358","author":"O'Callaghan","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jep.2024.118362_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5524772","article-title":"High-throughput untargeted serum metabolomics analysis of hyperuricemia patients by UPLC-Q-TOF\/MS","volume":"2021","author":"Qin","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"issue":"12","key":"10.1016\/j.jep.2024.118362_bib27","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","article-title":"Untargeted metabolomics strategies-challenges and emerging directions","volume":"27","author":"Schrimpe-Rutledge","year":"2016","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"6","key":"10.1016\/j.jep.2024.118362_bib28","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.fertnstert.2018.07.002","article-title":"Effects of medical comorbidity on male infertility and comorbidity treatment on spermatogenesis","volume":"110","author":"Shiraishi","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jep.2024.118362_bib29","article-title":"Alteration of gut microbiome and correlated amino acid metabolism contribute to hyperuricemia and Th17-driven inflammation in Uox-KO mice","volume":"13","author":"Song","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2024.118362_bib30","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/art.1780080429","article-title":"Role of the intestinal tract in the elimination of uric acid","volume":"8","author":"Sorensen","year":"1965","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.jep.2024.118362_bib31","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s43032-019-00098-1","article-title":"Declining BRCA-mediated DNA repair in sperm aging and its prevention by sphingosine-1-phosphate","volume":"27","author":"Stobezki","year":"2020","journal-title":"Reprod. Sci."},{"issue":"5","key":"10.1016\/j.jep.2024.118362_bib32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jgr.2021.01.001","article-title":"Saengmaeksan, a traditional herbal formulation consisting of Panax ginseng, ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats","volume":"45","author":"Sung","year":"2021","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jep.2024.118362_bib33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2019.05.004","article-title":"Inhibition of biliary network reconstruction by benzbromarone delays recovery from pre-existing liver injury","volume":"423","author":"Takemura","year":"2019","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.jep.2024.118362_bib34","first-page":"526","article-title":"Advances on hormone-like activity of Panax ginseng and ginsenosides","volume":"18","author":"Tian","year":"2020","journal-title":"Chin. J. Nat. Med."},{"issue":"7122","key":"10.1016\/j.jep.2024.118362_bib35","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.jep.2024.118362_bib36","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1080\/10408398.2021.1874287","article-title":"The gut microbiota as a target to control hyperuricemia pathogenesis: potential mechanisms and therapeutic strategies","volume":"62","author":"Wang","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2024.118362_bib37","article-title":"Role of sphingolipid metabolites in the homeostasis of steroid hormones and the maintenance of testicular functions","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"13","key":"10.1016\/j.jep.2024.118362_bib38","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1056\/NEJMoa1710895","article-title":"Cardiovascular safety of febuxostat or allopurinol in patients with gout","volume":"378","author":"White","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118362_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1897211","article-title":"Limosilactobacillus fermentum JL-3 isolated from \"Jiangshui\" ameliorates hyperuricemia by degrading uric acid","volume":"13","author":"Wu","year":"2021","journal-title":"Gut Microb."},{"issue":"2020","key":"10.1016\/j.jep.2024.118362_bib40","article-title":"Relationship between antimicrobial activity and amphipathic structure of ginsenosides","volume":"143","author":"Xue","year":"2020","journal-title":"Ind. Crops Prod."},{"issue":"17","key":"10.1016\/j.jep.2024.118362_bib41","doi-asserted-by":"crossref","first-page":"9221","DOI":"10.3390\/ijms22179221","article-title":"Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease","volume":"22","author":"Yanai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.jep.2024.118362_bib42","doi-asserted-by":"crossref","first-page":"E483","DOI":"10.1503\/cmaj.221575","article-title":"Allopurinol hypersensitivity syndrome","volume":"195","author":"Yaseen","year":"2023","journal-title":"CMAJ (Can. Med. Assoc. J.)"},{"issue":"23","key":"10.1016\/j.jep.2024.118362_bib45","doi-asserted-by":"crossref","first-page":"12412","DOI":"10.1039\/D2FO02702J","article-title":"Live and pasteurized Akkermansia muciniphila attenuate hyperuricemia in mice through modulating uric acid metabolism, inflammation, and gut microbiota","volume":"13","author":"Zhang","year":"2022","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.jep.2024.118362_bib43","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1142\/S0192415X19500587","article-title":"The effects of ginsenosides and anserine on the up-regulation of renal aquaporins 1-4 in hyperuricemic mice","volume":"47","author":"Zhang","year":"2019","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118362_bib44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jgr.2020.01.003","article-title":"Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid treatment","volume":"45","author":"Zhang","year":"2021","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jep.2024.118362_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131655","article-title":"Safety assessment of crude saponins from Chenopodium quinoa willd. husks: 90-day oral toxicity and gut microbiota & metabonomics study in rats","volume":"375","author":"Zhang","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2024.118362_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.953962","article-title":"Composition and diverse differences of intestinal microbiota in ulcerative colitis patients","volume":"12","author":"Zhu","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124006615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124006615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T22:12:47Z","timestamp":1717971167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124006615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":47,"alternative-id":["S0378874124006615"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118362","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the effects of rare ginsenosides on hyperuricemia and associated sperm damage via nontargeted metabolomics and gut microbiota","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118362"}}