{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:34:26Z","timestamp":1791254066540,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jep.2024.118445","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:41:20Z","timestamp":1717677680000},"page":"118445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Regulating effect of Qifu Yin on intestinal microbiota in mice with memory impairment induced by scopolamine hydrobromide"],"prefix":"10.1016","volume":"333","author":[{"given":"Shiqi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6840-2878","authenticated-orcid":false,"given":"Fanying","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2024.118445_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4238\/gmr.15038804","article-title":"Effects and mechanism of cerebroprotein hydrolysate on learning and memory ability in mice","volume":"15","author":"An","year":"2016","journal-title":"Genet. Mol. Res."},{"issue":"2","key":"10.1016\/j.jep.2024.118445_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cognit. Process."},{"issue":"1","key":"10.1016\/j.jep.2024.118445_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/pri.21767","article-title":"Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia","volume":"7","author":"Berridge","year":"2013","journal-title":"Prion"},{"key":"10.1016\/j.jep.2024.118445_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109737","article-title":"Mitochondria, the gut microbiome and ROS","volume":"75","author":"Ballard","year":"2020","journal-title":"Cell. Signal."},{"issue":"3","key":"10.1016\/j.jep.2024.118445_bib5","first-page":"309","article-title":"Advances in the relationship between intestinal flora and its metabolites and neurodegenerative diseases","volume":"40","author":"Cai","year":"2023","journal-title":"Application Chemistry"},{"issue":"11","key":"10.1016\/j.jep.2024.118445_bib6","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1248\/bpb.b21-00381","article-title":"Astragaloside IV ameliorates cognitive impairment and neuroinflammation in an oligomeric abeta induced Alzheimer's disease mouse model via inhibition of microglial activation and NADPH oxidase expression","volume":"44","author":"Chen","year":"2021","journal-title":"Biol. Pharm. Bull."},{"issue":"9","key":"10.1016\/j.jep.2024.118445_bib7","first-page":"2066","article-title":"The effect of Qifu yin on cognitive impairment and neuropathological changes in vascular dementia rats","volume":"37","author":"Cheng","year":"2015","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"36","key":"10.1016\/j.jep.2024.118445_bib8","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1039\/D3AY00899A","article-title":"Serum lipidomics reveal the mechanism of memory disorder improvement by Qifu decoction","volume":"15","author":"Deng","year":"2023","journal-title":"Anal. Methods"},{"issue":"2","key":"10.1016\/j.jep.2024.118445_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3892\/mmr.2023.12934","article-title":"ASK1 inhibitor NQDI-1 decreases oxidative stress and neuroapoptosis via the ASK1\/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in rats","volume":"27","author":"Duan","year":"2023","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.jep.2024.118445_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer's disease: targeting the cholinergic system","volume":"14","author":"Ferreira-Vieira","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jep.2024.118445_bib11","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3748\/wjg.v22.i2.501","article-title":"Gut microbiota imbalance and colorectal cancer","volume":"22","author":"Gagni\u00e8re","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.jep.2024.118445_bib12","first-page":"595","article-title":"Effect of combined application of probiotics on intestinal flora and cognitive function in patients with Alzheimer's disease","volume":"35","author":"He","year":"2022","journal-title":"Heilongjiang Medicine"},{"issue":"1","key":"10.1016\/j.jep.2024.118445_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2167172","article-title":"Gut-derived beta-amyloid: likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis","volume":"15","author":"Jin","year":"2023","journal-title":"Gut Microb."},{"issue":"1","key":"10.1016\/j.jep.2024.118445_bib14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41556-023-01299-2","article-title":"Vitamin B produced by gut bacteria modulates cholinergic signalling","volume":"26","author":"Kang","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.jep.2024.118445_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41575-019-0250-7","article-title":"Regulation of intestinal lipid metabolism: current concepts and relevance to disease","volume":"17","author":"Ko","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.jep.2024.118445_bib16","first-page":"2438","article-title":"Research progress on newly discovered chemical constituents and pharmacological effects of Glycyrrhizae Radix et Rhizoma","volume":"52","author":"Li","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"5","key":"10.1016\/j.jep.2024.118445_bib17","first-page":"77","article-title":"Mechanism of Oifu Decoction on Alzheimer's disease based on network pharmacolog","volume":"34","author":"Li","year":"2020","journal-title":"Acad J Shanghai Univ Tradit Chin Med"},{"key":"10.1016\/j.jep.2024.118445_bib18","article-title":"Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: a reflection based on the literature and experience","volume":"210","author":"Lissner","year":"2021","journal-title":"PharmacolBiochemBehav"},{"issue":"1","key":"10.1016\/j.jep.2024.118445_bib19","first-page":"9","article-title":"Effect the AGEs\/RAGE NF-KB pathway in Alzheimer's disease model rats of Qifu