{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:12:01Z","timestamp":1792512721014,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jep.2024.118407","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T16:02:05Z","timestamp":1717171325000},"page":"118407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Taohong Siwu decoction alleviates cognitive impairment by suppressing endoplasmic reticulum stress and apoptosis signaling pathway in vascular dementia rats"],"prefix":"10.1016","volume":"333","author":[{"given":"Ling-Ling","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Liang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Feng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.jep.2024.118407_bib1","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1523\/JNEUROSCI.1802-17.2017","article-title":"A critical role for the nucleus reuniens in long-term, but not short-term associative recognition memory formation","volume":"38","author":"Barker","year":"2018","journal-title":"J. Neurosci."},{"issue":"13","key":"10.1016\/j.jep.2024.118407_bib2","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1523\/JNEUROSCI.3154-05.2006","article-title":"The different effects on recognition memory of perirhinal kainate and nmda glutamate receptor antagonism: implications for underlying plasticity mechanisms","volume":"26","author":"Barker","year":"2006","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.jep.2024.118407_bib3","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1523\/JNEUROSCI.5289-06.2007","article-title":"Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex","volume":"27","author":"Barker","year":"2007","journal-title":"J. Neurosci."},{"issue":"29","key":"10.1016\/j.jep.2024.118407_bib4","doi-asserted-by":"crossref","first-page":"10721","DOI":"10.1523\/JNEUROSCI.6413-10.2011","article-title":"When is the hippocampus involved in recognition memory?","volume":"31","author":"Barker","year":"2011","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.jep.2024.118407_bib5","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1523\/JNEUROSCI.5171-06.2007","article-title":"Perceptual functions of perirhinal cortex in rats: zero-delay object recognition and simultaneous oddity discriminations","volume":"27","author":"Bartko","year":"2007","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.jep.2024.118407_bib6","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s11064-010-0346-5","article-title":"Vascular cognitive disorder. A biological and clinical overview","volume":"35","author":"Battistin","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2024.118407_bib7","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74342","article-title":"Endoplasmic reticulum stress activates human ire1alpha through reversible assembly of inactive dimers into small oligomers","volume":"11","author":"Belyy","year":"2022","journal-title":"Elife"},{"issue":"1\u20132","key":"10.1016\/j.jep.2024.118407_bib8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/00207458909002151","article-title":"The use of the morris water maze in the study of memory and learning","volume":"48","author":"Brandeis","year":"1989","journal-title":"Int. J. Neurosci."},{"issue":"2","key":"10.1016\/j.jep.2024.118407_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/15548627.2015.1121360","article-title":"Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders","volume":"12","author":"Cai","year":"2016","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.jep.2024.118407_bib10","first-page":"620","article-title":"Tao-hong-si-Wu decoction promotes angiogenesis after cerebral ischaemia in rats via platelet microparticles","volume":"18","author":"Chen","year":"2020","journal-title":"Chin. J. Nat. Med."},{"issue":"5","key":"10.1016\/j.jep.2024.118407_bib11","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1007\/s12035-016-9915-1","article-title":"Molecular mechanisms of vascular dementia: what can be learned from animal models of chronic cerebral hypoperfusion?","volume":"54","author":"Du","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"19","key":"10.1016\/j.jep.2024.118407_bib12","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1042\/CS20160727","article-title":"Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia","volume":"131","author":"Duncombe","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"issue":"3","key":"10.1016\/j.jep.2024.118407_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/hipo.20059","article-title":"Hippocampal lesions that abolish spatial maze performance spare object recognition memory at delays of up to 48 hours","volume":"15","author":"Forwood","year":"2005","journal-title":"Hippocampus"},{"issue":"49","key":"10.1016\/j.jep.2024.118407_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2208254119","article-title":"Spatial contextual recognition memory updating is modulated by dopamine release in the dorsal hippocampus from the locus coeruleus","volume":"119","author":"G\u00e1lvez-M\u00e1rquez","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13293-023-00518-7","article-title":"Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia","volume":"14","author":"Gannon","year":"2023","journal-title":"Biol. Sex Differ."},{"issue":"17","key":"10.1016\/j.jep.2024.118407_bib16","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.3390\/ijms21176127","article-title":"Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases","volume":"21","author":"Ghemrawi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118407_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118559","article-title":"Rg1 in combination with mannitol protects neurons against glutamate-induced er stress via the perk-eif2 alpha-atf4 signaling pathway","volume":"263","author":"Gu","year":"2020","journal-title":"Life Sci."