{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:00:38Z","timestamp":1787162438735,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872308"],"award-info":[{"award-number":["81872308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072719"],"award-info":[{"award-number":["82072719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["YNKT202203"],"award-info":[{"award-number":["YNKT202203"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012872"],"award-info":[{"award-number":["2023A1515012872"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010790"],"award-info":[{"award-number":["2021A1515010790"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A15150100790"],"award-info":[{"award-number":["2021A15150100790"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jep.2024.118467","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T02:39:41Z","timestamp":1718937581000},"page":"118467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Mechanistic insights into xanthomicrol as the active anti-HCC ingredient of Phytolacca acinosa Roxb.: A network pharmacology analysis and transcriptomics integrated experimental verification"],"prefix":"10.1016","volume":"333","author":[{"given":"Jiayao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pincheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jep.2024.118467_bib1","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/ptr.5179","article-title":"Antiangiogenic activity of xanthomicrol and calycopterin, two polymethoxylated hydroxyflavones in both in vitro and ex vivo models","volume":"28","author":"Abbaszadeh","year":"2014","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2024.118467_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155565","article-title":"Exploring the anti-skin inflammation substances and mechanism of Paeonia lactiflora Pall. flower via network pharmacology-HPLC integration","volume":"129","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118467_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111961","article-title":"Identification and characterization of potential antioxidant components in Isodon amethystoides (Benth.) Hara tea leaves by UPLC-LTQ-Orbitrap-MS","volume":"148","author":"Duan","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2024.118467_bib5","article-title":"The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR\/TLR4 pathways","author":"Duan","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"issue":"9","key":"10.1016\/j.jep.2024.118467_bib6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2174\/1389557514666140820122818","article-title":"Xanthomicrol: a comprehensive review of its chemistry, distribution, biosynthesis and pharmacological activity","volume":"14","author":"Fattahi","year":"2014","journal-title":"Mini Rev. Med. Chem."},{"issue":"6","key":"10.1016\/j.jep.2024.118467_bib7","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1053\/j.gastro.2023.08.052","article-title":"Traditional medicine pien tze Huang suppresses colorectal tumorigenesis through restoring gut microbiota and metabolites","volume":"165","author":"Gou","year":"2023","journal-title":"Gastroenterology"},{"issue":"14","key":"10.1016\/j.jep.2024.118467_bib8","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1055\/s-2007-990244","article-title":"Sonoran propolis: chemical composition and antiproliferative activity on cancer cell lines","volume":"73","author":"Hernandez","year":"2007","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.jep.2024.118467_bib9","first-page":"188","article-title":"Research progress on the chemical components and pharmacological effects of Phytolacca acinosa and the predictive analysis of its quality markers","volume":"47","author":"Huang","year":"2020","journal-title":"J. Int. Pharm. Res."},{"issue":"5","key":"10.1016\/j.jep.2024.118467_bib10","first-page":"434","article-title":"Research progress on the antitumor effects of traditional Chinese medicine Phytolacca","author":"Li","year":"2019","journal-title":"Southwest Mil. Med."},{"issue":"14","key":"10.1016\/j.jep.2024.118467_bib11","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1080\/14786419.2022.2042284","article-title":"Two new triterpene glycosides with antiproliferative activities on HepG2 from Phytolacca acinosa fruit fermentation broth","volume":"37","author":"Li","year":"2023","journal-title":"Nat. Prod. Res."},{"issue":"5","key":"10.1016\/j.jep.2024.118467_bib12","first-page":"323","article-title":"Network pharmacology approaches for research of Traditional Chinese Medicines","volume":"21","author":"Li","year":"2023","journal-title":"Chin. J. Nat. Med."},{"issue":"9","key":"10.1016\/j.jep.2024.118467_bib13","first-page":"2232","article-title":"Progress in the processing research of Phytolacca acinosa","volume":"44","author":"Lin","year":"2021","journal-title":"J. Chin. Med. Mater."},{"issue":"12","key":"10.1016\/j.jep.2024.118467_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201700361","article-title":"Novel flavones from the root of Phytolacca acinosa Roxb","volume":"14","author":"Ma","year":"2017","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2024.118467_bib16","first-page":"600","article-title":"Zhonghua zhong liu za zhi [Chinese journal of oncology]","volume":"44","year":"2022","journal-title":"Chin. J. Oncol."},{"key":"10.1016\/j.jep.2024.118467_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminf."},{"issue":"1","key":"10.1016\/j.jep.2024.118467_bib18","first-page":"17","article-title":"Cancer statistics, 2023. CA: a cancer","volume":"73","author":"Siegel","year":"2023","journal-title":"J. Clin."},{"key":"10.1016\/j.jep.2024.118467_bib19","article-title":"Traditional Chinese medicine and colorectal cancer: implications for drug discovery","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118467_bib20","first-page":"927","article-title":"The evolution of the properties and flavors of Phytolacca acinosa: a herbal textual research","volume":"4","author":"Wang","year":"2015","journal-title":"Shi Zhen Guo Yi Guo Yao"},{"issue":"3","key":"10.1016\/j.jep.2024.118467_bib21","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1021\/acsomega.2c07913","article-title":"Determination of the anti-oxidative stress mechanism of isodon suzhouensis leaves by employing bioinformatic and novel research Technology","volume":"8","author":"Wang","year":"2023","journal-title":"ACS Omega"},{"issue":"3","key":"10.1016\/j.jep.2024.118467_bib22","first-page":"479","article-title":"Integration strategy of network pharmacology in Traditional Chinese Medicine: a narrative review","volume":"42","author":"Wu","year":"2022","journal-title":"J. Tradit. Chin. Med."},{"issue":"10","key":"10.1016\/j.jep.2024.118467_bib23","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"12","key":"10.1016\/j.jep.2024.118467_bib24","article-title":"Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula","volume":"309","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124007669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124007669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T23:48:56Z","timestamp":1720741736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124007669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":22,"alternative-id":["S0378874124007669"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118467","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic insights into xanthomicrol as the active anti-HCC ingredient of Phytolacca acinosa Roxb.: A network pharmacology analysis and transcriptomics integrated experimental verification","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118467"}}