Yin","volume":"31","author":"Liu","year":"2015","journal-title":"Pharmacol Clin Chin Mater Med"},{"key":"10.1016\/j.jep.2024.118445_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8340192","article-title":"Modified Huang-Lian-Jie-Du decoction ameliorates A\u03b2 synaptotoxicity in a murine model of Alzheimer's disease","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2024.118445_bib21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bbi.2019.05.008","article-title":"Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort","volume":"80","author":"Liu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jep.2024.118445_bib22","article-title":"Danggui - shaoyao-San attenuates cognitive impairment via the microbiota\u2013gut\u2013brain Axis with regulation of lipid metabolism in scopolamine-induced amnesia","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118445_bib23","first-page":"1","article-title":"Modified Kaixin San improves memory and synaptic damage of mice with Alzheimer's disease by modulating a CaMK \u2161-PSD95 protein binding throughinhibition of neuroinflammation, a study of mechanism","volume":"2022","author":"Lu","year":"2022","journal-title":"China J. Chin. Mater. Med."},{"issue":"11","key":"10.1016\/j.jep.2024.118445_bib24","first-page":"1485","article-title":"Role of calcium\/calmodulin-dependent protein kinase ll in synaptic plasticity and neuropsychiatric disorders","volume":"34","author":"Ma","year":"2018","journal-title":"Chin. Pharmacol. Bull."},{"key":"10.1016\/j.jep.2024.118445_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jad.2022.04.106","article-title":"3,3'-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice","volume":"309","author":"Madison","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/j.jep.2024.118445_bib26","first-page":"365","article-title":"Phosphorylation and regulation of glutamate receptors by CaMK II","volume":"66","author":"Mao","year":"2014","journal-title":"Acta Physiol. Sin."},{"key":"10.1016\/j.jep.2024.118445_bib57","series-title":"Pharmacopoeia of the People\u2019s Republic of China","first-page":"1088","year":"2020"},{"issue":"8","key":"10.1016\/j.jep.2024.118445_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.764","article-title":"Effects of haloperidol, olanzapine, ziprasidone, and PHA-543613 on spatial learning and memory in the Morris water maze test in na\u00efve and MK-801-treated mice","volume":"7","author":"Ning","year":"2017","journal-title":"Brain Behav"},{"issue":"1","key":"10.1016\/j.jep.2024.118445_bib28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbrc.2015.01.137","article-title":"Calcium and mitochondria in the regulation of cell death","volume":"460","author":"Orrenius","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2024.118445_bib29","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00253-012-4323-6","article-title":"Alterations of the gut microbiota in high-fat diet mice is strongly linked to oxidative stress","volume":"97","author":"Qiao","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"9","key":"10.1016\/j.jep.2024.118445_bib30","first-page":"5199","article-title":"Effects of Danggui Shaoyao San on cognitive dysfunction and the changes of O-GlcNAcylation of estrogen alpha receptor in STZ induced diabetic female mice","volume":"36","author":"Shi","year":"2021","journal-title":"China J Tradit Chin Med Pharm"},{"key":"10.1016\/j.jep.2024.118445_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9771743","article-title":"Sevoflurane improves hemorrhagic shock and resuscitation-induced cognitive impairments and mitochondrial dysfunctions through SIRT1-mediated autophagy","volume":"2022","author":"Shu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.jep.2024.118445_bib32","first-page":"142","article-title":"Research progress on Polygala saponins in the treatment of cognitive impairment after stroke","volume":"27","author":"Song","year":"2021","journal-title":"Guiding J Tradit Chin Med Pharm"},{"issue":"1","key":"10.1016\/j.jep.2024.118445_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut microbiome alterations in Alzheimer's disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jep.2024.118445_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/bph.14515","article-title":"Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms","volume":"176","author":"Wang","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118445_bib35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13046-018-0922-0","article-title":"Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts","volume":"37","author":"Wang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.jep.2024.118445_bib36","first-page":"161","article-title":"Clinical research on traditional Chinese medicine treatment of mild-to-moderate ANS dementia complex","volume":"29","author":"Wang","year":"2014","journal-title":"China J. Chin. Med"},{"issue":"3","key":"10.1016\/j.jep.2024.118445_bib37","first-page":"205","article-title":"Treatment of 33 cases of Alzheimer's disease of marrow sea and air deficiency type with pressing acupuncture and Qifu yin","volume":"53","author":"Wang","year":"2018","journal-title":"Zhejiang J Tradit Chin Med"},{"key":"10.1016\/j.jep.2024.118445_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2022.116651","article-title":"Integrated lipidomics and network pharmacology analysis of the protective effects and mechanism of Yuanzhi San on rats with cognitive impairment","volume":"58","author":"Wang","year":"2022","journal-title":"Bioorg. Med. Chem."