},{"issue":"12","key":"10.1016\/j.jep.2024.118407_bib18","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.cellsig.2010.07.006","article-title":"Xbp1u inhibits the xbp1s-mediated upregulation of the inos gene expression in mammalian er stress response","volume":"22","author":"Guo","year":"2010","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s10020-018-0020-y","article-title":"Effects of creb1 gene silencing on cognitive dysfunction by mediating pka-creb signaling pathway in mice with vascular dementia","volume":"24","author":"Han","year":"2018","journal-title":"Mol. Med."},{"key":"10.1016\/j.jep.2024.118407_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51804","article-title":"Repression of viral gene expression and replication by the unfolded protein response effector xbp1u","volume":"9","author":"Hinte","year":"2020","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.jep.2024.118407_bib21","article-title":"Taohong siwu decoction ameliorates cognitive dysfunction through sirt6_er stress pathway in alzheimer's disease","volume":"314","author":"Hong-Yu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib22","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1038\/s41598-021-88206-7","article-title":"Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats","volume":"11","author":"Huang","year":"2021","journal-title":"Sci. Rep.-Uk"},{"issue":"4","key":"10.1016\/j.jep.2024.118407_bib23","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/01.STR.0000122624.32167.e0","article-title":"Decrease in cortical benzodiazepine receptors in symptomatic patients with leukoaraiosis","volume":"35","author":"Ihara","year":"2004","journal-title":"Stroke"},{"issue":"7230","key":"10.1016\/j.jep.2024.118407_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nature07661","article-title":"The unfolded protein response signals through high-order assembly of ire1","volume":"457","author":"Korennykh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.118407_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00351","article-title":"Dl-3-n-butylphthalide reduces cognitive impairment induced by chronic cerebral hypoperfusion through gdnf\/gfr\u03b11\/ret signaling preventing hippocampal neuron apoptosis","volume":"13","author":"Li","year":"2019","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.21037\/atm-20-2936","article-title":"The trend of indirect anastomosis formation in a 2-vessel occlusion plus encephalo-myo-synangiosis rat model","volume":"9","author":"Li","year":"2021","journal-title":"Ann. Transl. Med."},{"issue":"13","key":"10.1016\/j.jep.2024.118407_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108563","article-title":"A molecular mechanism for turning off ire1\u03b1 signaling during endoplasmic reticulum stress","volume":"33","author":"Li","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2024.118407_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173273","article-title":"Object recognition and morris water maze to detect cognitive impairment from mild hippocampal damage in rats: a reflection based on the literature and experience","volume":"210","author":"Lissner","year":"2021","journal-title":"Pharmacol. Biochem. Be."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-022-02393-2","article-title":"Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in ad-like mice by improving bdnf-related neuropathology","volume":"19","author":"Liu","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2024.118407_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.neuro.31.061307.090723","article-title":"Place cells, grid cells, and the brain's spatial representation system","volume":"31","author":"Moser","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"issue":"23","key":"10.1016\/j.jep.2024.118407_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131344","article-title":"Er stress and rho kinase activation underlie the vasculopathy of cadasil","volume":"4","author":"Neves","year":"2019","journal-title":"Jci Insight"},{"issue":"5","key":"10.1016\/j.jep.2024.118407_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02415-22","article-title":"SARS-cov-2 diverges from other betacoronaviruses in only partially activating the ire1alpha\/xbp1 endoplasmic reticulum stress pathway in human lung-derived cells","volume":"13","author":"Nguyen","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.jep.2024.118407_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155215","article-title":"Beta-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the camp\/pka\/creb pathway","volume":"123","author":"Ning","year":"2024","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.jep.2024.118407_bib34","doi-asserted-by":"crossref","first-page":"12604","DOI":"10.1002\/jcp.27332","article-title":"Dl\u20103\u2010n\u2010butylphthalide alleviates vascular cognitive impairment by regulating endoplasmic reticulum stress and the shh\/ptch1 signaling\u2010pathway in rats","volume":"234","author":"Niu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2024.118407_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101985","article-title":"Free-water imaging of the hippocampus is a sensitive marker of alzheimer's disease","volume":"24","author":"Ofori","year":"2019","journal-title":"Neuroimage Clin"},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(71)90358-1","article-title":"The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat","volume":"34","author":"O'Keefe","year":"1971","journal-title":"Brain Res."