{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:30:25Z","timestamp":1785799825081,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673764"],"award-info":[{"award-number":["81673764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jep.2024.118366","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T03:51:18Z","timestamp":1716004278000},"page":"118366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor\/phosphatidylinositol 3-kinase\/serine\/threonine protein kinase pathway"],"prefix":"10.1016","volume":"332","author":[{"given":"Jiadi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danning","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piwen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.jep.2024.118366_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147586","article-title":"Photobiomodulation by near-infrared 980-nm wavelengths regulates pre-osteoblast proliferation and viability through the PI3K\/Akt\/Bcl-2 pathway","volume":"22","author":"Agas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118366_bib2","series-title":"Japanese Kampo Medicines for the Treatment of Common Diseases","author":"Arumugam","year":"2017"},{"issue":"8","key":"10.1016\/j.jep.2024.118366_bib3","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00198-009-1107-7","article-title":"Increased serum osteopontin is a risk factor for osteoporosis in menopausal women","volume":"21","author":"Chang","year":"2010","journal-title":"Osteoporosis Int."},{"issue":"2","key":"10.1016\/j.jep.2024.118366_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22642","article-title":"Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl-2, and caspase-3 signaling pathways in BALB\/c mice","volume":"35","author":"Changizi","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"8","key":"10.1016\/j.jep.2024.118366_bib5","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.fct.2011.04.031","article-title":"Kaempferol protects MC3T3-E1 cells through antioxidant effect and regulation of mitochondrial function","volume":"49","author":"Choi","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2024.118366_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101608","article-title":"Osteocytes in bone aging: advances, challenges, and future perspectives","volume":"77","author":"Cui","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jep.2024.118366_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109796","article-title":"Anagliptin stimulates osteoblastic cell differentiation and mineralization","volume":"129","author":"Dong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118366_bib8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.semcancer.2019.05.012","article-title":"Role of the PI3K\/AKT\/mTOR signaling pathway in ovarian cancer: biological and therapeutic significance","volume":"59","author":"Ediriweera","year":"2019","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.jep.2024.118366_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13018-022-02965-1","article-title":"The effects and mechanism of paeoniflorin in promoting osteogenic differentiation of MC3T3-E1","volume":"17","author":"Guo","year":"2022","journal-title":"J. Orthop. Surg. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118366_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3892\/ijmm.2016.2826","article-title":"miR-214 suppresses the osteogenic differentiation of bone marrow-derived mesenchymal stem cells and these effects are mediated through the inhibition of the JNK and p38 pathways","volume":"39","author":"Guo","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2024.118366_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jare.2023.01.003","article-title":"Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss","volume":"53","author":"He","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jep.2024.118366_bib12","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jconrel.2023.01.071","article-title":"Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice","volume":"355","author":"Hwang","year":"2023","journal-title":"J. Contr. Release"},{"issue":"2","key":"10.1016\/j.jep.2024.118366_bib13","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.221810","article-title":"MRI quantification of cortical bone porosity, mineralization, and morphologic structure in postmenopausal osteoporosis","volume":"307","author":"Jones","year":"2023","journal-title":"Radiology"},{"issue":"6","key":"10.1016\/j.jep.2024.118366_bib14","doi-asserted-by":"crossref","first-page":"7331","DOI":"10.1096\/fj.201802465R","article-title":"JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4)","volume":"33","author":"Kusuyama","year":"2019","journal-title":"Faseb. J."},{"issue":"21","key":"10.1016\/j.jep.2024.118366_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218301","article-title":"Effects of estrogen receptor and wnt signaling activation on mechanically induced bone formation in a mouse model of postmenopausal bone loss","volume":"21","author":"Liedert","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2024.118366_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/me.2002-0206","article-title":"Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a \"ying yang\" relationship between ERalpha and ERbeta in mice","volume":"17","author":"Lindberg","year":"2003","journal-title":"Mol. Endocrinol."},{"issue":"31","key":"10.1016\/j.jep.2024.118366_bib17","doi-asserted-by":"crossref","first-page":"f3329","DOI":"10.1126\/sciadv.adf3329","article-title":"Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment","volume":"9","author":"Liu","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jep.2024.118366_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41413-019-0050-2","article-title":"Connexin 43 hemichannels protect bone loss during estrogen deficiency","volume":"7","author":"Ma","year":"2019","journal-title":"Bone Res"},{"issue":"5","key":"10.1016\/j.jep.2024.118366_bib19","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.cell.2021.02.002","article-title":"Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption","volume":"184","author":"McDonald","year":"2021","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jep.2024.118366_bib20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/jbmr.2082","article-title":"Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength","volume":"29","author":"Melville","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2024.118366_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114134","article-title":"beta-estradiol adjusts intestinal function via ERbeta and GPR30 mediated PI3K\/AKT signaling activation to alleviate postmenopausal dyslipidemia","volume":"180","author":"Meng","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118366_bib22","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1210\/endrev\/bnab015","article-title":"The relationship between bone and reproductive hormones beyond estrogens and androgens","volume":"42","author":"Mills","year":"2021","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.jep.2024.118366_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12964-023-01052-0","article-title":"Estrogen downregulates CD73\/adenosine axis hyperactivity via adaptive modulation PI3K\/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress","volume":"21","author":"Ndzie","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jep.2024.118366_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154509","article-title":"Equol exerts a protective effect on postmenopausal osteoporosis by upregulating OPG\/RANKL pathway","volume":"108","author":"Ni","year":"2023","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2024.118366_bib25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/jmcb\/mjz010","article-title":"Understanding p53 functions through p53 antibodies","volume":"11","author":"Sabapathy","year":"2019","journal-title":"J. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.jep.2024.118366_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15102845","article-title":"Role of estrogen receptor beta, G-protein coupled estrogen receptor and estrogen-related receptors in endometrial and ovarian cancer","volume":"15","author":"Schuler-Toprak","year":"2023","journal-title":"Cancers"},{"issue":"12","key":"10.1016\/j.jep.2024.118366_bib27","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s00439-022-02463-8","article-title":"GATA4 and estrogen receptor alpha bind at SNPs rs9921222 and rs10794639 to regulate AXIN1 expression in osteoblasts","volume":"141","author":"Suthon","year":"2022","journal-title":"Hum. Genet."},{"key":"10.1016\/j.jep.2024.118366_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144855","article-title":"Alkaline phosphatase: structure, expression and its function in bone mineralization","volume":"754","author":"Vimalraj","year":"2020","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.jep.2024.118366_bib29","first-page":"11","article-title":"Characteristics of Japanese kampo for diagnosis and medication","author":"Wang","year":"1998","journal-title":"Sichuan Traditional Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2024.118366_bib30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Res"},{"issue":"4","key":"10.1016\/j.jep.2024.118366_bib31","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.bbrc.2018.03.093","article-title":"Beneficial effects of paeoniflorin on osteoporosis induced by high-carbohydrate, high-fat diet-associated hyperlipidemia in vivo","volume":"498","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.jep.2024.118366_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.arcmed.2016.07.002","article-title":"Opposite function of ERalpha and ERbeta in controlling 17beta-Estradiol-mediated osteogenesis in osteoblasts","volume":"47","author":"Wang","year":"2016","journal-title":"Arch. Med. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118366_bib33","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1038\/s41467-023-40087-2","article-title":"Structures of p53\/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity","volume":"14","author":"Wei","year":"2023","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.jep.2024.118366_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14112708","article-title":"Risk factors for ovarian cancer: an umbrella review of the literature","volume":"14","author":"Whelan","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2024.118366_bib35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/1472-6882-13-277","article-title":"Si-Wu-tang extract stimulates bone formation through PI3K\/Akt\/NF-kappaB signaling pathways in osteoblasts","volume":"13","author":"Wu","year":"2013","journal-title":"BMC Compl. Alternative Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118366_bib36","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/jbmr.4731","article-title":"Osteocyte estrogen receptor beta (Ot-ERbeta) regulates bone turnover and skeletal adaptive response to mechanical loading differently in male and female growing and adult mice","volume":"38","author":"Xu","year":"2023","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jep.2024.118366_bib37","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.biopha.2017.01.130","article-title":"Inhibition of PI3K\/AKT\/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis","volume":"89","author":"Xue","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2024.118366_bib38","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bbrc.2020.09.054","article-title":"Senkyunolide H attenuates osteoclastogenesis and postmenopausal osteoporosis by regulating the NF-kappaB, JNK and ERK signaling pathways","volume":"533","author":"Yang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.jep.2024.118366_bib39","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1159\/000235618","article-title":"Estradiol increases the Bax\/Bcl-2 ratio and induces apoptosis in the anterior pituitary gland","volume":"90","author":"Zaldivar","year":"2009","journal-title":"Neuroendocrinology"},{"issue":"9","key":"10.1016\/j.jep.2024.118366_bib40","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1039\/D0FO00837K","article-title":"Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K\/AKT pathway","volume":"11","author":"Zhan","year":"2020","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.jep.2024.118366_bib41","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41401-022-00954-y","article-title":"A phase III randomized, double-blind, placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk","volume":"44","author":"Zhang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.jep.2024.118366_bib42","first-page":"17","article-title":"Systematic classification of Kampo decoction preparations for medical use\uff0dSiwu Tang as the basic formula","author":"Zhang","year":"1990","journal-title":"Tianjin Pharmacy"},{"key":"10.1016\/j.jep.2024.118366_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113696","article-title":"Virtual screening of the multi-gene regulatory molecular mechanism of Si-Wu-tang against non-triple-negative breast cancer based on network pharmacology combined with experimental validation","volume":"269","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2024.118366_bib44","first-page":"2750","article-title":"Phytoestrogen-like effect of Siwu Decoction and molecular mechanism: based on network pharmacology and in vivo experiment","volume":"47","author":"Zhang","year":"2022","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2024.118366_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.615191","article-title":"Leonurine promotes the osteoblast differentiation of rat BMSCs by activation of autophagy via the PI3K\/Akt\/mTOR pathway","volume":"9","author":"Zhao","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jep.2024.118366_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114431","article-title":"Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure","volume":"280","author":"Zhou","year":"2021","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124006652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124006652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T20:30:26Z","timestamp":1717446626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124006652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":46,"alternative-id":["S0378874124006652"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118366","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor\/phosphatidylinositol 3-kinase\/serine\/threonine protein kinase pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118366"}}