},{"issue":"4","key":"10.1016\/j.jep.2024.118445_bib39","first-page":"1599","article-title":"Research progress on heat-sensitive moxibustion in treating nervous system diseases","volume":"34","author":"Wang","year":"2019","journal-title":"China J Tradit Chin Med Pharm"},{"issue":"14","key":"10.1016\/j.jep.2024.118445_bib40","first-page":"46","article-title":"Clinical study on modified Qifu yin for mild- to- moderate vascular dementia with Syndrome of kidney deficiency and marrow depletion","volume":"53","author":"Wang","year":"2021","journal-title":"New J Tradit Chin Med"},{"issue":"12","key":"10.1016\/j.jep.2024.118445_bib41","first-page":"1078","article-title":"Pharmacological effects of verbascoside: research advances","volume":"47","author":"Wang","year":"2020","journal-title":"J Int Pharm Res"},{"issue":"4","key":"10.1016\/j.jep.2024.118445_bib42","first-page":"94","article-title":"Comparison of the effects among ginsenoside Rg1, Rb1 and Rg1+Rb1 onscopolamine-induced cognitive impairment in mice","volume":"32","author":"Wei","year":"2022","journal-title":"Chin. J. Comp. Med."},{"issue":"11","key":"10.1016\/j.jep.2024.118445_bib43","first-page":"2129","article-title":"Clinical study on the effect of suanzaoren decoction on improving sleep and cognitive function in patients with Alzheimer's disease","volume":"16","author":"Wu","year":"2021","journal-title":"World J Integr Tradit West Med"},{"issue":"5","key":"10.1016\/j.jep.2024.118445_bib44","first-page":"539","article-title":"Advance in intestinal flora affecting central nervous system diseases","volume":"24","author":"Wu","year":"2018","journal-title":"Chin. J. Rehabil. Theory Pract."},{"issue":"4","key":"10.1016\/j.jep.2024.118445_bib45","first-page":"363","article-title":"Study of recognition memory impairment and structural damage induced by continuous microwave radiation","volume":"26","author":"Wu","year":"2021","journal-title":"Chin J Stereology Image Analysis"},{"issue":"11","key":"10.1016\/j.jep.2024.118445_bib46","first-page":"167","article-title":"Yuanzhi powder regulates phosphorylation of tau protein through Pl3K\/AKT\/GSK-3\u03b2 pathway in Alzheimer's disease model rats","volume":"38","author":"Xie","year":"2020","journal-title":"Chin Arch Tradit Chin Med"},{"issue":"12","key":"10.1016\/j.jep.2024.118445_bib47","first-page":"138","article-title":"Protective effect of Qifu yin on neuronal apoptosis in rats with Alzheimer's disease induced by beta-amyloid Hippocampus","volume":"16","author":"Xing","year":"2010","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"23","key":"10.1016\/j.jep.2024.118445_bib48","first-page":"2892","article-title":"Effect of electroacupuncture at shenting and baihui acupoints on superoxide dismutase activity and malondialdehyde content in the brain tissue in a rat model of learning and memory lmpairment induced by cerebral ischemia-reperfusion injury","volume":"25","author":"Yan","year":"2022","journal-title":"Chin Gen Pract"},{"key":"10.1016\/j.jep.2024.118445_bib49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.lfs.2018.04.027","article-title":"The orphan nuclear receptor NR4A1 attenuates oxidative stress-induced \u03b2 cells apoptosis via up-regulation of glutathione peroxidase 1","volume":"203","author":"Yang","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2024.118445_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaw3159","article-title":"Host mitochondria influence gut microbiome diversity: a role for ROS","volume":"12","author":"Yardeni","year":"2019","journal-title":"Sci. Signal."},{"issue":"28","key":"10.1016\/j.jep.2024.118445_bib51","first-page":"4487","article-title":"Effect of ginsenoside Rg1 on learning and memory ability of brain aging mice induced by D-galactose","volume":"27","author":"Yang","year":"2023","journal-title":"Chin J Tissue Eng Res"},{"issue":"3","key":"10.1016\/j.jep.2024.118445_bib52","first-page":"109","article-title":"Effect of BuyangHuanwutang on hippocampal apoptosis factors and learning and memory abilities in mice with Alzheimer's disease","volume":"24","author":"Yu","year":"2018","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"9","key":"10.1016\/j.jep.2024.118445_bib53","first-page":"2123","article-title":"Effect of Baihe Jizi Tang on learning and memory and hippocampal ultrastructure in chronic stress depression rats","volume":"32","author":"Yuan","year":"2021","journal-title":"Lishizhen Med Mater Med Res"},{"issue":"7","key":"10.1016\/j.jep.2024.118445_bib54","first-page":"26","article-title":"Effects of Atractylodesmacrocephala on learning, memory, and antioxidant capacity in D-galactose induced aging mice","volume":"49","author":"Zhai","year":"2021","journal-title":"Acta Chin Med Pharmacol"},{"issue":"4","key":"10.1016\/j.jep.2024.118445_bib55","first-page":"505","article-title":"Effect of Qifu yin on expressing of AChE, ChAT in hippocampus of AD rats induced by A\u03b21-42","volume":"31","author":"Zhang","year":"2010","journal-title":"J Qiqihar M\u00e9d University"},{"issue":"8","key":"10.1016\/j.jep.2024.118445_bib56","first-page":"532","article-title":"Involvement of cholinergic dysfunction and oxidative damage in the effects of simulated weightlessness on learning and memory in rats","volume":"2018","author":"Zhang","year":"2018","journal-title":"BioMed Res. Int."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412400744X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412400744X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T23:47:48Z","timestamp":1720741668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412400744X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":57,"alternative-id":["S037887412400744X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118445","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulating effect of Qifu Yin on intestinal microbiota in mice with memory impairment induced by scopolamine hydrobromide","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118445"}}