},{"key":"10.1016\/j.jep.2024.118407_bib37","first-page":"1","article-title":"Ligustilide improves cognitive impairment via regulating the sirt1\/ire1\u03b1\/xbp1s\/chop pathway in vascular dementia rats","volume":"2022","author":"Peng","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.jep.2024.118407_bib38","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3390\/antiox11071395","article-title":"Hippocampal endoplasmic reticulum stress hastens motor and cognitive decline in adult male rats sustainedly exposed to high-sucrose diet","volume":"11","author":"Pinto","year":"2022","journal-title":"Antioxidants"},{"issue":"9","key":"10.1016\/j.jep.2024.118407_bib39","doi-asserted-by":"crossref","first-page":"9811","DOI":"10.1096\/fj.201801240RR","article-title":"Clustering of ire1\u03b1 depends on sensing er stress but not on its rnase activity","volume":"33","author":"Ricci","year":"2019","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2007.12.017","article-title":"How ire1 reacts to er stress","volume":"132","author":"Ron","year":"2008","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jep.2024.118407_bib41","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1007\/s12035-020-02202-y","article-title":"Celecoxib-dependent neuroprotection in a rat model of transient middle cerebral artery occlusion (tmcao) involves modifications in unfolded protein response (upr) and proteasome","volume":"58","author":"Santos-Galdiano","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"Endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jep.2024.118407_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.816347","article-title":"Effects and mechanisms of taohong siwu decoction on the prevention and treatment of myocardial injury","volume":"13","author":"Shao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118407_bib44","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.nlm.2016.06.016","article-title":"Temporary inactivation reveals that the ca1 region of the mouse dorsal hippocampus plays an equivalent role in the retrieval of long-term object memory and spatial memory","volume":"133","author":"Stackman","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"issue":"3","key":"10.1016\/j.jep.2024.118407_bib45","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/eji.201444461","article-title":"A riddle solved: why an intact ire1alpha\/xbp-1 signaling relay is key for humoral immune responses","volume":"44","author":"van Anken","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jep.2024.118407_bib46","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41168","article-title":"Inadequate bip availability defines endoplasmic reticulum stress","volume":"8","author":"Vitale","year":"2019","journal-title":"Elife"},{"issue":"7","key":"10.1016\/j.jep.2024.118407_bib47","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/aps.2009.82","article-title":"Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment","volume":"30","author":"Wang","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2024.118407_bib48","article-title":"Endoplasmic reticulum stress and the unfolded protein response in cerebral ischemia\/reperfusion injury","volume":"16","author":"Wang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"issue":"18","key":"10.1016\/j.jep.2024.118407_bib49","doi-asserted-by":"crossref","first-page":"9902","DOI":"10.3390\/ijms22189902","article-title":"Ferroptosis mechanisms involved in hippocampal-related diseases","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib50","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020810118","article-title":"Astrocyte-secreted il-33 mediates homeostatic synaptic plasticity in the adult hippocampus","volume":"118","author":"Wang","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"10.1016\/j.jep.2024.118407_bib51","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.3390\/ijms20246176","article-title":"Animal models of chronic cerebral hypoperfusion: from mouse to primate","volume":"20","author":"Washida","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.jep.2024.118407_bib52","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1161\/CIRCULATIONAHA.117.027448","article-title":"Cerebral perfusion and the risk of dementia: a population-based study","volume":"136","author":"Wolters","year":"2017","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib53","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40168-022-01255-6","article-title":"The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids","volume":"10","author":"Xiao","year":"2022","journal-title":"Microbiome"},{"issue":"10","key":"10.1016\/j.jep.2024.118407_bib54","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib55","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1080\/13880209.2022.2116460","article-title":"Tao-hong-si-Wu decoction improves depressive symptoms in model rats via amelioration of bdnf-creb-arginase i axis disorders","volume":"60","author":"Zhang","year":"2022","journal-title":"Pharm. Biol."},{"issue":"8","key":"10.1016\/j.jep.2024.118407_bib56","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.4103\/1673-5374.235251","article-title":"Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia","volume":"13","author":"Zhang","year":"2018","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib57","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-021-02250-8","article-title":"Nad+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ros production in chronic cerebral hypoperfusion models through sirt1\/pgc-1\u03b1 pathway","volume":"18","author":"Zhao","year":"2021","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.jep.2024.118407_bib58","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12974-022-02480-4","article-title":"Pentoxifylline alleviates ischemic white matter injury through up-regulating mertk-mediated myelin clearance","volume":"19","author":"Zheng","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2024.118407_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.602307","article-title":"Melatonin inhibits glucose-induced apoptosis in osteoblastic cell line through perk-eif2\u03b1-atf4 pathway","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124007062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124007062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T03:45:12Z","timestamp":1720755912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124007062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":59,"alternative-id":["S0378874124007062"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118407","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Taohong Siwu decoction alleviates cognitive impairment by suppressing endoplasmic reticulum stress and apoptosis signaling pathway in vascular dementia rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118407","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118407"}}